DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and TNKS

DIOPT Version :10

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_003738.2 Gene:TNKS / 8658 HGNCID:11941 Length:1327 Species:Homo sapiens


Alignment Length:1193 Identity:773/1193 - (64%)
Similarity:934/1193 - (78%) Gaps:66/1193 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 LRELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDE 88
            ||||.|||:.|::::||:|:....|||:|.|||||:|||||||:||::|||.||..||::.|.|:
Human   183 LRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247

  Fly    89 GGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRN 153
            |||.||||.|||||||||.|||..||.||..||||||||||||.|||:|||:.||||||:..|||
Human   248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRN 312

  Fly   154 SEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAA 218
            ::.|:.|:|||.:.:.||||||:|||||||||||.|::|:||||||||||||||||:||||||||
Human   313 TDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAA 377

  Fly   219 GYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEA 283
            ||||:.||::||.:|||||||||||||||||||||||::||:||::.||.|||.|||.|||||||
Human   378 GYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 442

  Fly   284 ASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKK 348
            |||:||||||||||.||||||:|||.|||:|.|||.|||||:.:|:|||.||.|.|:.|:::.||
Human   443 ASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKK 507

  Fly   349 LVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYD 413
            .:..||:||..|.:.:|.||.||.|...||||:.|||.|||:.:|||||.|:||||:|||..|.|
Human   508 TLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHND 572

  Fly   414 AMEVLLKQGAKVNALDSLGQTPLHRC--ARDEQAVRLLLSYAADTNIVSLEGLTAAQLASDSVLK 476
            .||||.|.|||:||||:||||.|||.  |...|..||||||.:|.:|:||:|.||||:.:::|.:
Human   573 VMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ 637

  Fly   477 LL-KNPP----DSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVV 536
            :| ::.|    |.:..||||:|||||:||:::..:.  :||||||:||||||||||||:|||.||
Human   638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ--NVNCRDLEGRHSTPLHFAAGYNRVSVV 700

  Fly   537 QFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDI 601
            ::||.|||:|:|.|||||||||||||||||||.||||:|||:|||:|||||||||||||||||:|
Human   701 EYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765

  Fly   602 CKLLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINC 666
            |||||||||||.||||||.||.|||||.|.|:.:||||.:|||||||||.|||||:|.|||:|||
Human   766 CKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINC 830

  Fly   667 RDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTV 731
            ||.||||||||||||||||.|.||||||:||||||||||||||||||:||||:||||||||:.|.
Human   831 RDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTC 895

  Fly   732 VNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLLQDAMATSL 796
            |||||||.||||||||||||||||:||||||||..|||||||||::||||||::.||.|||    
Human   896 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAM---- 956

  Fly   797 SQQALSASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVPLPLSS 861
            ..:||....:        |.||..:|...|.:|:.:.||          .||.|.::..||    
Human   957 PPEALPTCFK--------PQATVVSASLISPASTPSCLS----------AASSIDNLTGPL---- 999

  Fly   862 STRISPAQGAEANGAEGSSSDDLLPD--ADTITNVSGFLSSQQLHHLIELFEREQITLDILAEMG 924
               ...|.|..:|..:|::..:....  |....|:|.||.|..|.||.::||.||||||:||:||
Human  1000 ---AELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMG 1061

  Fly   925 HDDLKQVGVSAYGFRHKILKGIAQLRSTTGIGNN-------VNLCTLLVDLLPDDKEFVAVEEEM 982
            |::||::|::|||.|||::||:.:|..... |.|       ||..|:|:||.|:|||:.:|||||
Human  1062 HEELKEIGINAYGHRHKLIKGVERLLGGQQ-GTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEM 1125

  Fly   983 QATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQSNERMLFHGSPFIN 1047
            |:|||||||.|.|||.|.|||:||:|||.|:||.||:.||::|::|||....|||||||||||||
Human  1126 QSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFIN 1190

  Fly  1048 AIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSCYVCPRQLLLCRVA 1112
            ||:.:|||||||||||||||||||||:||||||||||||||.|||:|||:|||:|.||:|.|||.
Human  1191 AIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVT 1255

  Fly  1113 LGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLITYQIVKPDDSSSGT 1177
            |||||||:|.|||||||||||||:||||..||.:||||:|||||:||||||||||:||:      
Human  1256 LGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPE------ 1314

  Fly  1178 EDTRXWMPSVGSTPTTTSPALHQ 1200
                        .|:.|:.|..|
Human  1315 ------------APSQTATAAEQ 1325

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANKYR 9..330 CDD:440430 221/305 (72%)
ANK repeat 59..87 CDD:293786 17/27 (63%)
ANK repeat 89..120 CDD:293786 23/30 (77%)
ANK repeat 122..153 CDD:293786 23/30 (77%)
ANK repeat 212..240 CDD:293786 21/27 (78%)
ANK repeat 242..273 CDD:293786 23/30 (77%)
ANK repeat 275..306 CDD:293786 27/30 (90%)
ANKYR 334..623 CDD:440430 189/295 (64%)
ANK repeat 363..396 CDD:293786 18/32 (56%)
ANK repeat 398..429 CDD:293786 20/30 (67%)
ANK repeat 431..459 CDD:293786 16/29 (55%)
ANKYR 469..783 CDD:440430 243/318 (76%)
ANK repeat 483..515 CDD:293786 15/31 (48%)
ANK repeat 522..550 CDD:293786 20/27 (74%)
ANK repeat 552..583 CDD:293786 27/30 (90%)
ANK repeat 585..610 CDD:293786 23/24 (96%)
ANK repeat 638..668 CDD:293786 23/29 (79%)
ANK repeat 672..703 CDD:293786 27/30 (90%)
ANK repeat 705..736 CDD:293786 25/30 (83%)
ANK repeat 738..769 CDD:293786 26/30 (87%)
SAM_tankyrase1,2 887..952 CDD:188923 34/66 (52%)
tankyrase_like 948..1170 CDD:238718 162/228 (71%)
TNKSNP_003738.2 ANK 14. /evidence=ECO:0000255 683..712 22/28 (79%)
ANK repeat 686..714 CDD:293786 20/27 (74%)
ANK repeat 716..747 CDD:293786 27/30 (90%)
ANK 15. /evidence=ECO:0000255 716..745 25/28 (89%)
ANK repeat 749..780 CDD:293786 28/30 (93%)
ANK 16. /evidence=ECO:0000255 749..778 27/28 (96%)
ANK 17. /evidence=ECO:0000255 782..810 18/27 (67%)
Ank_4 806..857 CDD:372654 43/50 (86%)
ANK repeat 836..867 CDD:293786 27/30 (90%)
ANK 18. /evidence=ECO:0000255 836..865 25/28 (89%)
ANK repeat 869..900 CDD:293786 25/30 (83%)
ANK 19. /evidence=ECO:0000255 869..898 23/28 (82%)
ANK repeat 902..933 CDD:293786 26/30 (87%)
ANK 20. /evidence=ECO:0000255 902..931 25/28 (89%)
ANK 21. /evidence=ECO:0000255 935..964 18/32 (56%)
SAM_tankyrase1,2 1024..1089 CDD:188923 34/64 (53%)
tankyrase_like 1091..1313 CDD:238718 161/222 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..91
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..173
ANK 1. /evidence=ECO:0000255 181..209 12/25 (48%)
ANKYR 182..504 CDD:440430 229/320 (72%)
ANK 2. /evidence=ECO:0000255 215..244 19/28 (68%)
ANK repeat 218..246 CDD:293786 17/27 (63%)
ANK repeat 248..279 CDD:293786 23/30 (77%)
ANK 3. /evidence=ECO:0000255 248..277 22/28 (79%)
ANK repeat 281..312 CDD:293786 23/30 (77%)
ANK 4. /evidence=ECO:0000255 281..310 22/28 (79%)
ANKYR 288..628 CDD:440430 230/339 (68%)
ANK 5. /evidence=ECO:0000255 335..364 23/28 (82%)
ANK 6. /evidence=ECO:0000255 368..397 21/28 (75%)
ANK repeat 371..399 CDD:293786 21/27 (78%)
ANK repeat 401..432 CDD:293786 23/30 (77%)
ANK 7. /evidence=ECO:0000255 401..430 21/28 (75%)
ANK repeat 434..465 CDD:293786 27/30 (90%)
ANK 8. /evidence=ECO:0000255 434..463 25/28 (89%)
ANK 9. /evidence=ECO:0000255 521..553 16/31 (52%)
ANK repeat 523..555 CDD:293786 18/31 (58%)
ANK repeat 557..588 CDD:293786 20/30 (67%)
ANK 10. /evidence=ECO:0000255 557..586 18/28 (64%)
ANK repeat 590..619 CDD:293786 16/28 (57%)
ANK 11. /evidence=ECO:0000255 590..619 16/28 (57%)
ANK 12. /evidence=ECO:0000255 621..647 10/25 (40%)
ANKYR 632..953 CDD:440430 246/322 (76%)
ANK 13. /evidence=ECO:0000255 649..679 15/31 (48%)
Blue background indicates that the domain is not in the aligned region.

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