DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and TNKS

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_003738.2	Gene:	TNKS / 8658	HGNCID:	11941	Length:	1327	Species:	Homo sapiens

Alignment Length:	1193	Identity:	773/1193 - (64%)
Similarity:	934/1193 - (78%)	Gaps:	66/1193 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LRELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDE 88
            ||||.|||:.|::::||:|:....|||:|.|||||:|||||||:||::|||.||..||::.|.|:
Human   183 LRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247

  Fly    89 GGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRN 153
            |||.||||.|||||||||.|||..||.||..||||||||||||.|||:|||:.||||||:..|||
Human   248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRN 312

  Fly   154 SEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAA 218
            ::.|:.|:|||.:.:.||||||:|||||||||||.|::|:||||||||||||||||:||||||||
Human   313 TDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAA 377

  Fly   219 GYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEA 283
            ||||:.||::||.:|||||||||||||||||||||||::||:||::.||.|||.|||.|||||||
Human   378 GYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEA 442

  Fly   284 ASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKK 348
            |||:||||||||||.||||||:|||.|||:|.|||.|||||:.:|:|||.||.|.|:.|:::.||
Human   443 ASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKK 507

  Fly   349 LVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYD 413
            .:..||:||..|.:.:|.||.||.|...||||:.|||.|||:.:|||||.|:||||:|||..|.|
Human   508 TLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHND 572

  Fly   414 AMEVLLKQGAKVNALDSLGQTPLHRC--ARDEQAVRLLLSYAADTNIVSLEGLTAAQLASDSVLK 476
            .||||.|.|||:||||:||||.|||.  |...|..||||||.:|.:|:||:|.||||:.:::|.:
Human   573 VMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQ 637

  Fly   477 LL-KNPP----DSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVV 536
            :| ::.|    |.:..||||:|||||:||:::..:.  :||||||:||||||||||||:|||.||
Human   638 ILSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQ--NVNCRDLEGRHSTPLHFAAGYNRVSVV 700

  Fly   537 QFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDI 601
            ::||.|||:|:|.|||||||||||||||||||.||||:|||:|||:|||||||||||||||||:|
Human   701 EYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEI 765

  Fly   602 CKLLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINC 666
            |||||||||||.||||||.||.|||||.|.|:.:||||.:|||||||||.|||||:|.|||:|||
Human   766 CKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINC 830

  Fly   667 RDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTV 731
            ||.||||||||||||||||.|.||||||:||||||||||||||||||:||||:||||||||:.|.
Human   831 RDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTC 895

  Fly   732 VNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLLQDAMATSL 796
            |||||||.||||||||||||||||:||||||||..|||||||||::||||||::.||.|||
Human   896 VNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAM---- 956

  Fly   797 SQQALSASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVPLPLSS 861
            ..:||....:        |.||..:|...|.:|:.:.||          .||.|.::..||
Human   957 PPEALPTCFK--------PQATVVSASLISPASTPSCLS----------AASSIDNLTGPL---- 999

  Fly   862 STRISPAQGAEANGAEGSSSDDLLPD--ADTITNVSGFLSSQQLHHLIELFEREQITLDILAEMG 924
               ...|.|..:|..:|::..:....  |....|:|.||.|..|.||.::||.||||||:||:||
Human  1000 ---AELAVGGASNAGDGAAGTERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMG 1061

  Fly   925 HDDLKQVGVSAYGFRHKILKGIAQLRSTTGIGNN-------VNLCTLLVDLLPDDKEFVAVEEEM 982
            |::||::|::|||.|||::||:.:|..... |.|       ||..|:|:||.|:|||:.:|||||
Human  1062 HEELKEIGINAYGHRHKLIKGVERLLGGQQ-GTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEEM 1125

  Fly   983 QATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQSNERMLFHGSPFIN 1047
            |:|||||||.|.|||.|.|||:||:|||.|:||.||:.||::|::|||....|||||||||||||
Human  1126 QSTIREHRDGGNAGGIFNRYNVIRIQKVVNKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFIN 1190

  Fly  1048 AIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSCYVCPRQLLLCRVA 1112
            ||:.:|||||||||||||||||||||:||||||||||||||.|||:|||:|||:|.||:|.|||.
Human  1191 AIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRVT 1255

  Fly  1113 LGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLITYQIVKPDDSSSGT 1177
            |||||||:|.|||||||||||||:||||..||.:||||:|||||:||||||||||:||:
Human  1256 LGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLITYQIMKPE------ 1314

  Fly  1178 EDTRXWMPSVGSTPTTTSPALHQ 1200
                        .|:.|:.|..|
Human  1315 ------------APSQTATAAEQ 1325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	78/113 (69%)
		ANK repeat	59..87	CDD:293786	17/27 (63%)
		Ank_2	61..153	CDD:289560	65/91 (71%)
		ANK repeat	89..120	CDD:293786	23/30 (77%)
		ANK repeat	122..153	CDD:293786	23/30 (77%)
		ANK	202..316	CDD:238125	92/113 (81%)
		ANK repeat	212..240	CDD:293786	21/27 (78%)
		Ank_2	214..306	CDD:289560	74/91 (81%)
		ANK repeat	242..273	CDD:293786	23/30 (77%)
		ANK repeat	275..306	CDD:293786	27/30 (90%)
		ANK	361..478	CDD:238125	68/118 (58%)
		ANK repeat	363..396	CDD:293786	18/32 (56%)
		Ank_2	367..459	CDD:289560	58/93 (62%)
		ANK	393..573	CDD:238125	117/186 (63%)
		ANK repeat	398..429	CDD:293786	20/30 (67%)
		ANK repeat	431..459	CDD:293786	16/29 (55%)
		ANK repeat	483..515	CDD:293786	15/31 (48%)
		Ank_4	486..540	CDD:290365	34/53 (64%)
		ANK	512..637	CDD:238125	102/124 (82%)
		ANK repeat	522..550	CDD:293786	20/27 (74%)
		Ank_2	524..616	CDD:289560	77/91 (85%)
		ANK repeat	552..583	CDD:293786	27/30 (90%)
		ANK repeat	585..610	CDD:293786	23/24 (96%)
		ANK repeat	638..668	CDD:293786	23/29 (79%)
		Ank_4	641..693	CDD:290365	43/51 (84%)
		ANK	665..779	CDD:238125	98/113 (87%)
		ANK repeat	672..703	CDD:293786	27/30 (90%)
		Ank_2	677..769	CDD:289560	79/91 (87%)
		ANK repeat	705..736	CDD:293786	25/30 (83%)
		ANK repeat	738..769	CDD:293786	26/30 (87%)
		SAM_tankyrase1,2	887..952	CDD:188923	34/66 (52%)
		SAM	890..952	CDD:197735	33/61 (54%)
		tankyrase_like	948..1170	CDD:238718	162/228 (71%)
		PARP	961..1165	CDD:279038	153/203 (75%)
TNKS	NP_003738.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..91
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..173
		ANK 1. /evidence=ECO:0000255	181..209		12/25 (48%)
		ANK	208..322	CDD:238125	78/113 (69%)
		ANK 2. /evidence=ECO:0000255	215..244		19/28 (68%)
		ANK repeat	218..246	CDD:293786	17/27 (63%)
		Ank_2	220..312	CDD:289560	65/91 (71%)
		ANK repeat	248..279	CDD:293786	23/30 (77%)
		ANK 3. /evidence=ECO:0000255	248..277		22/28 (79%)
		ANK	276..455	CDD:238125	136/178 (76%)
		ANK repeat	281..312	CDD:293786	23/30 (77%)
		ANK 4. /evidence=ECO:0000255	281..310		22/28 (79%)
		ANK 5. /evidence=ECO:0000255	335..364		23/28 (82%)
		Ank_4	339..389	CDD:290365	40/49 (82%)
		ANK 6. /evidence=ECO:0000255	368..397		21/28 (75%)
		ANK repeat	371..399	CDD:293786	21/27 (78%)
		Ank_2	373..465	CDD:289560	74/91 (81%)
		ANK repeat	401..432	CDD:293786	23/30 (77%)
		ANK 7. /evidence=ECO:0000255	401..430		21/28 (75%)
		ANK repeat	434..465	CDD:293786	27/30 (90%)
		ANK 8. /evidence=ECO:0000255	434..463		25/28 (89%)
		ANK 9. /evidence=ECO:0000255	521..553		16/31 (52%)
		ANK	523..639	CDD:238125	68/115 (59%)
		ANK repeat	523..555	CDD:293786	18/31 (58%)
		Ank_2	526..619	CDD:289560	58/92 (63%)
		ANK repeat	557..588	CDD:293786	20/30 (67%)
		ANK 10. /evidence=ECO:0000255	557..586		18/28 (64%)
		ANK repeat	590..619	CDD:293786	16/28 (57%)
		ANK 11. /evidence=ECO:0000255	590..619		16/28 (57%)
		Ank_2	595..714	CDD:289560	65/120 (54%)
		ANK 12. /evidence=ECO:0000255	621..647		10/25 (40%)
		ANK 13. /evidence=ECO:0000255	649..679		15/31 (48%)
		ANK	676..801	CDD:238125	102/124 (82%)
		ANK 14. /evidence=ECO:0000255	683..712		22/28 (79%)
		ANK repeat	686..714	CDD:293786	20/27 (74%)
		Ank_2	688..780	CDD:289560	77/91 (85%)
		ANK repeat	716..747	CDD:293786	27/30 (90%)
		ANK 15. /evidence=ECO:0000255	716..745		25/28 (89%)
		ANK repeat	749..780	CDD:293786	28/30 (93%)
		ANK 16. /evidence=ECO:0000255	749..778		27/28 (96%)
		ANK 17. /evidence=ECO:0000255	782..810		18/27 (67%)
		Ank_4	803..857	CDD:290365	44/53 (83%)
		ANK	829..953	CDD:238125	105/123 (85%)
		ANK repeat	836..867	CDD:293786	27/30 (90%)
		ANK 18. /evidence=ECO:0000255	836..865		25/28 (89%)
		Ank_2	841..933	CDD:289560	79/91 (87%)
		ANK repeat	869..900	CDD:293786	25/30 (83%)
		ANK 19. /evidence=ECO:0000255	869..898		23/28 (82%)
		ANK repeat	902..933	CDD:293786	26/30 (87%)
		ANK 20. /evidence=ECO:0000255	902..931		25/28 (89%)
		ANK 21. /evidence=ECO:0000255	935..964		18/32 (56%)
		SAM_tankyrase1,2	1024..1089	CDD:188923	34/64 (53%)
		SAM	1030..1087	CDD:197735	32/56 (57%)
		tankyrase_like	1091..1313	CDD:238718	161/222 (73%)
		PARP	1105..1308	CDD:279038	153/202 (76%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146358
Domainoid	1	1.000	280	1.000	Domainoid score	I1687
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18405
Inparanoid	1	1.050	1525	1.000	Inparanoid score	I97
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47155
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004240
OrthoInspector	1	1.000	-	-		otm42257
orthoMCL	1	0.900	-	-		OOG6_105313
Panther	1	1.100	-	-	LDO	PTHR24180
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2498
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.760