DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and NAS6

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_011748.3 Gene:NAS6 / 853147 SGDID:S000003464 Length:228 Species:Saccharomyces cerevisiae


Alignment Length:271 Identity:81/271 - (29%)
Similarity:116/271 - (42%) Gaps:62/271 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   523 PLHFAAGFNRVPVVQFLLEHGAE-VYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDL-- 584
            |||.|...|....||.||..... :...|:.|.:|||.:.|:..:|:|..|:....|||:.|.  
Yeast     5 PLHQACMENEFFKVQELLHSKPSLLLQKDQDGRIPLHWSVSFQAHEITSFLLSKMENVNLDDYPD 69

  Fly   585 ---WKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDA 646
               |  ||.|.|.:.|..::.|.|...   |:|        .||.|                   
Yeast    70 DSGW--TPFHIACSVGNLEVVKSLYDR---PLK--------PDLNK------------------- 102

  Fly   647 AKKGNLARVQRLVTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLH 711
                        :|.:.:.|          ||||.|...||.:::|:||||.|..:||...||||
Yeast   103 ------------ITNQGVTC----------LHLAVGKKWFEVSQFLIENGASVRIKDKFNQIPLH 145

  Fly   712 NASSYGHLDIAALLI-KHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLL-AHGADAYMKNQEGQT 774
            .|:|.|.|.:..||. ..|:.||..||.|:|||..|..:|......||: .:||:..:.:.:|..
Yeast   146 RAASVGSLKLIELLCGLGKSAVNWQDKQGWTPLFHALAEGHGDAAVLLVEKYGAEYDLVDNKGAK 210

  Fly   775 PIELATADDVK 785
            ..::|..:.||
Yeast   211 AEDVALNEQVK 221

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125
ANK repeat 59..87 CDD:293786
Ank_2 61..153 CDD:289560
ANK repeat 89..120 CDD:293786
ANK repeat 122..153 CDD:293786
ANK 202..316 CDD:238125
ANK repeat 212..240 CDD:293786
Ank_2 214..306 CDD:289560
ANK repeat 242..273 CDD:293786
ANK repeat 275..306 CDD:293786
ANK 361..478 CDD:238125
ANK repeat 363..396 CDD:293786
Ank_2 367..459 CDD:289560
ANK 393..573 CDD:238125 17/50 (34%)
ANK repeat 398..429 CDD:293786
ANK repeat 431..459 CDD:293786
ANK repeat 483..515 CDD:293786
Ank_4 486..540 CDD:290365 7/16 (44%)
ANK 512..637 CDD:238125 35/119 (29%)
ANK repeat 522..550 CDD:293786 9/27 (33%)
Ank_2 524..616 CDD:289560 31/97 (32%)
ANK repeat 552..583 CDD:293786 11/30 (37%)
ANK repeat 585..610 CDD:293786 8/24 (33%)
ANK repeat 638..668 CDD:293786 2/29 (7%)
Ank_4 641..693 CDD:290365 9/51 (18%)
ANK 665..779 CDD:238125 42/115 (37%)
ANK repeat 672..703 CDD:293786 13/30 (43%)
Ank_2 677..769 CDD:289560 40/93 (43%)
ANK repeat 705..736 CDD:293786 13/31 (42%)
ANK repeat 738..769 CDD:293786 10/31 (32%)
SAM_tankyrase1,2 887..952 CDD:188923
SAM 890..952 CDD:197735
tankyrase_like 948..1170 CDD:238718
PARP 961..1165 CDD:279038
NAS6NP_011748.3 ANKYR 1..226 CDD:223738 81/271 (30%)
ANK repeat 1..33 CDD:293786 9/27 (33%)
ANK repeat 35..69 CDD:293786 12/33 (36%)
ANK repeat 71..104 CDD:293786 13/76 (17%)
ANK repeat 107..137 CDD:293786 14/39 (36%)
ANK repeat 139..171 CDD:293786 13/31 (42%)
ANK repeat 173..205 CDD:293786 10/31 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - oto100352
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24180
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1759
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.130

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