DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and KEG

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_196857.2	Gene:	KEG / 831197	AraportID:	AT5G13530	Length:	1625	Species:	Arabidopsis thaliana

Alignment Length:	548	Identity:	132/548 - (24%)
Similarity:	217/548 - (39%)	Gaps:	115/548 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SRSRAILSV-NLDAVMANDPLRELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYG 68
            |..|::|.. |.|...|      |..||:.|....|:.::.....|..........||.||...|
plant   498 SSVRSLLEAQNADGQSA------LHLACRRGSAELVEAILEYGEANVDIVDKDGDPPLVFALAAG 556

  Fly    69 RREVVEFLLNSGASIQACDEGGLHP--LHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAA 131
            ..:.|..|:..||::::....|..|  .|.|...|..:.:|.||.|||.||..|:...|.||.|.
plant   557 SPQCVHVLIKKGANVRSRLREGSGPSVAHVCSYHGQPDCMRELLVAGADPNAVDDEGETVLHRAV 621

  Fly   132 SKGKVDVCLALLQHGANH--TIRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLA 194
            :|...|..:.:|::|.:.  |:.|::..|||.:........:...:     :|.  |..|:...|
plant   622 AKKYTDCAIVILENGGSRSMTVSNAKCLTPLHMCVATWNVAVIKRW-----VEV--SSPEEISQA 679

  Fly   195 LLTPLNVN---CHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKD-KGGLVPLHNACSYGH 255
            :..|..|.   |.|:..|:.   |...|..   :|:||||.|||..|:| :.|...||.|....:
plant   680 INIPSPVGTALCMAASIRKD---HEKEGRE---LVQILLAAGADPTAQDAQHGRTALHTAAMANN 738

  Fly   256 FDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSA--IDAAPT 318
            .::.::::.||.|.|..::....|||.|.::......||||..|:|..:.:....:|  |.|...
plant   739 VELVRVILDAGVNANIRNVHNTIPLHMALARGANSCVSLLLESGSDCNIQDDEGDNAFHIAADAA 803

  Fly   319 RELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLME 383
            :.:||.:.:                                       |.:.:.|||.    .::
plant   804 KMIRENLDW---------------------------------------LIVMLRSPDA----AVD 825

  Fly   384 LLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVN-ALDSLGQ---------TPLH- 437
            :....|..:.:..:|      |..|.:..|.||.|||:|..:: .:..:|.         ||||
plant   826 VRNHSGKTVRDFLEA------LPREWISEDLMEALLKRGVHLSPTIYEVGDWVKFKRGITTPLHG 884

  Fly   438 -RCARDEQA--VRLLLSYAADTNIVSLEGLTAAQLASDSVLKLLKNPPDSETHLLEAA------- 492
             :.|:.:..  |:.:|. ..|..|....|  .|::.::.|:||:  |.|...|:...|
plant   885 WQGAKPKSVGFVQTILE-KEDMIIAFCSG--EARVLANEVVKLI--PLDRGQHVRLRADVKEPRF 944

  Fly   493 --KAGDLDTVRRIVLNNPISVNCRDLDG 518
              :....|:|..::        |.|.||
plant   945 GWRGQSRDSVGTVL--------CVDEDG 964

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	37/117 (32%)
		ANK repeat	59..87	CDD:293786	9/27 (33%)
		Ank_2	61..153	CDD:289560	31/95 (33%)
		ANK repeat	89..120	CDD:293786	13/32 (41%)
		ANK repeat	122..153	CDD:293786	9/32 (28%)
		ANK	202..316	CDD:238125	35/119 (29%)
		ANK repeat	212..240	CDD:293786	11/27 (41%)
		Ank_2	214..306	CDD:289560	30/92 (33%)
		ANK repeat	242..273	CDD:293786	8/30 (27%)
		ANK repeat	275..306	CDD:293786	10/30 (33%)
		ANK	361..478	CDD:238125	29/130 (22%)
		ANK repeat	363..396	CDD:293786	5/32 (16%)
		Ank_2	367..459	CDD:289560	24/105 (23%)
		ANK	393..573	CDD:238125	35/149 (23%)
		ANK repeat	398..429	CDD:293786	10/31 (32%)
		ANK repeat	431..459	CDD:293786	9/40 (23%)
		ANK repeat	483..515	CDD:293786	6/40 (15%)
		Ank_4	486..540	CDD:290365	8/42 (19%)
		ANK	512..637	CDD:238125	4/7 (57%)
		ANK repeat	522..550	CDD:293786
		Ank_2	524..616	CDD:289560
		ANK repeat	552..583	CDD:293786
		ANK repeat	585..610	CDD:293786
		ANK repeat	638..668	CDD:293786
		Ank_4	641..693	CDD:290365
		ANK	665..779	CDD:238125
		ANK repeat	672..703	CDD:293786
		Ank_2	677..769	CDD:289560
		ANK repeat	705..736	CDD:293786
		ANK repeat	738..769	CDD:293786
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
KEG	NP_196857.2	RING-HC_ScPSH1_like	9..56	CDD:319482
		RING-HC finger (C3HC4-type)	10..55	CDD:319482
		S_TKc	138..424	CDD:214567
		ANKYR	<427..571	CDD:223738	21/78 (27%)
		ANK repeat	472..508	CDD:293786	3/9 (33%)
		ANK repeat	510..542	CDD:293786	8/37 (22%)
		PHA03095	517..>857	CDD:222980	98/401 (24%)
		ANK repeat	544..575	CDD:293786	9/30 (30%)
		ANK repeat	577..610	CDD:293786	13/32 (41%)
		ANK repeat	688..722	CDD:293786	14/39 (36%)
		ANK repeat	725..756	CDD:293786	8/30 (27%)
		ANK repeat	758..789	CDD:293786	10/30 (33%)
		ANK repeat	791..828	CDD:293786	9/79 (11%)
		SH3_15	909..984	CDD:375773	15/68 (22%)
		SH3_15	1053..1110	CDD:375773
		SH3_15	1116..1166	CDD:375773
		SH3_15	1242..1363	CDD:375773
		SH3_15	1426..1488	CDD:375773
		SH3_15	1560..1617	CDD:375773
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000