DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and ank1b

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_021329092.1	Gene:	ank1b / 797662	ZFINID:	ZDB-GENE-091113-6	Length:	2091	Species:	Danio rerio

Alignment Length:	1295	Identity:	347/1295 - (26%)
Similarity:	525/1295 - (40%)	Gaps:	303/1295 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ANSSRSRAILSVNL-----------DAVMAN-DPLRELFEACKTGEIAKVKKLITPQTVNARDTA 54
            |.:|..||..|.||           |..:|| :.|..|..|.|.|.:..|.:|: ...::...|.
Zfish    78 ATTSFLRAARSGNLEKALDHIKNGIDINIANQNGLNGLHLASKEGHVKMVLELL-HNGIDLETTT 141

  Fly    55 GRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTT 119
            .:.:|.||.||..|:.:||..|:|.||::.|..:.|..||:......|.|||:.||:.||:.:..
Zfish   142 KKGNTALHIAALAGQEKVVAELINYGANVNAQSQKGFSPLYMAAQENHLEVVKYLLEHGANQSLP 206

  Fly   120 DNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEAA 184
            ....:|||..|..:|..:|...|:.:|..                        |:.|...|..||
Zfish   207 TEDGFTPLAVALQQGHENVVALLINYGTK------------------------GKVRLPALHIAA 247

  Fly   185 RSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHN 249
            |:. :.|..|:|...:.|.........||||:||.|..:.:.::||..||:|:...|.|:.|||.
Zfish   248 RND-DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLSVAQLLLNRGANVNFTPKNGITPLHI 311

  Fly   250 ACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAID 314
            |...|:..:.:||:..||.::|......||||.||....|.|..:||.:||.   |...:|:
Zfish   312 ASRRGNVIMVRLLLDRGAQIDAKTKDELTPLHCAARNGHVRVVEILLDQGAP---LQAKTKN--- 370

  Fly   315 AAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRK 379
                                                            |.:|:|:|.   .|...
Zfish   371 ------------------------------------------------GLSPIHMAA---QGDHM 384

  Fly   380 QLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLH-RCARDE 443
            ..:..|.:..:.:::.....|||||:||...|:..::|||.:|||.||....|.|||| .|.::.
Zfish   385 DCVRQLLQYNAEIDDITLDHLTPLHVAAHCGHHRMVKVLLDKGAKANARALNGFTPLHIACKKNH 449

  Fly   444 -QAVRLLLSYAADTNIVSLEGLTAAQLAS--------DSVLKLLKNPPDS----ETHLLEAAKAG 495
             :::.|||.::|....|:..|||...:|:        .|:|:...:|..|    ||.|..||:||
Zfish   450 MRSMDLLLKHSASLEAVTESGLTPLHVAAFMGHLNIVKSLLQRGASPNASNVKVETPLHMAARAG 514

  Fly   496 DLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNA 560
            ..: |.:.:|.|...|:.:..|.:  ||||.||......:|:.|:||.|...:|...|..|||.|
Zfish   515 HCE-VAQFLLQNNAQVDAKAKDDQ--TPLHCAARMGHKELVKLLMEHKANPDSATTAGHTPLHIA 576

  Fly   561 CSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPADL 625
            ...||.:.|.:|:...|.........|||||.|...||.|:.:|||:.||:|....::|.||..:
Zfish   577 AREGHAQTTRILLDENAQQTKMTKKGFTPLHVACKYGKVDVAELLLERGANPNAAGKNGLTPLHV 641

  Fly   626 -VKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNS-TPLHLAAGYNNFEC 688
             |..::.||.:||         ..||.        :|.|      ..||. |.||:||..|..|.
Zfish   642 AVHHNNLDVVKLL---------VSKGG--------SPHS------TARNGYTALHIAAKQNQLEV 683

  Fly   689 AEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQ 753
            |..||:.||:.|::...|:.|||.||..|..|:.||||..:..||..:|.|.||||..||:|...
Zfish   684 ASSLLQYGANANSESLQGITPLHLASQEGQPDMVALLISKQANVNLGNKNGLTPLHLVAQEGHVG 748

  Fly   754 LCSLLLAHGADAYMKNQEGQTPIELA----TADDVKCLLQDAMATSLSQQALSASTQSLTSSSPA 814
            :..:|:..||..|..::.|.||:.:|    ....||.|||        ||   |...|.|.....
Zfish   749 IADMLVKQGASVYAASRMGYTPLHVACHYGNIKMVKFLLQ--------QQ---AHVNSKTRLGYT 802

  Fly   815 PDATAAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVPLPLSSSTR-ISPAQGAEANGAEG 878
            |...||....|.           ..|:||..||         ||...:|. .||...|:..|.
Zfish   803 PLHQAAQQGHTD-----------IVTLLLKHGA---------LPNEITTNGTSPLGIAKRLGY-- 845

  Fly   879 SSSDDLLPDADTITNVSGFLSSQQLHHLIELFEREQITLDILAEMGHDDLKQVGVSAYGFRHKIL 943
            .|..|:|   ..:|..|..:.:.:.|.:  .|..   |:|.:.::..|:
Zfish   846 ISVIDVL---KLVTEESVSMITTEKHRM--SFPE---TVDEILDVSEDE---------------- 886

  Fly   944 KGIAQLRSTTG---IGNNVNLCTLLVDLLPDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNII 1005
             |:|||  |.|   :|.:......|.||...|.:|::.::    |:|:..........|:|.::.
Zfish   887 -GVAQL--TLGDELLGMDGARYLKLDDLKDQDDDFLSPKK----TLRDFESGMGTTNQFSRISVC 944

  Fly  1006 RVQKVQNRKLWERYAHRRQEIAEENFLQSNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIY 1070
            .:..|                                 |::.       ||    :.||.||
Zfish   945 DIYFV---------------------------------PYVG-------DE----LLGMDGA--- 962

  Fly  1071 FAEHSSKSNQYVYGIGGGIGCPSHKDK-SCYVCPRQLLL-CRVALGKSFLQYSAMKMAHAPPGHH 1133
                     :|       :.....||: ..::.|::.|. ....:|.: :.:|:......|
Zfish   963 ---------RY-------LKLDDLKDQDDDFLSPKKTLRDFESGMGTT-MSFSSFLFLFLP---- 1006

  Fly  1134 SVVGRPSAGGLHFAEYVVYRGEQ----SYPEYLITYQIVKPDDSSSGTEDT-RXWMPSVGSTPTT 1193
              |.|.|...::|..||   |::    ....||....:...||.....:.| |.:...:|:||
Zfish  1007 --VSRISVCDIYFVPYV---GDELLGMDGARYLKLDDLKDQDDDFLSPKKTLRDFESGMGTTP-- 1064

  Fly  1194 TSPALHQ-----PQTQQQPQQQQQQQPQPQQQQKAPLPLPPPQQQTS---APVAKRRPKH 1245
            .|||:.:     |:|..  ..|....|.|::..:..|....|..:||   :|||.  |.|
Zfish  1065 YSPAIPRIPCVSPETVM--LDQHTPVPLPKEYDEDSLIPSSPATETSDNVSPVAS--PIH 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	33/113 (29%)
		ANK repeat	59..87	CDD:293786	13/27 (48%)
		Ank_2	61..153	CDD:289560	31/91 (34%)
		ANK repeat	89..120	CDD:293786	11/30 (37%)
		ANK repeat	122..153	CDD:293786	8/30 (27%)
		ANK	202..316	CDD:238125	39/113 (35%)
		ANK repeat	212..240	CDD:293786	12/27 (44%)
		Ank_2	214..306	CDD:289560	34/91 (37%)
		ANK repeat	242..273	CDD:293786	11/30 (37%)
		ANK repeat	275..306	CDD:293786	12/30 (40%)
		ANK	361..478	CDD:238125	39/126 (31%)
		ANK repeat	363..396	CDD:293786	6/32 (19%)
		Ank_2	367..459	CDD:289560	30/93 (32%)
		ANK	393..573	CDD:238125	67/193 (35%)
		ANK repeat	398..429	CDD:293786	16/30 (53%)
		ANK repeat	431..459	CDD:293786	10/29 (34%)
		ANK repeat	483..515	CDD:293786	12/35 (34%)
		Ank_4	486..540	CDD:290365	18/53 (34%)
		ANK	512..637	CDD:238125	44/125 (35%)
		ANK repeat	522..550	CDD:293786	11/27 (41%)
		Ank_2	524..616	CDD:289560	35/91 (38%)
		ANK repeat	552..583	CDD:293786	10/30 (33%)
		ANK repeat	585..610	CDD:293786	12/24 (50%)
		ANK repeat	638..668	CDD:293786	4/29 (14%)
		Ank_4	641..693	CDD:290365	14/52 (27%)
		ANK	665..779	CDD:238125	45/114 (39%)
		ANK repeat	672..703	CDD:293786	15/31 (48%)
		Ank_2	677..769	CDD:289560	39/91 (43%)
		ANK repeat	705..736	CDD:293786	14/30 (47%)
		ANK repeat	738..769	CDD:293786	12/30 (40%)
		SAM_tankyrase1,2	887..952	CDD:188923	11/64 (17%)
		SAM	890..952	CDD:197735	11/61 (18%)
		tankyrase_like	948..1170	CDD:238718	39/230 (17%)
		PARP	961..1165	CDD:279038	34/209 (16%)
ank1b	XP_021329092.1	ANK repeat	80..108	CDD:293786	7/27 (26%)
		ANK	105..230	CDD:238125	40/125 (32%)
		ANK repeat	110..141	CDD:293786	7/31 (23%)
		ANK repeat	144..174	CDD:293786	13/29 (45%)
		ANK repeat	176..207	CDD:293786	11/30 (37%)
		ANK repeat	209..233	CDD:293786	7/23 (30%)
		ANK repeat	242..269	CDD:293786	8/27 (30%)
		ANK	266..391	CDD:238125	43/181 (24%)
		ANK repeat	272..302	CDD:293786	12/29 (41%)
		ANK repeat	304..335	CDD:293786	11/30 (37%)
		ANK repeat	337..367	CDD:293786	13/32 (41%)
		ANK repeat	370..401	CDD:293786	6/84 (7%)
		Ank_4	371..424	CDD:316185	15/55 (27%)
		ANK repeat	403..433	CDD:293786	15/29 (52%)
		ANK	431..556	CDD:238125	40/127 (31%)
		ANK repeat	436..467	CDD:293786	10/30 (33%)
		ANK repeat	469..500	CDD:293786	7/30 (23%)
		ANK repeat	502..533	CDD:293786	11/31 (35%)
		ANK	530..655	CDD:238125	46/135 (34%)
		ANK repeat	535..563	CDD:293786	12/29 (41%)
		ANK repeat	569..599	CDD:293786	10/29 (34%)
		ANK	600..721	CDD:238125	52/143 (36%)
		ANK repeat	601..632	CDD:293786	15/30 (50%)
		ANK repeat	634..662	CDD:293786	10/44 (23%)
		ANK repeat	667..695	CDD:293786	13/27 (48%)
		ANK	695..820	CDD:238125	47/146 (32%)
		ANK repeat	700..731	CDD:293786	14/30 (47%)
		ANK repeat	733..764	CDD:293786	12/30 (40%)
		ANK repeat	766..797	CDD:293786	13/41 (32%)
		ANK repeat	799..827	CDD:293786	10/47 (21%)
		Ank_4	800..852	CDD:316185	18/73 (25%)
		ZU5	1121..1225	CDD:128514	347/1295 (27%)
		Death_ank1	1614..1697	CDD:260067
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820