DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and ANKRD55

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_016865341.1	Gene:	ANKRD55 / 79722	HGNCID:	25681	Length:	623	Species:	Homo sapiens

Alignment Length:	802	Identity:	158/802 - (19%)
Similarity:	253/802 - (31%)	Gaps:	249/802 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   486 THLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAAD 550
            |.:.:||..||::.:..::..:|..:.|                                   .|
Human    29 TMVYQAASNGDVNALTAVIREDPSILEC-----------------------------------CD 58

  Fly   551 KGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKK 615
            ..|..||.:|.|....:..:||:|.|||:|:.|.:..|.|..|...|..:.|..||::||
Human    59 SEGCTPLMHAVSGRQADTVKLLLKMGANINMQDAYGRTSLCLATYLGWLEGCVSLLRNGA----- 118

  Fly   616 NRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNSTPLHLA 680
                          .|::.:            |.|.|                       |||.|
Human   119 --------------KHNIPD------------KNGRL-----------------------PLHAA 134

  Fly   681 AGYNNFECAEYLLE--NGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPL 743
            ....:......||:  |.:::|.||..|:.|||.|:.:.......:|:|........||...|.|
Human   135 TAEPDMRLLTVLLQQSNISEINHQDNEGMTPLHWAAFHNQPQHTQMLLKKGADPTLVDKDFKTAL 199

  Fly   744 HEAAQKGRTQLCSLLLAHGADAYMKN---QEGQTPIELATADDVKCLLQD-AMATSLSQQALSAS 804
            |.|.|.|...|||::|:|.....:.|   :.|:|.:.:|.|.....::.: |.....:.|||...
Human   200 HWAVQSGNRILCSIILSHHQGPSIINYDDESGKTCVHIAAAAGFSDIIHELARVPECNLQALDVD 264

  Fly   805 TQSLTSSSPAPD---ATAAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVPLPLSSST-RI 865
            ...|..:...|.   .|.....|..:.||.......|.|    .|.|| .:.|.|:|.::.| |:
Human   265 DSFLLCALFVPKGHLCTGLQLQGRPNVSSHCWSWEWTAT----CGTSM-RARPWPMPCTAVTRRV 324

  Fly   866 SPAQGAEANGAEGSSSDDLLPDADTITNVSGFLSSQQLHHLIELF---EREQITLDILAEMGHDD 927
            |.:....|.......|....|..          ..::.:.|.::|   ::|:       :..|
Human   325 SNSSPKRAEPTRPPPSQSSRPQK----------KERRFNVLNQIFCKNKKEE-------QRAH-- 370

  Fly   928 LKQVGVSAYGFRHKILKGIAQLRST--TGIGNNVNLCTLLVDLLPDDKEFVAVEEEMQATIREHR 990
              |...|...:|.:....:..:.:|  :.:|.|   |    ...|.|:  ||:.|..:.|    .
Human   371 --QKDPSRDRYREEDTSEVNDIITTFDSIVGTN---C----QEQPGDQ--VAMVEFKKKT----S 420

  Fly   991 DNGQAGGYFTRYNI-------------IRVQKVQNRKLWERYAHRRQEIAEENFLQSNERMLFHG 1042
            ||       ::|.:             ||.|.:....|            ..|||.::.|...|
Human   421 DN-------SKYLLPEKKPLARKGLPPIRTQSLPPITL------------GNNFLTASHRATSH- 465

  Fly  1043 SPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSCYVCPRQLL 1107
                               .|:..|..:.|:.|.||......:....||....|........|:.
Human   466 -------------------AGLSSAPHHMAQRSQKSRSEQDLLNNRTGCQMLLDNPWKSDSNQVF 511

  Fly  1108 ---LCRVALGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLITYQIVK 1169
               :..|:.....|.    ::....|||..|...|....||
Human   512 SYKVWTVSSSDKLLD----RLLSVRPGHQEVSVPPHLRHLH------------------------ 548

  Fly  1170 PDDSSSGTEDTRXWMPSVGSTPTTTSPALHQPQTQQQPQQQQQQQPQPQQQQKAPLPLPP----- 1229
                          .||.|......||..|  :.:..|..:....|.|.|:..:..||..
Human   549 --------------NPSSGQNFQHLSPNRH--KIRDLPFTRNNLAPLPDQKFLSGEPLRTNRVLP 597

  Fly  1230 --PQQQTSAPVAKRRPKHAKPS 1249
              |.|:..:..|:.....|.|:
Human   598 AIPSQRRHSTAAEESEHSANPT 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125
		ANK repeat	59..87	CDD:293786
		Ank_2	61..153	CDD:289560
		ANK repeat	89..120	CDD:293786
		ANK repeat	122..153	CDD:293786
		ANK	202..316	CDD:238125
		ANK repeat	212..240	CDD:293786
		Ank_2	214..306	CDD:289560
		ANK repeat	242..273	CDD:293786
		ANK repeat	275..306	CDD:293786
		ANK	361..478	CDD:238125
		ANK repeat	363..396	CDD:293786
		Ank_2	367..459	CDD:289560
		ANK	393..573	CDD:238125	14/86 (16%)
		ANK repeat	398..429	CDD:293786
		ANK repeat	431..459	CDD:293786
		ANK repeat	483..515	CDD:293786	7/28 (25%)
		Ank_4	486..540	CDD:290365	7/53 (13%)
		ANK	512..637	CDD:238125	25/124 (20%)
		ANK repeat	522..550	CDD:293786	0/27 (0%)
		Ank_2	524..616	CDD:289560	23/91 (25%)
		ANK repeat	552..583	CDD:293786	12/30 (40%)
		ANK repeat	585..610	CDD:293786	7/24 (29%)
		ANK repeat	638..668	CDD:293786	3/29 (10%)
		Ank_4	641..693	CDD:290365	7/51 (14%)
		ANK	665..779	CDD:238125	33/118 (28%)
		ANK repeat	672..703	CDD:293786	8/32 (25%)
		Ank_2	677..769	CDD:289560	29/93 (31%)
		ANK repeat	705..736	CDD:293786	7/30 (23%)
		ANK repeat	738..769	CDD:293786	11/30 (37%)
		SAM_tankyrase1,2	887..952	CDD:188923	7/67 (10%)
		SAM	890..952	CDD:197735	7/64 (11%)
		tankyrase_like	948..1170	CDD:238718	41/239 (17%)
		PARP	961..1165	CDD:279038	38/219 (17%)
ANKRD55	XP_016865341.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010