DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnks and ankrd55

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_012821580.1	Gene:	ankrd55 / 780326	XenbaseID:	XB-GENE-1013726	Length:	649	Species:	Xenopus tropicalis

Alignment Length:	727	Identity:	159/727 - (21%)
Similarity:	256/727 - (35%)	Gaps:	214/727 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   240 DKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTL 304
            |..|..||.:|.|....|..|||::.|||:|..|....|.|..|.....:|.|..||..||...:
Frog    51 DNEGCTPLMHAVSGRQVDTVKLLLKMGANINTQDACGRTSLSVATYLGWLEGCVSLLRNGAKQNI 115

  Fly   305 LNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHL 369
                        |.:                                          .|..|||.
Frog   116 ------------PDK------------------------------------------NGRLPLHA 126

  Fly   370 AVVSPDGKRKQLMELLTRKGSL--LNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLG 432
            |...||.:   |:.:|.::.:|  :|.::...:|.||.||........:.||::||....:|...
Frog   127 ATAEPDAR---LLAVLLQQSTLSEINHQDNEGMTSLHWAAFHNRPQHAQALLQKGADPTLVDKDF 188

  Fly   433 QTPLHRCARDEQAVRLLLSYAADTNIVSLEGLTAAQLASDSVLKLLKNPPDSETHLLEAAKAGDL 497
            :||||...  :...|:|.|...|..    :|.:......:          :.:|.:..||.||..
Frog   189 KTPLHWAV--QSGNRILCSIILDNQ----QGQSTINYDDE----------NGKTCMHIAAAAGYG 237

  Fly   498 DTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACS 562
            |.:..:......::...|:|.|  ||||:||...:...||.||:.|.::...|.....||..|..
Frog   238 DIICELARVPECNLQALDVDDR--TPLHWAAAAGKPECVQTLLKLGVDMNPRDINENTPLTYAMY 300

  Fly   563 YGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAK-----GKYDICKLLLK----------HGADP 612
            .||....:||    :..|.||  .|.|......|     |:..:...:..          |..|.
Frog   301 CGHTACIKLL----SQENRSD--PFQPFASPGTKAMRKEGRLTVLNQIFSCKKKKVDQKAHQKDK 359

  Fly   613 MKKNRDGATPADLV------------KESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPES-I 664
            ::.:|:..:..|.:            |:...:....|.|         |..:|..|:.:.|:| .
Frog   360 LRYHREETSEVDDIITTFDCILDTNCKDPPDERLNSLNG---------KKRVAESQKYLLPDSKE 415

  Fly   665 NCR---DAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHL------- 719
            ||:   ..:.::..|:.|  |:.      :|..|  .|.::|     |.:||..:.|.
Frog   416 NCKGLPPIRTQSLPPITL--GHT------FLTSN--SVISKD-----PQNNAFHFAHRSQKSKSE 465

  Fly   720 -DIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGA-----------DAYMKN--- 769
             |:....|..||:.:       .|.:.||.:        :|:|.|           ..:.||
Frog   466 HDLFDNRISCKTLKD-------NPWNIAANQ--------ILSHKAWTSPHPDNPKDHVFSKNTTR 515

  Fly   770 QEGQTPIELATADD----VKCLLQDAMATSLSQQALSASTQSLTSSS--PAPD--------ATAA 820
            .|||.|.::.:.::    :||    ..:..:||:........||.:|  |.||        ....
Frog   516 MEGQLPPQVPSMENTFSGIKC----HHSKQMSQEKPRIKEFCLTRNSLAPIPDHCVKKIQLPPGQ 576

  Fly   821 AAPGTSSSSSSAILSPTTETVLLPTGASMILS----------VPV----PLPLSSSTRISPAQGA 871
            ...|...|.|..:.|..|...|.|    :|:|          :||    ||   .:||:.||..:
Frog   577 VCQGVKKSMSLPLNSLRTGNNLSP----LIISKTQSHSLYSFLPVLRREPL---RTTRVLPAIPS 634

  Fly   872 EANGAEGSSSDD 883
            :...:...::.|
Frog   635 QKGQSTTENNSD 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125
		ANK repeat	59..87	CDD:293786
		Ank_2	61..153	CDD:289560
		ANK repeat	89..120	CDD:293786
		ANK repeat	122..153	CDD:293786
		ANK	202..316	CDD:238125	24/75 (32%)
		ANK repeat	212..240	CDD:293786	159/727 (22%)
		Ank_2	214..306	CDD:289560	24/65 (37%)
		ANK repeat	242..273	CDD:293786	13/30 (43%)
		ANK repeat	275..306	CDD:293786	9/30 (30%)
		ANK	361..478	CDD:238125	30/118 (25%)
		ANK repeat	363..396	CDD:293786	11/34 (32%)
		Ank_2	367..459	CDD:289560	27/93 (29%)
		ANK	393..573	CDD:238125	47/179 (26%)
		ANK repeat	398..429	CDD:293786	9/30 (30%)
		ANK repeat	431..459	CDD:293786	8/27 (30%)
		ANK repeat	483..515	CDD:293786	6/31 (19%)
		Ank_4	486..540	CDD:290365	17/53 (32%)
		ANK	512..637	CDD:238125	34/151 (23%)
		ANK repeat	522..550	CDD:293786	11/27 (41%)
		Ank_2	524..616	CDD:289560	26/106 (25%)
		ANK repeat	552..583	CDD:293786	8/30 (27%)
		ANK repeat	585..610	CDD:293786	5/39 (13%)
		ANK repeat	638..668	CDD:293786	8/33 (24%)
		Ank_4	641..693	CDD:290365	10/55 (18%)
		ANK	665..779	CDD:238125	29/138 (21%)
		ANK repeat	672..703	CDD:293786	6/30 (20%)
		Ank_2	677..769	CDD:289560	20/110 (18%)
		ANK repeat	705..736	CDD:293786	8/38 (21%)
		ANK repeat	738..769	CDD:293786	6/41 (15%)
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
ankrd55	XP_012821580.1	Ank_2	25..117	CDD:289560	24/77 (31%)
		ANK	49..208	CDD:238125	53/215 (25%)
		ANK repeat	53..84	CDD:293786	13/30 (43%)
		ANK repeat	86..117	CDD:293786	9/42 (21%)
		Ank_2	91..185	CDD:289560	29/150 (19%)
		ANK repeat	124..152	CDD:293786	9/30 (30%)
		ANK	149..310	CDD:238125	46/178 (26%)
		ANK repeat	154..185	CDD:293786	9/30 (30%)
		ANK repeat	187..255	CDD:293786	15/83 (18%)
		Ank_2	192..288	CDD:289560	27/113 (24%)
		ANK repeat	223..248	CDD:293786	6/24 (25%)
		ANK repeat	257..288	CDD:293786	13/32 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010