DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tnks and Tnks2

DIOPT Version :10

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_001157107.1 Gene:Tnks2 / 74493 MGIID:1921743 Length:1166 Species:Mus musculus


Alignment Length:1193 Identity:765/1193 - (64%)
Similarity:936/1193 - (78%) Gaps:63/1193 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 AILSVNLDAVMANDP-LRELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYGRREV 72
            |..|...:||   :| .|||||||:.|::.:||:|:||:.||:||||||||||||||||:||::|
Mouse    12 ACASAGAEAV---EPSARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDV 73

  Fly    73 VEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGKVD 137
            ||:||.:||::||.|:|||.||||.|||||||||.|||:.||.||..||||||||||||.|||:|
Mouse    74 VEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLQHGADPNARDNWNYTPLHEAAIKGKID 138

  Fly   138 VCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVN 202
            ||:.||||||..||||::.:|.|:|||.:.:.||||:|:||||||:||||.|::::|||||||||
Mouse   139 VCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGDYKKDELLESARSGNEEKMMALLTPLNVN 203

  Fly   203 CHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGA 267
            |||||||:||||||||||||:.||::||.:||||||||||.||||||||||||::||:||::.||
Mouse   204 CHASDGRKSTPLHLAAGYNRVKIVQLLLHHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGA 268

  Fly   268 NVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGH 332
            .|||.|||.||||||||||:|:||||||||.||||||||||:|||||.|||.:|:||:::|:|||
Mouse   269 CVNAMDLWQFTPLHEAASKNRIEVCSLLLSYGADPTLLNCHNKSAIDLAPTAQLKERLSYEFKGH 333

  Fly   333 CLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNK 397
            .||.|.|:.||:|.||.:..|:|||.||.|.:|.||.|..||..||||:.|||.|||:..|||.|
Mouse   334 SLLQAAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANTNEKTK 398

  Fly   398 AFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLHRCAR--DEQAVRLLLSYAADTNIVS 460
            .||||||:|:|..|.|.:||::|..||||||||||||.|||.|.  ..|..||||||..|.||:|
Mouse   399 EFLTPLHVASENAHNDVVEVVVKHEAKVNALDSLGQTSLHRAAHCGHLQTCRLLLSYGCDPNIIS 463

  Fly   461 LEGLTAAQLASDSVLKLLK-----NPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRH 520
            |:|.||.|:.:::|.:||:     ...:::..|||||||||::||:::....  ||||||::||.
Mouse   464 LQGFTALQMGNENVQQLLQEGASLGHSEADRQLLEAAKAGDVETVKKLCTVQ--SVNCRDIEGRQ 526

  Fly   521 STPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLW 585
            |||||||||:|||.||::||:|||:|:|.|||||||||||||||||||.||||||||.|||:|||
Mouse   527 STPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLW 591

  Fly   586 KFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKG 650
            ||||||||||||||:||||||:|||||.||||||.||.||||:.|.|:.:||||.:|||||||||
Mouse   592 KFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKG 656

  Fly   651 NLARVQRLVTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASS 715
            .||||::|.:|:::||||.|||:||||||||||||.|.|||||::||||||||||||||||||:|
Mouse   657 CLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAAS 721

  Fly   716 YGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELAT 780
            |||:|:||||||:...|||||||.||||||||||||||||:||||||||..:||||||||::|.:
Mouse   722 YGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVS 786

  Fly   781 ADDVKCLLQDAM-----ATSLSQQALS------ASTQSLTSSSPAPDATAAAAPGTSSSSSSAIL 834
            ||||..||..||     .|....|.||      |:..:|:|...:|.:.:||:...:.|.|.:.|
Mouse   787 ADDVSALLTAAMPPSALPTCYKPQVLSGVRGPGATADALSSGPSSPSSLSAASSLDNLSGSFSEL 851

  Fly   835 SPTTETVLLPTGASMILSVPVPLPLSSSTRISPAQGAEANGAEGSSSDDLLPDADTITNVSGFLS 899
            |..                     :|||            .|||::......|:....:::.|:.
Mouse   852 SAV---------------------VSSS------------AAEGATGLQRKEDSGIDFSITQFIR 883

  Fly   900 SQQLHHLIELFEREQITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRS-TTGIG-----NN 958
            :..|.||:::|||||||||:|.||||.:||::|::|||.|||::||:.:|.| ..|:.     ||
Mouse   884 NLGLEHLMDIFEREQITLDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNN 948

  Fly   959 VNLCTLLVDLLPDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRR 1023
            ....|:|:||.||||||.:||||||:|:|||||.|.|||.|.||||:::|||.|:||||||.|||
Mouse   949 SGSGTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGVFNRYNILKIQKVCNKKLWERYTHRR 1013

  Fly  1024 QEIAEENFLQSNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGG 1088
            :|::|||...:|||||||||||:|||:.:|||||||||||||||||||||:||||||||||||||
Mouse  1014 KEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGG 1078

  Fly  1089 IGCPSHKDKSCYVCPRQLLLCRVALGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYR 1153
            .|||.|||:|||:|.||||.|||.|||||||:|||||||:|||||||.||||..||..||||:||
Mouse  1079 TGCPIHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYR 1143

  Fly  1154 GEQSYPEYLITYQIVKPDDSSSG 1176
            |||:|||||||||||:|:....|
Mouse  1144 GEQAYPEYLITYQIVRPEGMVDG 1166

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANKYR 9..330 CDD:440430 227/321 (71%)
ANK repeat 59..87 CDD:293786 19/27 (70%)
ANK repeat 89..120 CDD:293786 23/30 (77%)
ANK repeat 122..153 CDD:293786 24/30 (80%)
ANK repeat 212..240 CDD:293786 21/27 (78%)
ANK repeat 242..273 CDD:293786 22/30 (73%)
ANK repeat 275..306 CDD:293786 26/30 (87%)
ANKYR 334..623 CDD:440430 189/295 (64%)
ANK repeat 363..396 CDD:293786 18/32 (56%)
ANK repeat 398..429 CDD:293786 18/30 (60%)
ANK repeat 431..459 CDD:293786 17/29 (59%)
ANKYR 469..783 CDD:440430 229/318 (72%)
ANK repeat 483..515 CDD:293786 15/31 (48%)
ANK repeat 522..550 CDD:293786 20/27 (74%)
ANK repeat 552..583 CDD:293786 28/30 (93%)
ANK repeat 585..610 CDD:293786 22/24 (92%)
ANK repeat 638..668 CDD:293786 19/29 (66%)
ANK repeat 672..703 CDD:293786 25/30 (83%)
ANK repeat 705..736 CDD:293786 23/30 (77%)
ANK repeat 738..769 CDD:293786 25/30 (83%)
SAM_tankyrase1,2 887..952 CDD:188923 32/65 (49%)
tankyrase_like 948..1170 CDD:238718 166/227 (73%)
Tnks2NP_001157107.1 ANK 1 23..52 16/28 (57%)
ANK 2 57..86 20/28 (71%)
ANKYR 60..343 CDD:440430 206/282 (73%)
ANK repeat 60..88 CDD:293786 19/27 (70%)
ANK repeat 90..121 CDD:293786 23/30 (77%)
ANK 3 90..119 22/28 (79%)
ANK repeat 123..154 CDD:293786 24/30 (80%)
ANK 4 123..152 22/28 (79%)
ANKYR 160..470 CDD:440430 209/309 (68%)
ANK 5 210..239 21/28 (75%)
ANK repeat 213..241 CDD:293786 21/27 (78%)
ANK repeat 243..274 CDD:293786 22/30 (73%)
ANK 6 243..272 20/28 (71%)
ANK repeat 276..307 CDD:293786 26/30 (87%)
ANK 7 276..305 24/28 (86%)
ANK 8 363..395 17/31 (55%)
ANK repeat 365..397 CDD:293786 18/31 (58%)
ANK repeat 399..430 CDD:293786 18/30 (60%)
ANK 9 399..428 16/28 (57%)
ANK 10 432..461 16/28 (57%)
ANK repeat 433..521 CDD:293786 41/89 (46%)
ANK 11 463..489 9/25 (36%)
ANKYR 485..782 CDD:440430 223/298 (75%)
ANK 12 525..554 21/28 (75%)
ANK repeat 528..556 CDD:293786 20/27 (74%)
HIF1AN-binding. /evidence=ECO:0000250|UniProtKB:Q9H2K2 545..553 5/7 (71%)
ANK repeat 558..589 CDD:293786 28/30 (93%)
ANK 13 558..587 26/28 (93%)
ANK repeat 591..622 CDD:293786 27/30 (90%)
ANK 14 591..620 26/28 (93%)
ANK 15 624..652 17/27 (63%)
ANK repeat 644..674 CDD:293786 19/29 (66%)
ANK 16 678..707 23/28 (82%)
ANK repeat 681..709 CDD:293786 23/27 (85%)
ANK repeat 711..742 CDD:293786 23/30 (77%)
ANK 17 711..740 21/28 (75%)
ANK repeat 744..775 CDD:293786 25/30 (83%)
ANK 18 744..773 25/28 (89%)
SAM_tankyrase1,2 871..936 CDD:188923 31/64 (48%)
tankyrase_like 938..1160 CDD:238718 164/221 (74%)

Return to query results.
Submit another query.