DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnks and Ankrd42

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_082941.2	Gene:	Ankrd42 / 73845	MGIID:	1921095	Length:	516	Species:	Mus musculus

Alignment Length:	457	Identity:	117/457 - (25%)
Similarity:	183/457 - (40%)	Gaps:	80/457 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 PDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQ-TPLH 437
            |...|::..:..:||        |...:.:|.|........:..::::||.:|.:|:|.| ||||
Mouse     9 PSKSRRETADSSSRK--------KVHFSSIHDAVRAGDVKQLSDIVERGANLNEVDALHQFTPLH 65

  Fly   438 RCARDE--QAVRLLLSYAADTNIVSLEGLTAAQLASDSVLKLLKNPPDSETHLLEAAKAGDLDTV 500
            ..|...  :.:..||...||....:..|.|||.:                     ||..|....:
Mouse    66 WAAHSGSLECLHWLLWSGADATQTTTRGWTAAHI---------------------AAIRGQDACL 109

  Fly   501 RRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGH 565
            :.:::|   ..|....|.|..||||.||.......:|.:|..|.:....||....|:|.|..:|.
Mouse   110 QALIIN---GANLATQDDRGCTPLHLAATHGHSFSLQIMLRSGVDPSVTDKREWKPVHYASFHGR 171

  Fly   566 YEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKH---GADPMKK-NRDGATPADLV 626
            ....:||||.|..:...|.....|:|.||.:|.....|.||..   ....:|. |.:|....||.
Mouse   172 LGCLQLLVKWGCGIEDVDYNGNLPVHLAAMEGHLHCLKFLLSRMNSATQALKAFNDNGENVLDLA 236

  Fly   627 KE-SDHDVAELLRG----------------PSALLDAAKKGNLARVQRLVTPESINCRDAQGRNS 674
            :. ...:|.|.::|                |..:  ||.||:|..:::|:....||..:.....|
Mouse   237 QRFLKQNVVEFIQGAQYEGSHPDDHDDLAFPGHV--AAFKGDLEVLKKLIGDGVINLNERDDNGS 299

  Fly   675 TPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALL-----IKHKTVVNA 734
            ||:|.|||..:.:|.::|:|.||:.|..:|.|..|...|..:.||....||     .:...:.:.
Mouse   300 TPMHKAAGQGHIDCLQWLIEMGAESNITNKAGETPSDVAKRFAHLAAVKLLEGLQKYEIDDIESD 364

  Fly   735 TDKWGFTPLH--EAAQKGRTQLCSLLLAHGADAYM----KNQEGQTPIELA----------TADD 783
            .|...|...|  |.:...:..|| |..:..|:|.|    |..|.:..:|:|          |.:|
Mouse   365 KDHINFFTRHGVEGSTDAKDDLC-LSESDKANARMRAHKKIVELRQLLEIAESNFKHLGGITEED 428

  Fly   784 VK 785
            :|
Mouse   429 LK 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125
		ANK repeat	59..87	CDD:293786
		Ank_2	61..153	CDD:289560
		ANK repeat	89..120	CDD:293786
		ANK repeat	122..153	CDD:293786
		ANK	202..316	CDD:238125
		ANK repeat	212..240	CDD:293786
		Ank_2	214..306	CDD:289560
		ANK repeat	242..273	CDD:293786
		ANK repeat	275..306	CDD:293786
		ANK	361..478	CDD:238125	26/106 (25%)
		ANK repeat	363..396	CDD:293786	4/21 (19%)
		Ank_2	367..459	CDD:289560	22/87 (25%)
		ANK	393..573	CDD:238125	45/182 (25%)
		ANK repeat	398..429	CDD:293786	5/30 (17%)
		ANK repeat	431..459	CDD:293786	11/30 (37%)
		ANK repeat	483..515	CDD:293786	5/31 (16%)
		Ank_4	486..540	CDD:290365	14/53 (26%)
		ANK	512..637	CDD:238125	39/129 (30%)
		ANK repeat	522..550	CDD:293786	9/27 (33%)
		Ank_2	524..616	CDD:289560	28/95 (29%)
		ANK repeat	552..583	CDD:293786	9/30 (30%)
		ANK repeat	585..610	CDD:293786	8/27 (30%)
		ANK repeat	638..668	CDD:293786	10/45 (22%)
		Ank_4	641..693	CDD:290365	16/51 (31%)
		ANK	665..779	CDD:238125	35/124 (28%)
		ANK repeat	672..703	CDD:293786	13/30 (43%)
		Ank_2	677..769	CDD:289560	28/102 (27%)
		ANK repeat	705..736	CDD:293786	7/35 (20%)
		ANK repeat	738..769	CDD:293786	9/36 (25%)
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
Ankrd42	NP_082941.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		5/25 (20%)
		ANK 1	25..54		4/28 (14%)
		Ank_4	26..80	CDD:290365	13/53 (25%)
		ANK	27..146	CDD:238125	35/142 (25%)
		ANK repeat	27..56	CDD:293786	5/28 (18%)
		ANK repeat	59..90	CDD:293786	10/30 (33%)
		ANK 2	59..88		10/28 (36%)
		Ank_2	64..156	CDD:289560	27/115 (23%)
		ANK repeat	92..123	CDD:293786	9/54 (17%)
		ANK 3	92..121		9/52 (17%)
		ANK	93..212	CDD:238125	38/142 (27%)
		ANK repeat	125..156	CDD:293786	10/30 (33%)
		ANK 4	125..154		10/28 (36%)
		ANK repeat	158..189	CDD:293786	9/30 (30%)
		ANK 5	158..187		9/28 (32%)
		Ank_4	159..212	CDD:290365	16/52 (31%)
		ANK	188..350	CDD:238125	45/163 (28%)
		ANK 6	191..220		8/28 (29%)
		Ank_2	197..328	CDD:289560	37/132 (28%)
		ANK 7	228..257		6/28 (21%)
		ANK 8	263..293		9/31 (29%)
		ANK repeat	297..328	CDD:293786	13/30 (43%)
		ANK 9	297..326		12/28 (43%)
		ANK 10	330..360		7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820