DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnks and Ankrd61

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_080008.1	Gene:	Ankrd61 / 66729	MGIID:	1913979	Length:	421	Species:	Mus musculus

Alignment Length:	613	Identity:	132/613 - (21%)
Similarity:	217/613 - (35%)	Gaps:	235/613 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 YTPLHEAASKGKVDVCLALLQ-HGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSG 187
            ::.|:||..|...:....||: |..|..:......|...|..:.|:|:.
Mouse    29 HSKLYEAIIKEDCNTIKTLLRNHPVNQPLTILANSTRYRLLSQQTQPIF---------------- 77

  Fly   188 AEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACS 252
                                     |:||||.|.:...:..||.:|||...:|..|
Mouse    78 -------------------------PIHLAAEYRKPQSLLCLLQHGADPEVRDAQG--------- 108

  Fly   253 YGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAP 317
                                    ||.||             |:       |||..:.|...:.|
Mouse   109 ------------------------FTTLH-------------LM-------LLNWPASSTTWSKP 129

  Fly   318 TRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVS---PDGKRK 379
            :.:: ::|..:.:.:.:|..|..||..       |::...|......:.||||::.   |
Mouse   130 STQI-QKILMDIQNNAVLCLCILCDHG-------AQVNARVDNSNKHSALHLAIIHGTYP----- 181

  Fly   380 QLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVN-ALDSLGQTPLHRCARDE 443
             ::..|.:.|:.:|..|::.:||||:||::|:.:.:|.|:..||.|| |:.|.|.|
Mouse   182 -VLSFLAQNGAQVNATNESSMTPLHMAADILNKNMIETLIAFGANVNCAISSTGNT--------- 236

  Fly   444 QAVRLLLSYAADTNIVSLEGLTAAQLASDSVLKLLKNPPDSETHLLEAAKAGDLDTVRRIVLNNP 508
             |::|                 |...||..|.:||            ||..|.:    |::|||.
Mouse   237 -ALKL-----------------AVCTASSKVGRLL------------AAGVGCI----RLLLNNG 267

  Fly   509 ISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLV 573
            ..||.:|.:|:  |.||.|....|..::..|||..|.|....:.|..|::            :.:
Mouse   268 AQVNAQDHEGQ--TALHEACFGGREAIISLLLEFEANVNILTRNGESPIY------------MYL 318

  Fly   574 KHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMK-KNRDGATPADLVKESDHDVAELL 637
            :..:|:....|                :.:||.:  ..|:: .|:.|..||.::...    .:||
Mouse   319 QRSSNIRDRSL----------------LARLLYR--TYPLRLSNKQGILPAGIMLPE----YQLL 361

  Fly   638 RGPSALLDAAKKGNLARVQRLVTPESI---NCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADV 699
            |  ..|:..:||.        :|.|:|   :.|:..|               |..::.||.
Mouse   362 R--ETLVKLSKKP--------LTLEAICKRSIRNVYG---------------EKYKFHLEK---- 397

  Fly   700 NAQDKGGLIP--LHNASSYGHLDIAALL 725
                   |:|  |.| |.||..|:..||
Mouse   398 -------LLPAKLWN-SIYGIYDLTYLL 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	9/39 (23%)
		ANK repeat	59..87	CDD:293786
		Ank_2	61..153	CDD:289560	8/29 (28%)
		ANK repeat	89..120	CDD:293786
		ANK repeat	122..153	CDD:293786	8/29 (28%)
		ANK	202..316	CDD:238125	22/113 (19%)
		ANK repeat	212..240	CDD:293786	11/27 (41%)
		Ank_2	214..306	CDD:289560	18/91 (20%)
		ANK repeat	242..273	CDD:293786	1/30 (3%)
		ANK repeat	275..306	CDD:293786	6/30 (20%)
		ANK	361..478	CDD:238125	32/120 (27%)
		ANK repeat	363..396	CDD:293786	8/35 (23%)
		Ank_2	367..459	CDD:289560	28/95 (29%)
		ANK	393..573	CDD:238125	50/180 (28%)
		ANK repeat	398..429	CDD:293786	14/31 (45%)
		ANK repeat	431..459	CDD:293786	4/27 (15%)
		ANK repeat	483..515	CDD:293786	9/31 (29%)
		Ank_4	486..540	CDD:290365	16/53 (30%)
		ANK	512..637	CDD:238125	24/125 (19%)
		ANK repeat	522..550	CDD:293786	10/27 (37%)
		Ank_2	524..616	CDD:289560	16/92 (17%)
		ANK repeat	552..583	CDD:293786	3/30 (10%)
		ANK repeat	585..610	CDD:293786	2/24 (8%)
		ANK repeat	638..668	CDD:293786	7/32 (22%)
		Ank_4	641..693	CDD:290365	9/54 (17%)
		ANK	665..779	CDD:238125	15/63 (24%)
		ANK repeat	672..703	CDD:293786	3/30 (10%)
		Ank_2	677..769	CDD:289560	13/51 (25%)
		ANK repeat	705..736	CDD:293786	10/23 (43%)
		ANK repeat	738..769	CDD:293786
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
Ankrd61	NP_080008.1	ANK 1	27..57		8/27 (30%)
		ANK	<32..114	CDD:238125	29/168 (17%)
		ANK 2	74..103		12/69 (17%)
		ANK	78..220	CDD:238125	47/208 (23%)
		ANK repeat	78..105	CDD:293786	11/26 (42%)
		Ank_2	79..197	CDD:289560	37/184 (20%)
		ANK repeat	107..164	CDD:293786	18/117 (15%)
		ANK 3	107..146		12/92 (13%)
		ANK	164..297	CDD:238125	50/183 (27%)
		ANK 4	166..195		7/34 (21%)
		ANK repeat	168..197	CDD:293786	8/34 (24%)
		Ank_2	171..274	CDD:289560	43/151 (28%)
		ANK repeat	199..274	CDD:293786	34/117 (29%)
		ANK 5	199..228		12/28 (43%)
		ANK 6	233..272		18/81 (22%)
		Ank_5	262..316	CDD:290568	19/67 (28%)
		ANK repeat	276..305	CDD:293786	11/30 (37%)
		ANK 7	276..305		11/30 (37%)
		ANK 8	309..342		7/62 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900