DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and ankfy1

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:XP_005171962.1 Gene:ankfy1 / 568480 ZFINID:ZDB-GENE-041222-1 Length:1167 Species:Danio rerio


Alignment Length:899 Identity:229/899 - (25%)
Similarity:338/899 - (37%) Gaps:232/899 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 VNLDAVMANDPLRELFEACKTGEIA-------KVKKLITPQTVNARDT-----AGRKSTPLHFAA 65
            :.:||.:..    :|.|....|::|       |::.:.|....|..|.     :|  .:.||.|.
Zfish   243 IEMDAQLPG----KLNELDNNGDLALDLALSKKLESIATTLVNNKADVDMVDQSG--WSLLHKAI 301

  Fly    66 GYGRREVVEFLLNSGASIQACDEGGLH-PLHNCCSF-----------GHAEVVRLLLKAGASPNT 118
            ..|......||:...|.:.|...|.:. |||..|||           |.|.:...||||||:||.
Zfish   302 QRGDEFASTFLIRHSAQVNAATVGAVETPLHLVCSFSPKKHSGEVMAGMARIAEALLKAGANPNM 366

  Fly   119 TDNWNYTPLHEAASKGKVDVCLALLQ-HGANHTIRNSEQKTPLELA----------------DEA 166
            .::...||||||...|...|...||| ...:..:::.|..|.|.||                |||
Zfish   367 QNSKGRTPLHEAVVSGNEPVFNQLLQCKQLDLELKDHEGSTALWLALQYITVASDPSVNPFEDEA 431

  Fly   167 TRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLA 231
              ||:.|           .|..|:...|.|.....|..|.|...:..:..||..........|..
Zfish   432 --PVVNG-----------TSFDENSFAARLIQRGSNPDAPDTNGNCLMQRAAVAGSEAAAIFLAT 483

  Fly   232 NGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAF-------------TPLHEA 283
            :||.|:..:|.|..|||.||..|...:|..|:|.|||.|.....|.             :|||.|
Zfish   484 HGAKVNHTNKWGETPLHTACRCGLAGLTVELLQQGANPNLQTDIALPGGVEKSQGVSQQSPLHLA 548

  Fly   284 ASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKK 348
            ...:..:|.|::|.:.|:.    .|:.:.:...|...|::.:                       
Zfish   549 IVHNHPDVVSVILEQKANA----LHATNNLQIIPDFSLKDSM----------------------- 586

  Fly   349 LVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLH-LAAELLHY 412
                          ..|.|.||:                            .|.:| :||:    
Zfish   587 --------------DQTVLGLAL----------------------------WTGMHTIAAQ---- 605

  Fly   413 DAMEVLLKQGAKVNALDSLGQTPLHRCAR--DEQAVRLLLSYAADTNIVSLEGLTAAQLASDSVL 475
                 ||..||.:|...|.|||.||...:  |.::...||.:.||.|:.:.||.||.|||..:.|
Zfish   606 -----LLGSGAAINDTMSDGQTLLHMAIKRQDSKSALFLLEHQADINVRTQEGQTALQLAISNQL 665

  Fly   476 KLL-----------------KNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNC--RDLDGRHS 521
            .|:                 .:||      |..|....|:.:...::.:.....|  ....|...
Zfish   666 PLVVDAICTRGADMSVVNEKGDPP------LWLALENGLEDIASTLVRHGCDATCWSSGPGGCQQ 724

  Fly   522 TPLHFAAGFNRVPVVQFLLEHGAEVYAA------------DKGGLVPLHNACSYGHYEVTELLVK 574
            |.||.|...|......||:..|.:|.::            .:.|..|||.|.|:|..||.:.|::
Zfish   725 TLLHRAIDENNEVTACFLIRSGCDVNSSRRPGPNGEGDEEARDGQCPLHLAASWGLEEVAQCLLE 789

  Fly   575 HGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMK-KNRDGATP-ADLVKESDHDVAE-- 635
            .|||||..|.....|:|.|.:..:..|.:||:.|....:. ::|.|.|| |..:...::..||  
Zfish   790 FGANVNAQDSEGRAPIHVAISNQQSVIIQLLISHPEIRLNIRDRQGMTPFACAMTHKNNKAAEAI 854

  Fly   636 LLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVN 700
            |.|.|.|                  .|.:   |.:|||.  ||:|...::.|...:|:...|:||
Zfish   855 LKREPGA------------------AEQV---DNKGRNF--LHVAVQNSDIESVLFLISVQANVN 896

  Fly   701 A--QDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGA 763
            :  ||...|.|||.|...|...|...|:.....||...|...|.||.|||:..:.:||:|:.:|.
Zfish   897 SRVQDSAKLSPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLSTICSVLIENGV 961

  Fly   764 DAYMKNQEGQTPIELAT----ADDVKCLLQDAMATSLSQQALSASTQSLTSSSP 813
            |....::.|...:.||.    .::|:.|        |::..:.|...:|...||
Zfish   962 DFAAVDENGNNALHLAVMQGRLNNVRAL--------LTESNVDAEAYNLRGQSP 1007

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125 42/131 (32%)
ANK repeat 59..87 CDD:293786 8/27 (30%)
Ank_2 61..153 CDD:289560 36/104 (35%)
ANK repeat 89..120 CDD:293786 17/42 (40%)
ANK repeat 122..153 CDD:293786 11/31 (35%)
ANK 202..316 CDD:238125 34/126 (27%)
ANK repeat 212..240 CDD:293786 6/27 (22%)
Ank_2 214..306 CDD:289560 30/104 (29%)
ANK repeat 242..273 CDD:293786 14/30 (47%)
ANK repeat 275..306 CDD:293786 9/43 (21%)
ANK 361..478 CDD:238125 33/119 (28%)
ANK repeat 363..396 CDD:293786 4/32 (13%)
Ank_2 367..459 CDD:289560 24/94 (26%)
ANK 393..573 CDD:238125 55/213 (26%)
ANK repeat 398..429 CDD:293786 9/31 (29%)
ANK repeat 431..459 CDD:293786 11/29 (38%)
ANK repeat 483..515 CDD:293786 4/33 (12%)
Ank_4 486..540 CDD:290365 11/55 (20%)
ANK 512..637 CDD:238125 41/142 (29%)
ANK repeat 522..550 CDD:293786 9/39 (23%)
Ank_2 524..616 CDD:289560 31/104 (30%)
ANK repeat 552..583 CDD:293786 15/30 (50%)
ANK repeat 585..610 CDD:293786 7/24 (29%)
ANK repeat 638..668 CDD:293786 4/29 (14%)
Ank_4 641..693 CDD:290365 10/51 (20%)
ANK 665..779 CDD:238125 37/115 (32%)
ANK repeat 672..703 CDD:293786 10/32 (31%)
Ank_2 677..769 CDD:289560 32/93 (34%)
ANK repeat 705..736 CDD:293786 10/30 (33%)
ANK repeat 738..769 CDD:293786 11/30 (37%)
SAM_tankyrase1,2 887..952 CDD:188923
SAM 890..952 CDD:197735
tankyrase_like 948..1170 CDD:238718
PARP 961..1165 CDD:279038
ankfy1XP_005171962.1 BTB 64..160 CDD:279045
BTB 73..160 CDD:197585
BACK 171..>239 CDD:197943
ANK repeat 225..257 CDD:293786 4/17 (24%)
Ank_2 226..321 CDD:289560 18/83 (22%)
ANK 254..391 CDD:238125 41/138 (30%)
ANK repeat 259..290 CDD:293786 6/30 (20%)
ANK repeat 292..323 CDD:293786 9/32 (28%)
Ank_2 297..402 CDD:289560 36/104 (35%)
ANK repeat 325..368 CDD:293786 17/42 (40%)
ANK 365..561 CDD:238125 58/208 (28%)
ANK repeat 370..402 CDD:293786 11/31 (35%)
ANK repeat 494..525 CDD:293786 14/30 (47%)
Ank_2 499..616 CDD:289560 37/194 (19%)
ANK repeat 540..572 CDD:293786 9/35 (26%)
ANK 542..672 CDD:238125 45/207 (22%)
ANK repeat 586..617 CDD:293786 13/104 (13%)
ANK repeat 619..650 CDD:293786 11/30 (37%)
Ank_2 624..711 CDD:289560 22/92 (24%)
ANK repeat 652..683 CDD:293786 9/30 (30%)
ANK repeat 685..710 CDD:293786 5/30 (17%)
Ank_2 690..798 CDD:289560 29/107 (27%)
ANK repeat 724..765 CDD:293786 9/40 (23%)
ANK 762..924 CDD:238125 56/184 (30%)
ANK repeat 767..798 CDD:293786 15/30 (50%)
Ank_2 772..858 CDD:289560 29/85 (34%)
ANK repeat 800..832 CDD:293786 7/31 (23%)
ANK repeat 834..867 CDD:293786 11/53 (21%)
ANK 864..990 CDD:238125 41/138 (30%)
ANK repeat 873..901 CDD:293786 8/27 (30%)
ANK repeat 906..934 CDD:293786 9/27 (33%)
Ank_2 908..1001 CDD:289560 27/100 (27%)
ANK 931..1062 CDD:238125 23/85 (27%)
ANK repeat 936..967 CDD:293786 11/30 (37%)
FYVE_ANFY1 1099..1161 CDD:277267
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1115202at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.010

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