DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and ankef1a

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_001020714.1 Gene:ankef1a / 566413 ZFINID:ZDB-GENE-041001-196 Length:779 Species:Danio rerio


Alignment Length:850 Identity:190/850 - (22%)
Similarity:296/850 - (34%) Gaps:233/850 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 LFEACKTGEIAKVKKLIT---PQTVN---ARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQA 85
            |.:..:.|:...::|||:   ...:|   .||..|    .||.||...:.:::|||::.||....
Zfish    18 LLQCIQDGDKTYIEKLISMGVDDLINLTEPRDGNG----VLHLAAVTNKPDMLEFLVDQGARPDV 78

  Fly    86 CDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTD----NWNYTPLH---------EAASKGKVD 137
            .|..|..||......|:..:|.||.|..|.....|    ...:..||         :....|..|
Zfish    79 QDRSGRTPLMLAAELGYDGIVSLLAKKNADMKLVDIEGKGVLFYCLHPTKRHMRCLQVVLNGNAD 143

  Fly   138 V------------------------CLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKD 178
            |                        ||::|:.||:....|.|                ||   :.
Zfish   144 VNNVSEAGIPVFLLACEQAQDCEGMCLSILERGADPNATNQE----------------TG---RT 189

  Fly   179 ELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGG 243
            .|:||||:||.:.:.|:|.. ..|.:|.|.:|....|.||......|:::|.|..|||......|
Zfish   190 ALMEAARAGALELVRAILKK-GGNVNALDKKRFHAAHFAAEKGFFEIIKVLSAYRADVGGVTTEG 253

  Fly   244 LVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPL-------HEAASK--SRVEVCSLLLSRG 299
            ..|||.|.|.|:.|..:.|.|.|.|....:.....|.       |:|..|  .:.|......|:|
Zfish   254 DTPLHFAASGGYTDCCRFLAQRGCNPKLKNQEGLLPRQIAKDCGHKATVKELKKAERLHGKSSKG 318

  Fly   300 A--DPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYT 362
            .  .|..|..|     |.:...|...|.|||......:      .|....|.....::..:|...
Zfish   319 GTNGPWALMLH-----DWSHENENELRSAFESATDGFI------GVEFVPKGTFVSVLKELHAPL 372

  Fly   363 GDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNA 427
            .|..:|:.:::.|.:|:..:.        :|:    ||..|.      :.....|:...|.|...
Zfish   373 DDVQIHILLLALDKRREGFIN--------IND----FLRGLK------YLPKTYVMASYGPKKKK 419

  Fly   428 LDSLGQT-------PLHRCA--------RDEQAVRLLL----SYAADTNIVSLEGLTAAQLASDS 473
            ....|:|       ||..|.        ||:......:    .:|.||.....:......:..|:
Zfish   420 AAKAGKTKKSKFNLPLPICTVPQDLIHRRDDGGPPHFMIESWQHATDTQRYDRDHRPERPIEDDT 484

  Fly   474 VLKLLKNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQF 538
            .. .:..|.....:|....|.||:::: |:.|:..:.|:.:|                       
Zfish   485 AW-YIDEPEKIYINLNYCVKTGDIESL-RLALSQKVPVDVKD----------------------- 524

  Fly   539 LLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICK 603
                  ..|.      .||..||:.|:||:.:.|:.:||:||..|.:|:||||.|...|:.||.:
Zfish   525 ------RFYK------TPLMAACASGNYEMAKFLLDNGADVNACDQFKWTPLHHACHAGQLDIIQ 577

  Fly   604 LLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRD 668
            |||:.||...:...:||||.....||                                    ||.
Zfish   578 LLLEAGASVDRPALNGATPLMRAIES------------------------------------CRP 606

  Fly   669 AQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALL-IKHKTVV 732
            :                  |.|||::.||.:||.:|.....|..|.:|....:..|| .|..|..
Zfish   607 S------------------CVEYLIKAGAKINAVNKTEQNCLDVAHAYADFRVVDLLQAKINTQP 653

  Fly   733 NATDKWGFTP--LHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDV--KCLLQDAMA 793
            ...|.....|  :|.......|           ...:|.::|..|...|:::..  |.:.:|::.
Zfish   654 RPKDNKKPQPVKIHHKPTPAST-----------PGSIKEKQGPVPTPTASSNSAVKKAMKKDSVI 707

  Fly   794 TSLSQ 798
            ...:|
Zfish   708 VHSTQ 712

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125 36/153 (24%)
ANK repeat 59..87 CDD:293786 9/27 (33%)
Ank_2 61..153 CDD:289560 30/128 (23%)
ANK repeat 89..120 CDD:293786 9/30 (30%)
ANK repeat 122..153 CDD:293786 10/63 (16%)
ANK 202..316 CDD:238125 36/124 (29%)
ANK repeat 212..240 CDD:293786 9/27 (33%)
Ank_2 214..306 CDD:289560 29/102 (28%)
ANK repeat 242..273 CDD:293786 12/30 (40%)
ANK repeat 275..306 CDD:293786 8/41 (20%)
ANK 361..478 CDD:238125 22/135 (16%)
ANK repeat 363..396 CDD:293786 5/32 (16%)
Ank_2 367..459 CDD:289560 20/110 (18%)
ANK 393..573 CDD:238125 35/198 (18%)
ANK repeat 398..429 CDD:293786 6/30 (20%)
ANK repeat 431..459 CDD:293786 10/46 (22%)
ANK repeat 483..515 CDD:293786 7/31 (23%)
Ank_4 486..540 CDD:290365 8/53 (15%)
ANK 512..637 CDD:238125 35/124 (28%)
ANK repeat 522..550 CDD:293786 1/27 (4%)
Ank_2 524..616 CDD:289560 28/91 (31%)
ANK repeat 552..583 CDD:293786 12/30 (40%)
ANK repeat 585..610 CDD:293786 12/24 (50%)
ANK repeat 638..668 CDD:293786 1/29 (3%)
Ank_4 641..693 CDD:290365 5/51 (10%)
ANK 665..779 CDD:238125 25/116 (22%)
ANK repeat 672..703 CDD:293786 8/30 (27%)
Ank_2 677..769 CDD:289560 20/94 (21%)
ANK repeat 705..736 CDD:293786 7/31 (23%)
ANK repeat 738..769 CDD:293786 3/32 (9%)
SAM_tankyrase1,2 887..952 CDD:188923
SAM 890..952 CDD:197735
tankyrase_like 948..1170 CDD:238718
PARP 961..1165 CDD:279038
ankef1aNP_001020714.1 Ank_2 18..113 CDD:372319 28/98 (29%)
ANK repeat 18..46 CDD:293786 6/27 (22%)
ANK repeat 49..80 CDD:293786 11/34 (32%)
ANK repeat 82..183 CDD:293786 20/100 (20%)
PHA02874 85..>293 CDD:165205 58/227 (26%)
ANK repeat 187..217 CDD:293786 12/33 (36%)
Ank_2 191..283 CDD:372319 34/92 (37%)
ANK repeat 219..250 CDD:293786 10/30 (33%)
ANK repeat 252..283 CDD:293786 12/30 (40%)
ANK repeat 498..524 CDD:293786 7/26 (27%)
PHA02874 <508..>739 CDD:165205 66/305 (22%)
ANK repeat 529..557 CDD:293786 12/27 (44%)
Ank_2 531..623 CDD:372319 42/145 (29%)
ANK repeat 559..590 CDD:293786 14/30 (47%)
ANK repeat 592..623 CDD:293786 16/84 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.900

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