DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnks and ankrd28b

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_009290540.1	Gene:	ankrd28b / 560747	ZFINID:	ZDB-GENE-070622-4	Length:	1052	Species:	Danio rerio

Alignment Length:	1011	Identity:	288/1011 - (28%)
Similarity:	387/1011 - (38%)	Gaps:	252/1011 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RAILSVNLDAVM----------AND-----PLRELFEACKTGEIAKVKKLITP--QTVNARDTAG 55
            ||:.|.:.:||.          |.|     ||    ......:..:..:.:.|  ..||..|.||
Zfish    80 RAVASCSEEAVQVLLKHSADVNARDKNWQTPL----HVAAANKAVRCAEALVPLLSNVNVSDRAG 140

  Fly    56 RKSTPLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTD 120
            |  |.||.||..|..|:|..||:.||:|.|.|:.....:|.....||.|||:||:..||.....|
Zfish   141 R--TALHHAAFSGHLEMVRLLLSRGANINAFDKKDRRAIHWAAYMGHMEVVKLLVSHGAEVPCKD 203

  Fly   121 NWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEAAR 185
            ...|||||.|||.|.:.|...||..|.:....|:...|||.:|....:.|:.     :||:|.
Zfish   204 KKAYTPLHAAASSGMISVVKYLLDMGVDMNEPNAYGNTPLHVACYNGQDVVV-----NELIEC-- 261

  Fly   186 SGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIG--IVEILLANGADVHAKDKGGLVPLH 248
             ||           |||.....|  ..|||..|. :|.|  .:|:|:.|||||:.|.|.|..|||
Zfish   262 -GA-----------NVNQVNEKG--FAPLHFTAA-SRHGALCLELLVGNGADVNIKSKDGKTPLH 311

  Fly   249 NACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAI 313
            ....:|.|..::.:||.||.::..|....||||.||......:.:.|::.|||......|....:
Zfish   312 MTAIHGRFSRSQAIIQNGAEIDCEDKNGNTPLHIAARYGHELLINTLITNGADTAKRGVHGMFPL 376

  Fly   314 DAAPTRELRERIAFEYKGHCLLDACRKC-----DVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVS 373
            ..|......             |.|||.     |:......             |.|.||.|..
Zfish   377 HLAALSGFS-------------DCCRKLLSSGFDIDTPDDF-------------GRTCLHAAAA- 414

  Fly   374 PDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLHR 438
              |...:.:.||...|:..|.|:....||||.||...:|..:..|:..||.||.||..|.||||.
Zfish   415 --GGNLECLNLLLNTGADFNRKDSFGRTPLHYAAANCNYQCLFALVGSGANVNELDKRGCTPLHY 477

  Fly   439 CA---RDEQAVRLLLSYAADTNIVSLEGLTAAQ-------------LASDSVLKLLKN------- 480
            .|   .|.:.:..||...|:..|...:|..|..             :||::.|.:|..
Zfish   478 AAASDADGKCLEYLLRNDANPGIRDNQGYNAVHYASAYGHRLCLELIASETPLDVLMETSGTDIL 542

  Fly   481 ------PPDSETHLLEAAKAG-------------DLDTVRR--------------------IVLN 506
                  .|.|..||  ||..|             ||| ||.                    :::|
Zfish   543 NDSDVLAPVSPLHL--AAYHGHHQALEVLVQSLLDLD-VRTAQGHTPLDLAAFKGHVECVDVLIN 604

  Fly   507 NPISVNCRDLDGRHSTPLHFAA-------------------------GFNRVPV----------- 535
            ...|:..:|...:. ||:|.||                         |..:.|:
Zfish   605 QGASILVKDYTLKR-TPIHAAATNGHSECLRLLIGNADLQSAVDIQDGIGQTPLMLSVLGGHTDC 668

  Fly   536 VQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYD 600
            |..|:..||.|.|.||.|...||.....||.|..|.|::|.|:..|.|....:|:|.|:|.|...
Zfish   669 VYSLINKGANVDAKDKWGRTALHRGAVTGHEECVEALLQHSASFMVRDCRGRSPVHLASACGHVG 733

  Fly   601 ICKLLLKHGAD-----PMKKNRDGATPADLVKESDHDVA-------ELLR----GP-SALLDAAK 648
            :...|| |.|.     |:..:..|.||......:.||..       ||..    .| |.|..|..
Zfish   734 VLGGLL-HAAQSVESIPVITDHQGYTPLHWACYNGHDTCVEVLLEQELFHKTEGNPFSPLHCAVI 797

  Fly   649 KGNLARVQRLV---TPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIP- 709
            ..|...|:.|:   :|..:|..|:  :|.||||.||..::.||.:.||.:.|.||..|.||..|
Zfish   798 NDNEGAVELLIETLSPVIVNANDS--KNRTPLHAAAFTDHVECLQLLLGHNAQVNCVDAGGKTPL 860

  Fly   710 ---------------------------------LHNASSYGHLDIAALLIKHK----TVVNATDK 737
                                             ||.|.|.|| :.:||||..|    .::|:|:.
Zfish   861 MMAAENGQTNAVEVLVSSAKADLTLQDANKNTALHLACSKGH-ETSALLILEKITDRNLINSTNA 924

  Fly   738 WGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTP-IELATADDVKCLLQDAMATSLSQQAL 801
            ...||||.||:.|.|.:...|||.||.....::.|.|| :..|...||...|...:||.:.....
Zfish   925 ALQTPLHVAARNGLTVVVQELLAKGASVLAVDENGYTPALACAPNKDVADCLALILATMMPVSPG 989

  Fly   802 SASTQSLTSS------SPAPDATAAAAPGTSSSSSS 831
            ..|..:||.|      ||....|..:.|...|..||
Zfish   990 GGSVPTLTFSAINHYTSPTKSVTFDSLPMLRSEHSS 1025

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	48/113 (42%)
		ANK repeat	59..87	CDD:293786	14/27 (52%)
		Ank_2	61..153	CDD:289560	38/91 (42%)
		ANK repeat	89..120	CDD:293786	10/30 (33%)
		ANK repeat	122..153	CDD:293786	13/30 (43%)
		ANK	202..316	CDD:238125	39/115 (34%)
		ANK repeat	212..240	CDD:293786	13/29 (45%)
		Ank_2	214..306	CDD:289560	35/93 (38%)
		ANK repeat	242..273	CDD:293786	10/30 (33%)
		ANK repeat	275..306	CDD:293786	10/30 (33%)
		ANK	361..478	CDD:238125	41/132 (31%)
		ANK repeat	363..396	CDD:293786	10/32 (31%)
		Ank_2	367..459	CDD:289560	33/94 (35%)
		ANK	393..573	CDD:238125	70/277 (25%)
		ANK repeat	398..429	CDD:293786	12/30 (40%)
		ANK repeat	431..459	CDD:293786	10/30 (33%)
		ANK repeat	483..515	CDD:293786	13/64 (20%)
		Ank_4	486..540	CDD:290365	21/122 (17%)
		ANK	512..637	CDD:238125	44/172 (26%)
		ANK repeat	522..550	CDD:293786	13/63 (21%)
		Ank_2	524..616	CDD:289560	35/132 (27%)
		ANK repeat	552..583	CDD:293786	11/30 (37%)
		ANK repeat	585..610	CDD:293786	8/24 (33%)
		ANK repeat	638..668	CDD:293786	9/37 (24%)
		Ank_4	641..693	CDD:290365	18/54 (33%)
		ANK	665..779	CDD:238125	49/152 (32%)
		ANK repeat	672..703	CDD:293786	14/30 (47%)
		Ank_2	677..769	CDD:289560	41/129 (32%)
		ANK repeat	705..736	CDD:293786	15/68 (22%)
		ANK repeat	738..769	CDD:293786	13/30 (43%)
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
ankrd28b	XP_009290540.1	ANK repeat	11..38	CDD:293786
		Ank_2	12..104	CDD:289560	6/23 (26%)
		ANK repeat	40..71	CDD:293786
		Ank	42..72	CDD:278452
		ANK	68..193	CDD:238125	38/118 (32%)
		ANK repeat	76..104	CDD:293786	6/23 (26%)
		ANK repeat	106..137	CDD:293786	5/34 (15%)
		Ank_2	111..203	CDD:289560	33/97 (34%)
		ANK	134..259	CDD:238125	51/131 (39%)
		ANK repeat	140..170	CDD:293786	16/31 (52%)
		ANK repeat	172..203	CDD:293786	10/30 (33%)
		Ank_2	177..269	CDD:289560	38/110 (35%)
		ANK repeat	205..236	CDD:293786	13/30 (43%)
		ANK repeat	238..269	CDD:293786	13/49 (27%)
		Ank_5	258..312	CDD:290568	26/70 (37%)
		ANK repeat	271..302	CDD:293786	14/33 (42%)
		ANK	300..416	CDD:238125	35/144 (24%)
		ANK repeat	305..336	CDD:293786	10/30 (33%)
		Ank_2	310..402	CDD:289560	26/104 (25%)
		ANK repeat	338..363	CDD:293786	7/24 (29%)
		ANK repeat	371..402	CDD:293786	7/43 (16%)
		Ank_2	376..468	CDD:289560	29/120 (24%)
		ANK	399..524	CDD:238125	38/140 (27%)
		ANK repeat	404..435	CDD:293786	10/46 (22%)
		ANK repeat	437..468	CDD:293786	12/30 (40%)
		ANK repeat	470..502	CDD:293786	11/31 (35%)
		Ank_2	475..613	CDD:289560	28/140 (20%)
		ANK repeat	552..580	CDD:293786	10/30 (33%)
		ANK	577..706	CDD:238125	28/130 (22%)
		ANK repeat	583..613	CDD:293786	2/29 (7%)
		Ank_2	587..683	CDD:289560	16/96 (17%)
		ANK repeat	618..650	CDD:293786	5/32 (16%)
		ANK	647..776	CDD:238125	37/129 (29%)
		ANK repeat	652..683	CDD:293786	7/30 (23%)
		ANK repeat	685..710	CDD:293786	9/24 (38%)
		Ank_4	686..735	CDD:290365	17/48 (35%)
		ANK repeat	718..746	CDD:293786	9/28 (32%)
		Ank_4	756..808	CDD:290365	13/51 (25%)
		ANK repeat	787..820	CDD:293786	9/32 (28%)
		Ank_2	792..887	CDD:289560	26/96 (27%)
		ANK	817..946	CDD:238125	41/131 (31%)
		ANK repeat	824..853	CDD:293786	13/28 (46%)
		ANK repeat	855..887	CDD:293786	3/31 (10%)
		Ank_2	860..956	CDD:289560	26/96 (27%)
		ANK repeat	889..920	CDD:293786	11/31 (35%)
		ANK repeat	925..956	CDD:293786	13/30 (43%)
		Ank_2	930..>990	CDD:289560	20/59 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010