Protein Alignment Tnks and tnksa

DIOPT Version :10

• Sequence 1: NP_001262963.1
• Gene: Tnks / 43095
• FlyBaseID: FBgn0027508
• Length: 1520
• Species: Drosophila melanogaster
• Sequence 2: XP_068075061.2
• Gene: tnksa / 559022
• ZFINID: ZDB-GENE-030131-7450
• Length: 1260
• Species: Danio rerio
• Alignment Length: 1188
• Identity: 789/1188 - (66%)
• Similarity: 940/1188 - (79%)
• Gaps: 74/1188 - (6%)

  Fly    25 RELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEG 89
            |||||||:.|::::||:|:....|||:|.|||||||||||||:||::|||.||.:||::.|.|:|
Zfish   110 RELFEACRNGDVSRVKRLVDSVNVNAKDMAGRKSTPLHFAAGFGRKDVVEHLLQTGANVHARDDG 174

  Fly    90 GLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNS 154
            ||.||||.|||||||||.|||..||.||..||||||||||||.|||:|||:.||||||:..|||:
Zfish   175 GLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNT 239

  Fly   155 EQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDGRR-------ST 212
            :.|:.|:|||.:.:.||||||:|||||||||||.|::|:||||||||||||||||:       ||
Zfish   240 DGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTSQKMLST 304

  Fly   213 PLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAF 277
            ||||||||||:.||::||.:|||||||||||||||||||||||::||:||::.||.|||.|||.|
Zfish   305 PLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQF 369

  Fly   278 TPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCD 342
            |||||||||:||||||||||.||||||:|||.|||:|.|||.||:||:.:|:|||.||.|.|:.|
Zfish   370 TPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELKERLTYEFKGHSLLQAAREAD 434

  Fly   343 VSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAA 407
            :::.||.:..||:||.||.|.:|.||.|||||..||||:.|||.|||:.:|||||.|:||||:||
Zfish   435 MTKVKKTLALEIINFKHPQTHETALHCAVVSPHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAA 499

  Fly   408 ELLHYDAMEVLLKQGAKVNALDSLGQTPLHRC--ARDEQAVRLLLSYAADTNIVSLEGLTAAQLA 470
            |..|.|.:|||.|.|||:||:|:||||.|||.  |...|..||||||.||..||||:|.||||:.
Zfish   500 ERAHNDILEVLQKHGAKMNAVDTLGQTALHRAALAGHLQTCRLLLSYGADPAIVSLQGFTAAQMG 564

  Fly   471 SDSVLKLL-KNPP----DSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGF 530
            :::|.::| :|.|    |.:..|||||||||||||::  |.:|.:||||||:||||||||||||:
Zfish   565 NEAVQQILNENIPVRNSDVDYRLLEAAKAGDLDTVKQ--LCSPQNVNCRDLEGRHSTPLHFAAGY 627

  Fly   531 NRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAA 595
            |||.||::||.|||:|:|.|||||||||||||||||||.||||:|||:|||:|||||||||||||
Zfish   628 NRVAVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAA 692

  Fly   596 KGKYDICKLLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVT 660
            ||||:||||||||||||.||||||.||.|:|||.|.|:.:||||.:|||||||||.|||||:|.:
Zfish   693 KGKYEICKLLLKHGADPTKKNRDGNTPLDMVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCS 757

  Fly   661 PESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALL 725
            .|:|||||.||||||||||||||||.|.||||||:||||||||||||||||||:||||:||||||
Zfish   758 LENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALL 822

  Fly   726 IKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLLQD 790
            ||:.|.|||||||.||||||||||||||||:||||||||..|||||||||::||||||::.||.|
Zfish   823 IKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLID 887

  Fly   791 AMATSLSQQALSASTQSLTSSSPAPDATAAAA----PGTSSSSSSA------ILSPTTETVLLPT 845
            ||    ..:||.:..:        |.||..:|    ||::.|..||      :..|.||  |..:
Zfish   888 AM----PPEALPSCFK--------PQATVVSASVISPGSTPSCLSAASSIDNLAGPLTE--LAVS 938

  Fly   846 GASMILSVPVPLPLSSSTRISPAQGAEANGAEGSSSDDLLPDADTITNVSGFLSSQQLHHLIELF 910
            |||                 .||.|  |.|.|....:..:.|    .|:|.||.|..|.||.::|
Zfish   939 GAS-----------------GPADG--ATGTERKEGEITILD----MNISQFLKSLGLEHLRDIF 980

  Fly   911 EREQITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRSTTGIGNNVNL---C----TLLVDL 968
            ||||||||:||:|||::||::|::|||.|||::|||.:|..... |.|..|   |    |:|:||
Zfish   981 EREQITLDVLADMGHEELKEIGINAYGHRHKLIKGIERLLGGQQ-GANPYLTFHCSGQGTVLIDL 1044

  Fly   969 LPDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQ 1033
            .||||||.:||||:|:|||||||.|.|||.|:||||:::|||.|:||.|||.||::|||:||...
Zfish  1045 APDDKEFQSVEEELQSTIREHRDGGNAGGVFSRYNILKIQKVVNKKLRERYTHRQKEIADENHNH 1109

  Fly  1034 SNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKS 1098
            .|||||||||||||||:.:|||||||||||||||||||||:||||||||||||||.|||:|||:|
Zfish  1110 HNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRS 1174

  Fly  1099 CYVCPRQLLLCRVALGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLI 1163
            ||:|.||:|.|||.|||||||:|||||||||||||||:||||..||.:||||:|||||:||||||
Zfish  1175 CYICHRQMLFCRVTLGKSFLQFSAMKMAHAPPGHHSVIGRPSVNGLAYAEYVIYRGEQAYPEYLI 1239

  Fly  1164 TYQIVKPDD---SSSGTE 1178
            ||||:|||.   |.:|.|
Zfish  1240 TYQIIKPDSTPPSPAGAE 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANKYR	9..330	CDD:440430	221/311 (71%)
		ANK repeat	59..87	CDD:293786	18/27 (67%)
		ANK repeat	89..120	CDD:293786	23/30 (77%)
		ANK repeat	122..153	CDD:293786	23/30 (77%)
		ANK repeat	212..240	CDD:293786	21/27 (78%)
		ANK repeat	242..273	CDD:293786	23/30 (77%)
		ANK repeat	275..306	CDD:293786	27/30 (90%)
		ANKYR	334..623	CDD:440430	198/295 (67%)
		ANK repeat	363..396	CDD:293786	20/32 (63%)
		ANK repeat	398..429	CDD:293786	19/30 (63%)
		ANK repeat	431..459	CDD:293786	17/29 (59%)
		ANKYR	469..783	CDD:440430	245/318 (77%)
		ANK repeat	483..515	CDD:293786	19/31 (61%)
		ANK repeat	522..550	CDD:293786	20/27 (74%)
		ANK repeat	552..583	CDD:293786	27/30 (90%)
		ANK repeat	585..610	CDD:293786	23/24 (96%)
		ANK repeat	638..668	CDD:293786	21/29 (72%)
		ANK repeat	672..703	CDD:293786	27/30 (90%)
		ANK repeat	705..736	CDD:293786	25/30 (83%)
		ANK repeat	738..769	CDD:293786	26/30 (87%)
		SAM_tankyrase1,2	887..952	CDD:188923	36/64 (56%)
		tankyrase_like	948..1170	CDD:238718	165/228 (72%)
tnksa	XP_068075061.2	None