DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and ank2b

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:XP_021333148.1 Gene:ank2b / 450043 ZFINID:ZDB-GENE-041010-165 Length:3634 Species:Danio rerio


Alignment Length:1500 Identity:370/1500 - (24%)
Similarity:568/1500 - (37%) Gaps:382/1500 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SRSRAILSVNLDAVMANDPLRELFEACKTGEIAKVKKLITPQT-VNARDTAGRKSTPLHFAAGYG 68
            ||.||      :....:|.......|.:.|.|.||.:.:.... :...:..|..:  ||.||..|
Zfish    34 SRERA------ERRRKSDSNTSFLRAARAGNIDKVLEYLKGGVDIGTSNQNGLNA--LHLAAKEG 90

  Fly    69 RREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASK 133
            ..::|:.||..|:|:.:..:.|...||.....|..:||::|.|.||:.|......:|||:.|:.:
Zfish    91 HVDLVQELLGRGSSVDSATKKGNTALHIASLAGQGDVVKILSKRGANINAQSQNGFTPLYMASQE 155

  Fly   134 GKVDVCLALLQHGANHTIRNSEQKTPLELA-------------DEATR-----PVLTGEYRKDEL 180
            ..:||...||::|.|.:|...:..|||.:|             :..|:     |.|....|||:.
Zfish   156 NHLDVVRYLLENGGNQSIATEDGFTPLAIALQQGHNQVVSILLENDTKGKVRLPALHIAARKDDT 220

  Fly   181 LEAARSGAEDRLLALLTPLNVNCHASDGRRS-TPLHLAAGYNRIGIVEILLANGADVHAKDKGGL 244
            ..||.....|....:.:.:.||....:|:.. ||||:||.|..:.:..:||..||.|....:.|:
Zfish   221 KSAALLLQNDHNADVQSKMMVNRTTENGKSGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGI 285

  Fly   245 VPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHS 309
            .|||.|...|:.::..||:..||.::|......||||.||.........|||.||| |.|     
Zfish   286 TPLHVASKRGNTNMVHLLLDRGAQIDAKTRDGLTPLHCAARSGHDTAVELLLERGA-PML----- 344

  Fly   310 KSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSP 374
                                              :|.|              .|.:|||:|.   
Zfish   345 ----------------------------------ARTK--------------NGLSPLHMAA--- 358

  Fly   375 DGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLH-R 438
            .|...:.::.|.:..:.:::....:||.||:||...||...::||.:.|..||....|.|||| .
Zfish   359 QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 423

  Fly   439 CARDE-QAVRLLLSYAADTNIVSLEGLTAAQLAS-----DSVLKLLKN--PPD-----SETHLLE 490
            |.::. :.:.||:.|.|....::..|||...:|:     :.||.||:|  .||     .||.|..
Zfish   424 CKKNRVKVMELLIKYGAFIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVSNIRGETALHM 488

  Fly   491 AAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLV 555
            ||:||.::.| |.:|.|...|:.|..:.:  ||||.|:...:..:||.||:|.|...||...|..
Zfish   489 AARAGQMEVV-RCLLRNGAMVDARAREDQ--TPLHIASRLGKTEIVQLLLQHMAHPDAATANGYT 550

  Fly   556 PLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNR-DG 619
            |||.|...||.:||.:|::.||..:::....|||||.|:..|..::.||||:..|.|....: :|
Zfish   551 PLHIAAREGHLDVTTVLLEAGAAHSLATKKGFTPLHVASKYGSLEVAKLLLQRRAPPDSAGKQNG 615

  Fly   620 ATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNS-TPLHLAAGY 683
            .||..:....|:....||     |||   ||        .:|.      |..:|. ||||:||..
Zfish   616 LTPLHVAAHYDNQKVALL-----LLD---KG--------ASPH------ATAKNGYTPLHIAAKK 658

  Fly   684 NNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQ 748
            |..|.|..||:.||:.|.|.|.|::|:|.||..||.::||||::....||.|.|.|.|.||.|||
Zfish   659 NQMEIATTLLQYGAETNIQTKQGVMPIHLASQEGHSEMAALLLQRGAQVNVTTKSGLTSLHLAAQ 723

  Fly   749 KGRTQLCSLLLAHGADAYMKNQEGQTPIELA----TADDVKCLLQDAMA---------TSLSQQA 800
            :.:..:..:|:..||:...:.:.|.||:.:|    .|..|..||:...:         |.|.|.|
Zfish   724 EDKVGVGEILVKQGANLDQQTKLGYTPLIVACHYGNAKMVNFLLKSGASVNDKTKNGYTPLHQAA 788

  Fly   801 LSAST---QSLTSSSPAPDA------TA-AAAPGTSSSSSSAILSPTTETVLLPTGA---SMILS 852
            ...:|   ..|......|:|      || |.|......|....|...||.::..|..   ...|:
Zfish   789 QQGNTHIINVLLQYGAKPNAITVNGNTALAIARRLGYISVVDTLRVVTEEIVTTTTTVTEKHKLN 853

  Fly   853 VPVPLPLSSSTRISPAQGAEANGA--EGSSSDDLL--PDADTITNVSGFLSSQQLHHLIELFERE 913
            ||     .:.|.:......|....  :|:.|||.:  ...||:|...|                |
Zfish   854 VP-----ETMTEVLDVSDEEVRRLVDDGAMSDDSIDFEGDDTMTGDGG----------------E 897

  Fly   914 QITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRSTTGIGNNVNLCTLLVDLLPDDKEFVAV 978
            .:..:.|.|:|.|.|.          .:.|.|:..||.:...|.:                    
Zfish   898 YLRAEDLRELGDDSLP----------GQYLDGMNYLRFSLEGGRS-------------------- 932

  Fly   979 EEEMQATIREHRDNGQAGGYFTRY-----NIIRVQKV-----QNRK-LWERYAHRRQEIAEENFL 1032
            :..:|:..|.:....|:  |::::     ::|...:|     :|.| .||      .|..:...|
Zfish   933 DSRLQSLDRSYTPTHQS--YYSKHYGIMEDVIYSNQVSSLGRENEKDSWE------TENLDNIAL 989

  Fly  1033 QSNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGI--GCPSHK 1095
            .|:.....|.||.            |.:            ::||....::....||.  || .|.
Zfish   990 SSSPAHSGHCSPC------------HDH------------DNSSFLVSFMVDARGGAMRGC-RHN 1029

  Fly  1096 DKSCYVCPRQL-----LLCR-----------------------VALGKSFLQY-SAMKMAHAPP- 1130
            .....:.||:.     :.||                       :.:|.|..|: ..:.:..||| 
Zfish  1030 GLRLIIPPRKCSAPTRVTCRLVKRHRLATMPPMVEGDGLASRLIEVGPSGAQFLGKLHLPTAPPP 1094

  Fly  1131 ---GHHSV-----VGRPSAGGL--------HFA-------EYVVYRGE----------------- 1155
               |...|     :|.|....|        |||       |.|:.|.|                 
Zfish  1095 LNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVILRSETGESWKEHHCEYTEEEL 1159

  Fly  1156 ---------------------------QSYPEYLITYQIVKPDDSSSGTEDTRXWMPSVGSTPTT 1193
                                       :.:|:|......:|.|.:..|        |..|...:|
Zfish  1160 NQVLNGMDERLDPPEELEKKRICRIITRDFPQYFAVVSRIKQDSNLIG--------PEGGVLSST 1216

  Fly  1194 TSPALHQ--PQTQQQPQQQQQQQPQPQQQQKAPLPLPPPQQQTSAPVAKRRPKHAKPSLQLQYQP 1256
            ..|.:..  |:.....:.:...|.||.........|  ..:.|.:|:....|:..|         
Zfish  1217 VVPEVQAVFPEGALTKRIRVGLQTQPMSVDVVRNML--GNKATFSPIVTLEPRRRK--------- 1270

  Fly  1257 YQPQHHPVVATAAAVTTTQPSPAGVFAHSNNNN-----NTSSGNVNNNNNDM---SPVSNSNSYS 1313
               .|.|:..|.....::.....|.|.......     :.:.|.......|:   :|::.:|...
Zfish  1271 ---FHKPITMTIPVPKSSADPALGSFGGGETPTLRLLCSITGGTTPAQWEDITGTTPLTFTNDCV 1332

  Fly  1314 SVDTN 1318
            |..||
Zfish  1333 SFTTN 1337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125 36/113 (32%)
ANK repeat 59..87 CDD:293786 10/27 (37%)
Ank_2 61..153 CDD:289560 32/91 (35%)
ANK repeat 89..120 CDD:293786 11/30 (37%)
ANK repeat 122..153 CDD:293786 11/30 (37%)
ANK 202..316 CDD:238125 39/114 (34%)
ANK repeat 212..240 CDD:293786 12/27 (44%)
Ank_2 214..306 CDD:289560 35/91 (38%)
ANK repeat 242..273 CDD:293786 11/30 (37%)
ANK repeat 275..306 CDD:293786 14/30 (47%)
ANK 361..478 CDD:238125 36/123 (29%)
ANK repeat 363..396 CDD:293786 7/32 (22%)
Ank_2 367..459 CDD:289560 28/93 (30%)
ANK 393..573 CDD:238125 69/193 (36%)
ANK repeat 398..429 CDD:293786 13/30 (43%)
ANK repeat 431..459 CDD:293786 10/29 (34%)
ANK repeat 483..515 CDD:293786 13/36 (36%)
Ank_4 486..540 CDD:290365 19/53 (36%)
ANK 512..637 CDD:238125 43/125 (34%)
ANK repeat 522..550 CDD:293786 12/27 (44%)
Ank_2 524..616 CDD:289560 36/91 (40%)
ANK repeat 552..583 CDD:293786 12/30 (40%)
ANK repeat 585..610 CDD:293786 11/24 (46%)
ANK repeat 638..668 CDD:293786 6/29 (21%)
Ank_4 641..693 CDD:290365 17/52 (33%)
ANK 665..779 CDD:238125 46/114 (40%)
ANK repeat 672..703 CDD:293786 15/31 (48%)
Ank_2 677..769 CDD:289560 39/91 (43%)
ANK repeat 705..736 CDD:293786 13/30 (43%)
ANK repeat 738..769 CDD:293786 10/30 (33%)
SAM_tankyrase1,2 887..952 CDD:188923 14/64 (22%)
SAM 890..952 CDD:197735 13/61 (21%)
tankyrase_like 948..1170 CDD:238718 51/331 (15%)
PARP 961..1165 CDD:279038 48/313 (15%)
ank2bXP_021333148.1 ANK repeat 45..76 CDD:293786 6/30 (20%)
Ank_4 47..99 CDD:316185 12/53 (23%)
ANK 76..198 CDD:238125 37/123 (30%)
ANK repeat 78..109 CDD:293786 11/32 (34%)
ANK repeat 111..142 CDD:293786 11/30 (37%)
ANK repeat 144..173 CDD:293786 10/28 (36%)
Ank_4 207..271 CDD:316185 18/63 (29%)
ANK repeat 210..237 CDD:293786 7/26 (27%)
ANK 249..370 CDD:238125 45/177 (25%)
ANK repeat 250..281 CDD:293786 12/30 (40%)
ANK repeat 283..314 CDD:293786 11/30 (37%)
ANK 311..436 CDD:238125 44/181 (24%)
ANK repeat 316..346 CDD:293786 14/69 (20%)
ANK repeat 349..380 CDD:293786 7/33 (21%)
ANK repeat 382..412 CDD:293786 12/29 (41%)
ANK repeat 415..446 CDD:293786 10/30 (33%)
Ank_4 418..469 CDD:316185 15/50 (30%)
ANK repeat 448..479 CDD:293786 11/30 (37%)
ANK 476..601 CDD:238125 48/127 (38%)
ANK repeat 481..512 CDD:293786 12/31 (39%)
ANK repeat 514..545 CDD:293786 12/32 (38%)
ANK repeat 547..572 CDD:293786 10/24 (42%)
ANK repeat 580..608 CDD:293786 12/27 (44%)
ANK 614..734 CDD:238125 52/141 (37%)
ANK repeat 614..645 CDD:293786 13/52 (25%)
ANK repeat 647..678 CDD:293786 15/30 (50%)
ANK 675..800 CDD:238125 41/124 (33%)
ANK repeat 680..709 CDD:293786 12/28 (43%)
ANK repeat 713..744 CDD:293786 10/30 (33%)
ANK repeat 746..777 CDD:293786 8/30 (27%)
ANK repeat 779..808 CDD:293786 7/28 (25%)
Ank_4 780..832 CDD:316185 13/51 (25%)
ZU5 1008..1145 CDD:128514 29/137 (21%)
Neuromodulin_N <1588..>1884 CDD:331332
DUF4045 <2885..3298 CDD:330572
Death_ank 3158..3241 CDD:260029
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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