DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and ANKHD1-EIF4EBP3

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_065741.3 Gene:ANKHD1-EIF4EBP3 / 404734 HGNCID:33530 Length:2617 Species:Homo sapiens


Alignment Length:2049 Identity:419/2049 - (20%)
Similarity:646/2049 - (31%) Gaps:806/2049 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 RELFEACKTGEIAKVKKL----------------------------------------------- 42
            |.|.|||..|::..|:||                                               
Human   207 RSLAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKG 271

  Fly    43 -ITP--------------------QTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQAC 86
             |||                    ..||::...|  :|.|.:|...|..::|:.|||.||:|:..
Human   272 DITPLMAASSGGYLDIVKLLLLHDADVNSQSATG--NTALTYACAGGFVDIVKVLLNEGANIEDH 334

  Fly    87 DEGGLHPLHNCCSFGHAEVVRLLLKAGASPNT--------------------------------- 118
            :|.|..||....|.||.||.|:||..||..||                                 
Human   335 NENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQE 399

  Fly   119 --TDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELA------------------ 163
              ||.. :|.|.||...|.|:|...||..||...:.....::||.||                  
Human   400 HKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463

  Fly   164 -----DEATRPVLTGEYRKDELLEAARSGAEDRLLALLTP-LNVNCHASDGRR------------ 210
                 ||...|          |:||||.|.|:.:..||.. .|:|....:.:.            
Human   464 LEEVNDEGYTP----------LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFS 518

  Fly   211 -----------------STPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDV 258
                             ||||..|:....:.:|:.|||:||:|||....|...|..||..||.||
Human   519 EVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDV 583

  Fly   259 TKLLIQAGANVNANDLWAFTPLHEAA------------SK----------------------SRV 289
            ..:|:||||::........|||.:||            ||                      ..:
Human   584 ADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHL 648

  Fly   290 EVCSLLLSRGADPT------------------------LLN-------------------CHSKS 311
            .|..|||:.|||||                        ||:                   ...:|
Human   649 AVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLPPPSQDQS 713

  Fly   312 AIDAAPTRELR--------ERIAFEYKGHCLLDACRKCDVSRAKKLVCA--EIVNFVHPYTGDTP 366
            .:...||..|.        :|.:.| ....||...:.....::..|..|  :::...|||   .|
Human   714 QVPRVPTHTLAMVVPPQEPDRTSQE-NSPALLGVQKGTSKQKSSSLQVADQDLLPSFHPY---QP 774

  Fly   367 LHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHL-AAELLHYDAMEVL------------ 418
            |...|...:||..:|       |..::...||.|..|.| ..|.|:.|.:|.|            
Human   775 LECIVEETEGKLNEL-------GQRISAIEKAQLKSLELIQGEPLNKDKIEELKKNREEQVQKKK 832

  Fly   419 --LKQGAKVNA--------------LDSLGQ---TPLH-RCAR---------------------- 441
              ||:..||..              |::.||   ..|| :|:.                      
Human   833 KILKELQKVERQLQMKTQQQFTKEYLETKGQKDTVSLHQQCSHRGVFPEGEGDGSLPEDHFSELP 897

  Fly   442 -------------DEQ------------AVRLLLS----YAAD-----TNIVSL----------- 461
                         |||            .|:.|.|    :::|     ||.:.|           
Human   898 QVDTILFKDNDVDDEQQSPPSAEQIDFVPVQPLSSPQCNFSSDLGSNGTNSLELQKVSGNQQIVG 962

  Fly   462 ------------------EGL---TAAQLASDSVLKLL--------------------------- 478
                              :||   |.||..:|::..|:                           
Human   963 QPQIAITGHDQGLLVQEPDGLMVATPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCS 1027

  Fly   479 ---------KNPP-----DSETH-------LLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHST 522
                     ..||     |.:.|       .|..|.||..:.:..:::.....:..||..|  .|
Human  1028 QTTSNVASQSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKG--FT 1090

  Fly   523 PLHFAAGFNRVPVVQFLLEHGAEVYA-ADKGGLVPLHNACSYGHYEVTELLVKHGANV---NVSD 583
            ||..||....|.||:.||:.|.::.| :::....||..|||.|..||.:||:..|||.   ||||
Human  1091 PLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD 1155

  Fly   584 LWKFTPLHEAAAKGKYDICKLLLKHGADPMKK--NRDGATPADLVKESDH--------------- 631
               :|||..||:.|..:|.|:||..||:...:  ::.|.:|..|...:.|               
Human  1156 ---YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217

  Fly   632 --------------------DVAELL------------RGPSALLDAAKKGNLARVQRLVTPE-- 662
                                :|..||            .|.:.|::|| .|..|.|.|::..:  
Human  1218 AQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAA-SGGYAEVGRVLLDKGA 1281

  Fly   663 SINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIK 727
            .:|.........|.|.:||...:::..|.|:..||.::.::|.|..||..||:.||.|:..||::
Human  1282 DVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQ 1346

  Fly   728 HKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIE------LATADDVKC 786
            ....|:|.|....|||..|.:||..::..         |:..:..|.|.:      :||..|.:.
Human  1347 AGADVDAADNRKITPLMSAFRKGHVKVVQ---------YLVKEVNQFPSDIECMRYIATITDKEL 1402

  Fly   787 L------------LQDAMATSLS--------------------QQALSASTQSL----------- 808
            |            .:|..|...:                    :|||:|..:..           
Human  1403 LKKCHQCVETIVKAKDQQAAEANKNASILLKELDLEKSREESRKQALAAKREKRKEKRKKKKEEQ 1467

  Fly   809 --------------TSSSP-------------------APDATAAAAPGTSSSS----------- 829
                          .|..|                   .|.||.....|.|::|           
Human  1468 KRKQEEDEENKPKENSELPEDEDEEENDEDVEQEVPIEPPSATTTTTIGISATSATFTNVFGKKR 1532

  Fly   830 SSAILSPTT-------ETVLLPTGASMILSVPVPLPLSSSTRISPA-QGAEAN---------GAE 877
            ::.:.:|:|       :|...|..|.:||         ....:|.| |.|:.|         ||.
Human  1533 ANVVTTPSTNRKNKKNKTKETPPTAHLIL---------PEQHMSLAQQKADKNKINGEPRGGGAG 1588

  Fly   878 GSSSDDLLPDADTITNVSGFLSSQQLHHLIELFEREQITLDILAEMGHDDLKQVGVSAYGFRHKI 942
            |:|..|.|...|..:..|....||:|:.::::...:..:|     :.|...::...:....:.: 
Human  1589 GNSDSDNLDSTDCNSESSSGGKSQELNFVMDVNSSKYPSL-----LLHSQEEKTSTATSKTQTR- 1647

  Fly   943 LKGIAQLRSTTGIGNNVNLCTLLVDL---LPDDKEFVAVEEEMQATIREHRDNGQAGGYFTRY-- 1002
            |:|.....|.:.....|:|.....::   |...|.....||..:..:|..:.........:|.  
Human  1648 LEGEVTPNSLSTSYKTVSLPLSSPNIKLNLTSPKRGQKREEGWKEVVRRSKKLSVPASVVSRIMG 1712

  Fly  1003 ----NIIRVQKVQNRKLWERYAHRRQEIAEENFLQSNERMLF---------HGSPFINAIVQRGF 1054
                ||..:|.|..       ||...:..::   ::.|||:.         :....|||::|...
Human  1713 RGGCNITAIQDVTG-------AHIDVDKQKD---KNGERMITIRGGTESTRYAVQLINALIQDPA 1767

  Fly  1055 DE-------RH-------AYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGC---------PSHK- 1095
            .|       .|       ..|...|.:|:.....||| |.:..|....:..         |::| 
Human  1768 KELEDLIPKNHIRTPASTKSIHANFSSGVGTTAASSK-NAFPLGAPTLVTSQATTLSTFQPANKL 1831

  Fly  1096 DKS---------------CYVCPRQLLLCRVALGKSFLQYSAMKMA------------------- 1126
            :|:               .|..|...||....:.:  :::..:.||                   
Human  1832 NKNVPTNVRSSFPVSLPLAYPHPHFALLAAQTMQQ--IRHPRLPMAQFGGTFSPSPNTWGPFPVR 1894

  Fly  1127 -------HAPPGHHSVVGRPS---------AGGLHFA------EYVVYRGEQSYPEYLITYQIVK 1169
                   ::.|.|::....|:         :.||..|      ..||...:|.......|...|:
Human  1895 PVNPGNTNSSPKHNNTSRLPNQNGTVLPSESAGLATASCPITVSSVVAASQQLCVTNTRTPSSVR 1959

  Fly  1170 ------------PDDSSSGTEDTRXWMPSVGSTPTTT--SPALHQPQTQQQPQQQQQQQPQPQQQ 1220
                        |....|....|...:|||.|.|.|:  :|....|.:..|.|..       .|:
Human  1960 KQLFACVPKTSPPATVISSVTSTCSSLPSVSSAPITSGQAPTTFLPASTSQAQLS-------SQK 2017

  Fly  1221 QKAPLPLPPPQQQTSA---PVAKR-RPKHAKPSL--QLQYQPYQPQHHPVVATAAAVTTTQPSPA 1279
            .::...:||.:::.|.   |:|.. .|.....|.  .....|..|:.||         ::.|:|.
Human  2018 MESFSAVPPTKEKVSTQDQPMANLCTPSSTANSCSSSASNTPGAPETHP---------SSSPTPT 2073

  Fly  1280 GVFAHSNNNNNTSSGNVNNNNNDMSPVSNSNSYSSVDTNQTLLNS---LANQQRNHRQPQ----- 1336
            .    ||........:|    :|:||:|...:.:|.....||.:.   .|:.|.....||     
Human  2074 S----SNTQEEAQPSSV----SDLSPMSMPFASNSEPAPLTLTSPRMVAADNQDTSNLPQLAVPA 2130

  Fly  1337 ---NHHHQQQQQANRSQKYSQFMIITPAVSIDRD 1367
               :|         |.|....|..:.|..:|.:|
Human  2131 PRVSH---------RMQPRGSFYSMVPNATIHQD 2155

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125 44/148 (30%)
ANK repeat 59..87 CDD:293786 11/27 (41%)
Ank_2 61..153 CDD:289560 39/126 (31%)
ANK repeat 89..120 CDD:293786 15/65 (23%)
ANK repeat 122..153 CDD:293786 11/30 (37%)
ANK 202..316 CDD:238125 47/219 (21%)
ANK repeat 212..240 CDD:293786 13/27 (48%)
Ank_2 214..306 CDD:289560 41/149 (28%)
ANK repeat 242..273 CDD:293786 13/30 (43%)
ANK repeat 275..306 CDD:293786 17/88 (19%)
ANK 361..478 CDD:238125 44/237 (19%)
ANK repeat 363..396 CDD:293786 7/32 (22%)
Ank_2 367..459 CDD:289560 35/180 (19%)
ANK 393..573 CDD:238125 69/349 (20%)
ANK repeat 398..429 CDD:293786 13/59 (22%)
ANK repeat 431..459 CDD:293786 14/87 (16%)
ANK repeat 483..515 CDD:293786 6/38 (16%)
Ank_4 486..540 CDD:290365 16/60 (27%)
ANK 512..637 CDD:238125 49/165 (30%)
ANK repeat 522..550 CDD:293786 12/28 (43%)
Ank_2 524..616 CDD:289560 39/97 (40%)
ANK repeat 552..583 CDD:293786 15/33 (45%)
ANK repeat 585..610 CDD:293786 10/24 (42%)
ANK repeat 638..668 CDD:293786 9/31 (29%)
Ank_4 641..693 CDD:290365 13/53 (25%)
ANK 665..779 CDD:238125 32/119 (27%)
ANK repeat 672..703 CDD:293786 8/30 (27%)
Ank_2 677..769 CDD:289560 28/91 (31%)
ANK repeat 705..736 CDD:293786 12/30 (40%)
ANK repeat 738..769 CDD:293786 7/30 (23%)
SAM_tankyrase1,2 887..952 CDD:188923 9/64 (14%)
SAM 890..952 CDD:197735 8/61 (13%)
tankyrase_like 948..1170 CDD:238718 52/331 (16%)
PARP 961..1165 CDD:279038 48/301 (16%)
ANKHD1-EIF4EBP3NP_065741.3 Ank_2 209..301 CDD:289560 13/91 (14%)
ANK repeat 209..235 CDD:293786 8/25 (32%)
ANK 232..358 CDD:238125 27/127 (21%)
ANK repeat 237..269 CDD:293786 0/31 (0%)
ANK repeat 274..302 CDD:293786 4/27 (15%)
Ank_2 276..365 CDD:289560 28/90 (31%)
ANK 299..425 CDD:238125 38/128 (30%)
ANK repeat 304..335 CDD:293786 12/32 (38%)
ANK repeat 337..369 CDD:293786 15/31 (48%)
ANK 367..491 CDD:238125 27/134 (20%)
ANK repeat 371..402 CDD:293786 0/30 (0%)
Ank_4 374..425 CDD:290365 9/51 (18%)
ANK repeat 406..435 CDD:293786 11/28 (39%)
Ank_2 409..500 CDD:289560 28/100 (28%)
ANK repeat 437..468 CDD:293786 4/30 (13%)
ANK repeat 470..500 CDD:293786 13/39 (33%)
ANK repeat 503..532 CDD:293786 0/28 (0%)
ANK 537..655 CDD:238125 35/117 (30%)
ANK repeat 537..565 CDD:293786 13/27 (48%)
Ank_2 539..629 CDD:289560 31/89 (35%)
ANK repeat 567..598 CDD:293786 13/30 (43%)
ANK repeat 600..629 CDD:293786 7/28 (25%)
Ank_2 605..694 CDD:289560 16/88 (18%)
ANK 630..>694 CDD:238125 11/63 (17%)
ANK repeat 634..664 CDD:293786 9/29 (31%)
MAP7 <780..>865 CDD:283355 21/91 (23%)
Prefoldin <814..852 CDD:298833 7/37 (19%)
ANK repeat 1056..1085 CDD:293786 4/28 (14%)
Ank_2 1059..1152 CDD:289560 32/94 (34%)
ANK 1083..1210 CDD:238125 48/131 (37%)
ANK repeat 1087..1119 CDD:293786 13/33 (39%)
ANK repeat 1121..1152 CDD:293786 13/30 (43%)
Ank_2 1126..1219 CDD:289560 32/95 (34%)
ANK repeat 1154..1185 CDD:293786 14/33 (42%)
ANK repeat 1189..1219 CDD:293786 4/29 (14%)
Ank_2 1194..1285 CDD:289560 13/91 (14%)
ANK repeat 1222..1254 CDD:293786 3/31 (10%)
ANK 1252..1378 CDD:238125 38/135 (28%)
ANK repeat 1256..1285 CDD:293786 8/29 (28%)
Ank_2 1261..1355 CDD:289560 29/94 (31%)
ANK repeat 1291..1322 CDD:293786 8/30 (27%)
ANK repeat 1324..1355 CDD:293786 12/30 (40%)
KH-I 1697..1759 CDD:238053 10/71 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1115202at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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