DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and Ank2

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001189070.1	Gene:	Ank2 / 38863	FlyBaseID:	FBgn0261788	Length:	13559	Species:	Drosophila melanogaster

Alignment Length:	1378	Identity:	340/1378 - (24%)
Similarity:	542/1378 - (39%)	Gaps:	291/1378 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NSSRSRAILSVNLDAVMAN------------DPLRELFEACKTGEIAKVKKLITPQTVNARDTAG 55
            |:|..||..:.||:.|:.:            :.|..|..|.|.|.|..|.:|:....:  .|:|.
  Fly    12 NTSFLRAARAGNLERVLEHLKNNIDINTSNANGLNALHLASKDGHIHVVSELLRRGAI--VDSAT 74

  Fly    56 RK-STPLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTT 119
            :| :|.||.|:..|:.|||:.||...||:....:.|..||:......|..||||||..||:.:..
  Fly    75 KKGNTALHIASLAGQEEVVKLLLEHNASVNVQSQNGFTPLYMAAQENHDAVVRLLLSNGANQSLA 139

  Fly   120 DNWNYTPLHEAASKGKVDVCLALLQHGANHTIR---------NSEQKTPLELADEATRPVLTGEY 175
            ....:|||..|..:|...|...||:......:|         ..:.|....|.|....|.:|.:.
  Fly   140 TEDGFTPLAVAMQQGHDKVVAVLLESDTRGKVRLPALHIAAKKDDVKAATLLLDNDHNPDVTSKS 204

  Fly   176 RKDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKD 240
            ....|..|:..|.:: :..||.....:.:.|.....:|||:||.:.:..:|.:||..|.::.||.
  Fly   205 GFTPLHIASHYGNQN-IANLLIQKGADVNYSAKHNISPLHVAAKWGKTNMVSLLLEKGGNIEAKT 268

  Fly   241 KGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLL 305
            :.||.|||.|...||..|..:|::.||.::|.......|||.||....|:...:||
  Fly   269 RDGLTPLHCAARSGHEQVVDMLLERGAPISAKTKNGLAPLHMAAQGEHVDAARILL--------- 324

  Fly   306 NCHSKSAIDAAPTRELRERIAFEYKGHC--------LLDACRKCDVSRAKKLVCAEIVNFVHPYT 362
              :.::.:|......|   .|.....||        |||  |..|.:       |..:|
  Fly   325 --YHRAPVDEVTVDYL---TALHVAAHCGHVRVAKLLLD--RNADAN-------ARALN------ 369

  Fly   363 GDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNA 427
            |.||||:|...   .|.:::|||.|.|:.::...::.|||||:||.:...:.:..||:..|..:.
  Fly   370 GFTPLHIACKK---NRLKVVELLLRHGASISATTESGLTPLHVAAFMGCMNIVIYLLQHDASPDV 431

  Fly   428 LDSLGQTPLHRCARDEQA--VRLLLSYAADTNIVSLEGLTAAQLAS-----DSVLKLLKN----- 480
            ....|:||||..||..|.  :|:||...|..:..:.|..|...:||     |.|:.||::
  Fly   432 PTVRGETPLHLAARANQTDIIRILLRNGAQVDARAREQQTPLHIASRLGNVDIVMLLLQHGAQVD 496

  Fly   481 --PPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHG 543
              ..|..|.|..|||.|. |.|..:::.|..:::.....|  .||||..|.:..:.|.|.||:..
  Fly   497 ATTKDMYTALHIAAKEGQ-DEVAAVLIENGAALDAATKKG--FTPLHLTAKYGHIKVAQLLLQKE 558

  Fly   544 AEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKH 608
            |:|.|..|.|:.|||.||.|.:.:|..||::.||:.:.:.....||||.||.|.:.||...||::
  Fly   559 ADVDAQGKNGVTPLHVACHYNNQQVALLLLEKGASPHATAKNGHTPLHIAARKNQMDIATTLLEY 623

  Fly   609 GADPMKKNRDGATPADLVKESDH-DVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGR 672
            ||....:::.|.||..|..:..| :::.||....|.::...|..|
  Fly   624 GALANAESKAGFTPLHLSSQEGHAEISNLLIEHKAAVNHPAKNGL-------------------- 668

  Fly   673 NSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDK 737
              ||:||.|..:|...||.|.:|||:::...|.|..|||.||.:|..::...|:::...|:|...
  Fly   669 --TPMHLCAQEDNVNVAEILEKNGANIDMATKAGYTPLHVASHFGQANMVRFLLQNGANVDAATS 731

  Fly   738 WGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLLQDAMATSLSQQALS 802
            .|:||||:.||:|...:.:|||.|.|:|..:...||||:.:              |..|...::.
  Fly   732 IGYTPLHQTAQQGHCHIVNLLLEHKANANAQTVNGQTPLHI--------------ARKLGYISVL 782

  Fly   803 ASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVPLPLSSS-TRIS 866
            .|.:::|..    |.||||                      |:.|.....|..|..:..| ...|
  Fly   783 DSLKTITKE----DETAAA----------------------PSQAEEKYRVVAPEAMHESFMSDS 821

  Fly   867 PAQGAEANGAEG------------SSSDDLLP---------DADTITNVSGFLSSQQLHHLIELF 910
            ..:|.|.|....            |..||.||         |::.:|..:.:.|.
  Fly   822 EEEGGEDNMLSDQPYRYLTVDEMKSLGDDSLPIDVTRDERMDSNRMTQSAEYASG---------- 876

  Fly   911 EREQITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRSTTG------IGNNVNLCTLLVDLL 969
                    :...:|.:.:.......||...|.......:.:.:|      :|..::..:.||..|
  Fly   877 --------VPPTIGEEVISPHKTQVYGSSPKATVDGVYIANGSGHDEPPHVGRKLSWKSFLVSFL 933

  Fly   970 PDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQS 1034
            .|.:         ...:|..|.:|      .|..|......|..::..||...::.:
  Fly   934 VDAR---------GGAMRGCRHSG------VRMIIPSRSTCQPTRVTCRYVKPQRTM-------- 975

  Fly  1035 NERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSC 1099
            :...|..|....:.:::.| .....:||.:.....:||....|.
  Fly   976 HPPQLMEGEALASRVLELG-PCSTKFIGPVVMEVPHFASLRGKE--------------------- 1018

  Fly  1100 YVCPRQLLLCRVALGKSFLQYS----------AMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRG 1154
                |::::.|...|:::.:::          .::....|   ..:.......|.|...:|.|
  Fly  1019 ----REIIILRSDNGETWREHTIDNSEEIIHDVLQQCFEP---EEIAQLEEQAGNHVCRFVTY-- 1074

  Fly  1155 EQSYPEYLITYQIVKPDDSSSGTEDTRXWMPSVGSTPTTTSPALHQPQTQQQPQQQQQQQPQPQQ 1219
              .:|:|......::.:..:.|        |..|...:|..|            |.|...||...
  Fly  1075 --DFPQYFAVVSRIRQEVHAIG--------PEGGMVSSTVVP------------QVQAVFPQGAL 1117

  Fly  1220 QQKAPLPLPPPQQQTSAP--VAKRRPKHAKPSLQLQYQPYQPQHHPVVATAAAVTTTQPSPAGVF 1282
            .:|..:.|   |.|...|  .||...:....|..:..:|.:.:.|      .|:|.:.|:|.
  Fly  1118 TKKIKVGL---QAQPVDPDLTAKLLGRGVAVSPIVTVEPRRRKFH------KAITLSMPAPK--- 1170

  Fly  1283 AHSNNNNNTSSGN 1295
            |||....|..|||
  Fly  1171 AHSQGMINQYSGN 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	37/123 (30%)
		ANK repeat	59..87	CDD:293786	12/27 (44%)
		Ank_2	61..153	CDD:289560	32/100 (32%)
		ANK repeat	89..120	CDD:293786	12/30 (40%)
		ANK repeat	122..153	CDD:293786	9/39 (23%)
		ANK	202..316	CDD:238125	34/113 (30%)
		ANK repeat	212..240	CDD:293786	10/27 (37%)
		Ank_2	214..306	CDD:289560	31/91 (34%)
		ANK repeat	242..273	CDD:293786	13/30 (43%)
		ANK repeat	275..306	CDD:293786	8/30 (27%)
		ANK	361..478	CDD:238125	40/123 (33%)
		ANK repeat	363..396	CDD:293786	12/32 (38%)
		Ank_2	367..459	CDD:289560	31/93 (33%)
		ANK	393..573	CDD:238125	63/193 (33%)
		ANK repeat	398..429	CDD:293786	10/30 (33%)
		ANK repeat	431..459	CDD:293786	12/29 (41%)
		ANK repeat	483..515	CDD:293786	10/31 (32%)
		Ank_4	486..540	CDD:290365	17/53 (32%)
		ANK	512..637	CDD:238125	44/125 (35%)
		ANK repeat	522..550	CDD:293786	12/27 (44%)
		Ank_2	524..616	CDD:289560	36/91 (40%)
		ANK repeat	552..583	CDD:293786	12/30 (40%)
		ANK repeat	585..610	CDD:293786	11/24 (46%)
		ANK repeat	638..668	CDD:293786	3/29 (10%)
		Ank_4	641..693	CDD:290365	11/51 (22%)
		ANK	665..779	CDD:238125	41/113 (36%)
		ANK repeat	672..703	CDD:293786	12/30 (40%)
		Ank_2	677..769	CDD:289560	35/91 (38%)
		ANK repeat	705..736	CDD:293786	10/30 (33%)
		ANK repeat	738..769	CDD:293786	14/30 (47%)
		SAM_tankyrase1,2	887..952	CDD:188923	7/64 (11%)
		SAM	890..952	CDD:197735	6/61 (10%)
		tankyrase_like	948..1170	CDD:238718	32/237 (14%)
		PARP	961..1165	CDD:279038	30/213 (14%)
Ank2	NP_001189070.1	ANK repeat	10..41	CDD:293786	7/28 (25%)
		Ank_4	11..64	CDD:290365	14/51 (27%)
		ANK	38..163	CDD:238125	41/126 (33%)
		ANK repeat	43..74	CDD:293786	9/32 (28%)
		Ank_2	48..135	CDD:289560	33/88 (38%)
		ANK repeat	76..107	CDD:293786	13/30 (43%)
		ANK repeat	109..134	CDD:293786	10/24 (42%)
		Ank_4	110..163	CDD:290365	18/52 (35%)
		Ank_4	172..225	CDD:290365	10/53 (19%)
		ANK repeat	175..202	CDD:293786	4/26 (15%)
		ANK	199..324	CDD:238125	37/125 (30%)
		ANK repeat	204..235	CDD:293786	5/31 (16%)
		Ank_2	209..300	CDD:289560	29/91 (32%)
		ANK repeat	237..268	CDD:293786	10/30 (33%)
		ANK	266..390	CDD:238125	44/155 (28%)
		ANK repeat	270..300	CDD:293786	12/29 (41%)
		ANK repeat	303..367	CDD:293786	19/86 (22%)
		Ank_2	308..399	CDD:289560	31/122 (25%)
		ANK	364..489	CDD:238125	42/140 (30%)
		ANK repeat	369..400	CDD:293786	13/39 (33%)
		ANK repeat	402..433	CDD:293786	10/30 (33%)
		Ank_4	403..456	CDD:290365	19/52 (37%)
		ANK repeat	435..466	CDD:293786	12/30 (40%)
		Ank_2	440..530	CDD:289560	27/90 (30%)
		ANK	463..588	CDD:238125	41/127 (32%)
		ANK repeat	468..497	CDD:293786	8/28 (29%)
		ANK repeat	501..530	CDD:293786	10/29 (34%)
		Ank_2	506..597	CDD:289560	34/93 (37%)
		ANK	529..654	CDD:238125	45/126 (36%)
		ANK repeat	535..565	CDD:293786	13/31 (42%)
		ANK repeat	567..598	CDD:293786	12/30 (40%)
		Ank_2	572..661	CDD:289560	31/88 (35%)
		ANK repeat	600..630	CDD:293786	13/29 (45%)
		ANK repeat	633..662	CDD:293786	8/28 (29%)
		ANK	661..785	CDD:238125	45/159 (28%)
		ANK repeat	666..697	CDD:293786	13/52 (25%)
		Ank_2	672..762	CDD:289560	35/89 (39%)
		ANK repeat	699..730	CDD:293786	10/30 (33%)
		ANK repeat	732..762	CDD:293786	14/29 (48%)
		ZU5	927..1030	CDD:128514	22/151 (15%)
		Death_ank	1417..1497	CDD:260029
		ER-remodelling	11936..>12013	CDD:258892
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3248
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810