DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and ANKRD30B

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_001354536.1 Gene:ANKRD30B / 374860 HGNCID:24165 Length:1525 Species:Homo sapiens


Alignment Length:459 Identity:106/459 - (23%)
Similarity:160/459 - (34%) Gaps:104/459 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   491 AAKAGDLDTVRRIVL-NNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGL 554
            ||..|.:..:.::.: ..|:::|.||:..|  |.||:|.......||.||::...::...|..|.
Human    45 AASRGQVQKLEKMTVGKKPVNLNKRDMKKR--TALHWACVNGHAEVVTFLVDRKCQLNVLDGEGR 107

  Fly   555 VPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDG 619
            .||..|..........:|:..||::|..|::..|.||.|.......:...||.:|          
Human   108 TPLMKALQCEREACANILIDAGADLNYVDVYGNTALHYAVYSENLLMVATLLSYG---------- 162

  Fly   620 ATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNSTPLHLAAGYN 684
                                  |:::...|.:|                      |||.||....
Human   163 ----------------------AVIEVQNKASL----------------------TPLLLAIQKR 183

  Fly   685 NFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQK 749
            :.:..|:||...|:.||.::.....|..|...|..:|..:|::....|.|.|..|.|....||..
Human   184 SKQTVEFLLTKNANANAFNESKCTALMLAICEGSSEIVGMLLQQNVDVFAEDIHGITAERYAAAC 248

  Fly   750 GRTQLCSLLLAH----GADAYMKNQEGQ---TPIELA-----TADDVKCLLQ---DAMATSLSQQ 799
            |...:...||.|    ..:....|.||.   ||.|.|     |.|..:.||:   |..|..:  :
Human   249 GVNYIHQQLLEHIRKLPKNPQNTNPEGTSTGTPDEAAPLAERTPDTAESLLEKTPDEAARLV--E 311

  Fly   800 ALSASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVP-------- 856
            ..||..|.|..      ||:.....::..:...||.||.||       |...|.|..        
Human   312 GTSAKIQCLGK------ATSGKFEQSTEETPRKILRPTKET-------SEKFSWPAKERSRKITW 363

  Fly   857 LPLSSSTRISPAQGAEANGAE----GSSSDDLLPDADTITNVSGFLSSQQLHHLIELF-----ER 912
            ....:|.:.....|...|..|    |:|:....|..:|.|..|..:....:..:..||     |.
Human   364 EEKETSVKTECVAGVTPNKTEVLEKGTSNMIACPTKETSTKASTNVDVSSVEPIFSLFGTRTIEN 428

  Fly   913 EQIT 916
            .|.|
Human   429 SQCT 432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125
ANK repeat 59..87 CDD:293786
Ank_2 61..153 CDD:289560
ANK repeat 89..120 CDD:293786
ANK repeat 122..153 CDD:293786
ANK 202..316 CDD:238125
ANK repeat 212..240 CDD:293786
Ank_2 214..306 CDD:289560
ANK repeat 242..273 CDD:293786
ANK repeat 275..306 CDD:293786
ANK 361..478 CDD:238125
ANK repeat 363..396 CDD:293786
Ank_2 367..459 CDD:289560
ANK 393..573 CDD:238125 21/82 (26%)
ANK repeat 398..429 CDD:293786
ANK repeat 431..459 CDD:293786
ANK repeat 483..515 CDD:293786 5/24 (21%)
Ank_4 486..540 CDD:290365 15/49 (31%)
ANK 512..637 CDD:238125 29/124 (23%)
ANK repeat 522..550 CDD:293786 8/27 (30%)
Ank_2 524..616 CDD:289560 24/91 (26%)
ANK repeat 552..583 CDD:293786 8/30 (27%)
ANK repeat 585..610 CDD:293786 6/24 (25%)
ANK repeat 638..668 CDD:293786 3/29 (10%)
Ank_4 641..693 CDD:290365 9/51 (18%)
ANK 665..779 CDD:238125 33/120 (28%)
ANK repeat 672..703 CDD:293786 11/30 (37%)
Ank_2 677..769 CDD:289560 25/95 (26%)
ANK repeat 705..736 CDD:293786 7/30 (23%)
ANK repeat 738..769 CDD:293786 8/34 (24%)
SAM_tankyrase1,2 887..952 CDD:188923 8/35 (23%)
SAM 890..952 CDD:197735 8/32 (25%)
tankyrase_like 948..1170 CDD:238718
PARP 961..1165 CDD:279038
ANKRD30BNP_001354536.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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