DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and Fem-1

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_611508.1 Gene:Fem-1 / 37344 FlyBaseID:FBgn0034542 Length:702 Species:Drosophila melanogaster


Alignment Length:715 Identity:168/715 - (23%)
Similarity:260/715 - (36%) Gaps:204/715 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   183 AARSGAEDRLLALLTPLN-VNCHA------------SDGRRSTPLHLAAGYNRIGIVEILLA--- 231
            |||||   ::|:.:..|| |:|.|            .||:..|||.:||....:..|:.||:   
  Fly    64 AARSG---QMLSFVEILNSVSCRAVQTHLVNTNFDQPDGQSLTPLTMAAMMGNVKFVKTLLSHYD 125

  Fly   232 -----------NGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAAS 285
                       :|..|:     |...|..|...||..:.|:|:||||.:|.|.....:||..|..
  Fly   126 VDLDRECNVIYDGMVVY-----GATALWVAAGMGHLQIVKMLVQAGAAINHNTKAQSSPLRAACY 185

  Fly   286 KSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAK-KL 349
            :.|:::...|:..|||....|..:.:.:..|           .||||.|:......:.|||. :.
  Fly   186 EGRLDIVEFLIDNGADVNATNLFNNNTLMIA-----------AYKGHHLVVKTLLQNGSRANDQA 239

  Fly   350 VCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDA 414
            :|           |.|.||.|..|  |....::.||....:|  :||:..:||...|||.||.|.
  Fly   240 LC-----------GATALHYAAES--GHLDVVVALLDHGATL--KKNELGITPALQAAERLHEDV 289

  Fly   415 MEV------LLKQGAKVNALDSLGQTPLHRCARDEQAVRLLLSYAADTNIVSLEGLTAAQLASDS 473
            :|.      |:....::.||:.||.|    .|.|:      :.|  |.|......|.|.||...:
  Fly   290 LEAFIERPELMSLEEQITALELLGAT----YANDK------IKY--DVNKAYGYLLRAMQLRYSN 342

  Fly   474 ----VLKLLKNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAA------ 528
                :.|.::....:..:.||.....:|..::   ||:            ||..:...|      
  Fly   343 PRGVIRKRVQPTVPAYDNWLETENLPELYAIK---LNH------------HSIHMESLAIRERIL 392

  Fly   529 GFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPL--- 590
            |.|...:.|.::..||.:  ||:|.........:|    ..:|.:::..:|: .||.:|..|   
  Fly   393 GRNNPELPQAIIYRGAVM--ADQGRFYQCQVLWNY----AIDLRMRNNVSVD-RDLLRFAQLFAQ 450

  Fly   591 ------------HEAAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKESDHDVAELL------ 637
                        |......|   |:..:::....:|:.:..|.|:....:::.:....|      
  Fly   451 ILRVENHNLTLDHVLPVLAK---CQQEIENNKFKIKEAKPNACPSLWQDQNNQNCITALYLIKIV 512

  Fly   638 -----RGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNSTPLHLAAG--------YNN---- 685
                 |.....:|......|..|.|.........:|.|    |.||:|..        |.|    
  Fly   513 THLARRKKDQNIDEEHIQQLFLVVRKFIQNDTRLQDGQ----TLLHIAVNGVMPVDEFYTNEMCR 573

  Fly   686 FEC---AEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAA 747
            |.|   |..|:..||.|.|.|.....|||            :|:   |.||.|         :..
  Fly   574 FPCYATALVLVHCGASVVAVDSDRNTPLH------------ILV---TKVNTT---------QDR 614

  Fly   748 QKGRTQLCSLLLAHGADAYMKNQEGQTPIELATA-----------------DDVKCLLQDAMATS 795
            |....::..|.:..||.....|..|||   .|||                 ..:|||...::||:
  Fly   615 QAEMARILELFVEAGAHLDAVNAAGQT---AATACKLPILANRLHAHQNAHTSLKCLAARSIATN 676

  Fly   796  795
              Fly   677  676

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125
ANK repeat 59..87 CDD:293786
Ank_2 61..153 CDD:289560
ANK repeat 89..120 CDD:293786
ANK repeat 122..153 CDD:293786
ANK 202..316 CDD:238125 36/139 (26%)
ANK repeat 212..240 CDD:293786 10/41 (24%)
Ank_2 214..306 CDD:289560 29/105 (28%)
ANK repeat 242..273 CDD:293786 12/30 (40%)
ANK repeat 275..306 CDD:293786 8/30 (27%)
ANK 361..478 CDD:238125 37/126 (29%)
ANK repeat 363..396 CDD:293786 10/32 (31%)
Ank_2 367..459 CDD:289560 30/97 (31%)
ANK 393..573 CDD:238125 45/195 (23%)
ANK repeat 398..429 CDD:293786 11/36 (31%)
ANK repeat 431..459 CDD:293786 8/27 (30%)
ANK repeat 483..515 CDD:293786 5/31 (16%)
Ank_4 486..540 CDD:290365 11/59 (19%)
ANK 512..637 CDD:238125 24/145 (17%)
ANK repeat 522..550 CDD:293786 6/33 (18%)
Ank_2 524..616 CDD:289560 20/112 (18%)
ANK repeat 552..583 CDD:293786 4/30 (13%)
ANK repeat 585..610 CDD:293786 5/39 (13%)
ANK repeat 638..668 CDD:293786 5/29 (17%)
Ank_4 641..693 CDD:290365 15/66 (23%)
ANK 665..779 CDD:238125 33/128 (26%)
ANK repeat 672..703 CDD:293786 14/45 (31%)
Ank_2 677..769 CDD:289560 26/106 (25%)
ANK repeat 705..736 CDD:293786 7/30 (23%)
ANK repeat 738..769 CDD:293786 4/30 (13%)
SAM_tankyrase1,2 887..952 CDD:188923
SAM 890..952 CDD:197735
tankyrase_like 948..1170 CDD:238718
PARP 961..1165 CDD:279038
Fem-1NP_611508.1 ANK 61..196 CDD:238125 40/139 (29%)
ANK repeat 103..129 CDD:293786 8/25 (32%)
Ank_2 105..206 CDD:289560 29/105 (28%)
ANK 142..262 CDD:238125 39/148 (26%)
ANK repeat 142..173 CDD:293786 12/35 (34%)
ANK repeat 178..206 CDD:293786 8/27 (30%)
Ank_2 180..266 CDD:289560 27/109 (25%)
ANK repeat 208..239 CDD:293786 9/41 (22%)
ANK repeat 241..266 CDD:293786 10/37 (27%)
Ank_4 244..294 CDD:290365 20/53 (38%)
ANK 548..685 CDD:238125 41/160 (26%)
ANK repeat 548..594 CDD:293786 16/49 (33%)
ANK repeat 596..636 CDD:293786 12/63 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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