DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and ANKDD1A

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_874362.3 Gene:ANKDD1A / 348094 HGNCID:28002 Length:522 Species:Homo sapiens


Alignment Length:432 Identity:120/432 - (27%)
Similarity:183/432 - (42%) Gaps:61/432 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   403 LHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLHRC--ARDEQAVRLLLSYAADTNIVSLEG-L 464
            ||.||...:...|:.|:.:.....|.:.:|:..||..  |..||||||||.:.|..:.....| |
Human    19 LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGAL 83

  Fly   465 TAAQLASDSVLKLLKNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAG 529
            |.|:|..            ....||.:|..|.| .:.:|::|:...::|...||  .|.||.||.
Human    84 TEARLCF------------GMNALLLSAWFGHL-RILQILVNSGAKIHCESKDG--LTLLHCAAQ 133

  Fly   530 FNRVPVVQFLLEHGAEVYA--ADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHE 592
            ...|||:.|::|...:|..  .||.|....|.|..:|..:..:.||..|.:.||.|....|.||.
Human   134 KGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198

  Fly   593 AAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKESDH-DVAELLRGPSALLDAAKKGNLARVQ 656
            ||.:|...:.:.|:..|.|..::|.:|.|.........| |..:||....:.::|          
Human   199 AAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNA---------- 253

  Fly   657 RLVTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDI 721
              :|.::::|          ||.||...:.:.:..|:..|...|..|..|..|||.|..:....:
Human   254 --LTQKNLSC----------LHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPAL 306

  Fly   722 AALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKC 786
            ..|||...:.|||.|....||||.||:.....:..:||..|.|..:::::|:|.:.:|...:...
Human   307 VRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVS 371

  Fly   787 LL-----------------QDAMATSLS-QQALSASTQSLTS 810
            |:                 .|....||| :|.....||.|.|
Human   372 LVDMIIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRS 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125
ANK repeat 59..87 CDD:293786
Ank_2 61..153 CDD:289560
ANK repeat 89..120 CDD:293786
ANK repeat 122..153 CDD:293786
ANK 202..316 CDD:238125
ANK repeat 212..240 CDD:293786
Ank_2 214..306 CDD:289560
ANK repeat 242..273 CDD:293786
ANK repeat 275..306 CDD:293786
ANK 361..478 CDD:238125 25/77 (32%)
ANK repeat 363..396 CDD:293786
Ank_2 367..459 CDD:289560 20/57 (35%)
ANK 393..573 CDD:238125 52/174 (30%)
ANK repeat 398..429 CDD:293786 7/25 (28%)
ANK repeat 431..459 CDD:293786 13/29 (45%)
ANK repeat 483..515 CDD:293786 8/31 (26%)
Ank_4 486..540 CDD:290365 19/53 (36%)
ANK 512..637 CDD:238125 40/127 (31%)
ANK repeat 522..550 CDD:293786 11/29 (38%)
Ank_2 524..616 CDD:289560 31/93 (33%)
ANK repeat 552..583 CDD:293786 9/30 (30%)
ANK repeat 585..610 CDD:293786 7/24 (29%)
ANK repeat 638..668 CDD:293786 3/29 (10%)
Ank_4 641..693 CDD:290365 7/51 (14%)
ANK 665..779 CDD:238125 33/113 (29%)
ANK repeat 672..703 CDD:293786 7/30 (23%)
Ank_2 677..769 CDD:289560 30/91 (33%)
ANK repeat 705..736 CDD:293786 11/30 (37%)
ANK repeat 738..769 CDD:293786 10/30 (33%)
SAM_tankyrase1,2 887..952 CDD:188923
SAM 890..952 CDD:197735
tankyrase_like 948..1170 CDD:238718
PARP 961..1165 CDD:279038
ANKDD1ANP_874362.3 ANK 1 14..43 6/23 (26%)
Ank_2 19..118 CDD:289560 32/111 (29%)
ANK repeat 19..45 CDD:293786 7/25 (28%)
ANK 43..179 CDD:238125 46/150 (31%)
ANK 2 47..76 13/28 (46%)
ANK repeat 48..78 CDD:293786 13/29 (45%)
ANK repeat 90..121 CDD:293786 8/43 (19%)
ANK 3 90..119 7/41 (17%)
Ank_2 95..189 CDD:289560 32/96 (33%)
ANK 122..245 CDD:238125 40/124 (32%)
ANK repeat 123..156 CDD:293786 13/34 (38%)
ANK 4 123..152 13/30 (43%)
ANK 5 158..187 7/28 (25%)
ANK repeat 159..189 CDD:293786 9/29 (31%)
Ank_2 163..253 CDD:289560 25/89 (28%)
ANK 186..311 CDD:238125 36/146 (25%)
ANK repeat 191..222 CDD:293786 9/30 (30%)
ANK 6 191..220 9/28 (32%)
ANK repeat 224..253 CDD:293786 6/28 (21%)
ANK 7 224..253 6/28 (21%)
ANK 252..377 CDD:238125 37/146 (25%)
ANK 8 257..286 7/38 (18%)
ANK repeat 260..288 CDD:293786 8/37 (22%)
Ank_2 262..354 CDD:289560 30/91 (33%)
ANK repeat 290..321 CDD:293786 11/30 (37%)
ANK 9 290..319 9/28 (32%)
ANK repeat 323..354 CDD:293786 10/30 (33%)
ANK 10 323..352 10/28 (36%)
ANK 11 356..385 4/28 (14%)
Death 426..494 CDD:260017
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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