DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and nompC

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_523483.2 Gene:nompC / 33768 FlyBaseID:FBgn0016920 Length:1761 Species:Drosophila melanogaster


Alignment Length:1181 Identity:291/1181 - (24%)
Similarity:433/1181 - (36%) Gaps:347/1181 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 NDPLRELFEACKTGEIAKVKKLITPQTVNARDTAG-RKSTPLHFAA----GYGRREVVEFLLNSG 80
            ||....|..|........||.|:|.:.|:...|.| |..|.:|..:    |.....:...|..:|
  Fly   158 NDNYNVLHIAAMYSREDVVKLLLTKRGVDPFSTGGSRSQTAVHLVSSRQTGTATNILRALLAAAG 222

  Fly    81 ASIQACDEG-GLHPLHNCCSFGHAEVVRLLLKAGASPN---TTDNWNYTPLHEAASKGKVDVCLA 141
            ..|:...:| |..||......|:..:.|.||.|..:..   ||.|.: |.||.||.:..||:...
  Fly   223 KDIRLKADGRGKIPLLLAVESGNQSMCRELLAAQTAEQLKATTANGD-TALHLAARRRDVDMVRI 286

  Fly   142 LLQHGANHTIRNSEQKTPLELA----DEATRPVLTGEYRKDELLEAARSGA--EDRLLALLTPLN 200
            |:.:|.|...:|.|.:|||.:|    |||......|       :.|:.|.|  :||     ||::
  Fly   287 LVDYGTNVDTQNGEGQTPLHIAAAEGDEALLKYFYG-------VRASASIADNQDR-----TPMH 339

  Fly   201 V---NCHA------------------SDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGL 244
            :   |.||                  .||  ||.:|:|:.........:|...|..:|..:|.|.
  Fly   340 LAAENGHAHVIEILADKFKASIFERTKDG--STLMHIASLNGHAECATMLFKKGVYLHMPNKDGA 402

  Fly   245 VPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHS 309
            ..:|.|.:|||..:...|:|.|..|:......:|.||.|...::..|...||..|||     .| 
  Fly   403 RSIHTAAAYGHTGIINTLLQKGEKVDVTTNDNYTALHIAVESAKPAVVETLLGFGAD-----VH- 461

  Fly   310 KSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGD--TPLHLAVV 372
               :.....||....||...|     |..| |.:...|......:.      |.|  ||:|:|  
  Fly   462 ---VRGGKLRETPLHIAARVK-----DGDR-CALMLLKSGASPNLT------TDDCLTPVHVA-- 509

  Fly   373 SPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLL----------KQGAKVNA 427
            :..|....||:||..:|..|.:.|.. .||||:|....|.|.:..|:          |....:|:
  Fly   510 ARHGNLATLMQLLEDEGDPLYKSNTG-ETPLHMACRACHPDIVRHLIETVKEKHGPDKATTYINS 573

  Fly   428 LDSLGQTPLHRCAR-----------DEQAVRLLLSYAADTNIVSLEGLTAAQLA---------SD 472
            ::..|.|.||...:           |:|.||:||...||   |:|:..||.:.|         :|
  Fly   574 VNEDGATALHYTCQITKEEVKIPESDKQIVRMLLENGAD---VTLQTKTALETAFHYCAVAGNND 635

  Fly   473 SVLKLLK--NPPDSE-----------THLLEAAKAGDLDTVRRIVLN------------------ 506
            .:::::.  ||.|.:           |.||.|...|.::.|..::.|                  
  Fly   636 VLMEMISHMNPTDIQKAMNRQSSVGWTPLLIACHRGHMELVNNLLANHARVDVFDTEGRSALHLA 700

  Fly   507 --------------NPISVNCRDLDGR---------------------HS-----------TPLH 525
                          |...:|.:...||                     |:           ||||
  Fly   701 AERGYLHVCDALLTNKAFINSKSRVGRTALHLAAMNGFTHLVKFLIKDHNAVIDILTLRKQTPLH 765

  Fly   526 FAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTEL-LVKHGANVN--------- 580
            .||...::.|.|.|||.||.:.|.|..|..|:|.|....:.||.:| |.:|.:.||         
  Fly   766 LAAASGQMEVCQLLLELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQQHPSLVNATSKDGNTC 830

  Fly   581 ------------VSDLWKF---------------TPLHEAAAKGKYDICKLLLKHGADPMKKNRD 618
                        :.:|.||               |||..||..|..|:.|.|::.||...::|:.
  Fly   831 AHIAAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKA 895

  Fly   619 GATPADLVKESDH-DVAELLRGPSALLDAAKK------------GNLARVQRLVT--PESINCRD 668
            |.|...|..::.| .|.::|:..::|...:||            |....|:.|:|  |.::....
  Fly   896 GFTAVHLAAQNGHGQVLDVLKSTNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSET 960

  Fly   669 AQGRN----------STPLHLAA--------------------------GYNNFECAEY------ 691
            ..|::          .|||||||                          |||....|.:      
  Fly   961 PTGQSLFGDLGTESGMTPLHLAAFSGNENVVRLLLNSAGVQVDAATIENGYNPLHLACFGGHMSV 1025

  Fly   692 ---LLENGAD-VNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRT 752
               ||...|: :.:||:.|...||.|:.:||:.:..:|:.....:||||:.|:||||.||:.|..
  Fly  1026 VGLLLSRSAELLQSQDRNGRTGLHIAAMHGHIQMVEILLGQGAEINATDRNGWTPLHCAAKAGHL 1090

  Fly   753 QLCSLLLAHGADAYMKNQEGQTPIELATAD--------------DVKCLLQD------AMATSLS 797
            ::..||...||....:...|...|..|.::              |...|::|      .|..|.:
  Fly  1091 EVVKLLCEAGASPKSETNYGCAAIWFAASEGHNEVLRYLMNKEHDTYGLMEDKRFVYNLMVVSKN 1155

  Fly   798 QQALSASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVPLPLSSS 862
            ..  :...|.....||||..|||      ..|:..|:..|.|..                  .:.
  Fly  1156 HN--NKPIQEFVLVSPAPVDTAA------KLSNIYIVLSTKEKE------------------RAK 1194

  Fly   863 TRISPAQGAEANGAE------GSSSDDLLPDADTITNVSGFLSSQQLHHLIELFEREQITLDI-- 919
            ..::..:..||...|      ||.|...:..|....||      :.|..|||..::|.|...:  
  Fly  1195 DLVAAGKQCEAMATELLALAAGSDSAGKILQATDKRNV------EFLDVLIENEQKEVIAHTVVQ 1253

  Fly   920 --LAEMGHDDL 928
              |.|:.|..|
  Fly  1254 RYLQELWHGSL 1264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125 36/122 (30%)
ANK repeat 59..87 CDD:293786 6/31 (19%)
Ank_2 61..153 CDD:289560 27/99 (27%)
ANK repeat 89..120 CDD:293786 10/34 (29%)
ANK repeat 122..153 CDD:293786 10/30 (33%)
ANK 202..316 CDD:238125 34/131 (26%)
ANK repeat 212..240 CDD:293786 6/27 (22%)
Ank_2 214..306 CDD:289560 26/91 (29%)
ANK repeat 242..273 CDD:293786 10/30 (33%)
ANK repeat 275..306 CDD:293786 10/30 (33%)
ANK 361..478 CDD:238125 42/148 (28%)
ANK repeat 363..396 CDD:293786 12/34 (35%)
Ank_2 367..459 CDD:289560 32/112 (29%)
ANK 393..573 CDD:238125 66/287 (23%)
ANK repeat 398..429 CDD:293786 10/40 (25%)
ANK repeat 431..459 CDD:293786 12/38 (32%)
ANK repeat 483..515 CDD:293786 10/74 (14%)
Ank_4 486..540 CDD:290365 20/117 (17%)
ANK 512..637 CDD:238125 50/194 (26%)
ANK repeat 522..550 CDD:293786 14/27 (52%)
Ank_2 524..616 CDD:289560 38/128 (30%)
ANK repeat 552..583 CDD:293786 11/52 (21%)
ANK repeat 585..610 CDD:293786 11/39 (28%)
ANK repeat 638..668 CDD:293786 8/43 (19%)
Ank_4 641..693 CDD:290365 20/110 (18%)
ANK 665..779 CDD:238125 42/159 (26%)
ANK repeat 672..703 CDD:293786 14/76 (18%)
Ank_2 677..769 CDD:289560 37/127 (29%)
ANK repeat 705..736 CDD:293786 9/30 (30%)
ANK repeat 738..769 CDD:293786 12/30 (40%)
SAM_tankyrase1,2 887..952 CDD:188923 13/46 (28%)
SAM 890..952 CDD:197735 12/43 (28%)
tankyrase_like 948..1170 CDD:238718
PARP 961..1165 CDD:279038
nompCNP_523483.2 ANK repeat 129..157 CDD:293786
Ank_2 131..228 CDD:289560 18/69 (26%)
ANK 155..319 CDD:238125 49/161 (30%)
ANK repeat 159..186 CDD:293786 7/26 (27%)
ANK repeat 232..265 CDD:293786 8/32 (25%)
Ank_2 237..331 CDD:289560 31/101 (31%)
ANK 263..387 CDD:238125 39/138 (28%)
ANK repeat 267..298 CDD:293786 11/31 (35%)
ANK repeat 300..331 CDD:293786 11/37 (30%)
Ank_2 305..398 CDD:289560 25/106 (24%)
ANK 329..454 CDD:238125 33/131 (25%)
ANK repeat 367..398 CDD:293786 9/32 (28%)
ANK repeat 400..431 CDD:293786 10/30 (33%)
Ank_2 405..498 CDD:289560 29/107 (27%)
ANK 428..555 CDD:238125 41/150 (27%)
ANK repeat 433..463 CDD:293786 11/38 (29%)
ANK repeat 469..499 CDD:293786 8/41 (20%)
ANK 496..641 CDD:238125 42/156 (27%)
ANK repeat 501..532 CDD:293786 12/32 (38%)
Ank_2 507..616 CDD:289560 33/114 (29%)
ANK repeat 534..575 CDD:293786 10/41 (24%)
ANK repeat 577..616 CDD:293786 13/41 (32%)
Ank_2 625..722 CDD:289560 13/96 (14%)
ANK 654..780 CDD:238125 20/125 (16%)
ANK repeat 660..690 CDD:293786 7/29 (24%)
ANK repeat 692..723 CDD:293786 2/30 (7%)
Ank_2 697..790 CDD:289560 19/92 (21%)
ANK 720..847 CDD:238125 30/126 (24%)
ANK repeat 725..757 CDD:293786 3/31 (10%)
ANK repeat 759..790 CDD:293786 14/30 (47%)
Ank_5 779..834 CDD:290568 18/54 (33%)
ANK 787..915 CDD:238125 33/127 (26%)
ANK repeat 792..824 CDD:293786 11/31 (35%)
ANK repeat 861..893 CDD:293786 11/31 (35%)
Ank_4 865..915 CDD:290365 17/49 (35%)
Ank_4 929..995 CDD:290365 13/65 (20%)
ANK repeat 932..972 CDD:293786 6/39 (15%)
ANK 969..1096 CDD:238125 35/126 (28%)
ANK repeat 974..1007 CDD:293786 7/32 (22%)
Ank_2 979..1074 CDD:289560 23/94 (24%)
ANK repeat 1009..1041 CDD:293786 7/31 (23%)
ANK 1039..1159 CDD:238125 33/121 (27%)
ANK repeat 1043..1074 CDD:293786 9/30 (30%)
Ank_2 1048..1135 CDD:289560 25/86 (29%)
ANK repeat 1076..1101 CDD:293786 10/24 (42%)
ANK repeat 1109..1134 CDD:293786 3/24 (13%)
Ion_trans <1393..1598 CDD:278921
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1115202at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm3248
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1759
SonicParanoid 00.000 Not matched by this tool.
54.850

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