DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and Ankdd1a

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001357800.1	Gene:	Ankdd1a / 330963	MGIID:	2686319	Length:	519	Species:	Mus musculus

Alignment Length:	700	Identity:	158/700 - (22%)
Similarity:	228/700 - (32%)	Gaps:	268/700 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PL-RELFEACKTGEIAKVKKLITPQ-TVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQA 85
            || |:|.||.:..::.::|:|...: .:.||:..||  ..||:|||.|..:.|..||..||::..
Mouse    14 PLERQLHEASRWNQVERMKELFEKRVNIRARNHVGR--VALHWAAGAGHEQAVRLLLERGAAVDD 76

  Fly    86 CDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGKVDVCLALLQHGANHT 150
            .|..|::.|.....|||.::|::|:.|||..:.......|.||.||.||.|
Mouse    77 VDSFGMNSLLLSAWFGHLQIVQILVNAGAKVHCESKDGLTLLHCAAQKGHV-------------- 127

  Fly   151 IRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLH 215
                              |||.  :..::|.:.|...| |:|               ||  |..|
Mouse   128 ------------------PVLA--FVMEDLEDVALDHA-DKL---------------GR--TAFH 154

  Fly   216 LAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPL 280
            .||.:.::..::.|:.:|.|...|||||...||.|.|.||.||.:.|:..|
Mouse   155 RAAEHGQLDALDFLVGSGCDHSVKDKGGNTALHLAASQGHVDVLQRLVDIG-------------- 205

  Fly   281 HEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSR 345
                                                                  ||
Mouse   206 ------------------------------------------------------LD--------- 207

  Fly   346 AKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELL 410
                                                          |.|:|...||.||.|||.:
Mouse   208 ----------------------------------------------LEEQNTEGLTALHAAAEGI 226

  Fly   411 HYDAMEVLLKQGAKVNALDSLGQTPLHRCA--RDEQAVRLLLSYAADTNIVSLEGLTAAQLASDS 473
            |.|.:.:||..|:.||||.....:.||..|  ..|...|.|:.....||:...:|.|...||
Mouse   227 HADCVMLLLGAGSNVNALTQKRLSCLHYAALGGSEDLSRALIKAGGCTNVADKQGTTPMHLA--- 288

  Fly   474 VLKLLKNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQF 538
               :..|.|.....|::.  ..|||.|                |.|..||||.||......|...
Mouse   289 ---VKHNFPGLVQLLIDG--HSDLDAV----------------DIRRQTPLHLAAEHAWQDVADM 332

  Fly   539 LLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVK---------------HGANVNVSDL---- 584
            ||..||::...||.|...|..|....|..:.::::|               .|::|:..:|
Mouse   333 LLIAGADLSLRDKQGKTALAVAARSNHVSLVDMIIKADRFYRWEKDHLSCRDGSDVSRKNLTFKQ 397

  Fly   585 --------------------------------WKFTPLHEAAAKGKYDICK----------LLLK 607
                                            |:||..|..|.:.::...:          |:..
Mouse   398 DHRQETQQLRSVLWRLASRYLRPNEWKKLAYSWQFTEAHVCAIEQQWTGTRSYQEHGHRMLLIWL 462

  Fly   608 HGADPMKKNRDGATPADLVKESDHDVAEL--LRGPSALLDAAKKGNLARV 655
            ||.....:|...|....||.....|:|:|  ...|:.||.....|:|..|
Mouse   463 HGVAAAGENPSKALFEGLVAIGRRDLADLWCSENPTKLLMNQSHGHLQSV 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	34/113 (30%)
		ANK repeat	59..87	CDD:293786	11/27 (41%)
		Ank_2	61..153	CDD:289560	30/91 (33%)
		ANK repeat	89..120	CDD:293786	10/30 (33%)
		ANK repeat	122..153	CDD:293786	8/30 (27%)
		ANK	202..316	CDD:238125	24/113 (21%)
		ANK repeat	212..240	CDD:293786	7/27 (26%)
		Ank_2	214..306	CDD:289560	21/91 (23%)
		ANK repeat	242..273	CDD:293786	12/30 (40%)
		ANK repeat	275..306	CDD:293786	0/30 (0%)
		ANK	361..478	CDD:238125	31/118 (26%)
		ANK repeat	363..396	CDD:293786	2/32 (6%)
		Ank_2	367..459	CDD:289560	27/93 (29%)
		ANK	393..573	CDD:238125	56/181 (31%)
		ANK repeat	398..429	CDD:293786	15/30 (50%)
		ANK repeat	431..459	CDD:293786	8/29 (28%)
		ANK repeat	483..515	CDD:293786	5/31 (16%)
		Ank_4	486..540	CDD:290365	14/53 (26%)
		ANK	512..637	CDD:238125	38/187 (20%)
		ANK repeat	522..550	CDD:293786	11/27 (41%)
		Ank_2	524..616	CDD:289560	27/152 (18%)
		ANK repeat	552..583	CDD:293786	7/45 (16%)
		ANK repeat	585..610	CDD:293786	7/34 (21%)
		ANK repeat	638..668	CDD:293786	5/17 (29%)
		Ank_4	641..693	CDD:290365	4/14 (29%)
		ANK	665..779	CDD:238125
		ANK repeat	672..703	CDD:293786
		Ank_2	677..769	CDD:289560
		ANK repeat	705..736	CDD:293786
		ANK repeat	738..769	CDD:293786
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
Ankdd1a	NP_001357800.1	Ank_2	19..108	CDD:372319	31/90 (34%)
		ANK repeat	19..45	CDD:293786	6/25 (24%)
		ANK repeat	47..78	CDD:293786	13/32 (41%)
		ANK repeat	80..110	CDD:293786	10/29 (34%)
		PHA03095	96..>368	CDD:222980	104/470 (22%)
		ANK repeat	113..146	CDD:293786	14/67 (21%)
		ANK repeat	149..179	CDD:293786	9/31 (29%)
		ANK repeat	181..212	CDD:293786	16/153 (10%)
		ANK repeat	214..243	CDD:293786	13/28 (46%)
		ANK repeat	250..278	CDD:293786	8/27 (30%)
		ANK repeat	280..311	CDD:293786	11/54 (20%)
		ANK repeat	313..344	CDD:293786	12/30 (40%)
		DD	420..491	CDD:387368	14/70 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900