Protein Alignment Tnks and Tnks2

DIOPT Version :10

• Sequence 1: NP_001262963.1
• Gene: Tnks / 43095
• FlyBaseID: FBgn0027508
• Length: 1520
• Species: Drosophila melanogaster
• Sequence 2: NP_001101077.2
• Gene: Tnks2 / 309512
• RGDID: 1305026
• Length: 1166
• Species: Rattus norvegicus
• Alignment Length: 1181
• Identity: 761/1181 - (64%)
• Similarity: 929/1181 - (78%)
• Gaps: 69/1181 - (5%)

  Fly    25 RELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEG 89
            |||||||:.|::.:||:|:||:.||:||||||||||||||||:||::|||:||.:||::||.|:|
  Rat    26 RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90

  Fly    90 GLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNS 154
            ||.||||.|||||||||.|||:.||.||..||||||||||||.|||:|||:.||||||..||||:
  Rat    91 GLIPLHNACSFGHAEVVNLLLQHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNT 155

  Fly   155 EQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAG 219
            :.:|.|:|||.:.:.||||:|:||||||:||||.|::::||||||||||||||||:|||||||||
  Rat   156 DGRTALDLADPSAKAVLTGDYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAG 220

  Fly   220 YNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAA 284
            |||:.||::||.:||||||||||.||||||||||||::||:||::.||.|||.|||.||||||||
  Rat   221 YNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAA 285

  Fly   285 SKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKL 349
            ||:||||||||||.||||||||||:|||||.|||.:|:||:::|:|||.||.|.|:.||:|.||.
  Rat   286 SKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTAQLKERLSYEFKGHSLLQAAREADVTRIKKH 350

  Fly   350 VCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDA 414
            :..|:|||.||.|.:|.||.|..||..||||:.|||.|||:..|||.|.||||||:|:|..|.|.
  Rat   351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANTNEKTKEFLTPLHVASENAHNDV 415

  Fly   415 MEVLLKQGAKVNALDSLGQTPLHRCAR--DEQAVRLLLSYAADTNIVSLEGLTAAQLASDSVLKL 477
            :||::|..||||||||||||.|||.|.  ..|..||||||..|.||:||:||||.|:.:::|.:|
  Rat   416 VEVVVKHEAKVNALDSLGQTSLHRAAHCGHLQTCRLLLSYGCDPNIISLQGLTALQMGNENVQQL 480

  Fly   478 LK-----NPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQ 537
            |:     ...:::..|||||||||::||:::....  ||||||::||.|||||||||:|||.||:
  Rat   481 LQEGVSLGHSEADRQLLEAAKAGDVETVKKLCTVQ--SVNCRDIEGRQSTPLHFAAGYNRVSVVE 543

  Fly   538 FLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDIC 602
            :||:|||:|:|.|||||||||||||||||||.||||||||.|||:|||||||||||||||||:||
  Rat   544 YLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEIC 608

  Fly   603 KLLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCR 667
            ||||:|||||.||||||.||.||||:.|.|:.:||||.:|||||||||.||||::|.:|:::|||
  Rat   609 KLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCR 673

  Fly   668 DAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVV 732
            |.|||:||||||||||||.|.|||||::||||||||||||||||||:||||:|:||||||:...|
  Rat   674 DTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACV 738

  Fly   733 NATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLLQDAM----- 792
            ||||||.||||||||||||||||:||||||||..:||||||||::|.:||||..||..||
  Rat   739 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSAL 803

  Fly   793 ATSLSQQALS------ASTQSLTSSSPAPDATAAAA-----PGTSSSSSSAILSPTTETVLLPTG 846
            .|....|.||      |:..:|:|...:|.:.:||:     .|:.|..|:.:.|.|||
  Rat   804 PTCYKPQVLSGVRSPGATADALSSGPSSPSSLSAASSLDNLAGSFSELSAVVSSSTTE------- 861

  Fly   847 ASMILSVPVPLPLSSSTRISPAQGAEANGAEGSSSDDLLPDADTITNVSGFLSSQQLHHLIELFE 911
                                        ||.|....:   |:....:::.|:.:..|.||:::||
  Rat   862 ----------------------------GATGLERKE---DSGIDFSITQFIRNLGLEHLMDIFE 895

  Fly   912 REQITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRS-TTGIG-----NNVNLCTLLVDLLP 970
            |||||||:|.||||.:||::|:||||.||:::||:.:|.| ..|:.     ||....|:|:||.|
  Rat   896 REQITLDVLVEMGHKELKEIGISAYGHRHRLIKGVERLISGQQGLNPYLTLNNSGSGTILIDLSP 960

  Fly   971 DDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQSN 1035
            |||||.:||||||:|:|||||.|.|||.|.||:|:::|||.|:||||||.|||:|::|||...:|
  Rat   961 DDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYSILKIQKVCNKKLWERYTHRRKEVSEENHNHAN 1025

  Fly  1036 ERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSCY 1100
            ||||||||||:|||:.:|||||||||||||||||||||:||||||||||||||.|||.|||:|||
  Rat  1026 ERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCY 1090

  Fly  1101 VCPRQLLLCRVALGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLITY 1165
            :|.||||.|||.|||||||:|||||||:|||||||.||||..||..||||:|||||:||||||||
  Rat  1091 ICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITY 1155

  Fly  1166 QIVKPDDSSSG 1176
            |||:|:....|
  Rat  1156 QIVRPEGMGDG 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANKYR	9..330	CDD:440430	223/304 (73%)
		ANK repeat	59..87	CDD:293786	19/27 (70%)
		ANK repeat	89..120	CDD:293786	23/30 (77%)
		ANK repeat	122..153	CDD:293786	24/30 (80%)
		ANK repeat	212..240	CDD:293786	21/27 (78%)
		ANK repeat	242..273	CDD:293786	22/30 (73%)
		ANK repeat	275..306	CDD:293786	27/30 (90%)
		ANKYR	334..623	CDD:440430	190/295 (64%)
		ANK repeat	363..396	CDD:293786	18/32 (56%)
		ANK repeat	398..429	CDD:293786	18/30 (60%)
		ANK repeat	431..459	CDD:293786	17/29 (59%)
		ANKYR	469..783	CDD:440430	229/318 (72%)
		ANK repeat	483..515	CDD:293786	15/31 (48%)
		ANK repeat	522..550	CDD:293786	20/27 (74%)
		ANK repeat	552..583	CDD:293786	28/30 (93%)
		ANK repeat	585..610	CDD:293786	22/24 (92%)
		ANK repeat	638..668	CDD:293786	19/29 (66%)
		ANK repeat	672..703	CDD:293786	25/30 (83%)
		ANK repeat	705..736	CDD:293786	23/30 (77%)
		ANK repeat	738..769	CDD:293786	25/30 (83%)
		SAM_tankyrase1,2	887..952	CDD:188923	32/65 (49%)
		tankyrase_like	948..1170	CDD:238718	165/227 (73%)
Tnks2	NP_001101077.2	ANKYR	60..343	CDD:440430	207/282 (73%)
		ANK repeat	60..88	CDD:293786	19/27 (70%)
		ANK repeat	90..121	CDD:293786	23/30 (77%)
		ANK repeat	123..154	CDD:293786	24/30 (80%)
		ANKYR	160..470	CDD:440430	211/309 (68%)
		ANK repeat	213..241	CDD:293786	21/27 (78%)
		ANK repeat	243..274	CDD:293786	22/30 (73%)
		ANK repeat	276..307	CDD:293786	27/30 (90%)
		ANK repeat	365..397	CDD:293786	18/31 (58%)
		ANK repeat	399..430	CDD:293786	18/30 (60%)
		ANK repeat	433..521	CDD:293786	42/89 (47%)
		ANKYR	487..789	CDD:440430	226/303 (75%)
		ANK repeat	528..556	CDD:293786	20/27 (74%)
		ANK repeat	558..589	CDD:293786	28/30 (93%)
		ANK repeat	591..622	CDD:293786	27/30 (90%)
		ANK repeat	644..674	CDD:293786	19/29 (66%)
		Ank_4	648..699	CDD:372654	38/50 (76%)
		ANK repeat	681..709	CDD:293786	23/27 (85%)
		ANK repeat	711..742	CDD:293786	23/30 (77%)
		ANK repeat	744..775	CDD:293786	25/30 (83%)
		SAM_tankyrase1,2	871..936	CDD:188923	31/64 (48%)
		tankyrase_like	938..1160	CDD:238718	163/221 (74%)