DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and Tnks2

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001101077.2	Gene:	Tnks2 / 309512	RGDID:	1305026	Length:	1166	Species:	Rattus norvegicus

Alignment Length:	1181	Identity:	761/1181 - (64%)
Similarity:	929/1181 - (78%)	Gaps:	69/1181 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEG 89
            |||||||:.|::.:||:|:||:.||:||||||||||||||||:||::|||:||.:||::||.|:|
  Rat    26 RELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDG 90

  Fly    90 GLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNS 154
            ||.||||.|||||||||.|||:.||.||..||||||||||||.|||:|||:.||||||..||||:
  Rat    91 GLIPLHNACSFGHAEVVNLLLQHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNT 155

  Fly   155 EQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAG 219
            :.:|.|:|||.:.:.||||:|:||||||:||||.|::::||||||||||||||||:|||||||||
  Rat   156 DGRTALDLADPSAKAVLTGDYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAG 220

  Fly   220 YNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAA 284
            |||:.||::||.:||||||||||.||||||||||||::||:||::.||.|||.|||.||||||||
  Rat   221 YNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAA 285

  Fly   285 SKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKL 349
            ||:||||||||||.||||||||||:|||||.|||.:|:||:::|:|||.||.|.|:.||:|.||.
  Rat   286 SKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTAQLKERLSYEFKGHSLLQAAREADVTRIKKH 350

  Fly   350 VCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDA 414
            :..|:|||.||.|.:|.||.|..||..||||:.|||.|||:..|||.|.||||||:|:|..|.|.
  Rat   351 LSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANTNEKTKEFLTPLHVASENAHNDV 415

  Fly   415 MEVLLKQGAKVNALDSLGQTPLHRCAR--DEQAVRLLLSYAADTNIVSLEGLTAAQLASDSVLKL 477
            :||::|..||||||||||||.|||.|.  ..|..||||||..|.||:||:||||.|:.:::|.:|
  Rat   416 VEVVVKHEAKVNALDSLGQTSLHRAAHCGHLQTCRLLLSYGCDPNIISLQGLTALQMGNENVQQL 480

  Fly   478 LK-----NPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQ 537
            |:     ...:::..|||||||||::||:::....  ||||||::||.|||||||||:|||.||:
  Rat   481 LQEGVSLGHSEADRQLLEAAKAGDVETVKKLCTVQ--SVNCRDIEGRQSTPLHFAAGYNRVSVVE 543

  Fly   538 FLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDIC 602
            :||:|||:|:|.|||||||||||||||||||.||||||||.|||:|||||||||||||||||:||
  Rat   544 YLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEIC 608

  Fly   603 KLLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCR 667
            ||||:|||||.||||||.||.||||:.|.|:.:||||.:|||||||||.||||::|.:|:::|||
  Rat   609 KLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCR 673

  Fly   668 DAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVV 732
            |.|||:||||||||||||.|.|||||::||||||||||||||||||:||||:|:||||||:...|
  Rat   674 DTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACV 738

  Fly   733 NATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLLQDAM----- 792
            ||||||.||||||||||||||||:||||||||..:||||||||::|.:||||..||..||
  Rat   739 NATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSAL 803

  Fly   793 ATSLSQQALS------ASTQSLTSSSPAPDATAAAA-----PGTSSSSSSAILSPTTETVLLPTG 846
            .|....|.||      |:..:|:|...:|.:.:||:     .|:.|..|:.:.|.|||
  Rat   804 PTCYKPQVLSGVRSPGATADALSSGPSSPSSLSAASSLDNLAGSFSELSAVVSSSTTE------- 861

  Fly   847 ASMILSVPVPLPLSSSTRISPAQGAEANGAEGSSSDDLLPDADTITNVSGFLSSQQLHHLIELFE 911
                                        ||.|....:   |:....:::.|:.:..|.||:::||
  Rat   862 ----------------------------GATGLERKE---DSGIDFSITQFIRNLGLEHLMDIFE 895

  Fly   912 REQITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRS-TTGIG-----NNVNLCTLLVDLLP 970
            |||||||:|.||||.:||::|:||||.||:::||:.:|.| ..|:.     ||....|:|:||.|
  Rat   896 REQITLDVLVEMGHKELKEIGISAYGHRHRLIKGVERLISGQQGLNPYLTLNNSGSGTILIDLSP 960

  Fly   971 DDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQSN 1035
            |||||.:||||||:|:|||||.|.|||.|.||:|:::|||.|:||||||.|||:|::|||...:|
  Rat   961 DDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYSILKIQKVCNKKLWERYTHRRKEVSEENHNHAN 1025

  Fly  1036 ERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSCY 1100
            ||||||||||:|||:.:|||||||||||||||||||||:||||||||||||||.|||.|||:|||
  Rat  1026 ERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCY 1090

  Fly  1101 VCPRQLLLCRVALGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLITY 1165
            :|.||||.|||.|||||||:|||||||:|||||||.||||..||..||||:|||||:||||||||
  Rat  1091 ICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITY 1155

  Fly  1166 QIVKPDDSSSG 1176
            |||:|:....|
  Rat  1156 QIVRPEGMGDG 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	82/113 (73%)
		ANK repeat	59..87	CDD:293786	19/27 (70%)
		Ank_2	61..153	CDD:289560	67/91 (74%)
		ANK repeat	89..120	CDD:293786	23/30 (77%)
		ANK repeat	122..153	CDD:293786	24/30 (80%)
		ANK	202..316	CDD:238125	93/113 (82%)
		ANK repeat	212..240	CDD:293786	21/27 (78%)
		Ank_2	214..306	CDD:289560	73/91 (80%)
		ANK repeat	242..273	CDD:293786	22/30 (73%)
		ANK repeat	275..306	CDD:293786	27/30 (90%)
		ANK	361..478	CDD:238125	68/118 (58%)
		ANK repeat	363..396	CDD:293786	18/32 (56%)
		Ank_2	367..459	CDD:289560	57/93 (61%)
		ANK	393..573	CDD:238125	114/186 (61%)
		ANK repeat	398..429	CDD:293786	18/30 (60%)
		ANK repeat	431..459	CDD:293786	17/29 (59%)
		ANK repeat	483..515	CDD:293786	15/31 (48%)
		Ank_4	486..540	CDD:290365	33/53 (62%)
		ANK	512..637	CDD:238125	99/124 (80%)
		ANK repeat	522..550	CDD:293786	20/27 (74%)
		Ank_2	524..616	CDD:289560	77/91 (85%)
		ANK repeat	552..583	CDD:293786	28/30 (93%)
		ANK repeat	585..610	CDD:293786	22/24 (92%)
		ANK repeat	638..668	CDD:293786	19/29 (66%)
		Ank_4	641..693	CDD:290365	38/51 (75%)
		ANK	665..779	CDD:238125	93/113 (82%)
		ANK repeat	672..703	CDD:293786	25/30 (83%)
		Ank_2	677..769	CDD:289560	75/91 (82%)
		ANK repeat	705..736	CDD:293786	23/30 (77%)
		ANK repeat	738..769	CDD:293786	25/30 (83%)
		SAM_tankyrase1,2	887..952	CDD:188923	32/65 (49%)
		SAM	890..952	CDD:197735	31/62 (50%)
		tankyrase_like	948..1170	CDD:238718	165/227 (73%)
		PARP	961..1165	CDD:279038	155/203 (76%)
Tnks2	NP_001101077.2	Ank_4	28..78	CDD:290365	34/49 (69%)
		ANK	50..164	CDD:238125	82/113 (73%)
		ANK repeat	60..88	CDD:293786	19/27 (70%)
		Ank_2	62..154	CDD:289560	67/91 (74%)
		ANK repeat	90..121	CDD:293786	23/30 (77%)
		ANK	118..297	CDD:238125	133/178 (75%)
		ANK repeat	123..154	CDD:293786	24/30 (80%)
		ANK repeat	213..241	CDD:293786	21/27 (78%)
		Ank_2	215..307	CDD:289560	73/91 (80%)
		ANK repeat	243..274	CDD:293786	22/30 (73%)
		ANK repeat	276..307	CDD:293786	27/30 (90%)
		ANK repeat	365..397	CDD:293786	18/31 (58%)
		Ank_2	368..461	CDD:289560	56/92 (61%)
		ANK	394..579	CDD:238125	114/186 (61%)
		ANK repeat	399..430	CDD:293786	18/30 (60%)
		ANK repeat	433..521	CDD:293786	42/89 (47%)
		Ank_2	437..556	CDD:289560	64/120 (53%)
		ANK	518..643	CDD:238125	99/124 (80%)
		ANK repeat	528..556	CDD:293786	20/27 (74%)
		Ank_2	530..622	CDD:289560	77/91 (85%)
		ANK repeat	558..589	CDD:293786	28/30 (93%)
		ANK repeat	591..622	CDD:293786	27/30 (90%)
		ANK repeat	644..674	CDD:293786	19/29 (66%)
		ANK	671..787	CDD:238125	94/115 (82%)
		ANK repeat	681..709	CDD:293786	23/27 (85%)
		Ank_2	683..775	CDD:289560	75/91 (82%)
		ANK repeat	711..742	CDD:293786	23/30 (77%)
		ANK repeat	744..775	CDD:293786	25/30 (83%)
		SAM_tankyrase1,2	871..936	CDD:188923	31/64 (48%)
		SAM	877..933	CDD:197735	29/55 (53%)
		tankyrase_like	938..1160	CDD:238718	163/221 (74%)
		PARP	952..1155	CDD:279038	155/202 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340112
Domainoid	1	1.000	278	1.000	Domainoid score	I1634
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1528	1.000	Inparanoid score	I89
OMA	1	1.010	-	-		QHG47155
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004240
OrthoInspector	1	1.000	-	-		otm46411
orthoMCL	1	0.900	-	-		OOG6_105313
Panther	1	1.100	-	-	O	PTHR24180
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2498
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900