DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and Ank1

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_038950490.1	Gene:	Ank1 / 306570	RGDID:	1309620	Length:	1946	Species:	Rattus norvegicus

Alignment Length:	1351	Identity:	325/1351 - (24%)
Similarity:	525/1351 - (38%)	Gaps:	324/1351 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ANSSRSRAILSVNLDAVMANDPLRE--------------LFEACKTGEIAKVKKLITPQTVNARD 52
            |.:|..||..|.|||..:  |.||.              |..|.|.|.:..|.:|:..:.: ...
  Rat    59 AATSFLRAARSGNLDKAL--DHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII-LET 120

  Fly    53 TAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPN 117
            |..:.:|.||.||..|:.|||..|:|.||::.|..:.|..||:......|.|||:.||:.||:.|
  Rat   121 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 185

  Fly   118 TTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLE 182
            ......:|||..|..:|..:|...|:.:|..                        |:.|...|..
  Rat   186 VATEDGFTPLAVALQQGHENVVAHLINYGTK------------------------GKVRLPALHI 226

  Fly   183 AARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPL 247
            |||:. :.|..|:|...:.|.........||||:||.|..:.:.::||..||.|:...:.|:.||
  Rat   227 AARND-DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 290

  Fly   248 HNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSA 312
            |.|...|:..:.:||:..||.:........||||.||....|.:..:||..||.......:..|.
  Rat   291 HIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSP 355

  Fly   313 IDAAPTRELRE--RIAFEYK-----------------GHC--------LLDACRKCDVSRAKKLV 350
            |..|...:..:  |:..:|.                 .||        |||...|.: |||
  Rat   356 IHMAAQGDHLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN-SRA---- 415

  Fly   351 CAEIVNFVHPYTGDTPLHLAVVSPDGKRK--QLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYD 413
                      ..|.||||:|.     |:.  ::||||.:.|:.::...::.|||||:|:.:.|..
  Rat   416 ----------LNGFTPLHIAC-----KKNHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLP 465

  Fly   414 AMEVLLKQGAKVNALDSLGQTPLHRCAR--DEQAVRLLLSYAADTNIVSLEGLT----AAQLASD 472
            .::.||::||..|..:...:||||..||  ..:..:.||...|..|..:.:..|    ||::...
  Rat   466 IVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKANAKAKDDQTPLHCAARIGHT 530

  Fly   473 SVLKLLKNPPDS--------ETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAG 529
            |::|||.....|        .|.|..||:.|.:||...: |....|..|....|  .||||.||.
  Rat   531 SMVKLLLENDASPNLATTAGHTPLHTAAREGHVDTALAL-LEKEASQACMTKKG--FTPLHVAAK 592

  Fly   530 FNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWK-FTPLHEA 593
            :.:|.:.:.||||.|...||.|.||.|||.|..:.:.::.:||:..|.:.: |..|. :||||.|
  Rat   593 YGKVRLAELLLEHDAHPNAAGKNGLTPLHVAVHHNNLDIVQLLLPRGGSPH-SPAWNGYTPLHIA 656

  Fly   594 AAKGKYDICKLLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRL 658
            |.:.:.::.:.||::|.....::..|.||..|..:..|  .|::   :.||.....|||.....|
  Rat   657 AKQNQIEVARSLLQYGGSANAESVQGVTPLHLAAQEGH--TEMV---ALLLSKQANGNLGNKSGL 716

  Fly   659 VTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAA 723
                            |||||.|...:...|:.|:::|..|:|..:.|..|||.||.||::.:..
  Rat   717 ----------------TPLHLVAQEGHVPVADVLIKHGVTVDATTRMGYTPLHVASHYGNIKLVK 765

  Fly   724 LLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELA------TAD 782
            .|::|:..|||..|.|::|||:|||:|.|.:.:|||.:||.....:..|.||:.:|      :..
  Rat   766 FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSNGTTPLAIAKRLGYISVT 830

  Fly   783 DVKCLLQDAMATSLSQQALSASTQSLTSSSPAPDATAAAAPGT-------SSSSSSAILSPTTET 840
            ||..::.|.                 ||.....|....:.|.|       |....:|.:|.|.:.
  Rat   831 DVLKVVTDE-----------------TSVVLVSDKHRMSYPETVDEILDVSEDEGTAHISLTGDE 878

  Fly   841 VL---------------------LPTGASMILSVPVP-LPLSSSTRISPAQGAEANGAEGSSSDD 883
            ::                     :|....::.|..:| :|..:...:......:...::....|.
  Rat   879 LVGSKAERRDSRDVGEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIRSEDQEQASKEYDEDS 943

  Fly   884 LLPDA---DTITNVSGFLSSQQLHHLIELFEREQITLDILAEMGHDDLKQVGVSAYGFRHKILKG 945
            |:|.:   :|..|:|...|......|:...                 :...|.|..|.||..|:.
  Rat   944 LIPSSPATETSDNISPVASPVHTGFLVSFM-----------------VDARGGSMRGSRHNGLRV 991

  Fly   946 I-------------------AQLRSTTGIGNNVNLCTLLVDLLPDDKEF---VAVEEEMQATIRE 988
            :                   .:|.:...:.....|.:.::.|.|...:|   |.||      |..
  Rat   992 VIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIALGPTGAQFLSPVIVE------IPH 1050

  Fly   989 HRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQSNERMLFHGSPFINAIVQRG 1053
            ...:|:..      ..:.|.:.:|..:|:.:..|                  :|..:::.|: .|
  Rat  1051 FASHGRGD------RELVVLRSENGSVWKEHKSR------------------YGESYLDQIL-NG 1090

  Fly  1054 FDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSCYVCPRQLLLCRVALGKSFL 1118
            .||....:..:                             .|.:.|.:......|..|.:.:...
  Rat  1091 MDEELGSLEEL-----------------------------EKKRVCRIITTDFPLYFVIMSRLCQ 1126

  Fly  1119 QYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLITYQI-----VKPDDSSSGTE 1178
            .|             ..:| |..|.|.  ..:|...:.::||..:|.::     .:|
  Rat  1127 DY-------------DTIG-PEGGSLR--SKLVPLVQATFPENAVTKKVKLALQAQP-------- 1167

  Fly  1179 DTRXWMPSVGSTPTTTSPALHQPQTQQQPQQQQQQQPQPQQQQKAPLPLPP 1229
                 :|....|....:.|...|....:|::::..:|...:     :||||
  Rat  1168 -----VPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLR-----IPLPP 1208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	35/113 (31%)
		ANK repeat	59..87	CDD:293786	14/27 (52%)
		Ank_2	61..153	CDD:289560	33/91 (36%)
		ANK repeat	89..120	CDD:293786	12/30 (40%)
		ANK repeat	122..153	CDD:293786	8/30 (27%)
		ANK	202..316	CDD:238125	36/113 (32%)
		ANK repeat	212..240	CDD:293786	12/27 (44%)
		Ank_2	214..306	CDD:289560	31/91 (34%)
		ANK repeat	242..273	CDD:293786	10/30 (33%)
		ANK repeat	275..306	CDD:293786	11/30 (37%)
		ANK	361..478	CDD:238125	39/124 (31%)
		ANK repeat	363..396	CDD:293786	12/34 (35%)
		Ank_2	367..459	CDD:289560	31/95 (33%)
		ANK	393..573	CDD:238125	63/193 (33%)
		ANK repeat	398..429	CDD:293786	12/30 (40%)
		ANK repeat	431..459	CDD:293786	10/29 (34%)
		ANK repeat	483..515	CDD:293786	11/39 (28%)
		Ank_4	486..540	CDD:290365	18/53 (34%)
		ANK	512..637	CDD:238125	43/125 (34%)
		ANK repeat	522..550	CDD:293786	13/27 (48%)
		Ank_2	524..616	CDD:289560	33/92 (36%)
		ANK repeat	552..583	CDD:293786	9/30 (30%)
		ANK repeat	585..610	CDD:293786	9/25 (36%)
		ANK repeat	638..668	CDD:293786	6/29 (21%)
		Ank_4	641..693	CDD:290365	13/51 (25%)
		ANK	665..779	CDD:238125	42/113 (37%)
		ANK repeat	672..703	CDD:293786	11/30 (37%)
		Ank_2	677..769	CDD:289560	37/91 (41%)
		ANK repeat	705..736	CDD:293786	13/30 (43%)
		ANK repeat	738..769	CDD:293786	14/30 (47%)
		SAM_tankyrase1,2	887..952	CDD:188923	12/86 (14%)
		SAM	890..952	CDD:197735	12/80 (15%)
		tankyrase_like	948..1170	CDD:238718	32/229 (14%)
		PARP	961..1165	CDD:279038	30/206 (15%)
Ank1	XP_038950490.1	ANK repeat	61..89	CDD:293786	10/29 (34%)
		Ank_2	63..154	CDD:403870	29/93 (31%)
		ANK repeat	91..122	CDD:293786	6/31 (19%)
		ANK repeat	125..155	CDD:293786	14/29 (48%)
		PHA02876	<137..>482	CDD:165207	109/389 (28%)
		ANK repeat	157..188	CDD:293786	12/30 (40%)
		ANK repeat	190..214	CDD:293786	7/23 (30%)
		ANK repeat	223..250	CDD:293786	8/27 (30%)
		ANK repeat	253..283	CDD:293786	12/29 (41%)
		ANK repeat	285..316	CDD:293786	10/30 (33%)
		ANK repeat	318..349	CDD:293786	11/30 (37%)
		ANK repeat	351..382	CDD:293786	5/30 (17%)
		ANK repeat	387..415	CDD:293786	7/28 (25%)
		ANK repeat	417..448	CDD:293786	12/35 (34%)
		PHA02875	429..>639	CDD:165206	69/212 (33%)
		ANK repeat	450..481	CDD:293786	12/30 (40%)
		ANK repeat	483..514	CDD:293786	10/30 (33%)
		ANK repeat	516..545	CDD:293786	8/28 (29%)
		ANK repeat	550..580	CDD:293786	10/30 (33%)
		ANK repeat	582..613	CDD:293786	14/32 (44%)
		Ank_2	593..>806	CDD:423045	79/234 (34%)
		ANK repeat	615..643	CDD:293786	9/27 (33%)
		ANK repeat	648..679	CDD:293786	9/30 (30%)
		ANK repeat	681..712	CDD:293786	11/35 (31%)
		ANK repeat	714..745	CDD:293786	12/46 (26%)
		ANK repeat	747..778	CDD:293786	13/30 (43%)
		ANK repeat	780..808	CDD:293786	14/27 (52%)
		Ank_4	781..833	CDD:372654	19/51 (37%)
		ZU5	966..1070	CDD:128514	19/132 (14%)
		UPA_2	1291..1420	CDD:375346
		Death_ank1	1456..1539	CDD:260067
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910