DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and Ankrd28

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:XP_038950906.1 Gene:Ankrd28 / 306264 RGDID:1559931 Length:1053 Species:Rattus norvegicus


Alignment Length:1068 Identity:294/1068 - (27%)
Similarity:430/1068 - (40%) Gaps:217/1068 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 MANDPLRE---LFEACKTGEIAKVKKLI-TPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNS 79
            ||...||:   |.:|...|:..:|:.|| ..:.||.:|  ..|.||||.||..|..|::|.|:.|
  Rat     1 MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQD--NEKRTPLHAAAYLGDAEIIELLILS 63

  Fly    80 GASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTD-NWNYTPLHEAASKGKVDVCLALL 143
            ||.:.|.|...|.|||...:....|.|::|||..|..|..| ||. ||||.||            
  Rat    64 GARVNAKDSKWLTPLHRAVASCSEEAVQILLKHSADVNARDKNWQ-TPLHIAA------------ 115

  Fly   144 QHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDG 208
               ||..::.:|.                                       |.||..|.:.||.
  Rat   116 ---ANKAVKCAES---------------------------------------LVPLLSNVNVSDR 138

  Fly   209 RRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNAND 273
            ...|.||.||......:|::||:.||:::|.||.....:|.|...||.:|.|||:..||.|...|
  Rat   139 AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKD 203

  Fly   274 LWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDAC 338
            ..::||||.|||...:.|...||..|.|....|.:..:.:..|.           |.|.      
  Rat   204 KKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVAC-----------YNGQ------ 251

  Fly   339 RKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPL 403
               ||...:.:.|...||..:. .|.||||.|..|..|  ...:|||...|:.:|.|:|...|||
  Rat   252 ---DVVVNELIDCGANVNQKNE-RGFTPLHFAAASTHG--ALCLELLVGNGADVNMKSKDGKTPL 310

  Fly   404 HLAAELLH--YDAMEVLLKQGAKVNALDSLGQTPLHRCAR--DEQAVRLLLSYAADTNIVSLEGL 464
            |:.|  ||  :...:.:::.||.::..|..|.||||..||  .|..:..|::..|||....:.|:
  Rat   311 HMTA--LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGM 373

  Fly   465 TAAQLA-----SDSVLKLLKN------PPD-SETHLLEAAKAGDLDTVRRIVLN----------- 506
            ....||     ||...|||.:      |.| ..|.|..||..|:|:.: .::||           
  Rat   374 FPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECL-NLLLNTGADFNKKDKF 437

  Fly   507 --NPI---SVNC---------------RDLDGRHSTPLHFAAGFNR-VPVVQFLLEHGAEVYAAD 550
              :|:   :.||               .|||.|..||||:||..:. ...:::||.:.|.....|
  Rat   438 GRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRD 502

  Fly   551 KGGLVPLHNACSYGHYEVTELLVKH----------GANVNVSD---LWKFTPLHEAAAKGKYDIC 602
            |.|...:|.:.:|||....:|:...          |.:: :||   ....:|||.||..|.:...
  Rat   503 KQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDM-LSDSDNRATISPLHLAAYHGHHQAL 566

  Fly   603 KLLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTP-ESINC 666
            ::|::...|...:|..|.||.||                    ||.||::..|..|:.. .||..
  Rat   567 EVLVQSLLDLDVRNSSGRTPLDL--------------------AAFKGHVECVDVLINQGASILV 611

  Fly   667 RDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNA---QDKGGLIPLHNASSYGHLDIAALLIKH 728
            :|...:. ||:|.||...:.||...|:.|....||   ||..|..||..:...||.|....|:..
  Rat   612 KDYVLKR-TPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNK 675

  Fly   729 KTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKC------- 786
            ...|:|.||||.|.||..|..|..:....||.|||...:::..|:|||.|:.|    |       
  Rat   676 GANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAA----CGHIGVLG 736

  Fly   787 -LLQDAMATSLSQQALSASTQSLTSSSPA--------------PDATAAAAPGTSSSSSSAILSP 836
             |||.  |||:............|:...|              .|..........|....|:::.
  Rat   737 ALLQS--ATSVDANPAIVDNHGYTALHWACYNGHETCVELLLEQDVFQKIDGNAFSPLHCAVIND 799

  Fly   837 T--TETVLLPTGASMILSVP-----VPLPLSSST------RISPAQGAEANGAEGSSSDDLLPDA 888
            .  ...:|:.|..:.|::.|     .||..::.|      ::..:|.|:.|.|:.:....|:..|
  Rat   800 NEGAAEMLIDTLGASIVNAPDSKGRTPLHAAAFTDHVECLQLLLSQNAQVNSADSTGKTPLMMAA 864

  Fly   889 DT-ITNVSGFLSSQQLHHLIELFEREQITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRST 952
            :. .||....|.|.....|....:.:...|.:....||:....:.:.....|:.|....|.|::.
  Rat   865 ENGQTNTVEMLVSSASADLTLQDKSKNTALHLACGKGHETSALLILEKITDRNLINATNAALQTP 929

  Fly   953 TGIGNNVNLCTLLVDLLPDDKEFVAVEE 980
            ..:.....|..::.:||......:||:|
  Rat   930 LHVAARNGLTMVVQELLGKGASVLAVDE 957

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125 41/114 (36%)
ANK repeat 59..87 CDD:293786 14/27 (52%)
Ank_2 61..153 CDD:289560 35/92 (38%)
ANK repeat 89..120 CDD:293786 11/30 (37%)
ANK repeat 122..153 CDD:293786 9/30 (30%)
ANK 202..316 CDD:238125 41/113 (36%)
ANK repeat 212..240 CDD:293786 11/27 (41%)
Ank_2 214..306 CDD:289560 36/91 (40%)
ANK repeat 242..273 CDD:293786 11/30 (37%)
ANK repeat 275..306 CDD:293786 12/30 (40%)
ANK 361..478 CDD:238125 43/125 (34%)
ANK repeat 363..396 CDD:293786 13/32 (41%)
Ank_2 367..459 CDD:289560 34/95 (36%)
ANK 393..573 CDD:238125 67/227 (30%)
ANK repeat 398..429 CDD:293786 9/32 (28%)
ANK repeat 431..459 CDD:293786 12/29 (41%)
ANK repeat 483..515 CDD:293786 12/63 (19%)
Ank_4 486..540 CDD:290365 21/85 (25%)
ANK 512..637 CDD:238125 40/153 (26%)
ANK repeat 522..550 CDD:293786 9/28 (32%)
Ank_2 524..616 CDD:289560 26/105 (25%)
ANK repeat 552..583 CDD:293786 7/40 (18%)
ANK repeat 585..610 CDD:293786 7/24 (29%)
ANK repeat 638..668 CDD:293786 8/30 (27%)
Ank_4 641..693 CDD:290365 16/52 (31%)
ANK 665..779 CDD:238125 41/116 (35%)
ANK repeat 672..703 CDD:293786 11/33 (33%)
Ank_2 677..769 CDD:289560 34/94 (36%)
ANK repeat 705..736 CDD:293786 9/30 (30%)
ANK repeat 738..769 CDD:293786 12/30 (40%)
SAM_tankyrase1,2 887..952 CDD:188923 13/65 (20%)
SAM 890..952 CDD:197735 12/62 (19%)
tankyrase_like 948..1170 CDD:238718 7/33 (21%)
PARP 961..1165 CDD:279038 6/20 (30%)
Ankrd28XP_038950906.1 ANK repeat 12..38 CDD:293786 8/25 (32%)
PHA03095 22..>310 CDD:222980 113/367 (31%)
ANK repeat 40..71 CDD:293786 15/30 (50%)
ANK repeat 76..104 CDD:293786 10/27 (37%)
ANK repeat 106..137 CDD:293786 15/85 (18%)
ANK repeat 140..170 CDD:293786 11/29 (38%)
ANK repeat 172..203 CDD:293786 11/30 (37%)
PHA03095 186..>454 CDD:222980 87/293 (30%)
ANK repeat 205..236 CDD:293786 12/30 (40%)
ANK repeat 238..269 CDD:293786 8/50 (16%)
ANK repeat 271..302 CDD:293786 13/32 (41%)
ANK repeat 305..336 CDD:293786 9/32 (28%)
ANK repeat 338..363 CDD:293786 9/24 (38%)
ANK repeat 371..402 CDD:293786 8/30 (27%)
ANK repeat 404..435 CDD:293786 8/31 (26%)
ANK repeat 437..468 CDD:293786 4/30 (13%)
ANK repeat 470..502 CDD:293786 10/31 (32%)
Ank_2 475..580 CDD:403870 26/105 (25%)
ANK repeat 552..580 CDD:293786 8/27 (30%)
PHA02874 554..>863 CDD:165205 88/335 (26%)
ANK repeat 582..613 CDD:293786 13/50 (26%)
ANK repeat 618..650 CDD:293786 11/32 (34%)
ANK repeat 652..683 CDD:293786 9/30 (30%)
ANK repeat 685..716 CDD:293786 12/30 (40%)
ANK repeat 718..747 CDD:293786 13/34 (38%)
ANK repeat 755..820 CDD:293786 8/64 (13%)
ANK repeat 823..853 CDD:293786 6/29 (21%)
Ank_2 827..920 CDD:403870 17/92 (18%)
ANK repeat 855..887 CDD:293786 7/31 (23%)
ANK repeat 889..920 CDD:293786 4/30 (13%)
ANK repeat 925..956 CDD:293786 5/30 (17%)
Ank 927..957 CDD:394980 5/29 (17%)
Ank_2 930..1006 CDD:423045 6/28 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1115202at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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