DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and Ankfy1

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001100488.2	Gene:	Ankfy1 / 303292	RGDID:	1309598	Length:	1169	Species:	Rattus norvegicus

Alignment Length:	829	Identity:	205/829 - (24%)
Similarity:	316/829 - (38%)	Gaps:	211/829 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKA 112
            |||. |.|.:.||||..|.|..::....:::.                      .|::...||:|
  Rat   315 VNAA-TVGAQETPLHLVALYSSKKYSADVMSE----------------------MAQIAEALLQA 356

  Fly   113 GASPNTTDNWNYTPLHEAASKGKVDVCLALLQ-HGANHTIRNSEQKTPLELA--------DEATR 168
            ||:||..|:...||||.:.......|...||| ...:..:::.|..|.|.||        |::..
  Rat   357 GANPNMQDSKGRTPLHLSIMARNEYVFNQLLQCKQLDLELKDHEGSTALWLAVQYITVSSDQSVN 421

  Fly   169 PVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDGRR-STPLHLAAGYNRIGIVEILLAN 232
            |.      :|..:....|..|:...|.|.....|..|.|... :..|..|||.........|..:
  Rat   422 PF------EDLPVVNGTSFDENSFAARLIQRGSNTDAPDTMTGNCLLQRAAGAGNEAAALFLATS 480

  Fly   233 GADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVN-------------------ANDLWAFT 278
            ||..:.::|.|..|||.||.:|..::|..|:|.|||.|                   |:.::..|
  Rat   481 GAHANHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPVPKESPVLMGSADGIYLQT 545

  Fly   279 PLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDV 343
            |||.|.:.:..:|.|::|.:.|:.    .|:.:.:...|...|:
  Rat   546 PLHMAIAYNHPDVVSVILEQKANA----LHATNNLQIIPDFSLK--------------------- 585

  Fly   344 SRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLH-LAA 407
                                           |.:.:.::.|             |..|.:| :||
  Rat   586 -------------------------------DSRDQTVLGL-------------ALWTGMHTIAA 606

  Fly   408 ELLHYDAMEVLLKQGAKVNALDSLGQTPLHRC--ARDEQAVRLLLSYAADTNIVSLEGLTAAQLA 470
            :         ||..||.:|...|.|||.||..  .:|.::...||.:.||.|:.:.:..||.|||
  Rat   607 Q---------LLGSGASINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDRETALQLA 662

  Fly   471 SDSVLKLL-----------------KNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNC--RDL 516
            ..:.|.|:                 .|||      |..|.|.:|:.:...::.:.....|  ...
  Rat   663 IKNQLPLVVDAICTRGADMSVPDEKGNPP------LWLALASNLEDIASTLVRHGCDATCWGPGP 721

  Fly   517 DGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYA------------ADKGGLVPLHNACSYGHYEVT 569
            .|...|.||.|...|......||:..|.:|.:            ..:.|..|||.|.|:|..|..
  Rat   722 SGCLQTLLHRAIDENNESTACFLIRSGCDVNSPRQPGTDGEGEEEARDGQTPLHLAASWGLEETV 786

  Fly   570 ELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMK-KNRDGATP-ADLVKESDHD 632
            :.|::.|||||..|....|.:|.|.:.....|.:||:.|.:..:. ::|.|.|| |..:...::.
  Rat   787 QCLLEFGANVNAQDAEGRTAVHVAISNQHSVIIQLLISHPSIELSIRDRQGLTPFACAMTYKNNK 851

  Fly   633 VAE-LLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENG 696
            .|| :|:..|...:..                    |.:|||.  ||:|...::.|...:|:...
  Rat   852 AAEAILKRESGAAEQV--------------------DNKGRNF--LHVAVQNSDIESVLFLISVQ 894

  Fly   697 ADVNA--QDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLL 759
            |:||:  ||...|.|||.|...|...|...|:.....||...|...|.||.|||:....:||:||
  Rat   895 ANVNSRVQDATKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLL 959

  Fly   760 AHGADAYMKNQEGQTPIELAT----ADDVKCLLQ----DAMATSLSQQA 800
            .:|.|....::.|...:.||.    .::::.||.    ||.|.:|..|:
  Rat   960 ENGVDFAAVDENGNNALHLAVMHGRLNNIRALLTECTVDAEAFNLRGQS 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	30/114 (26%)
		ANK repeat	59..87	CDD:293786	6/27 (22%)
		Ank_2	61..153	CDD:289560	21/92 (23%)
		ANK repeat	89..120	CDD:293786	8/30 (27%)
		ANK repeat	122..153	CDD:293786	8/31 (26%)
		ANK	202..316	CDD:238125	36/133 (27%)
		ANK repeat	212..240	CDD:293786	7/27 (26%)
		Ank_2	214..306	CDD:289560	32/110 (29%)
		ANK repeat	242..273	CDD:293786	15/49 (31%)
		ANK repeat	275..306	CDD:293786	9/30 (30%)
		ANK	361..478	CDD:238125	30/119 (25%)
		ANK repeat	363..396	CDD:293786	2/32 (6%)
		Ank_2	367..459	CDD:289560	24/94 (26%)
		ANK	393..573	CDD:238125	55/213 (26%)
		ANK repeat	398..429	CDD:293786	10/31 (32%)
		ANK repeat	431..459	CDD:293786	11/29 (38%)
		ANK repeat	483..515	CDD:293786	5/33 (15%)
		Ank_4	486..540	CDD:290365	12/55 (22%)
		ANK	512..637	CDD:238125	40/141 (28%)
		ANK repeat	522..550	CDD:293786	9/39 (23%)
		Ank_2	524..616	CDD:289560	30/104 (29%)
		ANK repeat	552..583	CDD:293786	14/30 (47%)
		ANK repeat	585..610	CDD:293786	7/24 (29%)
		ANK repeat	638..668	CDD:293786	1/29 (3%)
		Ank_4	641..693	CDD:290365	9/51 (18%)
		ANK	665..779	CDD:238125	38/115 (33%)
		ANK repeat	672..703	CDD:293786	10/32 (31%)
		Ank_2	677..769	CDD:289560	33/93 (35%)
		ANK repeat	705..736	CDD:293786	10/30 (33%)
		ANK repeat	738..769	CDD:293786	12/30 (40%)
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
Ankfy1	NP_001100488.2	BTB	61..156	CDD:279045
		BTB	69..156	CDD:197585
		BACK	167..>235	CDD:197943
		ANK repeat	221..253	CDD:293786
		ANK	250..387	CDD:238125	25/94 (27%)
		ANK repeat	255..286	CDD:293786
		Ank_2	260..364	CDD:289560	19/71 (27%)
		ANK repeat	288..319	CDD:293786	3/4 (75%)
		ANK repeat	321..364	CDD:293786	15/64 (23%)
		Ank_5	353..408	CDD:290568	19/54 (35%)
		ANK	361..563	CDD:238125	55/207 (27%)
		ANK repeat	366..398	CDD:293786	8/31 (26%)
		ANK repeat	491..521	CDD:293786	14/29 (48%)
		Ank_2	495..618	CDD:289560	37/200 (19%)
		ANK repeat	542..586	CDD:293786	12/99 (12%)
		ANK	544..674	CDD:238125	43/207 (21%)
		ANK repeat	588..616	CDD:293786	10/49 (20%)
		ANK repeat	621..652	CDD:293786	11/30 (37%)
		Ank_2	626..713	CDD:289560	22/92 (24%)
		ANK repeat	654..685	CDD:293786	7/30 (23%)
		ANK repeat	688..720	CDD:293786	8/37 (22%)
		Ank_2	692..800	CDD:289560	29/107 (27%)
		ANK repeat	726..767	CDD:293786	9/40 (23%)
		ANK	768..926	CDD:238125	52/179 (29%)
		ANK repeat	769..800	CDD:293786	14/30 (47%)
		Ank_2	774..860	CDD:289560	28/85 (33%)
		ANK	866..992	CDD:238125	40/147 (27%)
		Ank_2	875..969	CDD:289560	33/93 (35%)
		ANK repeat	875..903	CDD:293786	8/27 (30%)
		ANK repeat	905..936	CDD:293786	10/30 (33%)
		ANK	933..1064	CDD:238125	24/76 (32%)
		ANK repeat	938..969	CDD:293786	12/30 (40%)
		Ank_2	943..1074	CDD:289560	21/66 (32%)
		ANK repeat	1043..1068	CDD:293786
		FYVE_ANFY1	1101..1163	CDD:277267
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010