DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and Pidd1

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_001099788.2	Gene:	Pidd1 / 293625	RGDID:	1311792	Length:	917	Species:	Rattus norvegicus

Alignment Length:	1168	Identity:	231/1168 - (19%)
Similarity:	337/1168 - (28%)	Gaps:	483/1168 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEGGL 91
            :.|..|..|.|...:.....||.|  .|.|...|:..|...         ||....     .||.
  Rat     4 VLEGPKPEETAAAAEDAARPTVEA--VASRPGVPILLAGNQ---------LNLDLR-----PGGC 52

  Fly    92 HPLHNCCSFGHAEVVR---LLLKAGASPNTTDN------WNYTPLHE-----AASKGKVDVCLAL 142
            ..|...||..|.::::   |.|.....|...|:      |:...|..     ..|:|.:..||
  Rat    53 RRLQYLCSQQHTQLLQVEFLRLSTHEDPRLLDDTLAKVPWSLLRLRSLVLKGGQSRGALGACL-- 115

  Fly   143 LQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASD 207
              ||...|:       |..:.|.|                                    |.|
  Rat   116 --HGTLTTL-------PASMRDLA------------------------------------CLA-- 133

  Fly   208 GRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNAN 272
                   ||...:||:   |.|.....::|:.|
  Rat   134 -------HLDLSFNRL---ETLPTCVLELHSLD-------------------------------- 156

  Fly   273 DLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSK--SAIDAAPTRELRERIAFEYKGHCLL 335
                                :||||.       ||.|:  .|:.|.||      :.|....|.||
  Rat   157 --------------------ALLLSH-------NCLSELPEALGALPT------LTFLTVTHNLL 188

  Fly   336 DACRKC--DVSRAKKLVCAE-IVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNK 397
            :.....  .:|..::|..:| :::.:....||.                        |.|.|.|.
  Rat   189 ERLPPTLGSLSTLQRLDLSENLLDTIPSEIGDL------------------------SSLRELNL 229

  Fly   398 AFLTPLHLAAELLHYDAMEVLLKQGAKVNALDS----LGQTPL--HRCARDEQAVRLLLSYAADT 456
            |.....||.|.|....::.:|:...   |.|.|    |...||  ....||.| :|.|.:...|.
  Rat   230 ASNRLQHLPASLAGLRSLRLLVLHS---NLLTSVPPGLAHLPLITRLDLRDNQ-LRDLPAELLDA 290

  Fly   457 NIVSLEG--LTAAQLASDSVLKLLKNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGR 519
            ..|.|:|  |..|..|..|       |||          ...:..:.|:.|.:       |||..
  Rat   291 PFVRLQGNPLGEASPAPPS-------PPD----------ISQVPEMPRLFLTS-------DLDSF 331

  Fly   520 HSTP------------LHFAAGFNRVPV-VQFLLEHGAEVYAADKGGLVPL--HNACSYGHYEVT 569
            ..||            |.|.||....|: :.:.|       ...:.|||.|  |:....|..|
  Rat   332 LVTPHGCSVTLACGVRLQFPAGATTTPITIHYRL-------WLPEPGLVSLGPHDFLLSGVLE-- 387

  Fly   570 ELLVKHGA--NVNVSDLW-KFTP---------------------------LHEAAAKGKYDICK- 603
              |..||.  ..||| || .|.|                           |.|.|.|.::..|:
  Rat   388 --LQPHGVAFQQNVS-LWLLFVPPRVRVRRCREVVVRTRSDNIWNDLETHLEEEAPKRRWARCQV 449

  Fly   604 -----------------LLLKHGA--------------------DPMKKNRD-----GATPADLV 626
                             ||...||                    :|.:.:..     |.....|:
  Rat   450 PHFSWFLVVLRPVSNTCLLPPEGALLCSSGHPGVKVTFPPGVTEEPRQVSMQVVHMAGLELRALL 514

  Fly   627 KESDHDVAELL----RGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNSTPLHLAAGYNNFE 687
            :||:..|:.||    .||.:.|...       ..:|..|..:.     |.:....||...|..
  Rat   515 EESEAAVSPLLCLSQSGPPSFLQPV-------TVQLPLPPGVT-----GFSLDRSHLHLLYRT-- 565

  Fly   688 CAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKH----------KTVVN--ATDKWGF 740
               .|.....|::.|         .|..:.|| .|...:.|          ||.|.  |...|..
  Rat   566 ---PLTSTWDDISTQ---------VALEFTHL-YARFQVTHFSWYWLWYTTKTCVGGLARKAWER 617

  Fly   741 TPLHE----AAQKGRTQLCSLL-----------LAHGADAYMKNQEGQTPIEL------------ 778
            ..||.    |.|:.|.....||           |:...|.|...:..:| :|:
  Rat   618 LRLHRVNLIALQRRRDPEQVLLQCLPRSKVDATLSRLLDRYRGPEPSET-VEMFEGEKFFAAFER 681

  Fly   779 ---ATADDVKC---------------LLQDAMATSLSQQALSASTQ------SLTSSSPAPDATA 819
               ..||...|               :.:..:.|:|.::|.....|      ||....|.....|
  Rat   682 GIDVDADRPDCVDGRICFVFYSHLKNMKEVYITTALDREAQDVRGQVSFYRGSLPMEVPEEAEAA 746

  Fly   820 AAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVPLPLSSSTRISPAQGAEANGAEGSSSD-D 883
            ....||.                    |..:.::|:.||     |:..|||:      |..:| .
  Rat   747 RRRKGTD--------------------ALWMATLPIKLP-----RLRGAQGS------GQGTDFS 780

  Fly   884 LLP----DADTITNVSGFLSSQQLHHLIELFEREQITLDILAEMGHDDLKQVGVSAYGFRHKILK 944
            |:|    ||:|     |||:...|..:......:..|:.:...|.:..|:::       ||:...
  Rat   781 LMPLNLGDAET-----GFLTQSNLLSVASRLGSDWPTVALHLGMPYRKLQRI-------RHEFRD 833

  Fly   945 GI-AQLR--------STTG----IGNNVNLCTLLVDLLPDDKEFVAVEEEMQATIREHRDNGQ 994
            .: .|:|        |.||    :|:      |:..|...|::.||  ||::|.:...|...|
  Rat   834 DLDGQIRHMLFSWAESQTGQPGAVGH------LVQALEQSDRQDVA--EEVRAILELGRHKYQ 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	27/127 (21%)
		ANK repeat	59..87	CDD:293786	4/27 (15%)
		Ank_2	61..153	CDD:289560	22/105 (21%)
		ANK repeat	89..120	CDD:293786	9/33 (27%)
		ANK repeat	122..153	CDD:293786	9/35 (26%)
		ANK	202..316	CDD:238125	18/115 (16%)
		ANK repeat	212..240	CDD:293786	7/27 (26%)
		Ank_2	214..306	CDD:289560	12/91 (13%)
		ANK repeat	242..273	CDD:293786	0/30 (0%)
		ANK repeat	275..306	CDD:293786	4/30 (13%)
		ANK	361..478	CDD:238125	31/124 (25%)
		ANK repeat	363..396	CDD:293786	5/32 (16%)
		Ank_2	367..459	CDD:289560	22/97 (23%)
		ANK	393..573	CDD:238125	50/202 (25%)
		ANK repeat	398..429	CDD:293786	7/30 (23%)
		ANK repeat	431..459	CDD:293786	9/29 (31%)
		ANK repeat	483..515	CDD:293786	3/31 (10%)
		Ank_4	486..540	CDD:290365	12/66 (18%)
		ANK	512..637	CDD:238125	43/212 (20%)
		ANK repeat	522..550	CDD:293786	8/40 (20%)
		Ank_2	524..616	CDD:289560	33/162 (20%)
		ANK repeat	552..583	CDD:293786	12/34 (35%)
		ANK repeat	585..610	CDD:293786	10/70 (14%)
		ANK repeat	638..668	CDD:293786	5/29 (17%)
		Ank_4	641..693	CDD:290365	7/51 (14%)
		ANK	665..779	CDD:238125	29/155 (19%)
		ANK repeat	672..703	CDD:293786	5/30 (17%)
		Ank_2	677..769	CDD:289560	26/118 (22%)
		ANK repeat	705..736	CDD:293786	9/42 (21%)
		ANK repeat	738..769	CDD:293786	11/45 (24%)
		SAM_tankyrase1,2	887..952	CDD:188923	14/73 (19%)
		SAM	890..952	CDD:197735	12/70 (17%)
		tankyrase_like	948..1170	CDD:238718	16/59 (27%)
		PARP	961..1165	CDD:279038	10/34 (29%)
Pidd1	NP_001099788.2	leucine-rich repeat	132..154	CDD:275380	7/33 (21%)
		LRR	<135..>296	CDD:227223	50/256 (20%)
		leucine-rich repeat	155..177	CDD:275380	10/80 (13%)
		leucine-rich repeat	178..200	CDD:275380	4/21 (19%)
		leucine-rich repeat	201..223	CDD:275380	4/45 (9%)
		leucine-rich repeat	224..246	CDD:275380	8/21 (38%)
		leucine-rich repeat	247..269	CDD:275380	5/24 (21%)
		leucine-rich repeat	270..289	CDD:275380	5/19 (26%)
		ZU5	330..>403	CDD:413351	22/84 (26%)
		Peptidase_S68	428..460	CDD:402200	5/31 (16%)
		ZU5	<482..>544	CDD:413351	11/68 (16%)
		Death_PIDD	795..880	CDD:260049	20/99 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900