DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and ANK3

DIOPT Version :10

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_066267.2 Gene:ANK3 / 288 HGNCID:494 Length:4377 Species:Homo sapiens


Alignment Length:1443 Identity:348/1443 - (24%)
Similarity:529/1443 - (36%) Gaps:389/1443 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ANSSRSRAILSVNLDA------------VMANDPLRELFEACKTGEIAKVKKLITPQTVNARDTA 54
            ||:|..||..:.:|:.            :...:.|..|..|.|.|.:..|.:|: .:..|. |.|
Human    41 ANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELL-QREANV-DAA 103

  Fly    55 GRK-STPLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNT 118
            .:| :|.||.|:..|:.|||:.|:.:||::.|..:.|..||:......|.|||:.||..|||.:.
Human   104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSL 168

  Fly   119 TDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEA 183
            .....:|||..|..:|...|...||::.....:|               .|.|....|||:...|
Human   169 ATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVR---------------LPALHIAARKDDTKAA 218

  Fly   184 ARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLH 248
            |        |.|....|.:..:..|  .||||:||.|..|.:..:||...|.|....:..:.|||
Human   219 A--------LLLQNDNNADVESKSG--FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 273

  Fly   249 NACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTL--------- 304
            .|...|:.::.|||:..||.::|......||||..|.....:|..:||.|.| |.|         
Human   274 VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAA-PILSKTKNGLSP 337

  Fly   305 ---------LNCHSKSAIDAAPTRELRE--RIAFEYKGHC--------LLDACRKCDVSRAKKLV 350
                     |||.........|..::..  ..|.....||        |||  :|.: ..||.| 
Human   338 LHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD--KKAN-PNAKAL- 398

  Fly   351 CAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAM 415
                       .|.||||:|...   .|.::||||.:.|:.:....::.|||:|:||.:.|.:.:
Human   399 -----------NGFTPLHIACKK---NRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIV 449

  Fly   416 EVLLKQGAKVNALDSLGQTPLHRCARDEQA--VRLLLSYAADTNIVSLEGLTAAQLA-----SDS 473
            ..|:..||..|..:..|:|.||..||..||  ||.|:...|.....:.:..|...::     :|.
Human   450 SQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADI 514

  Fly   474 VLKLLKN--PPDSET-------HLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAG 529
            |.:||:.  .|::.|       ||  :|:.|..| |...:|::..|::.....|  .||||.||.
Human   515 VQQLLQQGASPNAATTSGYTPLHL--SAREGHED-VAAFLLDHGASLSITTKKG--FTPLHVAAK 574

  Fly   530 FNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAA 594
            :.::.|...||:..|...||.|.||.|||.|..|.:.:|..||:..||:.:.:....:||||.||
Human   575 YGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639

  Fly   595 AKGKYDICKLLLKHGADPMKKNRDGATPADLVKESDH-DVAELLRGPSALLDAAKKGNLARVQRL 658
            .|.:.||...||::|||.....|.|.....|..:..| |:..||.|.:|.::.:.|..|      
Human   640 KKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGL------ 698

  Fly   659 VTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAA 723
                            |||||||..:....||.|:..||.|:||.|.|..|||....||::.|..
Human   699 ----------------TPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVN 747

  Fly   724 LLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELA-------TA 781
            .|::|...|||..|.|:||||:|||:|.|.:.::||.:.|........|.|.:.:|       ..
Human   748 FLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVV 812

  Fly   782 DDVKCLLQDAMATSLSQQALSASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLLPTG 846
            |.:|.:.::.|.|                              |:.:....:..|.|...:|...
Human   813 DTLKIVTEETMTT------------------------------TTVTEKHKMNVPETMNEVLDMS 847

  Fly   847 ASMILSVPVPLPLSSSTRISPAQGAEANGAEGSSSDDLLPDADTITNVSGFLSSQQLHHLIELFE 911
            ...:.....|..||....||..:..|         |.:..|.|.      :|..|.         
Human   848 DDEVRKANAPEMLSDGEYISDVEEGE---------DAMTGDTDK------YLGPQD--------- 888

  Fly   912 REQITLDILAEMGHDDLKQVGVSAY--GFRHKILKGIAQLRSTTGIGNNVNLCTLLVD--LLPDD 972
                    |.|:|.|.|...|...:  |.|...|:..:..||.|...::....:::::  |:|..
Human   889 --------LKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSK 945

  Fly   973 KEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQSNER 1037
            ::.:....|..:....|                             |:.....:...|.:.|.  
Human   946 EQHLTFTREFDSDSLRH-----------------------------YSWAADTLDNVNLVSSP-- 979

  Fly  1038 MLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSCYVC 1102
              .|....::.:|    |.|                            ||.:....|......:.
Human   980 --IHSGFLVSFMV----DAR----------------------------GGSMRGSRHHGMRIIIP 1010

  Fly  1103 PRQL-----LLCRVALGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGL------------------ 1144
            ||:.     :.||:.        ...|:|:.||   .|.|...|..|                  
Human  1011 PRKCTAPTRITCRLV--------KRHKLANPPP---MVEGEGLASRLVEMGPAGAQFLGPVIVEI 1064

  Fly  1145 -HFA-------EYVVYRGE--------------------------------------------QS 1157
             ||.       |.:|.|.|                                            :.
Human  1065 PHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKD 1129

  Fly  1158 YPEYLITYQIVKPDDSSSGTEDTRXWMPSVGSTPTTTSPALH----QPQTQQQPQQQQQQQPQPQ 1218
            :|:|......:|.:.:..|        |..|...:||.|.:.    :....::.:...|.||.|.
Human  1130 FPQYFAVVSRIKQESNQIG--------PEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPD 1186

  Fly  1219 QQQKAPLPLPPPQQQTSAPVAKRRPKHAKPSLQLQYQPYQPQHHPVVATAAAVTTTQPSPAGVFA 1283
            :..|..|    ..:.|.:|:....|:..|            .|.|:..|   :....||..||  
Human  1187 EIVKKIL----GNKATFSPIVTVEPRRRK------------FHKPITMT---IPVPPPSGEGV-- 1230

  Fly  1284 HSNNNNNTSSGNV 1296
             ||.....::.|:
Human  1231 -SNGYKGDTTPNL 1242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANKYR 9..330 CDD:440430 97/353 (27%)
ANK repeat 59..87 CDD:293786 12/27 (44%)
ANK repeat 89..120 CDD:293786 12/30 (40%)
ANK repeat 122..153 CDD:293786 8/30 (27%)
ANK repeat 212..240 CDD:293786 12/27 (44%)
ANK repeat 242..273 CDD:293786 11/30 (37%)
ANK repeat 275..306 CDD:293786 12/48 (25%)
ANKYR 334..623 CDD:440430 99/304 (33%)
ANK repeat 363..396 CDD:293786 12/32 (38%)
ANK repeat 398..429 CDD:293786 11/30 (37%)
ANK repeat 431..459 CDD:293786 12/29 (41%)
ANKYR 469..783 CDD:440430 110/335 (33%)
ANK repeat 483..515 CDD:293786 9/38 (24%)
ANK repeat 522..550 CDD:293786 11/27 (41%)
ANK repeat 552..583 CDD:293786 12/30 (40%)
ANK repeat 585..610 CDD:293786 11/24 (46%)
ANK repeat 638..668 CDD:293786 4/29 (14%)
ANK repeat 672..703 CDD:293786 14/30 (47%)
ANK repeat 705..736 CDD:293786 12/30 (40%)
ANK repeat 738..769 CDD:293786 13/30 (43%)
SAM_tankyrase1,2 887..952 CDD:188923 14/66 (21%)
tankyrase_like 948..1170 CDD:238718 37/298 (12%)
ANK3NP_066267.2 ANKYR 1..305 CDD:440430 85/290 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..44 2/2 (100%)
ANK repeat 73..104 CDD:293786 9/32 (28%)
ANK 1 73..102 8/30 (27%)
ANK repeat 106..137 CDD:293786 13/30 (43%)
ANK 2 106..135 12/28 (43%)
ANK 3 139..168 12/28 (43%)
ANK repeat 139..164 CDD:293786 9/24 (38%)
ANK 4 172..201 8/28 (29%)
ANK 5 203..230 10/34 (29%)
ANK repeat 205..232 CDD:293786 9/34 (26%)
ANK repeat 234..265 CDD:293786 13/32 (41%)
ANK 6 234..263 13/30 (43%)
ANKYR 248..536 CDD:440430 84/306 (27%)
ANK repeat 267..298 CDD:293786 11/30 (37%)
ANK 7 267..296 10/28 (36%)
ANK 8 300..329 11/29 (38%)
ANK repeat 300..325 CDD:293786 9/24 (38%)
ANK repeat 333..364 CDD:293786 4/30 (13%)
ANK 9 333..362 4/28 (14%)
ANK 10 366..395 7/31 (23%)
ANK repeat 369..397 CDD:293786 8/30 (27%)
ANK repeat 399..430 CDD:293786 12/33 (36%)
ANK 11 399..428 12/31 (39%)
ANKYR 413..701 CDD:440430 95/314 (30%)
ANK repeat 432..463 CDD:293786 11/30 (37%)
ANK 12 432..461 10/28 (36%)
ANK repeat 465..496 CDD:293786 12/30 (40%)
ANK 13 465..494 12/28 (43%)
ANK repeat 498..529 CDD:293786 6/30 (20%)
ANK 14 498..527 6/28 (21%)
ANK repeat 531..560 CDD:293786 8/31 (26%)
ANK 15 531..560 8/31 (26%)
ANK repeat 564..593 CDD:293786 11/30 (37%)
ANK 16 564..593 11/30 (37%)
ANK repeat 597..626 CDD:293786 12/28 (43%)
ANK 17 597..626 12/28 (43%)
PHA02875 605..>800 CDD:165206 76/216 (35%)
ANK repeat 630..660 CDD:293786 14/29 (48%)
ANK 18 630..659 14/28 (50%)
ANK repeat 663..694 CDD:293786 8/30 (27%)
ANK 19 663..692 8/28 (29%)
ANK repeat 696..727 CDD:293786 15/52 (29%)
ANK 20 696..725 14/50 (28%)
ANK repeat 729..760 CDD:293786 12/30 (40%)
ANK 21 729..758 10/28 (36%)
ANK 22 762..791 13/28 (46%)
ANK repeat 762..790 CDD:293786 13/27 (48%)
ANK 23 795..825 6/29 (21%)
ZU5 982..1086 CDD:128514 24/146 (16%)
UPA domain. /evidence=ECO:0000250 1273..1407
UPA_2 1308..1437 CDD:375346
Herpes_BLLF1 <1393..1770 CDD:282904
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1519..1540
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1968..1987
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2159
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2176..2245
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2299..2322
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2383..2433
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2474..2508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2588..2751
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2795..2824
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3036..3067
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3131..3272
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3298..3516
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3538..3607
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3635..3718
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3868..3897
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4019..4090
Death_ank3 4088..4171 CDD:176781
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4251..4298
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4323..4377
Blue background indicates that the domain is not in the aligned region.

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