DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and ANK2

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_001373103.1 Gene:ANK2 / 287 HGNCID:493 Length:4183 Species:Homo sapiens


Alignment Length:1467 Identity:366/1467 - (24%)
Similarity:533/1467 - (36%) Gaps:417/1467 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ANSSRSRAILSVNLDAVMANDPLRELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAG 66
            :|:|..||..:.|||.|:         |..|.|        |...|.|....     ..||.||.
Human    48 SNASFLRAARAGNLDKVV---------EYLKGG--------IDINTCNQNGL-----NALHLAAK 90

  Fly    67 YGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAA 131
            .|...:|:.||..|:|:.:..:.|...||.....|.||||::|:|.||:.|......:|||:.||
Human    91 EGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 155

  Fly   132 SKGKVDVCLALLQHGANHTIRNSEQKTPLELA-------------DEATR-----PVLTGEYRKD 178
            .:..:||...||::|||.:....:..|||.:|             :..|:     |.|....|||
Human   156 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 220

  Fly   179 ELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGG 243
            :...||.....|....:.:.:.||.....|  .||||:||.|..:.:..:||..||.|....:.|
Human   221 DTKSAALLLQNDHNADVQSKMMVNRTTESG--FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 283

  Fly   244 LVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCH 308
            :.|||.|...|:.::.|||:..|..::|......||||.||.....:|..|||.||| |.|    
Human   284 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLL---- 343

  Fly   309 SKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVS 373
                                               :|.|              .|.:|||:|.  
Human   344 -----------------------------------ARTK--------------NGLSPLHMAA-- 357

  Fly   374 PDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLH- 437
             .|...:.::.|.:..:.:::....:||.||:||...||...::||.:.|..||....|.|||| 
Human   358 -QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 421

  Fly   438 RCARDE-QAVRLLLSYAADTNIVSLEGLTAAQLAS-----DSVLKLLKN--PPD-----SETHLL 489
            .|.::. :.:.||:.|.|....::..|||...:|:     :.||.||:|  .||     .||.|.
Human   422 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 486

  Fly   490 EAAKAGDLDTVRRIVLNNPISVNCRDLDGR---HSTPLHFAAGFNRVPVVQFLLEHGAEVYAADK 551
            .||:||.::.||.::.|..:      :|.|   ..||||.|:...:..:||.||:|.|...||..
Human   487 MAARAGQVEVVRCLLRNGAL------VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 545

  Fly   552 GGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKN 616
            .|..|||.:...|..:|..:|::.||..:::....|||||.||..|..|:.||||:..|......
Human   546 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 610

  Fly   617 RDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNS-TPLHLA 680
            ::|.||..:....|:....||     ||:   ||        .:|.      |..:|. ||||:|
Human   611 KNGLTPLHVAAHYDNQKVALL-----LLE---KG--------ASPH------ATAKNGYTPLHIA 653

  Fly   681 AGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHE 745
            |..|..:.|..||..||:.|...|.|:.|||.||..||.|:..||:.....::.:.|.|.|.||.
Human   654 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 718

  Fly   746 AAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELA----TADDVKCLLQDAM---------ATSLS 797
            |||:.:..:..:|..||||.....:.|.||:.:|    ....|..||:...         .|.|.
Human   719 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 783

  Fly   798 QQALSAST---QSLTSSSPAPDATAAAAPGTSSSSSSAI------------LSPTTETVLLPTGA 847
            |.|....|   ..|......|:||.|     :.:::.||            |...||.|...|..
Human   784 QAAQQGHTHIINVLLQHGAKPNATTA-----NGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTT 843

  Fly   848 ---SMILSVPVPLPLSSSTRISPAQGAEA---------NGAEGSSSDDLLPDADTITNVSGFLSS 900
               ...|:||     .:.|.:......||         :|...|.|.|     ||:|...|    
Human   844 ITEKHKLNVP-----ETMTEVLDVSDEEALKQFGDHFIDGEALSDSGD-----DTMTGDGG---- 894

  Fly   901 QQLHHLIELFEREQITLDILAEMGHDDL---------KQVGVSAYGFRHKILKGIAQLRSTTGIG 956
                        |.:..:.|.|:|.|.|         ..:..|..|.|...|:..:..||.|   
Human   895 ------------EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT--- 944

  Fly   957 NNVNLCTLLVDLLPDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAH 1021
              ::..:.|.|....|...|....::....:|...|..                  |..|     
Human   945 --LSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSY------------------RLSW----- 984

  Fly  1022 RRQEIAEENF----LQSNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYV 1082
                 ..||.    |.|:.......||.:         ||               ::||....::
Human   985 -----GTENLDNVALSSSPIHSGRASPCL---------ER---------------DNSSFLVSFM 1020

  Fly  1083 YGIGGGI--GCPSHKDKSCYVCPRQL-----LLCR-----------------------VALGKSF 1117
            ....||.  || .|......:.||:.     :.||                       :.:|.|.
Human  1021 VDARGGAMRGC-RHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSG 1084

  Fly  1118 LQY-SAMKMAHAPP----GHHSV-----VGRPSAGGL--------HFA-------EYVVYRGE-- 1155
            .|: ..:.:..|||    |...|     :|.|....|        |||       |.||.|.|  
Human  1085 AQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENG 1149

  Fly  1156 ------------------------------------------QSYPEYLITYQIVKPDDSSSGTE 1178
                                                      :.:|:|......:|.|.:..|  
Human  1150 DSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIG-- 1212

  Fly  1179 DTRXWMPSVGSTPTTTSPALHQ--PQTQQQPQQQQQQQPQPQQQQKAPLPLPPPQQQTSAPVAKR 1241
                  |..|...:|..|.:..  |:.....:.:...|.||...:.....|  ..:.|.:|:...
Human  1213 ------PEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKIL--GNKATFSPIVTL 1269

  Fly  1242 RPKHAKPSLQLQYQPYQPQHHPVVATAAAVTTTQPSP 1278
            .|:..|            .|.|       :|.|.|.|
Human  1270 EPRRRK------------FHKP-------ITMTIPVP 1287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125 39/113 (35%)
ANK repeat 59..87 CDD:293786 10/27 (37%)
Ank_2 61..153 CDD:289560 35/91 (38%)
ANK repeat 89..120 CDD:293786 13/30 (43%)
ANK repeat 122..153 CDD:293786 12/30 (40%)
ANK 202..316 CDD:238125 40/113 (35%)
ANK repeat 212..240 CDD:293786 12/27 (44%)
Ank_2 214..306 CDD:289560 36/91 (40%)
ANK repeat 242..273 CDD:293786 11/30 (37%)
ANK repeat 275..306 CDD:293786 15/30 (50%)
ANK 361..478 CDD:238125 36/123 (29%)
ANK repeat 363..396 CDD:293786 7/32 (22%)
Ank_2 367..459 CDD:289560 28/93 (30%)
ANK 393..573 CDD:238125 65/196 (33%)
ANK repeat 398..429 CDD:293786 13/30 (43%)
ANK repeat 431..459 CDD:293786 10/29 (34%)
ANK repeat 483..515 CDD:293786 11/36 (31%)
Ank_4 486..540 CDD:290365 18/56 (32%)
ANK 512..637 CDD:238125 42/127 (33%)
ANK repeat 522..550 CDD:293786 12/27 (44%)
Ank_2 524..616 CDD:289560 34/91 (37%)
ANK repeat 552..583 CDD:293786 9/30 (30%)
ANK repeat 585..610 CDD:293786 13/24 (54%)
ANK repeat 638..668 CDD:293786 5/29 (17%)
Ank_4 641..693 CDD:290365 15/52 (29%)
ANK 665..779 CDD:238125 43/114 (38%)
ANK repeat 672..703 CDD:293786 14/31 (45%)
Ank_2 677..769 CDD:289560 36/91 (40%)
ANK repeat 705..736 CDD:293786 11/30 (37%)
ANK repeat 738..769 CDD:293786 12/30 (40%)
SAM_tankyrase1,2 887..952 CDD:188923 15/73 (21%)
SAM 890..952 CDD:197735 14/70 (20%)
tankyrase_like 948..1170 CDD:238718 51/324 (16%)
PARP 961..1165 CDD:279038 48/306 (16%)
ANK2NP_001373103.1 Ank_2 35..>311 CDD:423045 87/286 (30%)
ANK repeat 80..111 CDD:293786 10/35 (29%)
ANK repeat 113..144 CDD:293786 13/30 (43%)
ANK repeat 146..171 CDD:293786 9/24 (38%)
Ank_2 202..>444 CDD:423045 82/300 (27%)
ANK repeat 212..247 CDD:293786 9/34 (26%)
ANK repeat 249..280 CDD:293786 13/32 (41%)
ANK repeat 282..313 CDD:293786 11/30 (37%)
ANK repeat 315..345 CDD:293786 15/69 (22%)
ANK repeat 348..379 CDD:293786 7/33 (21%)
ANK repeat 381..411 CDD:293786 12/29 (41%)
ANK repeat 414..445 CDD:293786 10/30 (33%)
PHA03095 421..>706 CDD:222980 102/312 (33%)
ANK repeat 447..478 CDD:293786 11/30 (37%)
ANK repeat 480..511 CDD:293786 11/36 (31%)
ANK repeat 513..542 CDD:293786 11/28 (39%)
ANK repeat 546..571 CDD:293786 7/24 (29%)
Ank_2 578..>802 CDD:423045 78/245 (32%)
ANK repeat 579..604 CDD:293786 13/24 (54%)
ANK repeat 612..643 CDD:293786 12/52 (23%)
ANK repeat 645..676 CDD:293786 14/30 (47%)
ANK repeat 678..707 CDD:293786 11/28 (39%)
ANK repeat 711..742 CDD:293786 12/30 (40%)
ANK repeat 744..775 CDD:293786 7/30 (23%)
ANK repeat 777..806 CDD:293786 7/28 (25%)
Ank_4 778..830 CDD:372654 12/56 (21%)
ZU5 1013..1150 CDD:128514 30/137 (22%)
UPA_2 1371..1500 CDD:375346
PspC_subgroup_1 1549..>1922 CDD:411407
PTZ00449 <1717..2161 CDD:185628
Streccoc_I_II <1843..>2027 CDD:411384
Spc7_N <2493..>2634 CDD:373822
rad2 <3031..>3565 CDD:273166
PRK14949 <3196..>3442 CDD:237863
Death_ank2 3614..3697 CDD:260066
NESP55 <3770..>3884 CDD:115071
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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