DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tnks and ANK2

DIOPT Version :10

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_001373103.1 Gene:ANK2 / 287 HGNCID:493 Length:4183 Species:Homo sapiens


Alignment Length:1467 Identity:366/1467 - (24%)
Similarity:533/1467 - (36%) Gaps:417/1467 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ANSSRSRAILSVNLDAVMANDPLRELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAG 66
            :|:|..||..:.|||.|:         |..|.|        |...|.|....     ..||.||.
Human    48 SNASFLRAARAGNLDKVV---------EYLKGG--------IDINTCNQNGL-----NALHLAAK 90

  Fly    67 YGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAA 131
            .|...:|:.||..|:|:.:..:.|...||.....|.||||::|:|.||:.|......:|||:.||
Human    91 EGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 155

  Fly   132 SKGKVDVCLALLQHGANHTIRNSEQKTPLELA-------------DEATR-----PVLTGEYRKD 178
            .:..:||...||::|||.:....:..|||.:|             :..|:     |.|....|||
Human   156 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 220

  Fly   179 ELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGG 243
            :...||.....|....:.:.:.||.....|  .||||:||.|..:.:..:||..||.|....:.|
Human   221 DTKSAALLLQNDHNADVQSKMMVNRTTESG--FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 283

  Fly   244 LVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCH 308
            :.|||.|...|:.::.|||:..|..::|......||||.||.....:|..|||.||| |.|    
Human   284 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGA-PLL---- 343

  Fly   309 SKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVS 373
                                               :|.|              .|.:|||:|.  
Human   344 -----------------------------------ARTK--------------NGLSPLHMAA-- 357

  Fly   374 PDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLH- 437
             .|...:.::.|.:..:.:::....:||.||:||...||...::||.:.|..||....|.|||| 
Human   358 -QGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 421

  Fly   438 RCARDE-QAVRLLLSYAADTNIVSLEGLTAAQLAS-----DSVLKLLKN--PPD-----SETHLL 489
            .|.::. :.:.||:.|.|....::..|||...:|:     :.||.||:|  .||     .||.|.
Human   422 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 486

  Fly   490 EAAKAGDLDTVRRIVLNNPISVNCRDLDGR---HSTPLHFAAGFNRVPVVQFLLEHGAEVYAADK 551
            .||:||.::.||.::.|..:      :|.|   ..||||.|:...:..:||.||:|.|...||..
Human   487 MAARAGQVEVVRCLLRNGAL------VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 545

  Fly   552 GGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKN 616
            .|..|||.:...|..:|..:|::.||..:::....|||||.||..|..|:.||||:..|......
Human   546 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 610

  Fly   617 RDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNS-TPLHLA 680
            ::|.||..:....|:....||     ||:   ||        .:|.      |..:|. ||||:|
Human   611 KNGLTPLHVAAHYDNQKVALL-----LLE---KG--------ASPH------ATAKNGYTPLHIA 653

  Fly   681 AGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHE 745
            |..|..:.|..||..||:.|...|.|:.|||.||..||.|:..||:.....::.:.|.|.|.||.
Human   654 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 718

  Fly   746 AAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELA----TADDVKCLLQDAM---------ATSLS 797
            |||:.:..:..:|..||||.....:.|.||:.:|    ....|..||:...         .|.|.
Human   719 AAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 783

  Fly   798 QQALSAST---QSLTSSSPAPDATAAAAPGTSSSSSSAI------------LSPTTETVLLPTGA 847
            |.|....|   ..|......|:||.|     :.:::.||            |...||.|...|..
Human   784 QAAQQGHTHIINVLLQHGAKPNATTA-----NGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTT 843

  Fly   848 ---SMILSVPVPLPLSSSTRISPAQGAEA---------NGAEGSSSDDLLPDADTITNVSGFLSS 900
               ...|:||     .:.|.:......||         :|...|.|.|     ||:|...|    
Human   844 ITEKHKLNVP-----ETMTEVLDVSDEEALKQFGDHFIDGEALSDSGD-----DTMTGDGG---- 894

  Fly   901 QQLHHLIELFEREQITLDILAEMGHDDL---------KQVGVSAYGFRHKILKGIAQLRSTTGIG 956
                        |.:..:.|.|:|.|.|         ..:..|..|.|...|:..:..||.|   
Human   895 ------------EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT--- 944

  Fly   957 NNVNLCTLLVDLLPDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAH 1021
              ::..:.|.|....|...|....::....:|...|..                  |..|     
Human   945 --LSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSY------------------RLSW----- 984

  Fly  1022 RRQEIAEENF----LQSNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYV 1082
                 ..||.    |.|:.......||.:         ||               ::||....::
Human   985 -----GTENLDNVALSSSPIHSGRASPCL---------ER---------------DNSSFLVSFM 1020

  Fly  1083 YGIGGGI--GCPSHKDKSCYVCPRQL-----LLCR-----------------------VALGKSF 1117
            ....||.  || .|......:.||:.     :.||                       :.:|.|.
Human  1021 VDARGGAMRGC-RHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSG 1084

  Fly  1118 LQY-SAMKMAHAPP----GHHSV-----VGRPSAGGL--------HFA-------EYVVYRGE-- 1155
            .|: ..:.:..|||    |...|     :|.|....|        |||       |.||.|.|  
Human  1085 AQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENG 1149

  Fly  1156 ------------------------------------------QSYPEYLITYQIVKPDDSSSGTE 1178
                                                      :.:|:|......:|.|.:..|  
Human  1150 DSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIG-- 1212

  Fly  1179 DTRXWMPSVGSTPTTTSPALHQ--PQTQQQPQQQQQQQPQPQQQQKAPLPLPPPQQQTSAPVAKR 1241
                  |..|...:|..|.:..  |:.....:.:...|.||...:.....|  ..:.|.:|:...
Human  1213 ------PEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKIL--GNKATFSPIVTL 1269

  Fly  1242 RPKHAKPSLQLQYQPYQPQHHPVVATAAAVTTTQPSP 1278
            .|:..|            .|.|       :|.|.|.|
Human  1270 EPRRRK------------FHKP-------ITMTIPVP 1287

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANKYR 9..330 CDD:440430 100/338 (30%)
ANK repeat 59..87 CDD:293786 10/27 (37%)
ANK repeat 89..120 CDD:293786 13/30 (43%)
ANK repeat 122..153 CDD:293786 12/30 (40%)
ANK repeat 212..240 CDD:293786 12/27 (44%)
ANK repeat 242..273 CDD:293786 11/30 (37%)
ANK repeat 275..306 CDD:293786 15/30 (50%)
ANKYR 334..623 CDD:440430 93/305 (30%)
ANK repeat 363..396 CDD:293786 7/32 (22%)
ANK repeat 398..429 CDD:293786 13/30 (43%)
ANK repeat 431..459 CDD:293786 10/29 (34%)
ANKYR 469..783 CDD:440430 111/333 (33%)
ANK repeat 483..515 CDD:293786 11/36 (31%)
ANK repeat 522..550 CDD:293786 12/27 (44%)
ANK repeat 552..583 CDD:293786 9/30 (30%)
ANK repeat 585..610 CDD:293786 13/24 (54%)
ANK repeat 638..668 CDD:293786 5/29 (17%)
ANK repeat 672..703 CDD:293786 14/31 (45%)
ANK repeat 705..736 CDD:293786 11/30 (37%)
ANK repeat 738..769 CDD:293786 12/30 (40%)
SAM_tankyrase1,2 887..952 CDD:188923 15/73 (21%)
tankyrase_like 948..1170 CDD:238718 51/324 (16%)
ANK2NP_001373103.1 ANKYR 61..419 CDD:440430 122/438 (28%)
ANK repeat 80..111 CDD:293786 10/35 (29%)
ANK repeat 113..144 CDD:293786 13/30 (43%)
ANK repeat 146..171 CDD:293786 9/24 (38%)
Ank_4 149..200 CDD:372654 16/50 (32%)
Ank_4 209..270 CDD:372654 18/62 (29%)
ANK repeat 212..247 CDD:293786 9/34 (26%)
ANK repeat 249..280 CDD:293786 13/32 (41%)
ANK repeat 282..313 CDD:293786 11/30 (37%)
ANK repeat 315..345 CDD:293786 15/69 (22%)
ANKYR 329..617 CDD:440430 102/350 (29%)
ANK repeat 348..379 CDD:293786 7/33 (21%)
ANK repeat 381..411 CDD:293786 12/29 (41%)
ANK repeat 414..445 CDD:293786 10/30 (33%)
ANK repeat 447..478 CDD:293786 11/30 (37%)
ANK repeat 480..511 CDD:293786 11/36 (31%)
ANK repeat 513..542 CDD:293786 11/28 (39%)
ANK repeat 546..571 CDD:293786 7/24 (29%)
ANKYR 566..831 CDD:440430 87/291 (30%)
ANK repeat 579..604 CDD:293786 13/24 (54%)
ANK repeat 612..643 CDD:293786 12/52 (23%)
ANK repeat 645..676 CDD:293786 14/30 (47%)
ANK repeat 678..707 CDD:293786 11/28 (39%)
ANK repeat 711..742 CDD:293786 12/30 (40%)
ANK repeat 744..775 CDD:293786 7/30 (23%)
ANK repeat 777..806 CDD:293786 7/28 (25%)
ZU5 1013..1150 CDD:128514 30/137 (22%)
UPA_2 1371..1500 CDD:375346
PTZ00121 <1580..2207 CDD:173412
PHA03307 1725..>2004 CDD:223039
rad2 <3031..>3565 CDD:273166
PRK12323 <3196..>3442 CDD:481241
Death_ank2 3614..3697 CDD:260066
NESP55 <3770..>3884 CDD:115071
Blue background indicates that the domain is not in the aligned region.

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