DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tnks and ANK1

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:XP_011542792.1 Gene:ANK1 / 286 HGNCID:492 Length:1969 Species:Homo sapiens


Alignment Length:1119 Identity:296/1119 - (26%)
Similarity:465/1119 - (41%) Gaps:214/1119 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SRSRAILSVNLDAVMANDPLRELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAGYGR 69
            |:|..:|.|..:.....:.|..|..|.|.|.:..|.:|:..:.: ...|..:.:|.||.||..|:
Human    92 SQSTGLLRVLYNQNRKKNGLNGLHLASKEGHVKMVVELLHKEII-LETTTKKGNTALHIAALAGQ 155

  Fly    70 REVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKG 134
            .|||..|:|.||::.|..:.|..||:......|.|||:.||:.||:.|......:|||..|..:|
Human   156 DEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 220

  Fly   135 KVDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPL 199
            ..:|...|:.:|..                        |:.|...|..|||:. :.|..|:|...
Human   221 HENVVAHLINYGTK------------------------GKVRLPALHIAARND-DTRTAAVLLQN 260

  Fly   200 NVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQ 264
            :.|.........||||:||.|..:.:.::||..||.|:...:.|:.|||.|...|:..:.:||:.
Human   261 DPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLD 325

  Fly   265 AGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRE--RIAF 327
            .||.:........||||.||....|.:..:||..||.......:..|.|..|...:..:  |:..
Human   326 RGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLL 390

  Fly   328 EY-----------------KGHC--------LLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPL 367
            :|                 ..||        |||...|.: |||              ..|.|||
Human   391 QYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPN-SRA--------------LNGFTPL 440

  Fly   368 HLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLG 432
            |:|...   ...::||||.:.|:.::...::.|||||:|:.:.|...::.||::||..|..:...
Human   441 HIACKK---NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 502

  Fly   433 QTPLHRCAR--DEQAVRLLLSYAADTNIVSLEGLT----AAQLASDSVLKLL----KNP----PD 483
            :||||..||  ..:..:.||...|..|..:.:..|    ||::...:::|||    .||    ..
Human   503 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTA 567

  Fly   484 SETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYA 548
            ..|.|..||:.|.::||..: |....|..|....|  .||||.||.:.:|.|.:.|||..|...|
Human   568 GHTPLHIAAREGHVETVLAL-LEKEASQACMTKKG--FTPLHVAAKYGKVRVAELLLERDAHPNA 629

  Fly   549 ADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWK-FTPLHEAAAKGKYDICKLLLKHGADP 612
            |.|.||.|||.|..:.:.::.:||:..|.:.: |..|. :||||.||.:.:.::.:.||::|...
Human   630 AGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH-SPAWNGYTPLHIAAKQNQVEVARSLLQYGGSA 693

  Fly   613 MKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNSTPL 677
            ..::..|.||..|..:..|  ||::   :.||.....|||.....|                |||
Human   694 NAESVQGVTPLHLAAQEGH--AEMV---ALLLSKQANGNLGNKSGL----------------TPL 737

  Fly   678 HLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTP 742
            ||.|...:...|:.|:::|..|:|..:.|..|||.||.||::.:...|::|:..|||..|.|::|
Human   738 HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSP 802

  Fly   743 LHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELA---------------------------- 779
            ||:|||:|.|.:.:|||.:||.....:.:|.||:.:|                            
Human   803 LHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETSFVLVSDKH 867

  Fly   780 ------TADDVKCLLQD---AMATSLSQQALSASTQSLTS--------------------SSPAP 815
                  |.|::..:.:|   |..|.:.::.:|...:...|                    .|||.
Human   868 RMSFPETVDEILDVSEDEGTAHITIMGEELISFKAERRDSRDVDEEKELLDFVPKLDQVVESPAI 932

  Fly   816 DATAAAAPGT---SSSSSSAILSPTTETVLLPTGASMILS---VPVPLPLSSSTRIS---PAQGA 871
            .....|.|.|   .|...........|..|:|:..:...|   .||..|:.:...:|   .|:|.
Human   933 PRIPCAMPETVVIRSEEQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGG 997

  Fly   872 EANGAEGSSSDDLLPDADTI--TNVS-GFLSSQQLHHLIELFEREQITLDILAEMGHDDLKQVGV 933
            ...|:..:....::|.....  |.:: ..:..|:|.....|.|.|.:...|:|         :|.
Human   998 SMRGSRHNGLRVVIPPRTCAAPTRITCRLVKPQKLSTPPPLAEEEGLASRIIA---------LGP 1053

  Fly   934 SAYGFRHKILKGIAQLRSTTGIGNNVNLCTLLVDLLPDDKEFVAVEEEMQATIREHRDNGQAGGY 998
            :...|...::..|....| .|.|               |:|.|.:..|..:..:|||        
Human  1054 TGAQFLSPVIVEIPHFAS-HGRG---------------DRELVVLRSENGSVWKEHR-------- 1094

  Fly   999 FTRYNIIRVQKVQN 1012
             :||....:.::.|
Human  1095 -SRYGESYLDQILN 1107

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125 35/113 (31%)
ANK repeat 59..87 CDD:293786 14/27 (52%)
Ank_2 61..153 CDD:289560 33/91 (36%)
ANK repeat 89..120 CDD:293786 12/30 (40%)
ANK repeat 122..153 CDD:293786 8/30 (27%)
ANK 202..316 CDD:238125 36/113 (32%)
ANK repeat 212..240 CDD:293786 12/27 (44%)
Ank_2 214..306 CDD:289560 31/91 (34%)
ANK repeat 242..273 CDD:293786 10/30 (33%)
ANK repeat 275..306 CDD:293786 11/30 (37%)
ANK 361..478 CDD:238125 37/122 (30%)
ANK repeat 363..396 CDD:293786 11/32 (34%)
Ank_2 367..459 CDD:289560 30/93 (32%)
ANK 393..573 CDD:238125 63/193 (33%)
ANK repeat 398..429 CDD:293786 12/30 (40%)
ANK repeat 431..459 CDD:293786 10/29 (34%)
ANK repeat 483..515 CDD:293786 10/31 (32%)
Ank_4 486..540 CDD:290365 19/53 (36%)
ANK 512..637 CDD:238125 44/125 (35%)
ANK repeat 522..550 CDD:293786 13/27 (48%)
Ank_2 524..616 CDD:289560 33/92 (36%)
ANK repeat 552..583 CDD:293786 9/30 (30%)
ANK repeat 585..610 CDD:293786 9/25 (36%)
ANK repeat 638..668 CDD:293786 6/29 (21%)
Ank_4 641..693 CDD:290365 13/51 (25%)
ANK 665..779 CDD:238125 42/113 (37%)
ANK repeat 672..703 CDD:293786 11/30 (37%)
Ank_2 677..769 CDD:289560 37/91 (41%)
ANK repeat 705..736 CDD:293786 13/30 (43%)
ANK repeat 738..769 CDD:293786 14/30 (47%)
SAM_tankyrase1,2 887..952 CDD:188923 11/67 (16%)
SAM 890..952 CDD:197735 11/64 (17%)
tankyrase_like 948..1170 CDD:238718 13/65 (20%)
PARP 961..1165 CDD:279038 10/52 (19%)
ANK1XP_011542792.1 ANK 47..163 CDD:238125 21/71 (30%)
ANK repeat 47..75 CDD:293786
ANK 108..229 CDD:238125 40/121 (33%)
ANK repeat 109..140 CDD:293786 7/31 (23%)
Ank_2 114..204 CDD:289560 32/90 (36%)
ANK repeat 143..173 CDD:293786 14/29 (48%)
ANK 170..324 CDD:238125 50/178 (28%)
ANK repeat 175..206 CDD:293786 12/30 (40%)
ANK repeat 208..232 CDD:293786 7/23 (30%)
ANK repeat 241..268 CDD:293786 8/27 (30%)
Ank_2 242..333 CDD:289560 30/91 (33%)
ANK 265..390 CDD:238125 37/124 (30%)
ANK repeat 271..301 CDD:293786 12/29 (41%)
ANK repeat 303..334 CDD:293786 10/30 (33%)
Ank_2 308..397 CDD:289560 24/88 (27%)
ANK repeat 336..367 CDD:293786 11/30 (37%)
ANK repeat 369..400 CDD:293786 5/30 (17%)
Ank 402..432 CDD:278452 6/30 (20%)
ANK repeat 405..433 CDD:293786 7/28 (25%)
ANKYR 406..619 CDD:223738 69/233 (30%)
ANK 430..555 CDD:238125 41/142 (29%)
ANK repeat 435..466 CDD:293786 11/33 (33%)
ANK repeat 468..499 CDD:293786 12/30 (40%)
ANK repeat 501..532 CDD:293786 10/30 (33%)
ANK 529..654 CDD:238125 42/127 (33%)
ANK repeat 534..563 CDD:293786 8/28 (29%)
ANK repeat 568..598 CDD:293786 10/30 (33%)
ANK repeat 600..631 CDD:293786 14/32 (44%)
Ank_2 605..696 CDD:289560 33/91 (36%)
ANK repeat 633..661 CDD:293786 9/27 (33%)
ANK repeat 666..697 CDD:293786 9/30 (30%)
ANK 666..695 CDD:197603 9/28 (32%)
ANK 694..819 CDD:238125 48/145 (33%)
ANK repeat 699..730 CDD:293786 12/35 (34%)
Ank_2 704..795 CDD:289560 33/111 (30%)
ANK repeat 732..763 CDD:293786 12/46 (26%)
ANK repeat 765..796 CDD:293786 13/30 (43%)
Ank_5 785..839 CDD:290568 23/53 (43%)
ANK repeat 798..826 CDD:293786 14/27 (52%)
ZU5 984..1088 CDD:128514 23/128 (18%)
Death_ank1 1474..1557 CDD:260067
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.