DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and ANKRD17

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_115593.3	Gene:	ANKRD17 / 26057	HGNCID:	23575	Length:	2603	Species:	Homo sapiens

Alignment Length:	2241	Identity:	476/2241 - (21%)
Similarity:	700/2241 - (31%)	Gaps:	907/2241 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LFEACKTGEIAKVKKLITPQT-VNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEGG 90
            |..|...|.:..||.|:..:. |||:.:.|  :|.|.:|...|..:||:.||.|||||:..:|.|
Human   305 LMAAANGGHVKIVKLLLAHKADVNAQSSTG--NTALTYACAGGYVDVVKVLLESGASIEDHNENG 367

  Fly    91 LHPLHNCCSFGHAEVVRLLLKAGASPNT-----------------------------------TD 120
            ..||....|.||.||.||||:.||..||                                   ||
Human   368 HTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD 432

  Fly   121 NWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELA---------------------- 163
            .. :|.|.||...|.|:|...||..||...:.....::||.||
Human   433 EM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEV 496

  Fly   164 -DEATRPVLTGEYRKDELLEAARSGAEDRLLALL-TPLNVNCHASDGRR---------------- 210
             ||...|          |:||||.|.|:.:..|| ...|:|....:.:.
Human   497 NDEGYTP----------LMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVAD 551

  Fly   211 -------------STPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLL 262
                         ||||..||....:.:|:.|||.||:|||....|...|..||..||.||..:|
Human   552 FLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616

  Fly   263 IQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGAD---PTLLNCHSKSAIDAA-------- 316
            :||||::........|||.:||....|.....|:|:||:   .|..|.|:..::..|
Human   617 LQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVE 681

  Fly   317 --------PTRELRE----RIAFEYKGH----C-LLDACRKC----------------DVSRAKK 348
                    ||..|::    .|.....||    | |||.....                |::||.:
Human   682 LLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPR 746

  Fly   349 LVCAEIVNFVHPYTGDTP---------------------LHLAVVSPD----------------- 375
            :....:...|.|...|.|                     .||...|.|
Human   747 VPVQALPMVVPPQEPDKPPANVATTLPIRNKAASKQKSSSHLPANSQDVQGYITNQSPESIVEEA 811

  Fly   376 -GKRKQL----------------MEL---------------------LTRKGSLLNEKNK----- 397
             ||..:|                :||                     :.:|..:|.|..|
Human   812 QGKLTELEQRIKEAIEKNAQLQSLELAHADQLTKEKIEELNKTREEQIQKKQKILEELQKVEREL 876

  Fly   398 ---------------------------------AFLTPLHLAAELLHYDAME------VLLKQGA 423
                                             ..|||:.:..:|...|...      ||||...
Human   877 QLKTQQQLKKQYLEVKAQRIQLQQQQQQSCQHLGLLTPVGVGEQLSEGDYARLQQVDPVLLKDEP 941

  Fly   424 KVNALDSLGQTPLHRCARDEQAVRLL---LSYAADTNIVSLEG-------LTAAQLA--SDSVLK 476
            :..|. .:|..|:...|. .||:.|.   |...:..|:..|:|       |..||||  ...:|
Human   942 QQTAA-QMGFAPIQPLAM-PQALPLAAGPLPPGSIANLTELQGVIVGQPVLGQAQLAGLGQGIL- 1003

  Fly   477 LLKNPPDSETHLLEAAKAGDL-DTVRRIVL----------NNP-------------------ISV 511
                 .:::..|:.|:.|..| ||:..|:.          |.|                   ||.
Human  1004 -----TETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIISP 1063

  Fly   512 NCR-------DLDGR----HSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGH 565
            :..       |:|.:    |.|.|..|.......:||.|||.||.:...||.|..||..|.:.||
Human  1064 SAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGH 1128

  Fly   566 YEVTELLVKHGANVNV-SDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKES 629
            ..|.|:|:.:||::.. |:..|.|||..|.:.|:.::.:|||..||:...:|....||..|....
Human  1129 VGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASG 1193

  Fly   630 DH-DVAELL--------------RGPSALLDAAKKGNLARVQRLVTPES-INCRDAQGRNSTPLH 678
            .: ::.::|              .|.|.|:.||..|:.|.|:.|:...| ||.:....|| |.|.
Human  1194 GYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRN-TALT 1257

  Fly   679 LAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNA------TDK 737
            ||......|....||:..|:|..:.|.||.||..|:|.|:.::..:|:.....|||      .|
Human  1258 LACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRD- 1321

  Fly   738 WGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELAT----ADDVKCLLQ-----DA-- 791
               |.|..||.||..:.|.||:..||...::|::|.||:.||.    .|.|:.|:|     ||
Human  1322 ---TALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAAD 1383

  Fly   792 --------------------------------------MATSLSQQALSASTQSLTSSSPAPDAT 818
                                                  :||...::.|......:.|...|.|..
Human  1384 NRKITPLMAAFRKGHVKVVRYLVKEVNQFPSDSECMRYIATITDKEMLKKCHLCMESIVQAKDRQ 1448

  Fly   819 AAAA------------------------------------------------------------- 822
            ||.|
Human  1449 AAEANKNASILLEELDLEKLREESRRLALAAKREKRKEKRRKKKEEQRRKLEEIEAKNKENFELQ 1513

  Fly   823 -------------------PGTSSSSSSAILSPTTETV------------------------LLP 844
                               |.:::::::..:|.|..|:                        :.|
Human  1514 AAQEKEKLKVEDEPEVLTEPPSATTTTTIGISATWTTLAGSHGKRNNTITTTSSKRKNRKNKITP 1578

  Fly   845 TGASMILSVPVPLPL-----------SSST---------RISPAQGAEANGAEGSSSDDLLPDAD 889
            ....:|...|:|:..           ||||         |||......:|......||:..|...
Human  1579 ENVQIIFDDPLPISYSQPEKVNGESKSSSTSESGDSDNMRISSCSDESSNSNSSRKSDNHSPAVV 1643

  Fly   890 TITNVSGFLSSQQLHHLIELFEREQITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLR-STT 953
            |.|     :||::...::..|.:|:                         .|.:.|.|.:: |.|
Human  1644 TTT-----VSSKKQPSVLVTFPKEE-------------------------RKSVSGKASIKLSET 1678

  Fly   954 ---GIGNNVNLCTL-----LVDLLPDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKV 1010
               |..|:::.||.     |..  |:.|..||..:..|     .|:.|
Human  1679 ISEGTSNSLSTCTKSGPSPLSS--PNGKLTVASPKRGQ-----KREEG----------------- 1719

  Fly  1011 QNRKLWERYAHRRQEIAEENFLQSNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHS 1075
                 |:....|.::::..:.:.|  |::..|...||||  |.|.          ||.|...:..
Human  1720 -----WKEVVRRSKKVSVPSTVIS--RVIGRGGCNINAI--REFT----------GAHIDIDKQK 1765

  Fly  1076 SKSNQYVYGIGGG---------------------------------------IGCPSHKDKSCYV 1101
            .|:...:..|.||                                       ||..:....:...
Human  1766 DKTGDRIITIRGGTESTRQATQLINALIKDPDKEIDELIPKNRLKSSSANSKIGSSAPTTTAANT 1830

  Fly  1102 CPRQLLLCRVALGKSF------------------------------------LQYSAMKMAHA-- 1128
            ....:.:..|||..:.                                    |.|...:.|||
Human  1831 SLMGIKMTTVALSSTSQTATALTVPAISSASTHKTIKNPVNNVRPGFPVSLPLAYPPPQFAHALL 1895

  Fly  1129 ----------------------PPGHHSVVG----RP---------------------------- 1139
                                  ||. .|..|    ||
Human  1896 AAQTFQQIRPPRLPMTHFGGTFPPA-QSTWGPFPVRPLSPARATNSPKPHMVPRHSNQNSSGSQV 1959

  Fly  1140 -SAGGLHFAEYVV------------YRGEQSYP----EYLITYQIVKPDDSSSGTEDTRXW---- 1183
             |||.|..:....            ..|..|.|    :..:|  :||..::::.|..|. .
Human  1960 NSAGSLTSSPTTTTSSSASTVPGTSTNGSPSSPSVRRQLFVT--VVKTSNATTTTVTTTASNNNT 2022

  Fly  1184 --------MPSVG-----STPTTTSPALHQP---------------------------------- 1201
                    ||:..     |:|::.||.. ||
Human  2023 APTNATYPMPTAKEHYPVSSPSSPSPPA-QPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVE 2086

  Fly  1202 -------------------QTQQQPQQQQQQQPQPQ-QQQKAPLP----LPPPQQQTSAPVAKRR 1242
                               ..||||.....|:|:|. ||.:.|.|    ..||...:|||||.
Human  2087 TTNTRPPNSSSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAV-- 2149

  Fly  1243 PKHAKPSLQLQYQPYQ-PQHHPVVATAAAVTTTQPSPAGVFA-HSNNNNNTSSGNVNNNNNDMSP 1305
            |..|..:..:...|.. ||..|.:.|.|    .:|.|.|..| |.|      |.:|.|::..:..
Human  2150 PSTAPVTYPMPQTPMGCPQPTPKMETPA----IRPPPHGTTAPHKN------SASVQNSSVAVLS 2204

  Fly  1306 VSNSNSYSSVDTNQTLLNSLANQQRNHRQPQNHHHQQQQQANRSQKYSQFMIITPAVSIDRDFEY 1370
            |::.....||.::..|.::|:.|.    ..||..|    .||:.        |.|..|....|..
Human  2205 VNHIKRPHSVPSSVQLPSTLSTQS----ACQNSVH----PANKP--------IAPNFSAPLPFGP 2253

  Fly  1371 ESHLDFEDFANAAHNNGNLFRLGLRRSDSSSDDSGHSSDSSSFRSNYNPYLHHS----------- 1424
            .|.| ||:...:||    .|..|...|..|:.:| ..|..||:..|.:| ||.|
Human  2254 FSTL-FENSPTSAH----AFWGGSVVSSQSTPES-MLSGKSSYLPNSDP-LHQSDTSKAPGFRPP 2311

  Fly  1425 -RQHLLSKGG-------NGGGGGASRHFYAFTSSWRWCSLLCAAMRCFGAGGAGHGNAPYSSSL- 1480
             ::...|..|       .|....:|.|...|.|:       .:..:.:|. ||..|.||.:::.
Human  2312 LQRPAPSPSGIVNMDSPYGSVTPSSTHLGNFASN-------ISGGQMYGP-GAPLGGAPAAANFN 2368

  Fly  1481 -QHHR----LRRCSSYNAENAYEHFAAPFKA 1506
             ||..    |..|||.:.:::.:..::..:|
Human  2369 RQHFSPLSLLTPCSSASNDSSAQSVSSGVRA 2399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	48/148 (32%)
		ANK repeat	59..87	CDD:293786	13/27 (48%)
		Ank_2	61..153	CDD:289560	42/126 (33%)
		ANK repeat	89..120	CDD:293786	16/65 (25%)
		ANK repeat	122..153	CDD:293786	11/30 (37%)
		ANK	202..316	CDD:238125	42/145 (29%)
		ANK repeat	212..240	CDD:293786	14/27 (52%)
		Ank_2	214..306	CDD:289560	36/94 (38%)
		ANK repeat	242..273	CDD:293786	13/30 (43%)
		ANK repeat	275..306	CDD:293786	11/33 (33%)
		ANK	361..478	CDD:238125	41/248 (17%)
		ANK repeat	363..396	CDD:293786	14/108 (13%)
		Ank_2	367..459	CDD:289560	31/193 (16%)
		ANK	393..573	CDD:238125	62/276 (22%)
		ANK repeat	398..429	CDD:293786	10/36 (28%)
		ANK repeat	431..459	CDD:293786	8/30 (27%)
		ANK repeat	483..515	CDD:293786	11/68 (16%)
		Ank_4	486..540	CDD:290365	19/94 (20%)
		ANK	512..637	CDD:238125	42/137 (31%)
		ANK repeat	522..550	CDD:293786	10/27 (37%)
		Ank_2	524..616	CDD:289560	34/92 (37%)
		ANK repeat	552..583	CDD:293786	11/31 (35%)
		ANK repeat	585..610	CDD:293786	9/24 (38%)
		ANK repeat	638..668	CDD:293786	12/30 (40%)
		Ank_4	641..693	CDD:290365	18/52 (35%)
		ANK	665..779	CDD:238125	40/119 (34%)
		ANK repeat	672..703	CDD:293786	11/30 (37%)
		Ank_2	677..769	CDD:289560	32/97 (33%)
		ANK repeat	705..736	CDD:293786	11/36 (31%)
		ANK repeat	738..769	CDD:293786	11/30 (37%)
		SAM_tankyrase1,2	887..952	CDD:188923	9/65 (14%)
		SAM	890..952	CDD:197735	9/62 (15%)
		tankyrase_like	948..1170	CDD:238718	57/378 (15%)
		PARP	961..1165	CDD:279038	51/356 (14%)
ANKRD17	NP_115593.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..143
		ANK 1	233..262
		Ank_2	238..330	CDD:289560	8/24 (33%)
		ANK repeat	238..264	CDD:293786
		ANK	261..387	CDD:238125	34/83 (41%)
		ANK repeat	266..298	CDD:293786
		ANK 2	266..295
		ANK 3	300..329		7/23 (30%)
		ANK repeat	303..331	CDD:293786	9/25 (36%)
		Ank_2	305..394	CDD:289560	38/90 (42%)
		ANK	328..454	CDD:238125	42/128 (33%)
		ANK repeat	333..364	CDD:293786	14/32 (44%)
		ANK 4	333..362		14/30 (47%)
		ANK 5	366..395		14/28 (50%)
		ANK repeat	366..394	CDD:293786	14/27 (52%)
		ANK	396..520	CDD:238125	27/134 (20%)
		ANK repeat	400..431	CDD:293786	0/30 (0%)
		ANK 6	400..429		0/28 (0%)
		Ank_4	403..454	CDD:290365	9/51 (18%)
		ANK 7	433..462		11/29 (38%)
		ANK repeat	435..464	CDD:293786	11/28 (39%)
		Ank_2	438..529	CDD:289560	28/100 (28%)
		ANK repeat	466..497	CDD:293786	4/30 (13%)
		ANK 8	466..495		4/28 (14%)
		ANK repeat	499..529	CDD:293786	13/39 (33%)
		ANK 9	499..528		12/38 (32%)
		ANK repeat	532..561	CDD:293786	0/28 (0%)
		ANK 10	533..562		0/28 (0%)
		Ank_4	536..584	CDD:290365	7/47 (15%)
		ANK 11	563..592		13/28 (46%)
		ANK	566..684	CDD:238125	41/117 (35%)
		ANK repeat	566..594	CDD:293786	14/27 (52%)
		Ank_2	568..659	CDD:289560	35/90 (39%)
		ANK repeat	596..627	CDD:293786	13/30 (43%)
		ANK 12	596..625		13/28 (46%)
		ANK repeat	629..658	CDD:293786	10/28 (36%)
		ANK 13	629..658		10/28 (36%)
		Ank_2	634..723	CDD:289560	22/88 (25%)
		ANK	662..>723	CDD:238125	13/60 (22%)
		ANK repeat	663..693	CDD:293786	5/29 (17%)
		ANK 14	663..692		4/28 (14%)
		ANK 15	696..725		7/28 (25%)
		OmpH	794..>893	CDD:281871	10/98 (10%)
		AhaH	805..881	CDD:131972	9/75 (12%)
		ANKYR	1046..1272	CDD:223738	64/226 (28%)
		ANK 16	1082..1111		11/28 (39%)
		ANK	1082..1110	CDD:197603	11/27 (41%)
		ANK repeat	1084..1113	CDD:293786	10/28 (36%)
		ANK	1111..1238	CDD:238125	38/126 (30%)
		ANK repeat	1115..1147	CDD:293786	11/31 (35%)
		ANK 17	1115..1144		11/28 (39%)
		ANK repeat	1149..1180	CDD:293786	11/30 (37%)
		ANK 18	1149..1178		11/28 (39%)
		ANK repeat	1182..1213	CDD:293786	4/30 (13%)
		ANK 19	1182..1211		4/28 (14%)
		ANK repeat	1217..1247	CDD:293786	12/29 (41%)
		ANK 20	1217..1246		11/28 (39%)
		ANK repeat	1250..1282	CDD:293786	11/32 (34%)
		ANK 21	1251..1280		11/29 (38%)
		ANK	1280..1406	CDD:238125	36/129 (28%)
		ANK repeat	1284..1313	CDD:293786	9/28 (32%)
		ANK 22	1284..1313		9/28 (32%)
		Ank_2	1289..1383	CDD:289560	32/97 (33%)
		ANK 23	1319..1348		12/32 (38%)
ANK repeat	1321..1350	CDD:293786	12/32 (38%)
ANK repeat	1352..1383	CDD:293786	11/30 (37%)
ANK 24	1352..1381		9/28 (32%)
ANK 25	1385..1414		0/28 (0%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1479..1500		0/20 (0%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1517..1717		40/236 (17%)
NusA	<1720..1767	CDD:223273	14/60 (23%)
KH-I	1727..1789	CDD:238053	16/75 (21%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1906..1995		13/89 (15%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2011..2192		42/193 (22%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2273..2332		14/60 (23%)
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2381..2423		4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920