DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tnks and Rnasel

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_036012.1 Gene:Rnasel / 24014 MGIID:1098272 Length:735 Species:Mus musculus


Alignment Length:293 Identity:88/293 - (30%)
Similarity:143/293 - (48%) Gaps:29/293 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   483 DSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVY 547
            :.::.|::|.:.||:..|::::.....:..|.|..|  .||||.|....||.:|..||.|||:.:
Mouse    24 EDDSSLIKAVQKGDVVRVQQLLEKGADANACEDTWG--WTPLHNAVQAGRVDIVNLLLSHGADPH 86

  Fly   548 AADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADP 612
            ...|.|..|...|...|..::.|:|:..||:||..|...||...|||.:|..:..:.|...||: 
Mouse    87 RRKKNGATPFIIAGIQGDVKLLEILLSCGADVNECDENGFTAFMEAAERGNAEALRFLFAKGAN- 150

  Fly   613 MKKNRDGATPADLVKESDHDVAELLR-GPSALLDAAKKGNLARVQRLVTPE---SINCRDAQGRN 673
                      .:|.:::..|...|.: |.:||:.||:||:| .|.|::..:   .::.||..|||
Mouse   151 ----------VNLRRQTTKDKRRLKQGGATALMSAAEKGHL-EVLRILLNDMKAEVDARDNMGRN 204

  Fly   674 STPLHLAAGYNNFEC------AEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTV- 731
            :    |.....|::|      ...|:::|||||.:.:.|..||..|....|..:..:|:..:.: 
Mouse   205 A----LIRTLLNWDCENVEEITSILIQHGADVNVRGERGKTPLIAAVERKHTGLVQMLLSREGIN 265

  Fly   732 VNATDKWGFTPLHEAAQKGRTQLCSLLLAHGAD 764
            ::|.|..|.|.|..|..|...::..|||..|||
Mouse   266 IDARDNEGKTALLIAVDKQLKEIVQLLLEKGAD 298

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125
ANK repeat 59..87 CDD:293786
Ank_2 61..153 CDD:289560
ANK repeat 89..120 CDD:293786
ANK repeat 122..153 CDD:293786
ANK 202..316 CDD:238125
ANK repeat 212..240 CDD:293786
Ank_2 214..306 CDD:289560
ANK repeat 242..273 CDD:293786
ANK repeat 275..306 CDD:293786
ANK 361..478 CDD:238125
ANK repeat 363..396 CDD:293786
Ank_2 367..459 CDD:289560
ANK 393..573 CDD:238125 27/89 (30%)
ANK repeat 398..429 CDD:293786
ANK repeat 431..459 CDD:293786
ANK repeat 483..515 CDD:293786 6/31 (19%)
Ank_4 486..540 CDD:290365 16/53 (30%)
ANK 512..637 CDD:238125 39/124 (31%)
ANK repeat 522..550 CDD:293786 13/27 (48%)
Ank_2 524..616 CDD:289560 32/91 (35%)
ANK repeat 552..583 CDD:293786 10/30 (33%)
ANK repeat 585..610 CDD:293786 7/24 (29%)
ANK repeat 638..668 CDD:293786 10/33 (30%)
Ank_4 641..693 CDD:290365 17/60 (28%)
ANK 665..779 CDD:238125 33/107 (31%)
ANK repeat 672..703 CDD:293786 11/36 (31%)
Ank_2 677..769 CDD:289560 28/95 (29%)
ANK repeat 705..736 CDD:293786 7/31 (23%)
ANK repeat 738..769 CDD:293786 11/27 (41%)
SAM_tankyrase1,2 887..952 CDD:188923
SAM 890..952 CDD:197735
tankyrase_like 948..1170 CDD:238718
PARP 961..1165 CDD:279038
RnaselNP_036012.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
ANK repeat 24..55 CDD:293786 5/30 (17%)
ANK 1 24..53 5/28 (18%)
Binding to TMEV Leader protein. /evidence=ECO:0000269|PubMed:29652922 26..51 5/24 (21%)
Ank_2 <29..88 CDD:403870 21/60 (35%)
ANK 2 58..87 14/30 (47%)
ANK repeat 59..89 CDD:293786 14/31 (45%)
Ank_2 61..>298 CDD:423045 78/252 (31%)
ANK repeat 91..122 CDD:293786 10/30 (33%)
ANK 3 91..120 9/28 (32%)
ANK repeat 124..154 CDD:293786 9/40 (23%)
ANK 4 124..153 9/39 (23%)
ANK repeat 167..199 CDD:293786 10/32 (31%)
ANK 5 167..197 10/30 (33%)
ANK 6 201..234 11/36 (31%)
2-5A binding (P-loop) 1 229..242 6/12 (50%)
ANK repeat 238..270 CDD:293786 7/31 (23%)
ANK 7 238..268 6/29 (21%)
2-5A binding (P-loop) 2 253..275 4/21 (19%)
ANK 8 272..301 11/27 (41%)
ANK repeat 272..297 CDD:293786 8/24 (33%)
ANK 9 303..328
PKc_like 361..585 CDD:419665
RNase_RNase-L 588..707 CDD:199218
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 714..735
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

Return to query results.
Submit another query.