DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnks and Ankle1

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	NP_766344.2	Gene:	Ankle1 / 234396	MGIID:	1918775	Length:	534	Species:	Mus musculus

Alignment Length:	539	Identity:	117/539 - (21%)
Similarity:	177/539 - (32%)	Gaps:	158/539 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 VEILLANGADVHAKDKGGLVPLHNACSYGH---FDVTKLLIQAGANVNANDLWAFTPLHEAASKS 287
            ||.||..|||.:.....|...:|.|....|   ....::|::.||:.||......||:|.||:..
Mouse    23 VEELLRLGADPNLVLDDGAAAVHLAARASHPRALHCLRMLLRWGADPNARSAEGLTPVHVAAAWG 87

  Fly   288 RVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCA 352
            ......||||||.||||.:......:|          .|.:.:.|                 .||
Mouse    88 CCGALELLLSRGGDPTLRDQDGLRPLD----------WALQQRHH-----------------NCA 125

  Fly   353 EIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEV 417
            .::..:     |||     ..||..|               |..:.|    |:|     ..:.|.
Mouse   126 RVLQEL-----DTP-----TQPDETR---------------EPTETF----HVA-----QGSFET 156

  Fly   418 LLKQG---AKVNALDSLGQTPLHRCARDEQAVRLLL-----------SYAADTNIV--------- 459
            ...||   |:.:.:....:..:||...:.:||.:.:           .|::|.:.|
Mouse   157 ETCQGPALAESSGVSQDSELHVHRAELEVEAVEVAVHPQSSEATENSDYSSDASFVTAVEDSLQP 221

  Fly   460 -----SLEGLTAAQLASDSVLKLLKNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGR 519
                 :|| |.|....:...:...|..|:.:..:| ...|.|.|        .|:.....||...
Mouse   222 GRPGGALE-LVAGLWVTRGAVSAGKGAPNCQPQVL-TLTARDTD--------KPVLPGDGDLGAL 276

  Fly   520 H---STPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNV 581
            |   |.|          |:....|...........|.:.|.    :.|||    |.....|..:.
Mouse   277 HPHSSVP----------PMSDLQLLQALRALGYSPGPVTPF----TRGHY----LRRLQEAQASR 323

  Fly   582 SDLWKFTPLHEAAAKGKYDICKLLLKHGA------DPMKKNRDGATPADLVKESDHDVAELLRGP 640
            :|:.....|.||...|....|::..:..|      ||:||.|:|.|.:..        ..||..|
Mouse   324 ADVGHSQELAEALRTGTIPDCQVDEEALAQCFQRLDPLKKWREGITKSSF--------TYLLLDP 380

  Fly   641 SALLDAAKKGNLARVQRLVTPESINC---------RDAQGRNSTPLHLAAGYNNFE----CAEYL 692
            ....|..     ||...|...|.:.|         :..:.|....|..|.||::..    |.:
Mouse   381 RLTKDLP-----ARASSLTLAECLQCFVRAIFYVGKGTRARPDAHLWEAFGYHDQPRKQVCPK-- 438

  Fly   693 LENGADVNAQDKGGLIPLH 711
            :....|:.|..: |:|.||
Mouse   439 VRRILDIWASGR-GIISLH 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125
		ANK repeat	59..87	CDD:293786
		Ank_2	61..153	CDD:289560
		ANK repeat	89..120	CDD:293786
		ANK repeat	122..153	CDD:293786
		ANK	202..316	CDD:238125	32/92 (35%)
		ANK repeat	212..240	CDD:293786	7/13 (54%)
		Ank_2	214..306	CDD:289560	31/82 (38%)
		ANK repeat	242..273	CDD:293786	9/33 (27%)
		ANK repeat	275..306	CDD:293786	15/30 (50%)
		ANK	361..478	CDD:238125	25/144 (17%)
		ANK repeat	363..396	CDD:293786	7/32 (22%)
		Ank_2	367..459	CDD:289560	17/105 (16%)
		ANK	393..573	CDD:238125	39/210 (19%)
		ANK repeat	398..429	CDD:293786	7/33 (21%)
		ANK repeat	431..459	CDD:293786	6/38 (16%)
		ANK repeat	483..515	CDD:293786	5/31 (16%)
		Ank_4	486..540	CDD:290365	11/56 (20%)
		ANK	512..637	CDD:238125	28/133 (21%)
		ANK repeat	522..550	CDD:293786	3/27 (11%)
		Ank_2	524..616	CDD:289560	19/97 (20%)
		ANK repeat	552..583	CDD:293786	7/30 (23%)
		ANK repeat	585..610	CDD:293786	5/24 (21%)
		ANK repeat	638..668	CDD:293786	7/38 (18%)
		Ank_4	641..693	CDD:290365	12/64 (19%)
		ANK	665..779	CDD:238125	13/60 (22%)
		ANK repeat	672..703	CDD:293786	8/34 (24%)
		Ank_2	677..769	CDD:289560	11/39 (28%)
		ANK repeat	705..736	CDD:293786	4/7 (57%)
		ANK repeat	738..769	CDD:293786
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
Ankle1	NP_766344.2	ANK 1. /evidence=ECO:0000255	4..35		7/11 (64%)
		ANK	26..128	CDD:238125	34/128 (27%)
		Ank_2	26..106	CDD:289560	29/79 (37%)
		ANK 2. /evidence=ECO:0000255	39..71		7/31 (23%)
		ANK repeat	75..106	CDD:293786	15/30 (50%)
		ANK 3. /evidence=ECO:0000255	75..104		13/28 (46%)
		Ank_4	76..128	CDD:290365	20/78 (26%)
		ANK 4. /evidence=ECO:0000255	108..137		8/65 (12%)
		LEM	285..322	CDD:295412	8/44 (18%)
		GIY-YIG_COG3680_Meta	372..484	CDD:198401	21/101 (21%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q8NAG6	498..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900