DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnks and Ankrd29

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_017173356.1	Gene:	Ankrd29 / 225187	MGIID:	2687055	Length:	381	Species:	Mus musculus

Alignment Length:	354	Identity:	97/354 - (27%)
Similarity:	144/354 - (40%)	Gaps:	73/354 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 LSYAADTNIVSLEGLTAAQLASDSVLKLLKNP-------PDS---ETH----LLEAAKAGDLDTV 500
            :|:..:|.:.: ....||:..:.::||||.|.       .||   :||    |:.|:.||.:|.|
Mouse    71 MSFKKETPLAN-AAFWAAKRGNLALLKLLLNSGRVDVDCRDSVRRDTHGTTLLMVASYAGHIDCV 134

  Fly   501 RRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGH 565
            |.:||.. ..:|.:...|  :|.|.|||......||:||...||......|.|...|..|..|||
Mouse   135 RELVLQG-ADINLQRESG--TTALFFAAQQGHNDVVRFLFGFGASTECRTKDGGTALLAASQYGH 196

  Fly   566 YEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKESD 630
            ..|.|.|:|||||::.......|.|..||..|..|:.:|||..||...:..:||
Mouse   197 MPVVETLLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLSSGAKVNQPRQDG----------- 250

  Fly   631 HDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLEN 695
                                                       :.||.:|:...:.|....:|..
Mouse   251 -------------------------------------------TAPLWIASQMGHSEVVRVMLLR 272

  Fly   696 GADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLA 760
            |||.:|....|...|..|::.|:.|:...|:|....:... |.|.:.||.|...|..:..:|||.
Mouse   273 GADRDAARNDGTTALLKAANKGYNDVIEELLKFSPTLGIL-KNGTSALHAAVLSGNVKTVALLLE 336

  Fly   761 HGADAYMKNQEGQTPIELATADDVKCLLQ 789
            .|||..::|:..:.|.||...:.:..||:
Mouse   337 AGADPALRNKANELPAELTKNERILHLLR 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125
		ANK repeat	59..87	CDD:293786
		Ank_2	61..153	CDD:289560
		ANK repeat	89..120	CDD:293786
		ANK repeat	122..153	CDD:293786
		ANK	202..316	CDD:238125
		ANK repeat	212..240	CDD:293786
		Ank_2	214..306	CDD:289560
		ANK repeat	242..273	CDD:293786
		ANK repeat	275..306	CDD:293786
		ANK	361..478	CDD:238125	6/27 (22%)
		ANK repeat	363..396	CDD:293786
		Ank_2	367..459	CDD:289560	2/8 (25%)
		ANK	393..573	CDD:238125	44/136 (32%)
		ANK repeat	398..429	CDD:293786
		ANK repeat	431..459	CDD:293786	2/8 (25%)
		ANK repeat	483..515	CDD:293786	14/38 (37%)
		Ank_4	486..540	CDD:290365	21/57 (37%)
		ANK	512..637	CDD:238125	41/124 (33%)
		ANK repeat	522..550	CDD:293786	11/27 (41%)
		Ank_2	524..616	CDD:289560	36/91 (40%)
		ANK repeat	552..583	CDD:293786	14/30 (47%)
		ANK repeat	585..610	CDD:293786	9/24 (38%)
		ANK repeat	638..668	CDD:293786	0/29 (0%)
		Ank_4	641..693	CDD:290365	4/51 (8%)
		ANK	665..779	CDD:238125	31/113 (27%)
		ANK repeat	672..703	CDD:293786	9/30 (30%)
		Ank_2	677..769	CDD:289560	27/91 (30%)
		ANK repeat	705..736	CDD:293786	7/30 (23%)
		ANK repeat	738..769	CDD:293786	11/30 (37%)
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
Ankrd29	XP_017173356.1	ANK repeat	76..110	CDD:293786	8/34 (24%)
		ANK repeat	117..148	CDD:293786	11/31 (35%)
		Ank_2	122..213	CDD:372319	37/93 (40%)
		ANK repeat	150..181	CDD:293786	12/32 (38%)
		ANK repeat	183..214	CDD:293786	14/30 (47%)
		ANK repeat	216..244	CDD:293786	11/27 (41%)
		Ank_4	219..270	CDD:372654	17/104 (16%)
		ANK repeat	249..278	CDD:293786	10/82 (12%)
		Ank_2	254..345	CDD:372319	27/91 (30%)
		ANK repeat	282..312	CDD:293786	7/29 (24%)
		ANK repeat	314..345	CDD:293786	11/30 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910