DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tnks and unc-44

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:NP_001367345.1 Gene:unc-44 / 177366 WormBaseID:WBGene00006780 Length:6994 Species:Caenorhabditis elegans


Alignment Length:1470 Identity:366/1470 - (24%)
Similarity:544/1470 - (37%) Gaps:417/1470 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 SVNLDAVMANDPLR-----ELFEACKTGEIAKVKKLITPQT-VNARDTAGRKSTPLHFAAGYGRR 70
            |..:.|..|.:|.|     ....|.:.|::.||.:|:...| :|..:..|..|  ||.|:..|..
 Worm    17 SQEVQAPAAPEPGRAEGSASFLRAARAGDLEKVLELLRAGTDINTSNANGLNS--LHLASKEGHS 79

  Fly    71 EVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGK 135
            |||..|:...|.:.|....|...||.....|.:.:|.:|::.||:.|......:|||:.||.:..
 Worm    80 EVVRELIKRQAQVDAATRKGNTALHIASLAGQSLIVTILVENGANVNVQSVNGFTPLYMAAQENH 144

  Fly   136 VDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLN 200
            .:|...||:||||..:...:..|||.:|.:.                     ..||::|:|..  
 Worm   145 EEVVKYLLKHGANQALSTEDGFTPLAVALQQ---------------------GHDRVVAVLLE-- 186

  Fly   201 VNCHASDGRRSTP-LHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQ 264
               :.|.|:...| ||:||..:......:||.|..:.....|.|..|||.|..|||.:|.:||::
 Worm   187 ---NDSKGKVRLPALHIAAKKDDTTAATLLLQNEHNPDVTSKSGFTPLHIAAHYGHENVGQLLLE 248

  Fly   265 AGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEY 329
            .|||||.......:|||.|....|..:.:|||||||                             
 Worm   249 KGANVNYQARHNISPLHVATKWGRTNMANLLLSRGA----------------------------- 284

  Fly   330 KGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNE 394
                ::|       ||.|.|:              ||||.|..|   ...|:::||..:|:.::.
 Worm   285 ----IID-------SRTKDLL--------------TPLHCAARS---GHDQVVDLLVVQGAPISA 321

  Fly   395 KNKAFLTPLHLAAELLHYDAMEVLLKQGAKVN--ALDSLGQTPLHRCAR--DEQAVRLLLSYAAD 455
            |.|..|.|||:||:..|.||...||...|.|:  .:|.|  ||||..|.  ..:..:|||..:||
 Worm   322 KTKNGLAPLHMAAQGDHVDAARTLLYHRAPVDDVTVDYL--TPLHVAAHCGHVRVAKLLLDRSAD 384

  Fly   456 TNIVSLEGLTAAQLASD----SVLKLL--------KNPPDSETHLLEAAKAGDLDTVRRIVLN-- 506
            .|..:|.|.|...:|..    .|::||        .......|.|..||..|.::.|..::..  
 Worm   385 PNSRALNGFTPLHIACKKNRIKVVELLLKYRAAIEATTESGLTPLHVAAFMGAINIVIYLLQQGA 449

  Fly   507 NPISVNCRDLDG-RHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTE 570
            ||      |::. |..||||.||..|:..||:.|:.:||:|.|..:....|||.|...|:.::..
 Worm   450 NP------DVETVRGETPLHLAARANQTDVVRVLIRNGAKVDAQARELQTPLHIASRLGNTDIVI 508

  Fly   571 LLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKESDHDVAE 635
            ||::.|||.|.:....::|||.||.:|:.::..:||.|.||.....:.|.||..|          
 Worm   509 LLLQAGANSNATTRDNYSPLHIAAKEGQEEVAGILLDHNADKTLLTKKGFTPLHL---------- 563

  Fly   636 LLRGPSALLDAAKKGNLARVQRLV---TPESINCRDAQGRNS-TPLHLAAGYNNFECAEYLLENG 696
                      |:|.|||..|:.|:   ||.     |.:|:|. ||||:||.|||.:.|..|||||
 Worm   564 ----------ASKYGNLEVVRLLLERGTPV-----DIEGKNQVTPLHVAAHYNNDKVAMLLLENG 613

  Fly   697 ADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAH 761
            |...|..|.|..|||.|:....::||:.|::.|...||..:.||||||.:||:|..::..||:.:
 Worm   614 ASAKAAAKNGYTPLHIAAKKNQMEIASTLLQFKADPNAKSRAGFTPLHLSAQEGHKEISGLLIEN 678

  Fly   762 GADAYMKNQEGQTPIELATADD---------------------------VKCLL-QDAMATSLSQ 798
            |:|...|...|.|.:.|...:|                           |.|.. |..|...|.:
 Worm   679 GSDVGAKANNGLTAMHLCAQEDHVPVAQILYNNGAEINSKTNAGYTPLHVACHFGQLNMVKFLVE 743

  Fly   799 QALSASTQSLTSSSPAPDATA-------------AAAPGTSSSSSSAILS--------PTTETVL 842
            .......::..|.:|...|..             .|:|...:::....||        ...||:.
 Worm   744 NGADVGEKTRASYTPLHQAAQQGHNNCVRYLLENGASPNEQTATGQTPLSIAQRLGYVSVVETLR 808

  Fly   843 LPTGASMILSVPVPLPLSSSTRISPAQGAEANGAEGSSSDDLLPDADTITNVSGFLSSQQLHHLI 907
            ..|..::|...     .:...|..|......|....|.|:|....|:              |..:
 Worm   809 TVTETTVITET-----TTVDERYKPQNPEAMNETMFSESEDEGQAAE--------------HEAV 854

  Fly   908 ELFEREQITLDILAEMGHDDLKQ-----VGVSAYGFRHKILKGIAQLRSTTGIGNNVNLCTLLVD 967
            ...|::          ..|:|.|     .||      |.|..|...|:.:..:.|...:..:...
 Worm   855 AAHEKD----------FSDNLTQGLQDSTGV------HMIHTGEQLLQRSQELENGGAIPKINSG 903

  Fly   968 LLPDDKEF-----VAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIA 1027
            .:..:|||     ||....:..:      |.|:.|...|...|..| .|.:.|            
 Worm   904 GMSPEKEFAKIAPVATSSPIATS------NSQSFGIAPRAGSISGQ-FQQQPL------------ 949

  Fly  1028 EENFLQSNERMLFHGS---PFINAIVQRGFDERHAYIGGMF-GAGIYFAEHSSKSN--------- 1079
                         ||:   ..:..:|:|.  :.|....|.: ..|:...|:....|         
 Worm   950 -------------HGAGPEDNLEELVRRA--QNHPINAGNYDNGGVAMLENGHADNVPIGHHVTQ 999

  Fly  1080 -----------QYVYGIGGGI--GCPSHKDKSCYVCPRQL-----LLCRVALGKSFLQYSAMKMA 1126
                       .::....||.  || .|......|.||:.     :.||      :|:..  |:|
 Worm  1000 PSKLQHRTFLISFLVDARGGAMRGC-RHSGVRIIVPPRKASQPIRVTCR------YLRKD--KLA 1055

  Fly  1127 HAPP---GHH---SVVGRPSAGGL----------HFA-------EYVVYRGE--QSYPEYLITYQ 1166
            |.||   |..   .::....||..          |||       |.|:.|.:  |.:.|    :|
 Worm  1056 HPPPLSEGEELASRILEMAPAGAKFLGPVILEVPHFASLRDREREIVILRSDDGQHWKE----HQ 1116

  Fly  1167 IVKPDDS-------SSGTED------------TRXW---MPSVGSTPTTTSPALH---------- 1199
            :...:|:       |...||            || .   .|...:..|.....:|          
 Worm  1117 LEATEDAVQEVLNESFDAEDLAQLDDLQTPRITRILTSDFPMYFAVVTRVRQEVHCVGPEGGVII 1181

  Fly  1200 ---QPQTQ---------QQPQQQQQQQPQPQQ-------QQKAPLPLPPPQQQTSAPVAKRRPKH 1245
               .|:.|         :..:...|.||.||:       .:.|..|:        ..|..||.|.
 Worm  1182 SSVVPRVQAIFPDGSLTKTIKVSVQAQPVPQEMVTRLHGNRVAVSPI--------VTVEPRRRKF 1238

  Fly  1246 AKP-------------SLQLQYQPYQPQHHPVVATAAAVT 1272
            .||             .:..||...|.|..|.:....::|
 Worm  1239 HKPITLCIPLPQSNNRGMLTQYSGQQGQEPPTLRLLCSIT 1278

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125 37/113 (33%)
ANK repeat 59..87 CDD:293786 10/27 (37%)
Ank_2 61..153 CDD:289560 31/91 (34%)
ANK repeat 89..120 CDD:293786 9/30 (30%)
ANK repeat 122..153 CDD:293786 12/30 (40%)
ANK 202..316 CDD:238125 39/114 (34%)
ANK repeat 212..240 CDD:293786 8/28 (29%)
Ank_2 214..306 CDD:289560 36/91 (40%)
ANK repeat 242..273 CDD:293786 16/30 (53%)
ANK repeat 275..306 CDD:293786 12/30 (40%)
ANK 361..478 CDD:238125 43/124 (35%)
ANK repeat 363..396 CDD:293786 10/32 (31%)
Ank_2 367..459 CDD:289560 36/95 (38%)
ANK 393..573 CDD:238125 65/198 (33%)
ANK repeat 398..429 CDD:293786 13/32 (41%)
ANK repeat 431..459 CDD:293786 12/29 (41%)
ANK repeat 483..515 CDD:293786 8/33 (24%)
Ank_4 486..540 CDD:290365 19/56 (34%)
ANK 512..637 CDD:238125 42/125 (34%)
ANK repeat 522..550 CDD:293786 14/27 (52%)
Ank_2 524..616 CDD:289560 34/91 (37%)
ANK repeat 552..583 CDD:293786 11/30 (37%)
ANK repeat 585..610 CDD:293786 9/24 (38%)
ANK repeat 638..668 CDD:293786 9/32 (28%)
Ank_4 641..693 CDD:290365 22/55 (40%)
ANK 665..779 CDD:238125 48/114 (42%)
ANK repeat 672..703 CDD:293786 18/31 (58%)
Ank_2 677..769 CDD:289560 40/91 (44%)
ANK repeat 705..736 CDD:293786 11/30 (37%)
ANK repeat 738..769 CDD:293786 13/30 (43%)
SAM_tankyrase1,2 887..952 CDD:188923 12/69 (17%)
SAM 890..952 CDD:197735 11/66 (17%)
tankyrase_like 948..1170 CDD:238718 52/282 (18%)
PARP 961..1165 CDD:279038 49/264 (19%)
unc-44NP_001367345.1 ANK repeat 32..63 CDD:293786 7/30 (23%)
PHA03095 37..>387 CDD:222980 129/436 (30%)
ANK repeat 65..96 CDD:293786 12/32 (38%)
ANK repeat 98..129 CDD:293786 9/30 (30%)
ANK repeat 131..156 CDD:293786 9/24 (38%)
ANK repeat 197..224 CDD:293786 7/26 (27%)
ANK repeat 226..257 CDD:293786 16/30 (53%)
PHA02876 <242..>648 CDD:165207 159/495 (32%)
ANK repeat 259..290 CDD:293786 14/70 (20%)
ANK repeat 292..322 CDD:293786 11/46 (24%)
ANK repeat 325..356 CDD:293786 13/30 (43%)
ANK repeat 358..389 CDD:293786 13/32 (41%)
ANK repeat 391..422 CDD:293786 6/30 (20%)
ANK repeat 424..455 CDD:293786 9/36 (25%)
ANK repeat 457..488 CDD:293786 15/30 (50%)
ANK repeat 490..519 CDD:293786 10/28 (36%)
ANK repeat 523..552 CDD:293786 11/28 (39%)
Ank_2 555..>780 CDD:423045 71/249 (29%)
ANK repeat 556..586 CDD:293786 14/54 (26%)
ANK repeat 589..620 CDD:293786 18/30 (60%)
ANK repeat 622..652 CDD:293786 10/29 (34%)
ANK repeat 655..685 CDD:293786 13/29 (45%)
ANK repeat 688..719 CDD:293786 4/30 (13%)
ANK repeat 721..752 CDD:293786 5/30 (17%)
ANK repeat 754..784 CDD:293786 5/29 (17%)
Ank_4 756..807 CDD:372654 7/50 (14%)
ZU5 1008..1110 CDD:128514 25/110 (23%)
UPA_2 1337..1472 CDD:375346
Death_ank 1503..1580 CDD:260029
PTZ00449 <1770..2112 CDD:185628
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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