DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tnks and Ank3

DIOPT Version :9

Sequence 1:NP_001262963.1 Gene:Tnks / 43095 FlyBaseID:FBgn0027508 Length:1520 Species:Drosophila melanogaster
Sequence 2:XP_036011414.1 Gene:Ank3 / 11735 MGIID:88026 Length:4691 Species:Mus musculus


Alignment Length:1445 Identity:351/1445 - (24%)
Similarity:559/1445 - (38%) Gaps:324/1445 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ANSSRSRAILSVNLDA------------VMANDPLRELFEACKTGEIAKVKKLITPQTVNARDTA 54
            ||:|..||..:.:|:.            :...:.|..|..|.|.|.:..|.:|: .:..|. |.|
Mouse    41 ANASYLRAARAGHLEKALDYIKNGVDVNICNQNGLNALHLASKEGHVEVVSELL-QREANV-DAA 103

  Fly    55 GRK-STPLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNT 118
            .:| :|.||.|:..|:.|||:.|:.:||::.|..:.|..||:......|.||||.||..|||.:.
Mouse   104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGASQSL 168

  Fly   119 TDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEA 183
            .....:|||..|..:|...|...||::.....:|               .|.|....|||:...|
Mouse   169 ATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVR---------------LPALHIAARKDDTKAA 218

  Fly   184 ARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLH 248
            |.....|....:.:.:.||.....|  .||||:||.|..|.:..:||...|.|....:..:.|||
Mouse   219 ALLLQNDTNADVESKMVVNRATESG--FTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLH 281

  Fly   249 NACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAI 313
            .|...|:.::.|||:..||.::|......||||..|.....:|..:||.|.| |.|         
Mouse   282 VASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRSA-PIL--------- 336

  Fly   314 DAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKR 378
                                          |:.|              .|.:|||:|.   .|..
Mouse   337 ------------------------------SKTK--------------NGLSPLHMAT---QGDH 354

  Fly   379 KQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLH-RCARD 442
            ...::||.:....:::....:||.||:||...||...:|||.:.|..||....|.|||| .|.::
Mouse   355 LNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKASPNAKALNGFTPLHIACKKN 419

  Fly   443 E-QAVRLLLSYAADTNIVSLEGLTAAQLAS-----DSVLKLLKN--PPDS-----ETHLLEAAKA 494
            . :.:.|||.:.|....|:..|||...:|:     :.|.:|:.:  .|::     ||.|..||::
Mouse   420 RIRVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARS 484

  Fly   495 GDLDTVRRIVLNN-PISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLH 558
            |..:.||.:|.:. .:....:|    ..||||.:|...:..:||.||:.||...||...|..|||
Mouse   485 GQAEVVRYLVQDGAQVEAKAKD----DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLH 545

  Fly   559 NACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPA 623
            .|...||.:|...|:.|||:::::....|||||.||..||.::..|||:..|.|....:.|.||.
Mouse   546 LAAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVASLLLQKSASPDAAGKSGLTPL 610

  Fly   624 DLVKESDHDVAELLRGPSALLD-------AAKKGNLARVQRLVTPESINCRDAQGRNSTPLHLAA 681
            .:....|:....||     |||       |||.|                       .||||:||
Mouse   611 HVAAHYDNQKVALL-----LLDQGASPHAAAKNG-----------------------YTPLHIAA 647

  Fly   682 GYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEA 746
            ..|..:.|..|||.|||.||..:.|:..:|.|:..||:|:.:||:.....||.::|.|.||||.|
Mouse   648 KKNQMDIATSLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLSRNANVNLSNKSGLTPLHLA 712

  Fly   747 AQKGRTQLCSLLLAHGADAYMKNQEGQTPIEL----ATADDVKCLLQDAMA---------TSLSQ 798
            ||:.|..:..:|:..||....:.:.|.||:.:    .....|..|||.:..         |:|.|
Mouse   713 AQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTALHQ 777

  Fly   799 QALSASTQSL-----TSSSP---APDATAAAAPGTSSSSSSAI--LSPTTETVLLPTGASMILSV 853
            .|....|..:     .::||   ..:...|.|........|.:  |...||.::..|..:....:
Mouse   778 AAQQGHTHIINVLLQNNASPNELTVNGNTALAIARRLGYISVVDTLKVVTEEIMTTTTITEKHKM 842

  Fly   854 PVPLPLSSSTRISPAQGAEANGAEGSSSDDLLPDADTITNVSGFLSSQQLHHLIELFEREQITLD 918
            .||..::....:|..:..:|:..|..|..:.:.|.:.....:.|...:....|::  ..:.||.|
Mouse   843 NVPETMNEVLDMSDDEVRKASAPEKLSDGEYISDGEEGDKCTWFKIPKVQEVLVK--SEDAITGD 905

  Fly   919 ILAEMGHDDLKQVG---VSAYGF------RHKILKGIAQLRSTTGIGNNVNLCTLLVD--LLPDD 972
            ....:|..|||::|   :.|.|:      .......|:..||.|...::....:::::  |:|..
Mouse   906 TDKYLGPQDLKELGDDSLPAEGYVGFSLGARSASPKISSDRSYTLNRSSYARDSMMIEELLVPSK 970

  Fly   973 KEFVAVEEEMQATIREH-------RDN-----------------------------GQAGGYF-- 999
            ::.:....|..:....|       .||                             ...||..  
Mouse   971 EQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPVHSGCSSPLPQYDSRFLVSFMVDARGGSMRG 1035

  Fly  1000 TRYNIIRV---------------QKVQNRKL--------WERYAHRRQEI--AEENFLQS----- 1034
            :|::.:|:               :.|:..||        .|..|.|..|:  |...||..     
Mouse  1036 SRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGKLHLPT 1100

  Fly  1035 -----NERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSH 1094
                 ||     |...::.|:|.| .:...:||.:.....:|.....|.                
Mouse  1101 HPPPVNE-----GESLVSRILQLG-PQGTKFIGPVIVEIPHFGSMRGKE---------------- 1143

  Fly  1095 KDKSCYVCPRQLLLCRVALGKSFLQY----SAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGE 1155
                     |:|::.|...|:::.::    ....:|....|....:..|...|......::   .
Mouse  1144 ---------RELIVLRSENGETWKEHQFDSKNEDLAELLNGMDEELDSPEELGTKRICRII---T 1196

  Fly  1156 QSYPEYLITYQIVKPDDSSSGTEDTRXWMPSVGSTPTTTSPALH----QPQTQQQPQQQQQQQPQ 1216
            :.:|:|......:|.:.:..|        |..|...:||.|.:.    :....::.:...|.||.
Mouse  1197 KDFPQYFAVVSRIKQESNQIG--------PEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPV 1253

  Fly  1217 PQQQQKAPLPLPPPQQQTSAPVAKRRPKHAKPSLQLQYQPYQPQHHPVVATAAAVTTTQPSPAGV 1281
            |::..|..|    ..:.|.:|:....|:..|            .|.|:..|   :....||..||
Mouse  1254 PEETVKKIL----GNKATFSPIVTVEPRRRK------------FHKPITMT---IPVPPPSGEGV 1299

  Fly  1282 FAHSNNNNNTSSGNV 1296
               ||.....::.|:
Mouse  1300 ---SNGYKGDATPNL 1311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TnksNP_001262963.1 ANK 49..163 CDD:238125 38/114 (33%)
ANK repeat 59..87 CDD:293786 12/27 (44%)
Ank_2 61..153 CDD:289560 32/91 (35%)
ANK repeat 89..120 CDD:293786 13/30 (43%)
ANK repeat 122..153 CDD:293786 8/30 (27%)
ANK 202..316 CDD:238125 37/113 (33%)
ANK repeat 212..240 CDD:293786 12/27 (44%)
Ank_2 214..306 CDD:289560 33/91 (36%)
ANK repeat 242..273 CDD:293786 11/30 (37%)
ANK repeat 275..306 CDD:293786 12/30 (40%)
ANK 361..478 CDD:238125 38/123 (31%)
ANK repeat 363..396 CDD:293786 8/32 (25%)
Ank_2 367..459 CDD:289560 30/93 (32%)
ANK 393..573 CDD:238125 63/194 (32%)
ANK repeat 398..429 CDD:293786 14/30 (47%)
ANK repeat 431..459 CDD:293786 10/29 (34%)
ANK repeat 483..515 CDD:293786 9/37 (24%)
Ank_4 486..540 CDD:290365 16/54 (30%)
ANK 512..637 CDD:238125 44/124 (35%)
ANK repeat 522..550 CDD:293786 12/27 (44%)
Ank_2 524..616 CDD:289560 37/91 (41%)
ANK repeat 552..583 CDD:293786 12/30 (40%)
ANK repeat 585..610 CDD:293786 12/24 (50%)
ANK repeat 638..668 CDD:293786 7/36 (19%)
Ank_4 641..693 CDD:290365 15/58 (26%)
ANK 665..779 CDD:238125 42/117 (36%)
ANK repeat 672..703 CDD:293786 16/30 (53%)
Ank_2 677..769 CDD:289560 37/91 (41%)
ANK repeat 705..736 CDD:293786 10/30 (33%)
ANK repeat 738..769 CDD:293786 12/30 (40%)
SAM_tankyrase1,2 887..952 CDD:188923 15/73 (21%)
SAM 890..952 CDD:197735 14/70 (20%)
tankyrase_like 948..1170 CDD:238718 43/300 (14%)
PARP 961..1165 CDD:279038 40/282 (14%)
Ank3XP_036011414.1 Ank_2 59..>304 CDD:423045 78/263 (30%)
ANK repeat 73..104 CDD:293786 9/32 (28%)
ANK repeat 106..137 CDD:293786 13/30 (43%)
ANK repeat 139..164 CDD:293786 10/24 (42%)
Ank_2 195..>437 CDD:423045 81/315 (26%)
ANK repeat 205..240 CDD:293786 9/34 (26%)
ANK repeat 242..273 CDD:293786 13/32 (41%)
ANK repeat 275..306 CDD:293786 11/30 (37%)
ANK repeat 308..333 CDD:293786 9/24 (38%)
ANK repeat 341..372 CDD:293786 8/33 (24%)
PHA03095 377..>665 CDD:222980 106/319 (33%)
ANK repeat 377..405 CDD:293786 13/27 (48%)
ANK repeat 407..438 CDD:293786 10/30 (33%)
ANK repeat 440..471 CDD:293786 7/30 (23%)
ANK repeat 473..504 CDD:293786 9/30 (30%)
ANK repeat 506..537 CDD:293786 13/34 (38%)
ANK repeat 539..568 CDD:293786 12/28 (43%)
Ank_2 559..>796 CDD:423045 82/264 (31%)
ANK repeat 572..601 CDD:293786 14/28 (50%)
ANK repeat 605..634 CDD:293786 9/33 (27%)
ANK repeat 638..669 CDD:293786 17/53 (32%)
ANK repeat 671..702 CDD:293786 10/30 (33%)
ANK repeat 704..735 CDD:293786 12/30 (40%)
ANK repeat 737..768 CDD:293786 7/30 (23%)
ANK repeat 770..798 CDD:293786 6/27 (22%)
Ank_4 771..823 CDD:372654 10/51 (20%)
ZU5 1018..1155 CDD:128514 27/167 (16%)
UPA_2 1377..1506 CDD:375346
Herpes_BLLF1 <1542..1949 CDD:282904
DUF2890 3296..>3412 CDD:314108
Death_ank3 4113..4196 CDD:176781
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4177
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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