DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnks and Ank1

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_006509052.1	Gene:	Ank1 / 11733	MGIID:	88024	Length:	1950	Species:	Mus musculus

Alignment Length:	1349	Identity:	337/1349 - (24%)
Similarity:	514/1349 - (38%)	Gaps:	320/1349 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ANSSRSRAILSVNLDAVMANDPLRE--------------LFEACKTGEIAKVKKLITPQTVNARD 52
            |.:|..||..|.|||..:  |.||.              |..|.|.|.:..|.:|:..:.: ...
Mouse    63 AATSFLRAARSGNLDKAL--DHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEII-LET 124

  Fly    53 TAGRKSTPLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPN 117
            |..:.:|.||.||..|:.|||..|:|.||::.|..:.|..||:......|.|||:.||:.||:.|
Mouse   125 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 189

  Fly   118 TTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLE 182
            ......:|||..|..:|..:|...|:.:|..                        |:.|...|..
Mouse   190 VATEDGFTPLAVALQQGHENVVAHLINYGTK------------------------GKVRLPALHI 230

  Fly   183 AARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPL 247
            |||:. :.|..|:|...:.|.........||||:||.|..:.:.::||..||.|:...:.|:.||
Mouse   231 AARND-DTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPL 294

  Fly   248 HNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSA 312
            |.|...|:..:.:||:..||.:........||||.||....|.:..:||..||.
Mouse   295 HIASRRGNVIMVRLLLDRGAQIETRTKDELTPLHCAARNGHVRISEILLDHGAP----------- 348

  Fly   313 IDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGK 377
                                                 :.|:..|      |.:|:|:|.   .|.
Mouse   349 -------------------------------------IQAKTKN------GLSPIHMAA---QGD 367

  Fly   378 RKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLH-RCAR 441
            ....:.||.:..:.:::.....|||||:||...|:...:|||.:|||.|:....|.|||| .|.:
Mouse   368 HLDCVRLLLQYNAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 432

  Fly   442 DE-QAVRLLLSYAADTNIVSLEGLTAAQLAS-DSVLKLLKN-------PPDS----ETHLLEAAK 493
            :. :.:.|||...|..:.|:..|||...:|| ...|.::||       |..|    ||.|..||:
Mouse   433 NHIRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAAR 497

  Fly   494 AGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLH 558
            ||..: |.:.:|.|....|.:..|.:  ||||.||......:|:.|||:||....|...|..|||
Mouse   498 AGHTE-VAKYLLQNKAKANAKAKDDQ--TPLHCAARIGHTGMVKLLLENGASPNLATTAGHTPLH 559

  Fly   559 NACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPA 623
            .|...||.:....|::..|:........|||||.||..||..:.:|||:|.|.|....::|.||.
Mouse   560 TAAREGHVDTALALLEKEASQACMTKKGFTPLHVAAKYGKVRLAELLLEHDAHPNAAGKNGLTPL 624

  Fly   624 DL-VKESDHDVAELL--RGPS---------ALLDAAKKGNLARVQR--LVTPESINCRDAQGRNS 674
            .: |..::.|:.:||  ||.|         ..|..|.|.|...|.|  |....|.|....||  .
Mouse   625 HVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQIEVARSLLQYGGSANAESVQG--V 687

  Fly   675 TPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWG 739
            |||||||...:.|....||...|:.|..:|.||.|||..|..||:.:|.:||||...|:||.:.|
Mouse   688 TPLHLAAQEGHTEMVALLLSKQANGNLGNKSGLTPLHLVSQEGHVPVADVLIKHGVTVDATTRMG 752

  Fly   740 FTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELAT----ADDVKCLLQDAMATSLSQQA 800
            :||||.|:..|..:|...||.|.||...|.:.|.:|:..|.    .|.|..||::
Mouse   753 YTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKN---------- 807

  Fly   801 LSASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLL--------PTGASMILSVPVPL 857
             .||...::|:...|.|.|......|.:....:::..|..||:        |.....||.|...
Mouse   808 -GASPNEVSSNGTTPLAIAKRLGYISVTDVLKVVTDETSVVLVSDKHRMSYPETVDEILDVSED- 870

  Fly   858 PLSSSTRISPAQGAEANGAEGSSSD-----------DLLPDAD------------TITNVSGFLS 899
              ..:..|| ..|.|..|::....|           |.:|..|            .:|..:..:.
Mouse   871 --EGTAHIS-IMGDELVGSKAERRDSRDVGEEKELLDFVPKLDQVVESPAIPRIPCVTPETVVIR 932

  Fly   900 SQQLHHLIELFEREQITLDILAEMGHDDLKQV-----------------GVSAYGFRHKILKGI- 946
            |:......:.::.:.:.....|....|::..|                 |.|..|.||..|:.:
Mouse   933 SEDQEQASKEYDEDSLIPSSPATETSDNISPVASPVHTGFLVSFMVDARGGSMRGSRHNGLRVVI 997

  Fly   947 ------------------AQLRSTTGIGNNVNLCTLLVDLLPDDKEF---VAVEEEMQATIREHR 990
                              .:|.:...:.....|.:.::.|.|...:|   |.||      |....
Mouse   998 PPRTCAAPTRITCRLVKPQKLNTPPPLAEEEGLASRIIALGPTGAQFLSPVIVE------IPHFA 1056

  Fly   991 DNGQAGGYFTRYNIIRVQKVQNRKLWERYAHRRQEIAEENFLQSNERMLFHGSPFINAIVQRGFD 1055
            .:|:..      ..:.|.:.:|..:|:.:..|                  :|..:::.|: .|.|
Mouse  1057 SHGRGD------RELVVLRSENGSVWKEHKSR------------------YGESYLDQIL-NGMD 1096

  Fly  1056 ERHAYIGGMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSCYVCPRQLLLCRVALGKSFLQY 1120
            |....:..:                             .|.:.|.:......|..|.:.:....|
Mouse  1097 EELGSLEEL-----------------------------EKKRVCRIITTDFPLYFVIMSRLCQDY 1132

  Fly  1121 SAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLITYQI-----VKPDDSSSGTEDT 1180
                         ..:| |..|.|.  ..:|...:.::||..:|.::     .:|
Mouse  1133 -------------DTIG-PEGGSLR--SKLVPLVQATFPENAVTKKVKLALQAQP---------- 1171

  Fly  1181 RXWMPSVGSTPTTTSPALHQPQTQQQPQQQQQQQPQPQQQQKAPLPLPP 1229
               :|....|....:.|...|....:|::::..:|...:     :||||
Mouse  1172 ---VPDELVTKLLGNQATFSPIVTVEPRRRKFHRPIGLR-----IPLPP 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	35/113 (31%)
		ANK repeat	59..87	CDD:293786	14/27 (52%)
		Ank_2	61..153	CDD:289560	33/91 (36%)
		ANK repeat	89..120	CDD:293786	12/30 (40%)
		ANK repeat	122..153	CDD:293786	8/30 (27%)
		ANK	202..316	CDD:238125	34/113 (30%)
		ANK repeat	212..240	CDD:293786	12/27 (44%)
		Ank_2	214..306	CDD:289560	31/91 (34%)
		ANK repeat	242..273	CDD:293786	10/30 (33%)
		ANK repeat	275..306	CDD:293786	11/30 (37%)
		ANK	361..478	CDD:238125	39/119 (33%)
		ANK repeat	363..396	CDD:293786	7/32 (22%)
		Ank_2	367..459	CDD:289560	30/93 (32%)
		ANK	393..573	CDD:238125	68/193 (35%)
		ANK repeat	398..429	CDD:293786	15/30 (50%)
		ANK repeat	431..459	CDD:293786	10/29 (34%)
		ANK repeat	483..515	CDD:293786	12/35 (34%)
		Ank_4	486..540	CDD:290365	18/53 (34%)
		ANK	512..637	CDD:238125	44/125 (35%)
		ANK repeat	522..550	CDD:293786	12/27 (44%)
		Ank_2	524..616	CDD:289560	35/91 (38%)
		ANK repeat	552..583	CDD:293786	9/30 (30%)
		ANK repeat	585..610	CDD:293786	13/24 (54%)
		ANK repeat	638..668	CDD:293786	12/40 (30%)
		Ank_4	641..693	CDD:290365	20/62 (32%)
		ANK	665..779	CDD:238125	48/113 (42%)
		ANK repeat	672..703	CDD:293786	12/30 (40%)
		Ank_2	677..769	CDD:289560	40/91 (44%)
		ANK repeat	705..736	CDD:293786	15/30 (50%)
		ANK repeat	738..769	CDD:293786	13/30 (43%)
		SAM_tankyrase1,2	887..952	CDD:188923	13/112 (12%)
		SAM	890..952	CDD:197735	12/97 (12%)
		tankyrase_like	948..1170	CDD:238718	32/229 (14%)
		PARP	961..1165	CDD:279038	30/206 (15%)
Ank1	XP_006509052.1	ANK repeat	454..485	CDD:293786	9/30 (30%)
		ANK repeat	487..518	CDD:293786	11/31 (35%)
		ANK repeat	520..549	CDD:293786	13/30 (43%)
		ANK repeat	554..584	CDD:293786	9/29 (31%)
		ANK repeat	586..617	CDD:293786	15/30 (50%)
		Ank_2	597..>810	CDD:393464	79/225 (35%)
		ANK repeat	619..647	CDD:293786	10/27 (37%)
		ANK repeat	652..682	CDD:293786	9/29 (31%)
		ANK repeat	685..716	CDD:293786	14/32 (44%)
		ANK repeat	718..749	CDD:293786	15/30 (50%)
		ANK repeat	751..782	CDD:293786	13/30 (43%)
		ANK repeat	784..812	CDD:293786	9/38 (24%)
		Ank_4	785..837	CDD:372654	14/62 (23%)
		ZU5	970..1074	CDD:128514	18/115 (16%)
		UPA_2	1295..1424	CDD:375346
		Death_ank1	1460..1543	CDD:260067
		ANK repeat	65..93	CDD:293786	10/29 (34%)
		Ank_2	67..158	CDD:372319	29/93 (31%)
		ANK repeat	95..126	CDD:293786	6/31 (19%)
		ANK repeat	129..159	CDD:293786	14/29 (48%)
		PHA02876	<141..>486	CDD:165207	116/426 (27%)
		ANK repeat	161..192	CDD:293786	12/30 (40%)
		ANK repeat	194..218	CDD:293786	7/23 (30%)
		ANK repeat	227..254	CDD:293786	8/27 (30%)
		ANK repeat	257..287	CDD:293786	12/29 (41%)
		ANK repeat	289..320	CDD:293786	10/30 (33%)
		ANK repeat	322..353	CDD:293786	12/78 (15%)
		ANK repeat	355..386	CDD:293786	8/39 (21%)
		ANK repeat	391..419	CDD:293786	14/27 (52%)
		ANK repeat	421..452	CDD:293786	10/30 (33%)
		PHA02875	433..>643	CDD:165206	71/212 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810