DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and Ank2

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_036018747.1	Gene:	Ank2 / 109676	MGIID:	88025	Length:	4152	Species:	Mus musculus

Alignment Length:	1473	Identity:	363/1473 - (24%)
Similarity:	531/1473 - (36%)	Gaps:	429/1473 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ANSSRSRAILSVNLDAVMANDPLRELFEACKTGEIAKVKKLITPQTVNARDTAGRKSTPLHFAAG 66
            :|:|..||..:.|||.|:         |..|.|        |...|.|....     ..||.||.
Mouse    48 SNASFLRAARAGNLDKVV---------EYLKGG--------IDINTCNQNGL-----NALHLAAK 90

  Fly    67 YGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAA 131
            .|...:|:.||..|:|:.:..:.|...||.....|.||||::|:|.||:.|......:|||:.||
Mouse    91 EGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAA 155

  Fly   132 SKGKVDVCLALLQHGANHTIRNSEQKTPLELA-------------DEATR-----PVLTGEYRKD 178
            .:..:||...||::|||.:....:..|||.:|             :..|:     |.|....|||
Mouse   156 QENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 220

  Fly   179 ELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGG 243
            :...||.....|....:.:.:.||.....|  .||||:||.|..:.:..:||..||.|....:.|
Mouse   221 DTKSAALLLQNDHNADVQSKMMVNRTTESG--FTPLHIAAHYGNVNVATLLLNRGAAVDFTARNG 283

  Fly   244 LVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCH 308
            :.|||.|...|:.::.|||:..|..::|......||||.||.....:|..|||.|.| |.|
Mouse   284 ITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERKA-PLL---- 343

  Fly   309 SKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVS 373
                                               :|.|              .|.:|||:|.
Mouse   344 -----------------------------------ARTK--------------NGLSPLHMAA-- 357

  Fly   374 PDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLH- 437
             .|...:.::.|.:..:.:::....:||.||:||...||...::||.:.|..||....|.||||
Mouse   358 -QGDHVECVKHLLQYKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 421

  Fly   438 RCARDE-QAVRLLLSYAADTNIVSLEGLTAAQLAS-----DSVLKLLKN--PPD-----SETHLL 489
            .|.::. :.:.||:.|.|....::..|||...:|:     :.||.||:|  .||     .||.|.
Mouse   422 ACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALH 486

  Fly   490 EAAKAGDLDTVRRIVLNNPISVNCRDLDGR---HSTPLHFAAGFNRVPVVQFLLEHGAEVYAADK 551
            .||:||.::.||.::.|..:      :|.|   ..||||.|:...:..:||.||:|.|...||..
Mouse   487 MAARAGQVEVVRCLLRNGAL------VDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATT 545

  Fly   552 GGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKN 616
            .|..|||.:...|..:|..:|::.||..:::....|||||.||..|..|:.||||:..|......
Mouse   546 NGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAG 610

  Fly   617 RDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNS-TPLHLA 680
            ::|.||..:....|:....||     ||:   ||        .:|.      |..:|. ||||:|
Mouse   611 KNGLTPLHVAAHYDNQKVALL-----LLE---KG--------ASPH------ATAKNGYTPLHIA 653

  Fly   681 AGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHE 745
            |..|..:.|..||..||:.|...|.|:.|||.||..||.|:..||:.....::.:.|.|.|.||.
Mouse   654 AKKNQMQIASTLLNYGAETNTVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHL 718

  Fly   746 AAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELA----TADDVKCLLQDAM---------ATSLS 797
            |||:.:..:..:|..||||.....:.|.||:.:|    ....|..||:...         .|.|.
Mouse   719 AAQEDKVNVADILTKHGADRDAYTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 783

  Fly   798 QQALSAST---QSLTSSSPAPDATAAAAPGTSSSSSSAI------------LSPTTETVLLPTGA 847
            |.|....|   ..|......|:||.|     :.:::.||            |...||.|...|..
Mouse   784 QAAQQGHTHIINVLLQHGAKPNATTA-----NGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTT 843

  Fly   848 ---SMILSVPVPLPLSSSTRISPAQGAEA---------NGAEGSSSDDLLPDADTITNVSGFLSS 900
               ...|:||     .:.|.:......||         :|...|.|.|     ||:|...|
Mouse   844 ITEKHKLNVP-----ETMTEVLDVSDEEALKQFGDHFIDGEAFSDSGD-----DTVTGDGG---- 894

  Fly   901 QQLHHLIELFEREQITLDILAEMGHDDL---------KQVGVSAYGFRHKILKGIAQLRSTTGIG 956
                        |.:..:.|.|:|.|.|         ..:..|..|.|...|:..:..||.|
Mouse   895 ------------EYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHT--- 944

  Fly   957 NNVNLCTLLVDLLPDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAH 1021
              ::..:.|.|....|...|....::.|..:|...|..                  |..|
Mouse   945 --LSHASYLRDSAMIDDTVVIPSHQVSALAKEAERNSY------------------RLSW----- 984

  Fly  1022 RRQEIAEENFLQSNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSN------- 1079
                 ..||.    :.:....||.                            ||.:|:
Mouse   985 -----GTENL----DNVALSSSPI----------------------------HSGRSSPCLDRDN 1012

  Fly  1080 -----QYVYGIGGGI--GCPSHKDKSCYVCPRQL-----LLCR---------------------- 1110
                 .::....||.  || .|......:.||:.     :.||
Mouse  1013 SSFLVSFMVDARGGAMRGC-RHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASR 1076

  Fly  1111 -VALGKSFLQY-SAMKMAHAPP----GHHSV-----VGRPSAGGL--------HFA-------EY 1149
             :.:|.|..|: ..:.:..|||    |...|     :|.|....|        |||       |.
Mouse  1077 LIEVGPSGAQFLGKLHLPTAPPPLNEGESLVSRILQLGPPGTKFLGPVIVEIPHFAALRGKEREL 1141

  Fly  1150 VVYRGE--------------------------------------------QSYPEYLITYQIVKP 1170
            ||.|.|                                            :.:|:|......:|.
Mouse  1142 VVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQ 1206

  Fly  1171 DDSSSGTEDTRXWMPSVGSTPTTTSPALHQPQTQQQPQQQQQQQPQPQQQQKAPLPLPPPQQQTS 1235
            |.:..|.|.     ..:.||..:...|:. |:.....:.:...|.||...:.....|  ..:.|.
Mouse  1207 DSNLIGPEG-----GVLSSTVVSQVQAVF-PEGALTKRIRVGLQAQPMHSELVKKIL--GNKATF 1263

  Fly  1236 APVAKRRPKHAKPSLQLQYQPYQPQHHPVVATAAAVTTTQPSP 1278
            :|:....|:..|            .|.|       :|.|.|.|
Mouse  1264 SPIVTLEPRRRK------------FHKP-------ITMTIPVP 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	39/113 (35%)
		ANK repeat	59..87	CDD:293786	10/27 (37%)
		Ank_2	61..153	CDD:289560	35/91 (38%)
		ANK repeat	89..120	CDD:293786	13/30 (43%)
		ANK repeat	122..153	CDD:293786	12/30 (40%)
		ANK	202..316	CDD:238125	39/113 (35%)
		ANK repeat	212..240	CDD:293786	12/27 (44%)
		Ank_2	214..306	CDD:289560	35/91 (38%)
		ANK repeat	242..273	CDD:293786	11/30 (37%)
		ANK repeat	275..306	CDD:293786	14/30 (47%)
		ANK	361..478	CDD:238125	36/123 (29%)
		ANK repeat	363..396	CDD:293786	7/32 (22%)
		Ank_2	367..459	CDD:289560	28/93 (30%)
		ANK	393..573	CDD:238125	65/196 (33%)
		ANK repeat	398..429	CDD:293786	13/30 (43%)
		ANK repeat	431..459	CDD:293786	10/29 (34%)
		ANK repeat	483..515	CDD:293786	11/36 (31%)
		Ank_4	486..540	CDD:290365	18/56 (32%)
		ANK	512..637	CDD:238125	42/127 (33%)
		ANK repeat	522..550	CDD:293786	12/27 (44%)
		Ank_2	524..616	CDD:289560	34/91 (37%)
		ANK repeat	552..583	CDD:293786	9/30 (30%)
		ANK repeat	585..610	CDD:293786	13/24 (54%)
		ANK repeat	638..668	CDD:293786	5/29 (17%)
		Ank_4	641..693	CDD:290365	15/52 (29%)
		ANK	665..779	CDD:238125	43/114 (38%)
		ANK repeat	672..703	CDD:293786	14/31 (45%)
		Ank_2	677..769	CDD:289560	36/91 (40%)
		ANK repeat	705..736	CDD:293786	11/30 (37%)
		ANK repeat	738..769	CDD:293786	12/30 (40%)
		SAM_tankyrase1,2	887..952	CDD:188923	15/73 (21%)
		SAM	890..952	CDD:197735	14/70 (20%)
		tankyrase_like	948..1170	CDD:238718	49/332 (15%)
		PARP	961..1165	CDD:279038	46/314 (15%)
Ank2	XP_036018747.1	PHA03095	46..>354	CDD:222980	106/383 (28%)
		ANK repeat	80..111	CDD:293786	10/35 (29%)
		ANK repeat	113..144	CDD:293786	13/30 (43%)
		ANK repeat	146..171	CDD:293786	9/24 (38%)
		Ank_2	202..>444	CDD:423045	81/300 (27%)
		ANK repeat	212..247	CDD:293786	9/34 (26%)
		ANK repeat	249..280	CDD:293786	13/32 (41%)
		ANK repeat	282..313	CDD:293786	11/30 (37%)
		ANK repeat	315..345	CDD:293786	14/69 (20%)
		ANK repeat	348..379	CDD:293786	7/33 (21%)
		ANK repeat	381..411	CDD:293786	12/29 (41%)
		ANK repeat	414..445	CDD:293786	10/30 (33%)
		PHA03095	421..>706	CDD:222980	102/312 (33%)
		ANK repeat	447..478	CDD:293786	11/30 (37%)
		ANK repeat	480..511	CDD:293786	11/36 (31%)
		ANK repeat	513..542	CDD:293786	11/28 (39%)
		ANK repeat	546..571	CDD:293786	7/24 (29%)
		Ank_2	578..>802	CDD:423045	78/245 (32%)
		ANK repeat	579..604	CDD:293786	13/24 (54%)
		ANK repeat	612..643	CDD:293786	12/52 (23%)
		ANK repeat	645..676	CDD:293786	14/30 (47%)
		ANK repeat	678..707	CDD:293786	11/28 (39%)
		ANK repeat	711..742	CDD:293786	12/30 (40%)
		ANK repeat	744..775	CDD:293786	7/30 (23%)
		ANK repeat	777..806	CDD:293786	7/28 (25%)
		Ank_4	778..830	CDD:372654	12/56 (21%)
		ZU5	1013..1150	CDD:128514	28/137 (20%)
		UPA_2	1371..1500	CDD:375346
		PHA03307	1823..>2031	CDD:223039
		PTZ00449	<2261..2668	CDD:185628
		COG5665	<2758..>2989	CDD:227952
		PHA03307	3210..>3537	CDD:223039
		Death_ank2	3595..3678	CDD:260066
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810