DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnks and ankrd42

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_002942124.2	Gene:	ankrd42 / 100498077	XenbaseID:	XB-GENE-5888011	Length:	514	Species:	Xenopus tropicalis

Alignment Length:	429	Identity:	113/429 - (26%)
Similarity:	174/429 - (40%)	Gaps:	96/429 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 LHLAAELLHYDAMEVLLKQGAKVNALDSLGQ-TPLHRCARDE--QAVRLLLSYAADTNIVSLEGL 464
            :|.|......:.:..:::.|..:|..|.|.: ||||..|...  :.:..||.:.||.:.|:..|.
Frog    22 IHEAVRGGDVEQLAAIVQSGTGINDPDPLHKFTPLHWAAHSGSLECLHWLLWHGADVSDVTTRGW 86

  Fly   465 TAAQLAS----DSVLKLLKNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDL---DGRHST 522
            |||.||:    |:.::.|                               .||..||   |.||..
Frog    87 TAAHLAAIRGQDACMQAL-------------------------------IVNGADLSAKDDRHCC 120

  Fly   523 PLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVKHGANVNVSDLWKF 587
            |.|.||.......:|.:|..|.::.::|:.|..|:|.|..:|.....:||.:.||.:..:||...
Frog   121 PAHLAAAHGHSFTLQSVLRSGVDINSSDRTGWKPVHYAAFHGRLGCLQLLFRWGATLEDADLNGN 185

  Fly   588 TPLHEAAAKGKYDICKLLLKHGADPMK----KNRDGATPADLVK----------------ESDH- 631
            .|.|.||.:|.....|.|:...:...:    .|.:|.||.||.:                |.||
Frog   186 IPAHLAAMEGHLHCLKFLVSKASSVTRVLEATNMNGETPKDLARKLYKDNIVQYIDGVEYERDHP 250

  Fly   632 DVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENG 696
            |..|.|..|:.:  ||.||:|..:::||....||..:...:.:||||.|||....||.::|||.|
Frog   251 DEQENLAFPAHV--AAFKGDLVTLRKLVESGIININERDDKGATPLHKAAGQGQLECLQWLLEMG 313

  Fly   697 ADVNAQDKGGLIPLHNASSYGHLDIAALL--------------------IKHKTVVNATDKWGFT 741
            ||.|..::.|..|...|..:..|....||                    .:...|..:||...:.
Frog   314 ADYNITNEAGETPKDVAKRFAKLAAVKLLGGNVAGEDSDEELNDEDPAYFERHGVEGSTDHPDYL 378

  Fly   742 PLHEA-AQKGRTQLCSLLLAHGADAYMKNQEGQTPIELA 779
            .|.|: .|:.|           |.||.:.::.:..:|:|
Frog   379 SLSESEKQQAR-----------ARAYKRIKDVEKLMEVA 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125
		ANK repeat	59..87	CDD:293786
		Ank_2	61..153	CDD:289560
		ANK repeat	89..120	CDD:293786
		ANK repeat	122..153	CDD:293786
		ANK	202..316	CDD:238125
		ANK repeat	212..240	CDD:293786
		Ank_2	214..306	CDD:289560
		ANK repeat	242..273	CDD:293786
		ANK repeat	275..306	CDD:293786
		ANK	361..478	CDD:238125	23/81 (28%)
		ANK repeat	363..396	CDD:293786
		Ank_2	367..459	CDD:289560	15/58 (26%)
		ANK	393..573	CDD:238125	45/179 (25%)
		ANK repeat	398..429	CDD:293786	4/25 (16%)
		ANK repeat	431..459	CDD:293786	10/30 (33%)
		ANK repeat	483..515	CDD:293786	2/31 (6%)
		Ank_4	486..540	CDD:290365	12/56 (21%)
		ANK	512..637	CDD:238125	43/148 (29%)
		ANK repeat	522..550	CDD:293786	7/27 (26%)
		Ank_2	524..616	CDD:289560	25/95 (26%)
		ANK repeat	552..583	CDD:293786	9/30 (30%)
		ANK repeat	585..610	CDD:293786	7/24 (29%)
		ANK repeat	638..668	CDD:293786	10/29 (34%)
		Ank_4	641..693	CDD:290365	18/51 (35%)
		ANK	665..779	CDD:238125	34/134 (25%)
		ANK repeat	672..703	CDD:293786	16/30 (53%)
		Ank_2	677..769	CDD:289560	30/112 (27%)
		ANK repeat	705..736	CDD:293786	7/50 (14%)
		ANK repeat	738..769	CDD:293786	7/31 (23%)
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
ankrd42	XP_002942124.2	ANK repeat	22..48	CDD:293786	4/25 (16%)
		PHA02874	29..>359	CDD:165205	99/362 (27%)
		ANK repeat	50..82	CDD:293786	10/31 (32%)
		ANK repeat	84..115	CDD:293786	12/61 (20%)
		ANK repeat	150..181	CDD:293786	9/30 (30%)
		ANK repeat	183..213	CDD:293786	7/29 (24%)
		ANK repeat	289..320	CDD:293786	16/30 (53%)
		Smc	376..>472	CDD:224117	9/42 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920