DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and tnks

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_004911090.1	Gene:	tnks / 100497226	XenbaseID:	XB-GENE-5828012	Length:	1306	Species:	Xenopus tropicalis

Alignment Length:	1194	Identity:	770/1194 - (64%)
Similarity:	936/1194 - (78%)	Gaps:	56/1194 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ANSSRSRAILSVNLDAVMANDPL-------RELFEACKTGEIAKVKKLITPQTVNARDTAGRKST 59
            |.|..|..|..|....:....||       |||||||:.|::::|::|:.|..|||:|.||||||
Frog   132 AESPESGVIGGVGSGGIGPGGPLSAVSGAFRELFEACRNGDVSRVRRLLEPGNVNAKDMAGRKST 196

  Fly    60 PLHFAAGYGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNY 124
            |||||||:||::|||.||.:||::.|.|:|||.||||.|||||||||.|||..||.||..|||||
Frog   197 PLHFAAGFGRKDVVEHLLQTGANVHARDDGGLIPLHNACSFGHAEVVTLLLCQGADPNARDNWNY 261

  Fly   125 TPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSGAE 189
            ||||||:.|||:|||:.||||||:.:|||::.|:.|:|||.:.:.||||||:|||||||||||.|
Frog   262 TPLHEASIKGKIDVCIVLLQHGADPSIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNE 326

  Fly   190 DRLLALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYG 254
            ::|:||||||||||||||||:||||||||||||:.||::||.:||||||||||||||||||||||
Frog   327 EKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYG 391

  Fly   255 HFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTR 319
            ||:||:||::.||.|||.|||.||||||||||:||||||||||.||||||:|||.|||:|.|||.
Frog   392 HFEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTP 456

  Fly   320 ELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMEL 384
            ||:||:::|:|||.||.|.|:.|:::.||.:..||:||..|.:.:|.||.||.|...||||:.||
Frog   457 ELKERLSYEFKGHSLLQAAREADMAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQITEL 521

  Fly   385 LTRKGSLLNEKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLHRCARDE--QAVR 447
            |.|||:.:|||||.|:||||:|||..|.|.:|||.|.|||:||||:||||.|||.|...  |..|
Frog   522 LLRKGASVNEKNKDFMTPLHVAAERAHNDVVEVLHKHGAKMNALDTLGQTALHRAALGGHLQTCR 586

  Fly   448 LLLSYAADTNIVSLEGLTAAQLASDSVLKLL--KNPP----DSETHLLEAAKAGDLDTVRRIVLN 506
            ||||:.:|.:||||:|.||||:.:::|.::|  ::.|    |.:..||||:||||||||:::..:
Frog   587 LLLSFGSDASIVSLQGFTAAQMGNEAVQQILNVESTPVRTSDVDYRLLEASKAGDLDTVKQLCSS 651

  Fly   507 NPISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAEVYAADKGGLVPLHNACSYGHYEVTEL 571
            .  :||||||:||||||||||||:|||.||::||.|||:|:|.|||||||||||||||||||.||
Frog   652 Q--NVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAEL 714

  Fly   572 LVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKESDHDVAEL 636
            ||:|||:|||:|||||||||||||||||:||||||||||||.||||||.||.||||:.|.|:.:|
Frog   715 LVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKDGDTDIQDL 779

  Fly   637 LRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNA 701
            |||.:|||||||||.|||||:|.|.|:|||||.||||||||||||||||.|.||||||:||||||
Frog   780 LRGDAALLDAAKKGCLARVQKLCTQENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNA 844

  Fly   702 QDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAY 766
            ||||||||||||:||||:||||||||:.|.|||||||.||||||||||||||||:||||||||..
Frog   845 QDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 909

  Fly   767 MKNQEGQTPIELATADDVKCLLQDAMATSLSQQALSASTQSLTSSSPAPDATAAAAPGTSSSSSS 831
            |||||.|||::||||||::.||.|||    ..:||....:        |.||..:|...|.:|:.
Frog   910 MKNQESQTPLDLATADDIRALLIDAM----PPEALPTCFK--------PQATVVSASIISPASTP 962

  Fly   832 AILSPTTETVLLPTGASMILSVPVPLPLSSSTRISPAQGAEANGAEGSSSDDLLPDADT--ITNV 894
            :.||          .||.|.::..||       ...|.|..:|..:|::..:......|  ..|:
Frog   963 SCLS----------AASSIDNLTGPL-------AELAVGGVSNAGDGAAGTERKEGEVTGLDMNI 1010

  Fly   895 SGFLSSQQLHHLIELFEREQITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRSTTGIGNN- 958
            :.||.|..|.||.::||.||||||:||:|||::||::|::|||.|||::||:.:|..... |.|
Frog  1011 NQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQ-GTNP 1074

  Fly   959 ------VNLCTLLVDLLPDDKEFVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWE 1017
                  |:..|:|:||..||||:.:||||||.:||||||.|.|||.|.|||:||:|||.|:||.|
Frog  1075 YLTFHCVSQGTVLLDLASDDKEYQSVEEEMQNSIREHRDGGNAGGVFNRYNVIRIQKVVNKKLRE 1139

  Fly  1018 RYAHRRQEIAEENFLQSNERMLFHGSPFINAIVQRGFDERHAYIGGMFGAGIYFAEHSSKSNQYV 1082
            |:.||::|::|||....|||||||||||||||:.:|||||||||||||||||||||:||||||||
Frog  1140 RFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYV 1204

  Fly  1083 YGIGGGIGCPSHKDKSCYVCPRQLLLCRVALGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFA 1147
            ||||||.|||:|||:|||:|.||:|.|||.|||||||:|.|||||||||||||:||||..||.:|
Frog  1205 YGIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSFLQFSTMKMAHAPPGHHSVIGRPSVNGLAYA 1269

  Fly  1148 EYVVYRGEQSYPEYLITYQIVKPD 1171
            |||:|||||:||||||||||:||:
Frog  1270 EYVIYRGEQAYPEYLITYQIMKPE 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	78/113 (69%)
		ANK repeat	59..87	CDD:293786	18/27 (67%)
		Ank_2	61..153	CDD:289560	64/91 (70%)
		ANK repeat	89..120	CDD:293786	23/30 (77%)
		ANK repeat	122..153	CDD:293786	22/30 (73%)
		ANK	202..316	CDD:238125	93/113 (82%)
		ANK repeat	212..240	CDD:293786	21/27 (78%)
		Ank_2	214..306	CDD:289560	75/91 (82%)
		ANK repeat	242..273	CDD:293786	24/30 (80%)
		ANK repeat	275..306	CDD:293786	27/30 (90%)
		ANK	361..478	CDD:238125	67/118 (57%)
		ANK repeat	363..396	CDD:293786	18/32 (56%)
		Ank_2	367..459	CDD:289560	56/93 (60%)
		ANK	393..573	CDD:238125	117/187 (63%)
		ANK repeat	398..429	CDD:293786	19/30 (63%)
		ANK repeat	431..459	CDD:293786	15/29 (52%)
		ANK repeat	483..515	CDD:293786	16/31 (52%)
		Ank_4	486..540	CDD:290365	35/53 (66%)
		ANK	512..637	CDD:238125	101/124 (81%)
		ANK repeat	522..550	CDD:293786	20/27 (74%)
		Ank_2	524..616	CDD:289560	77/91 (85%)
		ANK repeat	552..583	CDD:293786	27/30 (90%)
		ANK repeat	585..610	CDD:293786	23/24 (96%)
		ANK repeat	638..668	CDD:293786	22/29 (76%)
		Ank_4	641..693	CDD:290365	42/51 (82%)
		ANK	665..779	CDD:238125	97/113 (86%)
		ANK repeat	672..703	CDD:293786	27/30 (90%)
		Ank_2	677..769	CDD:289560	79/91 (87%)
		ANK repeat	705..736	CDD:293786	25/30 (83%)
		ANK repeat	738..769	CDD:293786	26/30 (87%)
		SAM_tankyrase1,2	887..952	CDD:188923	33/66 (50%)
		SAM	890..952	CDD:197735	33/63 (52%)
		tankyrase_like	948..1170	CDD:238718	160/228 (70%)
		PARP	961..1165	CDD:279038	152/203 (75%)
tnks	XP_004911090.1	Ank_4	164..214	CDD:290365	31/49 (63%)
		ANK	186..300	CDD:238125	78/113 (69%)
		ANK repeat	196..224	CDD:293786	18/27 (67%)
		Ank_2	198..290	CDD:289560	64/91 (70%)
		ANK repeat	226..257	CDD:293786	23/30 (77%)
		ANK repeat	259..290	CDD:293786	22/30 (73%)
		Ank_4	317..367	CDD:290365	40/49 (82%)
		ANK	339..453	CDD:238125	93/113 (82%)
		ANK repeat	349..377	CDD:293786	21/27 (78%)
		Ank_2	351..443	CDD:289560	75/91 (82%)
		ANK repeat	379..410	CDD:293786	24/30 (80%)
		ANK repeat	412..443	CDD:293786	27/30 (90%)
		ANK repeat	501..533	CDD:293786	18/31 (58%)
		Ank_2	504..598	CDD:289560	56/93 (60%)
		ANK	530..716	CDD:238125	117/187 (63%)
		ANK repeat	535..566	CDD:293786	19/30 (63%)
		ANK repeat	568..598	CDD:293786	15/29 (52%)
		ANK	655..780	CDD:238125	101/124 (81%)
		ANK repeat	665..693	CDD:293786	20/27 (74%)
		Ank_2	667..759	CDD:289560	77/91 (85%)
		ANK repeat	695..726	CDD:293786	27/30 (90%)
		ANK repeat	728..759	CDD:293786	28/30 (93%)
		ANK repeat	781..811	CDD:293786	22/29 (76%)
		Ank_4	782..836	CDD:290365	43/53 (81%)
		ANK	808..932	CDD:238125	104/123 (85%)
		ANK repeat	815..846	CDD:293786	27/30 (90%)
		Ank_2	820..912	CDD:289560	79/91 (87%)
		ANK repeat	848..879	CDD:293786	25/30 (83%)
		ANK repeat	881..912	CDD:293786	26/30 (87%)
		SAM_tankyrase1,2	1003..1068	CDD:188923	33/64 (52%)
		SAM	1009..1066	CDD:197735	31/56 (55%)
		tankyrase_like	1070..1292	CDD:238718	159/222 (72%)
		PARP	1090..1287	CDD:279038	149/196 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	282	1.000	Domainoid score	I1631
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H18405
Inparanoid	1	1.050	1522	1.000	Inparanoid score	I98
OMA	1	1.010	-	-		QHG47155
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004240
OrthoInspector	1	1.000	-	-		otm49487
Panther	1	1.100	-	-	LDO	PTHR24180
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1759
SonicParanoid	1	1.000	-	-		X2498
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.100