DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnks and zfp1

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_017945878.1	Gene:	zfp1 / 100493692	XenbaseID:	XB-GENE-6465737	Length:	507	Species:	Xenopus tropicalis

Alignment Length:	672	Identity:	126/672 - (18%)
Similarity:	186/672 - (27%)	Gaps:	257/672 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   590 LHEAAAKGKYDICKLLLKHGADPMKKNRDGATPAD-----LVKESDHDVAELLRGPSALLDAAKK 649
            ||:.......:|..||...|....||:.|||.|..     |.....|.|...:....|...|.:|
Frog    20 LHQRILSLTLEIIYLLTGEGYTVTKKSGDGAPPQTCTDCMLGGACRHHVTPTVGALHAPGSALQK 84

  Fly   650 GNLARVQRLVTPESINCRDAQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNAS 714
            .|..|:..|:              |..:.|..|.....|                      .:.|
Frog    85 ENAKRILELI--------------SNIIQLLTGEVAIRC----------------------EDVS 113

  Fly   715 SYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELA 779
            .|..|                ::|.:                  |......|::..||.......
Frog   114 LYFSL----------------EEWQY------------------LKGNKSRYLEGMEGSVQQTDC 144

  Fly   780 TADDVKCLLQDAMATSLSQQALSASTQSLTSSSPAPDATAA----------------AAPGTSSS 828
            ..:||....:...........:.|...||..|...|:...|                ||.|....
Frog   145 PKEDVGSDAEPLWYRDREFPEIVAEEPSLWESPTLPNTPTAPQRPPNRISRGFNEELAAWGRGKG 209

  Fly   829 SSSAILSPTTETVLLPTGASMILSVPVPLP---LSSSTRISPAQGAEANGAEGSSSD-------- 882
            |     .|.|..:    |..     |...|   ||:|..:...:..|.:..||..||
Frog   210 S-----DPLTRQM----GPD-----PCTNPNDSLSASILLRDIKEEEDSWEEGKESDFSIVTVTE 260

  Fly   883 --DLLPDADTITNVSGFLSSQQLHHLIELFEREQITLDILAE---------MGHDDLKQVGVSAY 936
              :.:||.::..| :.|.|       :.:.|.|..:..:...         :||.||
Frog   261 PMEEMPDPESSAN-NTFSS-------VTISELETTSFQVAPNRGGSHKSHFIGHKDL-------- 309

  Fly   937 GFRHKILKGIAQLRSTTGIGNNVNLCTLLVDLLPDDKEFVAVEEEMQATIREHRDN--------- 992
             .||:          .|..|.|:..|::.      .|.|.     .:|.:.||..|
Frog   310 -VRHQ----------RTQTGQNLFACSVC------GKCFT-----RRAKLIEHFRNHTGEKPFAC 352

  Fly   993 GQAGGYFTRYNIIRVQKVQNRKLWERYAHR----------RQEIAEENFLQSNERMLFHGSPFI- 1046
            .:.|..||.    |.:.|.:::     ||:          ::..|.:|.|..:.|:.....||.
Frog   353 DECGKRFTH----RAKLVDHQR-----AHKGEKPFTCSECKKSFARQNELNRHFRIHTGEKPFSC 408

  Fly  1047 ----NAIVQRGFDERHAYIG------GMFGAGIYFAEHSSKSNQYVYGIGGGIGCPSHKDKSCYV 1101
                ....||...|.|..|.      .....|..||.|:..:..::...|       .|..||.|
Frog   409 SECGKCFKQRSHLEVHYRIHTGEKPISCSECGQCFARHTELNRHFITHTG-------EKPFSCSV 466

  Fly  1102 CPRQLLLCRVALGKSFLQYSAMKMAHAPPGHHSVVGRPSAGGLHFAEYVVYRGEQSYPEYLITYQ 1166
            |           ||.|             |..|.:.|      ||.   ::.||:.....:.|.
Frog   467 C-----------GKCF-------------GLRSGLTR------HFR---IHTGEKRKSRAVRTC- 497

  Fly  1167 IVKPDDSSSGTEDTRXWMPSVG 1188
               ||.:|.         |.||
Frog   498 ---PDQNSG---------PGVG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125
		ANK repeat	59..87	CDD:293786
		Ank_2	61..153	CDD:289560
		ANK repeat	89..120	CDD:293786
		ANK repeat	122..153	CDD:293786
		ANK	202..316	CDD:238125
		ANK repeat	212..240	CDD:293786
		Ank_2	214..306	CDD:289560
		ANK repeat	242..273	CDD:293786
		ANK repeat	275..306	CDD:293786
		ANK	361..478	CDD:238125
		ANK repeat	363..396	CDD:293786
		Ank_2	367..459	CDD:289560
		ANK	393..573	CDD:238125
		ANK repeat	398..429	CDD:293786
		ANK repeat	431..459	CDD:293786
		ANK repeat	483..515	CDD:293786
		Ank_4	486..540	CDD:290365
		ANK	512..637	CDD:238125	15/51 (29%)
		ANK repeat	522..550	CDD:293786
		Ank_2	524..616	CDD:289560	7/25 (28%)
		ANK repeat	552..583	CDD:293786
		ANK repeat	585..610	CDD:293786	5/19 (26%)
		ANK repeat	638..668	CDD:293786	6/29 (21%)
		Ank_4	641..693	CDD:290365	10/51 (20%)
		ANK	665..779	CDD:238125	12/113 (11%)
		ANK repeat	672..703	CDD:293786	4/30 (13%)
		Ank_2	677..769	CDD:289560	9/91 (10%)
		ANK repeat	705..736	CDD:293786	3/30 (10%)
		ANK repeat	738..769	CDD:293786	3/30 (10%)
		SAM_tankyrase1,2	887..952	CDD:188923	12/73 (16%)
		SAM	890..952	CDD:197735	11/70 (16%)
		tankyrase_like	948..1170	CDD:238718	49/251 (20%)
		PARP	961..1165	CDD:279038	45/233 (19%)
zfp1	XP_017945878.1	KRAB_A-box	107..141	CDD:383038	9/89 (10%)
		COG5048	<262..469	CDD:227381	51/271 (19%)
		C2H2 Zn finger	324..344	CDD:275368	6/30 (20%)
		C2H2 Zn finger	352..372	CDD:275368	5/28 (18%)
		C2H2 Zn finger	380..400	CDD:275368	4/19 (21%)
		C2H2 Zn finger	408..428	CDD:275368	4/19 (21%)
		C2H2 Zn finger	436..456	CDD:275368	4/19 (21%)
		C2H2 Zn finger	464..484	CDD:275368	11/52 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010