DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and XB5813854

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_031760270.1	Gene:	XB5813854 / 100492885	XenbaseID:	XB-GENE-5813855	Length:	1640	Species:	Xenopus tropicalis

Alignment Length:	874	Identity:	244/874 - (27%)
Similarity:	368/874 - (42%)	Gaps:	182/874 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 KLITPQTVNARDTAGRKSTPLHFAAGYGRREVVEFLLNS-GASIQACDEGGLHPLHNCCSFGHAE 104
            ||:.....||..|.....||||.||..|...:||.|... .:::.|..:.|...:|....:||.|
Frog   242 KLLHQCRANANLTDKMDRTPLHVAAERGNTNIVEILTEKFRSNVLARTKEGNTLMHIASQYGHPE 306

  Fly   105 VVRLLLKAGASPNTTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADEATRP 169
            .....||.|...:..:......||.||::|.|.|..||||.||:...|..:..|.|.:|.|:.:|
Frog   307 TALAFLKRGVLLHMPNKAGAVCLHAAATRGHVAVVRALLQKGAHVDARTKDNYTALHIAAESCKP 371

  Fly   170 VLTGEYRKDELLEAARSGAEDRL---LALLTPLNVNCHASDGRRSTPLHLAAGYNRIGIVEILLA 231
            ::.     ..||   ..||:.:|   .|..|||:|.....||.:              :.|:|:.
Frog   372 LVV-----QTLL---GFGAQVQLKGGKAQETPLHVAARIKDGEK--------------VAEMLIK 414

  Fly   232 NGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLL 296
            :|||::.:.:.|...:|.|..:|:..:...||:.|............|||.|.....:.:..::|
Frog   415 SGADINVEQENGETAMHVAAQHGNLQMISALIEEGGEPTWQSKNQENPLHTAVRHCHLPIVEVIL 479

  Fly   297 S-----RG-ADPTLLNC------------HSKSAIDAAPTRELRE-----RIAFEYKGHCLLDAC 338
            :     || ||  .:.|            |..:|:....|....|     ||..|:.|
Frog   480 TYLANERGRAD--AVGCVNQANKAGETPLHLAAAVKKEMTHTQGEDVKIIRILMEHDG------- 535

  Fly   339 RKCDVSRAKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELL-----TRKGSLLNEKNKA 398
               |:||....            |.:||||..  :..|....|:|::     :|....:|::.|.
Frog   536 ---DISRPTNT------------TSETPLHYC--ARVGNEDVLLEMIRHISSSRIQQTMNKQAKN 583

  Fly   399 FLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQTPLHRCARD--EQAVRLLLSYAADTNIVSL 461
            ..:||.:|||..|...:::||:..|:|:..|..|:..||..|.:  :|...:||.:.|..|..:.
Frog   584 GRSPLLVAAEQGHTGIVQILLQNQARVDVFDEHGKAALHLAAENGHDQIADILLKHKAFVNAKTK 648

  Fly   462 EGLT----AAQLASDSVLKLLKNPPDSETHLL--------------EAAKAGDLDTVRRIVLNNP 508
            .|||    .||...:.::|||     .||||.              .||..|.|| |...:||..
Frog   649 LGLTPLHLCAQNGFNHLVKLL-----VETHLACIDAMSLTKRTPLHMAALNGQLD-VCNSLLNMK 707

  Fly   509 ISVNCRDLDGRHSTPLHFAAGFNRVPVVQFLLEHGAE-VYAADKGGLVPLHNACSYGHYEVTELL 572
            ..||..|::|:  ||||.||..:...||:..|:|..| |.:|:..|....|.|.|.|...|.:.|
Frog   708 ADVNATDIEGQ--TPLHLAAENDHSEVVKLFLKHKPELVTSANMEGSTCAHIAASKGSAAVIKEL 770

  Fly   573 VKH---GANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKKNRDGATPADLVKESDH-DV 633
            :|.   ||....:.....||||.|||.|..|..|:||:.||....:|.:|.|...|..::.| .|
Frog   771 LKFNKTGATTARNKTNDSTPLHLAAAGGHTDAVKVLLETGASASDENGEGMTAIHLAAKNGHIHV 835

  Fly   634 AELLRGP------------SALLDAAKKGNLARVQRLVT--------------PESINCRDAQGR 672
            .|.|:|.            :||..||..|.|..|:.::|              |:.::.:: |.|
Frog   836 LEALKGSVSFRITSTKTGLTALHVAAHFGQLDFVREILTKVPATMTSEPPKSVPDLLHMKE-QSR 899

  Fly   673 NS--TPLHLAAGYNNFECAEYLL-----------------------ENG-------------ADV 699
            .|  ||||||:...:......||                       :||             :.:
Frog   900 ESGYTPLHLASQSGHESLVRLLLNYPGVQADTATTRQGSTPIHLAAQNGHTAVVGLLLSKSTSQL 964

  Fly   700 NAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVNATDKWGFTPLHEAAQKGRTQLCSLLLAHGAD 764
            :.:||.|...||.|::.||:::...||.....:|.|||.|:.|||.||:.|.......|:..||:
Frog   965 HMKDKRGRTCLHLAAANGHIEMMRALIGQGAEINVTDKNGWCPLHFAARSGFLDTIRFLVECGAN 1029

  Fly   765 AYMKNQEGQTPIELATA----DDVKCLLQ 789
            ..::.::|:|.|:.|.|    |.|..||:
Frog  1030 PILECKDGKTAIQYAAANNHQDVVSFLLK 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	38/114 (33%)
		ANK repeat	59..87	CDD:293786	11/28 (39%)
		Ank_2	61..153	CDD:289560	30/92 (33%)
		ANK repeat	89..120	CDD:293786	8/30 (27%)
		ANK repeat	122..153	CDD:293786	13/30 (43%)
		ANK	202..316	CDD:238125	26/131 (20%)
		ANK repeat	212..240	CDD:293786	5/27 (19%)
		Ank_2	214..306	CDD:289560	21/97 (22%)
		ANK repeat	242..273	CDD:293786	7/30 (23%)
		ANK repeat	275..306	CDD:293786	9/36 (25%)
		ANK	361..478	CDD:238125	37/127 (29%)
		ANK repeat	363..396	CDD:293786	9/37 (24%)
		Ank_2	367..459	CDD:289560	28/98 (29%)
		ANK	393..573	CDD:238125	65/200 (33%)
		ANK repeat	398..429	CDD:293786	10/30 (33%)
		ANK repeat	431..459	CDD:293786	9/29 (31%)
		ANK repeat	483..515	CDD:293786	14/45 (31%)
		Ank_4	486..540	CDD:290365	23/67 (34%)
		ANK	512..637	CDD:238125	47/129 (36%)
		ANK repeat	522..550	CDD:293786	12/28 (43%)
		Ank_2	524..616	CDD:289560	35/95 (37%)
		ANK repeat	552..583	CDD:293786	10/33 (30%)
		ANK repeat	585..610	CDD:293786	12/24 (50%)
		ANK repeat	638..668	CDD:293786	10/55 (18%)
		Ank_4	641..693	CDD:290365	18/67 (27%)
		ANK	665..779	CDD:238125	40/151 (26%)
		ANK repeat	672..703	CDD:293786	12/68 (18%)
		Ank_2	677..769	CDD:289560	32/127 (25%)
		ANK repeat	705..736	CDD:293786	9/30 (30%)
		ANK repeat	738..769	CDD:293786	10/30 (33%)
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
XB5813854	XP_031760270.1	Ank_2	<5..81	CDD:423045
		ANK repeat	51..82	CDD:293786
		Ank_2	54..>277	CDD:423045	14/34 (41%)
		ANK repeat	84..115	CDD:293786
		ANK repeat	155..186	CDD:293786
		ANK repeat	191..222	CDD:293786
		ANK repeat	224..255	CDD:293786	4/12 (33%)
		Ank_2	241..>485	CDD:423045	72/264 (27%)
		ANK repeat	291..322	CDD:293786	8/30 (27%)
		ANK repeat	324..355	CDD:293786	13/30 (43%)
		ANK repeat	357..387	CDD:293786	9/37 (24%)
		ANK repeat	425..455	CDD:293786	7/29 (24%)
		Ank_2	438..>741	CDD:423045	89/336 (26%)
		ANK repeat	458..499	CDD:293786	10/42 (24%)
		ANK repeat	501..539	CDD:293786	9/47 (19%)
		ANK repeat	545..581	CDD:293786	9/37 (24%)
		ANK repeat	583..614	CDD:293786	10/30 (33%)
		ANK repeat	616..647	CDD:293786	9/30 (30%)
		ANK repeat	683..714	CDD:293786	10/31 (32%)
		ANK repeat	716..748	CDD:293786	13/33 (39%)
		Ank_4	719..771	CDD:372654	19/51 (37%)
		ANK repeat	786..817	CDD:293786	14/30 (47%)
		Ank_2	791..875	CDD:403870	28/83 (34%)
		ANK repeat	901..934	CDD:293786	9/32 (28%)
		trp	906..1553	CDD:273311	41/153 (27%)
		ANK repeat	937..968	CDD:293786	2/30 (7%)
		ANK repeat	970..1001	CDD:293786	9/30 (30%)
		ANK repeat	1003..1028	CDD:293786	8/24 (33%)
		ANK repeat	1036..1061	CDD:293786	9/23 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010