DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tnks and LOC100490559

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_031750905.1	Gene:	LOC100490559 / 100490559	-ID:	-	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	679	Identity:	129/679 - (18%)
Similarity:	220/679 - (32%)	Gaps:	188/679 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   565 HYEVTELLVKH----------------GANVNVSDLWKFTP----------LHEAAAKGKYDICK 603
            |....|:.::|                |.:|..:::.|..|          ..||::...|...|
Frog   134 HMLTEEVAIRHEEAGSYFSSEEWDYLKGNHVFYTEVIKENPQQQLRSQDDGKEEASSIRSYMEAK 198

  Fly   604 LLLKHGADPMKKNRDGATPADLVKESDHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRD 668
            ::..:.|    ..|....|.:.....|:..|.:...|:|..:..:  :.:.:..| |..::....
Frog   199 VISNNKA----PKRCSPCPREEGNPMDNSAAPISNYPTASWEGER--SESSIDPL-TGRTLGTMH 256

  Fly   669 AQGRNSTPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNASSYGHLDIAALLIKHKTVVN 733
            ..|.:.:.|:..:..|...|..:  |.|....:.......|:...||    .:....::::.|..
Frog   257 IWGHSQSSLNDTSMGNKETCPSW--EGGGRAKSPIGPHTDPIQGTSS----PVLGSKLRNRFVKE 315

  Fly   734 ATDKW------GFTPLHEAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLLQDAM 792
            .:..|      .::.|.|...:..|....:.|...:...   :|..:|.|...:.|..|.|....
Frog   316 ESASWDKEGCSSYSALPEPVSEPGTPTLHMSLCAASSGI---KEEYSPWEEGESVDYSCTLTPEA 377

  Fly   793 ATSLSQQALSASTQSLTSSSPAPDATAAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVPL 857
            ..:....|....|...:.||...:.||:...|.||...   ::|..|.:.:|       ..|.|.
Frog   378 VQTAHTPAPGGPTFHYSRSSGIKEETASRQAGESSEFG---INPPKELIRVP-------DPPTPT 432

  Fly   858 --PLSSSTRISPAQGAEANGA-------EGSSSDDLLPDADTITNVSGFLSSQQLHHLIELFERE 913
              |.:.|..|..:...:...|       :.:||.|.:..|||..:::.:..:.:|        .:
Frog   433 IRPTNQSPTIYKSHVIKVESASWGERPLDYNSSTDPIEAADTSAHITRYPLNNRL--------SD 489

  Fly   914 QITLDILAEMGHDDLKQVGVSA-YGFRHKIL---KGIAQLRSTTGIGNNVNLCTLLVDLLPDDKE 974
            ....|..||:....|....|:| |.:..:..   .|.|:.|.|                 |..|:
Frog   490 MEFSDCAAELTRVQLSAPAVAAMYSYAEQPYPSHAGPARHRRT-----------------PKGKK 537

  Fly   975 -FVAVEEEMQATIREHRDNGQAGGYFTRYNIIRVQKVQNRKLWERYAHR---RQEIAEENFLQSN 1035
             |..:|               .|..|||...:         |..:.:||   |...||..
Frog   538 LFTCLE---------------CGKCFTRNTTL---------LSHQRSHREGMRLTCAECG----- 573

  Fly  1036 ERMLFHGSPFINAIVQRGFDERHAYIGGMFGA----GIYFAEHSSKSN-QYVY---------GIG 1086
              :.|   |..:::|    ..:..:.||...|    |:.||.:||..| |.|:         ..|
Frog   574 --LCF---PRYSSLV----SHQQIHTGGKAFACSECGLCFARYSSLLNHQKVHPGEKPFACSECG 629

  Fly  1087 GGIGCPS--------HKDKSCYVCPRQLLLCRVALGKSFLQYSAM---KMAHAPPGHHSVVGR-- 1138
            .|....|        |..:..|.||.    |    ||.|.:.:|:   ..|||       :|:
Frog   630 KGFSRNSNLVRHKRMHTGEKPYSCPE----C----GKCFTRNAALIKHLTAHA-------LGKLF 679

  Fly  1139 -PSAGGLHFAEYVV-------YRGEQSYP 1159
             .|..||.|.....       :.|.|.||
Frog   680 ACSQCGLCFTRSATLLSHQKSHAGGQPYP 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125
		ANK repeat	59..87	CDD:293786
		Ank_2	61..153	CDD:289560
		ANK repeat	89..120	CDD:293786
		ANK repeat	122..153	CDD:293786
		ANK	202..316	CDD:238125
		ANK repeat	212..240	CDD:293786
		Ank_2	214..306	CDD:289560
		ANK repeat	242..273	CDD:293786
		ANK repeat	275..306	CDD:293786
		ANK	361..478	CDD:238125
		ANK repeat	363..396	CDD:293786
		Ank_2	367..459	CDD:289560
		ANK	393..573	CDD:238125	2/7 (29%)
		ANK repeat	398..429	CDD:293786
		ANK repeat	431..459	CDD:293786
		ANK repeat	483..515	CDD:293786
		Ank_4	486..540	CDD:290365
		ANK	512..637	CDD:238125	16/97 (16%)
		ANK repeat	522..550	CDD:293786
		Ank_2	524..616	CDD:289560	12/76 (16%)
		ANK repeat	552..583	CDD:293786	5/33 (15%)
		ANK repeat	585..610	CDD:293786	6/34 (18%)
		ANK repeat	638..668	CDD:293786	4/29 (14%)
		Ank_4	641..693	CDD:290365	7/51 (14%)
		ANK	665..779	CDD:238125	18/119 (15%)
		ANK repeat	672..703	CDD:293786	5/30 (17%)
		Ank_2	677..769	CDD:289560	14/97 (14%)
		ANK repeat	705..736	CDD:293786	4/30 (13%)
		ANK repeat	738..769	CDD:293786	5/36 (14%)
		SAM_tankyrase1,2	887..952	CDD:188923	14/68 (21%)
		SAM	890..952	CDD:197735	12/65 (18%)
		tankyrase_like	948..1170	CDD:238718	54/251 (22%)
		PARP	961..1165	CDD:279038	52/238 (22%)
LOC100490559	XP_031750905.1	zf-C2H2	539..561	CDD:395048	7/45 (16%)
		C2H2 Zn finger	541..559	CDD:275368	6/41 (15%)
		C2H2 Zn finger	569..589	CDD:275368	5/33 (15%)
		COG5048	<597..744	CDD:227381	32/127 (25%)
		C2H2 Zn finger	597..617	CDD:275368	7/19 (37%)
		C2H2 Zn finger	625..645	CDD:275368	3/19 (16%)
		zf-H2C2_2	637..662	CDD:404364	8/32 (25%)
		C2H2 Zn finger	653..673	CDD:275368	7/27 (26%)
		C2H2 Zn finger	681..701	CDD:275368	4/19 (21%)
		C2H2 Zn finger	709..729	CDD:275368	129/679 (19%)
		C2H2 Zn finger	737..757	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1115202at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010