DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and LOC100487727

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_031756415.1	Gene:	LOC100487727 / 100487727	-ID:	-	Length:	908	Species:	Xenopus tropicalis

Alignment Length:	1035	Identity:	225/1035 - (21%)
Similarity:	377/1035 - (36%)	Gaps:	263/1035 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 RKSTPLHFAAG--------YGRREVVEFLLNSGASIQACDEGGLHPLHNCCSFGHAEVVRLLLKA 112
            |::..:.||.|        .|.|:.|..||.:||.|...:..||..||..|...:.|:|:.|::.
Frog    38 RRAARVRFAQGAVFMAACSAGDRDEVRELLAAGAPINGTNVDGLTALHQACIDENIEMVQFLVEN 102

  Fly   113 GASPNTTDNWNYTPLHEAASKGKVDVCLALLQHGANHTIRNSEQKTPLELADE-ATRPVLTGEYR 176
            |::.|..||..:||||.|||.|.|.:...|:.:||:....|||.:.||:::.| |...:|..|.:
Frog   103 GSNVNQPDNEGWTPLHAAASCGFVSIAQFLITNGASVAAVNSEGELPLDVSHESAMEKLLKSEVK 167

  Fly   177 KDEL-LEAARSGAEDRLLALLTPLNVNC-HASDGRRSTPLHLAAGYNRIGIVEILLANGADVHAK 239
            |..: .:.||...|:.:|..:... :|| .|.|.|..|.
Frog   168 KQGVDADVARREEEEVMLRDVRHW-LNCGKAEDVRHPTT-------------------------- 205

  Fly   240 DKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPLHEAASKSRVEVCSLLLSRGADPTL 304
               |...||.|.:.|:.:|.:||:|.|.:|:|.|...:||||.||...:.|.|.||
Frog   206 ---GATTLHVASAKGYNEVIRLLLQLGFDVDARDFDGWTPLHAAAHWGQEEACRLL--------- 258

  Fly   305 LNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSRAKKLVCAEIVNFVHPYTGDTPLHL 369
                    ::|.                        ||:         ||:|.|    |.|.:.:
Frog   259 --------VEAL------------------------CDM---------EIINKV----GQTAMDV 278

  Fly   370 AVVSPDGKRKQLMELLTRKGSLLN-EKNKAFLTPLHLAAELLHYDAMEVLLKQGAKVNALDSLGQ 433
            |    |...:.::|.|..|.|:|. ||.|.               |.:::.:.....||.:...:
Frog   279 A----DDSLESVLEKLKDKQSVLRLEKKKM---------------APQIMNQTSLNQNAANKSRR 324

  Fly   434 TPLHRCARDEQ-AVRL--LLSYAADTNIVSLEGLTAAQLASDSVLKLLKNPPDSETHLLEA-AKA 494
            :.:.|.:..|: |:|:  ....|.....|.|..:..| :.||:     ::..|:|:..::| .:.
Frog   325 SSISRMSSQEKVALRVQDKERRAQPPPPVGLPSIPTA-VGSDA-----ESGSDTESQKVKAQERI 383

  Fly   495 GDLDTVRRIVLNNPISVNCRDL-DGRHSTPLHFAAGFNRVPVVQF----LLEHGAEVYAADKGGL 554
            .:|:...| .|..|.:.....| |...|.|   |:|..|..:.:.    .|..|.   |.::|..
Frog   384 NNLNNQLR-NLPEPAAKKTSSLQDQEKSEP---ASGSWRASLRKTGSTGALSTGT---APEEGRR 441

  Fly   555 VPLHNACSYGHYEVTELLVKHGANVNVSDLWKFTPLHEAAAKGKYDICKLLLKHGADPMKK---N 616
            ..|..:.|.......|   |.|:.:.::.:                          .|.:|   |
Frog   442 AALPKSASSSQLSERE---KAGSELRLARV--------------------------PPNQKLFSN 477

  Fly   617 RDGATPADLVKES--------DHDVAELLRGPSALLDAAKKGNLARVQRLVTPESINCRDAQGRN 673
            ::.|....|.:.|        :..::.|.|.....| |.|..|....:.|:||:.    :|...|
Frog   478 QENARDTVLGQRSYLRQRTDGEDSISSLRRQRGETL-ANKTENSIPRRELLTPKP----EAPVPN 537

  Fly   674 STPLHLAAGYNNFECAEYLLENGADVNAQDKGGLIPLHNAS------SYGHLDIAALLIKHKTVV 732
            .||: .|...|.....:.|.......||... ..:|:.|..      ||
Frog   538 KTPI-AAKEENQISTPDALGRRTGTTNAITT-NTVPVVNTETKERRRSY---------------- 584

  Fly   733 NATDKWGFTPLH----EAAQKGRTQLCSLLLAHGADAYMKNQEGQTPIELATADDVKCLLQDAMA 793
                   .||:.    ||.:|.|::       |...: .::.:|.|..:|..|:.|....||...
Frog   585 -------LTPVRDEEAEAQRKARSR-------HARQS-RRSTQGVTLTDLKEAEKVMKGQQDNKE 634

  Fly   794 TSLSQQALSASTQSLTSSSPAPDAT--AAAAPGTSSSSSSAILSPTTETVLLPTGASMILSVPVP 856
            ...:.:.:.|..:.....|.....|  .|:..||..|..:.|.|       |.....:.|:.|..
Frog   635 AEATPEPVKAQEEETNRESQVKARTGRGASEEGTEVSWRARIAS-------LQKSDLLGLTTPDS 692

  Fly   857 LPLSSST--RISPAQGAEANGAEGSSSDDLLPDADTITNVSGFLSSQQLHHL-----IELFEREQ 914
            .|.||.:  |.:..|..|:...:.|..|:...|.....|.:|....::....     :.|..|:.
Frog   693 APTSSGSHRRTTGGQSLESKEMQKSQEDEKESDEKGGKNKAGVKDRRRPRGKRRSTGVPLTTRDS 757

  Fly   915 ITLDILAEMGHDDLKQVGVSAYGFRHKILKGIAQLRSTTGIGNNVNLCTLLVDLLPDDKEFVAVE 979
            ...|...|.|:.:..|..|...     :.:..::..:.|.:....:|.:    ...|.::|..:.
Frog   758 DEEDSEDEEGNGESTQTQVDGL-----VSRADSRFHTRTTVQGEPSLAS----EYRDTRDFKKLY 813

  Fly   980 EEMQATIREHRDNGQAGGYFTRYNIIRVQKVQN--RKLWERYAHRRQEIAEENFLQSNER 1037
            ||:.      ||||:     .|..::..|.:.|  :...||...|::...:.:||...|:
Frog   814 EELM------RDNGR-----LRSQLLNTQNLVNETKAELERAQQRQERSVDRSFLIDTEK 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	41/114 (36%)
		ANK repeat	59..87	CDD:293786	11/35 (31%)
		Ank_2	61..153	CDD:289560	35/99 (35%)
		ANK repeat	89..120	CDD:293786	10/30 (33%)
		ANK repeat	122..153	CDD:293786	12/30 (40%)
		ANK	202..316	CDD:238125	29/114 (25%)
		ANK repeat	212..240	CDD:293786	1/27 (4%)
		Ank_2	214..306	CDD:289560	23/91 (25%)
		ANK repeat	242..273	CDD:293786	12/30 (40%)
		ANK repeat	275..306	CDD:293786	10/30 (33%)
		ANK	361..478	CDD:238125	25/120 (21%)
		ANK repeat	363..396	CDD:293786	10/33 (30%)
		Ank_2	367..459	CDD:289560	18/95 (19%)
		ANK	393..573	CDD:238125	37/189 (20%)
		ANK repeat	398..429	CDD:293786	3/30 (10%)
		ANK repeat	431..459	CDD:293786	5/30 (17%)
		ANK repeat	483..515	CDD:293786	7/32 (22%)
		Ank_4	486..540	CDD:290365	12/59 (20%)
		ANK	512..637	CDD:238125	22/140 (16%)
		ANK repeat	522..550	CDD:293786	7/31 (23%)
		Ank_2	524..616	CDD:289560	14/98 (14%)
		ANK repeat	552..583	CDD:293786	6/30 (20%)
		ANK repeat	585..610	CDD:293786	0/24 (0%)
		ANK repeat	638..668	CDD:293786	8/29 (28%)
		Ank_4	641..693	CDD:290365	13/51 (25%)
		ANK	665..779	CDD:238125	22/123 (18%)
		ANK repeat	672..703	CDD:293786	8/30 (27%)
		Ank_2	677..769	CDD:289560	16/101 (16%)
		ANK repeat	705..736	CDD:293786	4/36 (11%)
		ANK repeat	738..769	CDD:293786	7/34 (21%)
		SAM_tankyrase1,2	887..952	CDD:188923	10/69 (14%)
		SAM	890..952	CDD:197735	9/66 (14%)
		tankyrase_like	948..1170	CDD:238718	19/92 (21%)
		PARP	961..1165	CDD:279038	18/79 (23%)
LOC100487727	XP_031756415.1	PHA03095	50..>279	CDD:222980	84/312 (27%)
		ANK repeat	51..77	CDD:293786	8/25 (32%)
		ANK repeat	79..110	CDD:293786	10/30 (33%)
		ANK repeat	112..143	CDD:293786	12/30 (40%)
		ANK repeat	145..236	CDD:293786	30/120 (25%)
		ANK repeat	238..269	CDD:293786	15/80 (19%)
		IPD_PPP1R12	575..624	CDD:424067	13/79 (16%)
		PRKG1_interact	808..907	CDD:406350	16/66 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910