DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tnks and Ankdd1a

DIOPT Version :9

Sequence 1:	NP_001262963.1	Gene:	Tnks / 43095	FlyBaseID:	FBgn0027508	Length:	1520	Species:	Drosophila melanogaster
Sequence 2:	XP_006243362.1	Gene:	Ankdd1a / 100362785	RGDID:	1586052	Length:	509	Species:	Rattus norvegicus

Alignment Length:	681	Identity:	155/681 - (22%)
Similarity:	222/681 - (32%)	Gaps:	266/681 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PL-RELFEACKTGEIAKVKKLITPQ-TVNARDTAGRKSTPLHFAAGYGRREVVEFLLNSGASIQA 85
            || |:|.||.:..::.|:|:|:..: .:.||:..||  ..||:|||.|..:.|..||..||::..
  Rat    14 PLERQLHEASRNNQVGKMKELLGKRVNIRARNHVGR--VALHWAAGGGHEQAVRLLLEHGAAVDD 76

  Fly    86 CDEGGLHPLHNCCSFGHAEVVRLLLKAGASPNTTDNWNYTPLHEAASKGKVDVCLALLQHGANHT 150
            .|..|:..|.....|||.::|::|:.|||..:.......|.||.||.||.:.|...:::
  Rat    77 VDSFGMTALLLSAWFGHLQIVQILVNAGARVHWESKDGLTLLHCAAQKGHMPVLAFIME------ 135

  Fly   151 IRNSEQKTPLELADEATRPVLTGEYRKDELLEAARSGAEDRLLALLTPLNVNCHASDGRRSTPLH 215
                      :|.|.|              |:.|     |:|               ||  |..|
  Rat   136 ----------DLEDVA--------------LDHA-----DKL---------------GR--TAFH 154

  Fly   216 LAAGYNRIGIVEILLANGADVHAKDKGGLVPLHNACSYGHFDVTKLLIQAGANVNANDLWAFTPL 280
            .||.:.::..::.|:.:|.|...|||.|...||.|.|.||.||.:.|:..|
  Rat   155 RAAEHGQLDALDFLVGSGCDHSVKDKDGNTALHLAASQGHMDVLQRLVDIG-------------- 205

  Fly   281 HEAASKSRVEVCSLLLSRGADPTLLNCHSKSAIDAAPTRELRERIAFEYKGHCLLDACRKCDVSR 345
                                                                  ||
  Rat   206 ------------------------------------------------------LD--------- 207

  Fly   346 AKKLVCAEIVNFVHPYTGDTPLHLAVVSPDGKRKQLMELLTRKGSLLNEKNKAFLTPLHLAAELL 410
                                                          |.|:|...||.||.|||.:
  Rat   208 ----------------------------------------------LEEQNTEGLTALHAAAEGI 226

  Fly   411 HYDAMEVLLKQGAKVNALDSLGQTPLHRCAR--DEQAVRLLLSYAADTNIVSLEGLTAAQLASDS 473
            |.|.:..||..|:.||||...|.:..|..||  .|...|.|:.....|::...:|.|...||
  Rat   227 HADCVVFLLSAGSNVNALTQKGLSCFHYAARSGSEDMSRALVKAGGRTDVADKQGTTPMHLA--- 288

  Fly   474 VLKLLKNPPDSETHLLEAAKAGDLDTVRRIVLNNPISVNCRDLDGRHSTPLHFAAGFNRVPVVQF 538
               :..|.|.....|:||  ..|||.                :|.|..||||.||......|.:.
  Rat   289 ---VKHNFPGLVQLLIEA--HSDLDA----------------MDIRQQTPLHLAAEHAWQDVAEM 332

  Fly   539 LLEHGAEVYAADKGGLVPLHNACSYGHYEVTELLVK----------HGANVNVSDL--------- 584
            ||..||::...||.|...|..|....|..:.::::|          |.:..:.|||
  Rat   333 LLIAGADLSLRDKQGKTALAVAARSNHISLVDMIIKADRFYRWEKDHLSCRDDSDLSRKNLTFKQ 397

  Fly   585 --------------------------------WKFTPLHEAAAKGKYDICK----------LLLK 607
                                            |:||..|..|.:.::...:          |:..
  Rat   398 DHRQETQQLRSVLWRLASRYLRPNEWKKLAYSWQFTEAHVCAIEQQWTGTRSYQEHGHRMLLIWL 462

  Fly   608 HGADPMKKNRDGATPADLVKESDHDVAELLR 638
            ||.....||...|...||:.....|:||..|
  Rat   463 HGVATAGKNPSKALFEDLMAIGRRDLAESTR 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tnks	NP_001262963.1	ANK	49..163	CDD:238125	34/113 (30%)
		ANK repeat	59..87	CDD:293786	11/27 (41%)
		Ank_2	61..153	CDD:289560	30/91 (33%)
		ANK repeat	89..120	CDD:293786	10/30 (33%)
		ANK repeat	122..153	CDD:293786	8/30 (27%)
		ANK	202..316	CDD:238125	23/113 (20%)
		ANK repeat	212..240	CDD:293786	7/27 (26%)
		Ank_2	214..306	CDD:289560	20/91 (22%)
		ANK repeat	242..273	CDD:293786	11/30 (37%)
		ANK repeat	275..306	CDD:293786	0/30 (0%)
		ANK	361..478	CDD:238125	31/118 (26%)
		ANK repeat	363..396	CDD:293786	2/32 (6%)
		Ank_2	367..459	CDD:289560	27/93 (29%)
		ANK	393..573	CDD:238125	57/181 (31%)
		ANK repeat	398..429	CDD:293786	15/30 (50%)
		ANK repeat	431..459	CDD:293786	8/29 (28%)
		ANK repeat	483..515	CDD:293786	6/31 (19%)
		Ank_4	486..540	CDD:290365	15/53 (28%)
		ANK	512..637	CDD:238125	40/185 (22%)
		ANK repeat	522..550	CDD:293786	11/27 (41%)
		Ank_2	524..616	CDD:289560	28/152 (18%)
		ANK repeat	552..583	CDD:293786	6/40 (15%)
		ANK repeat	585..610	CDD:293786	7/34 (21%)
		ANK repeat	638..668	CDD:293786	1/1 (100%)
		Ank_4	641..693	CDD:290365
		ANK	665..779	CDD:238125
		ANK repeat	672..703	CDD:293786
		Ank_2	677..769	CDD:289560
		ANK repeat	705..736	CDD:293786
		ANK repeat	738..769	CDD:293786
		SAM_tankyrase1,2	887..952	CDD:188923
		SAM	890..952	CDD:197735
		tankyrase_like	948..1170	CDD:238718
		PARP	961..1165	CDD:279038
Ankdd1a	XP_006243362.1	Ank_2	19..108	CDD:289560	32/90 (36%)
		ANK repeat	19..45	CDD:293786	7/25 (28%)
		ANK	43..169	CDD:238125	47/179 (26%)
		ANK repeat	47..78	CDD:293786	13/32 (41%)
		ANK repeat	80..110	CDD:293786	10/29 (34%)
		ANK	112..235	CDD:238125	52/297 (18%)
		ANK repeat	113..146	CDD:293786	13/67 (19%)
		Ank_4	114..169	CDD:290365	21/106 (20%)
		ANK repeat	149..179	CDD:293786	9/31 (29%)
		Ank_2	153..243	CDD:289560	38/212 (18%)
		ANK	178..301	CDD:238125	49/251 (20%)
		ANK repeat	181..212	CDD:293786	15/153 (10%)
		ANK repeat	214..245	CDD:293786	15/30 (50%)
		ANK	242..367	CDD:238125	42/148 (28%)
		ANK repeat	247..278	CDD:293786	8/30 (27%)
		Ank_2	252..344	CDD:289560	32/115 (28%)
		ANK repeat	280..311	CDD:293786	12/54 (22%)
		ANK repeat	313..344	CDD:293786	12/30 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900