Protein Alignment Ssadh and ALDH1A2

DIOPT Version :10

• Sequence 1: NP_651408.1
• Gene: Ssadh / 43092
• FlyBaseID: FBgn0039349
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_003879.2
• Gene: ALDH1A2 / 8854
• HGNCID: 15472
• Length: 518
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 161/481 - (33%)
• Similarity: 259/481 - (53%)
• Gaps: 19/481 - (3%)

  Fly    30 KALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYE-SKEWRSLTAKDR 93
            |..::..|.:|.:.: .|.|.|||.|..:.:|.....||..||:.||:.|:. ...||.:.|.:|
Human    39 KIFINNEWQNSESGR-VFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASER 102

  Fly    94 SNLLKKWHKLIEQHSQEIAEIMTAESGKPINES-----KGEVAYGNAFVEWFAEEARRIYGEIVP 153
            ..||.|...|:|:....:|.:.:...|||..::     :|.:.....:..|    |.:|:|..:|
Human   103 GRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW----ADKIHGMTIP 163

  Fly   154 SASPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAV 218
             ...:.......:||||...|.|||||:.|...|...||..|.|||:||:|.|||:||.:..|..
Human   164 -VDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIK 227

  Fly   219 DAGIPKGVINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSADG---IKRICLELGG 280
            :||.|.||||:: .......|........:..|:||||||||||:  ..|.|   :||:.|||||
Human   228 EAGFPPGVINIL-PGYGPTAGAAIASHIGIDKIAFTGSTEVGKLI--QEAAGRSNLKRVTLELGG 289

  Fly   281 NAPFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQG 345
            .:|.|:|..||::.||:.|....|.|.||.|.:.:|.||::|:|::||.:..:|.:...:|....
Human   290 KSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFD 354

  Fly   346 CDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEV 410
            ...:.||.|::.|:||:...::...::.|.:..||:.|..|| .|..||:.::|....::..||:
Human   355 PTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG-FFIEPTVFSNVTDDMRIAKEEI 418

  Fly   411 FGPVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAPF 475
            ||||..|:||:..:|.:::||::..||....::.::.:...|:..::.|.|.:|......|::||
Human   419 FGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPF 483

  Fly   476 GGVKESGVGREGSKHGIDDYVDIKYI 501
            ||.|.||.|||..:.|:.:|.::|.:
Human   484 GGFKMSGNGREMGEFGLREYSEVKTV 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_651408.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	157/462 (34%)
ALDH1A2	NP_003879.2	ALDH_F1AB_F2_RALDH1	32..512	CDD:143459	161/481 (33%)