Protein Alignment Ssadh and ALDH4A1

DIOPT Version :9

• Sequence 1: NP_001014665.1
• Gene: Ssadh / 43092
• FlyBaseID: FBgn0039349
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_003739.2
• Gene: ALDH4A1 / 8659
• HGNCID: 406
• Length: 563
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 141/499 - (28%)
• Similarity: 228/499 - (45%)
• Gaps: 45/499 - (9%)

  Fly    19 RMRGFSALVQDKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVAD---AQKAIDAAKQAY 80
            ||.....:|.|:.:    |    .:...::| :|.|..  .||.....||   ..|||:||..|
Human    60 RMEAIPCVVGDEEV----W----TSDVQYQV-SPFNHG--HKVAKFCYADKSLLNKAIEAALAA- 112

  Fly    81 ESKEWRSLTAKDRSNLLKKWHKLIE--QHSQEIAEIMTAESGKPINESKGEVAYGNAFVEWF--- 140
             .|||......||:.:..|...::.  :.::.:|:.|..: ||.:.::  |:......:::|
Human   113 -RKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQ-GKTVIQA--EIDAAAELIDFFRFN 173

  Fly   141 AEEARRIYGEIVPSASPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSED 205
            |:.|..:.|:...|..|:....|.:...|..|.|:|:|| .|:....|||....|..|:.|||:.
Human   174 AKYAVELEGQQPISVPPSTNSTVYRGLEGFVAAISPFNF-TAIGGNLAGAPALMGNVVLWKPSDT 237

  Fly   206 TPLTALAVAKLAVDAGIPKGVINVVTTNKAAPI-GDLFCKSPDVRGISFTGSTEVGKLLFRNSAD 269
            ..|.:.||.::..:||:|..:|..|..:  .|: ||....|..:.||:||||....|.|::..|.
Human   238 AMLASYAVYRILREAGLPPNIIQFVPAD--GPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQ 300

  Fly   270 GI------KRICLELGGNAPFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFV 328
            .:      .|:..|.||.....|..|||:|..|.|.:.|.|...||.|.:.:|.:|..|::.:..
Human   301 NLDRFHTFPRLAGECGGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIK 365

  Fly   329 GQLKKRVEALKIGD-GQGCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYA 392
            |:|.:....:|:|| .:........:|:...|.::..::|.|||..:..||.|....|....|..
Human   366 GRLLEEHSRIKVGDPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVE 430

  Fly   393 PTIVTDVPPSAQLYSEEVFGPVVSIIRFRDE--EEAVKKANDTRR-GLAGYFYSENLQQVFRVAK 454
            |.||....|...:..||:||||:|:..:.|:  :|.::..:.|.. ||.|..:|::...|....|
Human   431 PCIVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATK 495

  Fly   455 --RLEVGMVGVNE---GIISAAEAPFGGVKESGVG-REGSKHGI 492
              |...|...:|:   |.| ..:.||||.:.||.. :.|..|.|
Human   496 VLRNAAGNFYINDKSTGSI-VGQQPFGGARASGTNDKPGGPHYI 538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	136/469 (29%)
ALDH4A1	NP_003739.2	ALDH_F4-17_P5CDH	32..553	CDD:143441	141/499 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810