DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and ALD6

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_015264.1	Gene:	ALD6 / 856044	SGDID:	S000005982	Length:	500	Species:	Saccharomyces cerevisiae

Alignment Length:	474	Identity:	155/474 - (32%)
Similarity:	255/474 - (53%)	Gaps:	11/474 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 GAWVDSSNAKA----TFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAKDRSN 95
            |.::::...||    |:.|.:|:....:.:|.:.|..|.:.||:.|.:|:...||.:...::|..
Yeast    27 GLFINNKFMKAQDGKTYPVEDPSTENTVCEVSSATTEDVEYAIECADRAFHDTEWATQDPRERGR 91

  Fly    96 LLKKWHKLIEQHSQEIAEIMTAESGKPINESKGEVAYGNAFVEWFAEEARRIYGEIVPSASPNRE 160
            ||.|....:|.....::.|...::||.:..::|:|......:...|..|.::.|..:.:......
Yeast    92 LLSKLADELESQIDLVSSIEALDNGKTLALARGDVTIAINCLRDAAAYADKVNGRTINTGDGYMN 156

  Fly   161 IIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAVDAGIPKG 225
            ...: :||||...|.|||||:.|:..|...|||.|...::||:..|||.||..|.|....|||.|
Yeast   157 FTTL-EPIGVCGQIIPWNFPIMMLAWKIAPALAMGNVCILKPAAVTPLNALYFASLCKKVGIPAG 220

  Fly   226 VINVVTTNKAAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSAD-GIKRICLELGGNAPFIVFDS 289
            |:|:| ......:|......|.:|.::|||||||||.:..:|:: .:|:|.|||||.:..:|||.
Yeast   221 VVNIV-PGPGRTVGAALTNDPRIRKLAFTGSTEVGKSVAVDSSESNLKKITLELGGKSAHLVFDD 284

  Fly   290 ADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEA-LKIGDG-QGCDVQIGP 352
            |:|:|.:...:...|:|.||.|.|.:|.:||:.:||:.:...|..:|. :|:|:. ...:.| |.
Yeast   285 ANIKKTLPNLVNGIFKNAGQICSSGSRIYVQEGIYDELLAAFKAYLETEIKVGNPFDKANFQ-GA 348

  Fly   353 LINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFGPVVSI 417
            :.|..||:.:..:::..:.:.|.|:.||:.:.||| .|..||:..||....::..||:|||||::
Yeast   349 ITNRQQFDTIMNYIDIGKKEGAKILTGGEKVGDKG-YFIRPTVFYDVNEDMRIVKEEIFGPVVTV 412

  Fly   418 IRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAPFGGVKESG 482
            .:|:..||.|:.||.:..||.....:|:|....:|||.|:.|.|.:|......:..||||||:||
Yeast   413 AKFKTLEEGVEMANSSEFGLGSGIETESLSTGLKVAKMLKAGTVWINTYNDFDSRVPFGGVKQSG 477

  Fly   483 VGREGSKHGIDDYVDIKYI 501
            .|||..:.....|.::|.:
Yeast   478 YGREMGEEVYHAYTEVKAV 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	151/456 (33%)
ALD6	NP_015264.1	ALDH_F1-2_Ald2-like	23..498	CDD:143410	155/474 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810