DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and UGA2

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_009560.1	Gene:	UGA2 / 852291	SGDID:	S000000210	Length:	497	Species:	Saccharomyces cerevisiae

Alignment Length:	482	Identity:	218/482 - (45%)
Similarity:	311/482 - (64%)	Gaps:	5/482 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LVQDKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTA 90
            |.::...:||.||..::  ..|||.:||:|.:|.:||...|:..::|||.|.:.:  |.:::.|.
Yeast    16 LFRESGYIDGKWVKGTD--EVFEVVDPASGEIIARVPEQPVSVVEEAIDVAYETF--KTYKNTTP 76

  Fly    91 KDRSNLLKKWHKLIEQHSQEIAEIMTAESGKPINESKGEVAYGNAFVEWFAEEARRIYGEIVPSA 155
            ::|:..|:..:.|:.::..::|.|:|.|:||.:.|:|||:.|..::.||:||||.|:||..:...
Yeast    77 RERAKWLRNMYNLMLENLDDLATIITLENGKALGEAKGEIKYAASYFEWYAEEAPRLYGATIQPL 141

  Fly   156 SPNREIIVMKQPIGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAKLAVDA 220
            :|:..:..::||:||..:|.|||||.|||||||.||||.|||||:||...|||:|||:|.||..|
Yeast   142 NPHNRVFTIRQPVGVCGIICPWNFPSAMITRKAAAALAVGCTVVIKPDSQTPLSALAMAYLAEKA 206

  Fly   221 GIPKGVINVVTTNKAAP-IGDLFCKSPDVRGISFTGSTEVGKLLFRNSADGIKRICLELGGNAPF 284
            |.|||..||:.::...| :|...|:||.|:.::|||||.|||:|.:.|:..:|::..||||||||
Yeast   207 GFPKGSFNVILSHANTPKLGKTLCESPKVKKVTFTGSTNVGKILMKQSSSTLKKLSFELGGNAPF 271

  Fly   285 IVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALKIGDGQGCDVQ 349
            |||:.||:::|::.|||.|||..|||||.|||.:|..|:.|||...|.:||:...||.|......
Yeast   272 IVFEDADLDQALEQAMACKFRGLGQTCVCANRLYVHSSIIDKFAKLLAERVKKFVIGHGLDPKTT 336

  Fly   350 IGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFGPV 414
            .|.:||.....||....:||..|.|.::|.|..|.:.|..||||.|::.||.:|.:..||.|||:
Yeast   337 HGCVINSSAIEKVERHKQDAIDKGAKVVLEGGRLTELGPNFYAPVILSHVPSTAIVSKEETFGPL 401

  Fly   415 VSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEAPFGGVK 479
            ..|..|...||.|..||||..|||.|.:|:|:..::.|::.||.|||..|.|:.|....||||||
Yeast   402 CPIFSFDTMEEVVGYANDTEFGLAAYVFSKNVNTLYTVSEALETGMVSCNTGVFSDCSIPFGGVK 466

  Fly   480 ESGVGREGSKHGIDDYVDIKYICMGNL 506
            |||.|||||.:||:||..:|.|.:|||
Yeast   467 ESGFGREGSLYGIEDYTVLKTITIGNL 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	208/454 (46%)
UGA2	NP_009560.1	SSADH	37..486	CDD:188167	206/450 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343989
Domainoid	1	1.000	416	1.000	Domainoid score	I78
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H840
Inparanoid	1	1.050	429	1.000	Inparanoid score	I277
Isobase	1	0.950	-	0.930827	Normalized mean entropy	S643
OMA	1	1.010	-	-		QHG63174
OrthoFinder	1	1.000	-	-		FOG0003728
OrthoInspector	1	1.000	-	-		oto99168
orthoMCL	1	0.900	-	-		OOG6_102015
Panther	1	1.100	-	-	LDO	PTHR43353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1397
SonicParanoid	1	1.000	-	-		X2584
TreeFam	1	0.960	-	-
	15	14.740