DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and ALDH5A1

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_733936.1	Gene:	ALDH5A1 / 7915	HGNCID:	408	Length:	548	Species:	Homo sapiens

Alignment Length:	553	Identity:	267/553 - (48%)
Similarity:	364/553 - (65%)	Gaps:	56/553 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWRQLSGVARTGSSLSLCRMR---------------------------GFS-ALVQDKALVDGAW 37
            :|.:..|..|.||:...||:|                           |.| ||::..:.|.|.|
Human     5 IWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRW 69

  Fly    38 VDSSNAKATFEVRNPANGAVIGKVPNMTVADAQKAIDAAKQAYESKEWRSLTAKDRSNLLKKWHK 102
            :.   |.|||.|::||:||.:|.|.:..|.:|:.|:.||.:|:  ..||.::||:||:||:||:.
Human    70 LP---AAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAF--CRWREVSAKERSSLLRKWYN 129

  Fly   103 LIEQHSQEIAEIMTAESGKPINESKGEVAYGNAFVEWFAEEARRIYGEIVPSASPNREIIVMKQP 167
            |:.|:..::|.|:|||||||:.|:.||:.|...|:|||:|||||:||:|:.:.:.:|..:|:|||
Human   130 LMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQP 194

  Fly   168 IGVAALITPWNFPMAMITRKAGAALAAGCTVVVKPSEDTPLTALAVAK-------------LAVD 219
            |||||:|||||||.||||||.||||||||||||||:||||.:|||:|:             ||..
Human   195 IGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAEVNQGFLLDLDPLLLASQ 259

  Fly   220 AGIPKGVINVVTTNK--AAPIGDLFCKSPDVRGISFTGSTEVGKLLFRNSADGIKRICLELGGNA 282
            ||||.||.||:..::  |..:|:..|..|.|..|||||||..||:|..::|:.:||:.:||||.|
Human   260 AGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLA 324

  Fly   283 PFIVFDSADIEKAVDGAMASKFRNCGQTCVSANRFFVQDSVYDKFVGQLKKRVEALK----IGDG 343
            ||||||||::::||.|||||||||.|||||.:|:|.||..::|.||   |...||:|    :|:|
Human   325 PFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFV---KAFAEAMKKNLRVGNG 386

  Fly   344 QGCDVQIGPLINEMQFNKVSGFVEDARSKKANIILGGQPLPDKGSLFYAPTIVTDVPPSAQLYSE 408
            .......||||||....||...|.||.||.|.::.||: ....|..|:.||::.:|........|
Human   387 FEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGK-RHQLGKNFFEPTLLCNVTQDMLCTHE 450

  Fly   409 EVFGPVVSIIRFRDEEEAVKKANDTRRGLAGYFYSENLQQVFRVAKRLEVGMVGVNEGIISAAEA 473
            |.|||:..:|:|..||||:..||....||||||||::..|::|||::|||||||||||:||:.|.
Human   451 ETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVEC 515

  Fly   474 PFGGVKESGVGREGSKHGIDDYVDIKYICMGNL 506
            ||||||:||:||||||:|||:|:::||:|.|.|
Human   516 PFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	245/472 (52%)
ALDH5A1	NP_733936.1	SSADH	78..541	CDD:188167	243/468 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147757
Domainoid	1	1.000	483	1.000	Domainoid score	I402
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H840
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1382
Isobase	1	0.950	-	0.930827	Normalized mean entropy	S643
OMA	1	1.010	-	-		QHG63174
OrthoDB	1	1.010	-	-		D233411at33208
OrthoFinder	1	1.000	-	-		FOG0003728
OrthoInspector	1	1.000	-	-		oto88842
orthoMCL	1	0.900	-	-		OOG6_102015
Panther	1	1.100	-	-	LDO	PTHR43353
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1397
SonicParanoid	1	1.000	-	-		X2584
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750