DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ssadh and aldh1a3

DIOPT Version :9

Sequence 1:	NP_001014665.1	Gene:	Ssadh / 43092	FlyBaseID:	FBgn0039349	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001038210.1	Gene:	aldh1a3 / 751785	ZFINID:	ZDB-GENE-061128-2	Length:	513	Species:	Danio rerio

Alignment Length:	512	Identity:	178/512 - (34%)
Similarity:	271/512 - (52%)	Gaps:	33/512 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SGVARTGSSLSLCRMRGFSALVQDKALVDGAWVDSSNAKATFEVRNPANGAVIGKVPNMTVADAQ 70
            :|.:|..|...|.:....:.:...|..::..|..||..| .|...|||.|..|..:.....||..
Zfish     9 NGDSRNTSPPPLPQPVKITEIKHTKIFINNEWHTSSKGK-QFPTINPATGVKICDIEEADKADVD 72

  Fly    71 KAIDAAKQA-YESKEWRSLTAKDRSNLLKKWHKLIEQHSQEIAEIMTAESGKPINESKGEVAYGN 134
            :|:.|||.| .....||.:.|..|..||.:...|:|:....:|.:.:.::|||         :.:
Zfish    73 EAVKAAKAAGQRGSVWRRMDASSRGRLLNRLADLLERERAVLATLESKDTGKP---------FLH 128

  Fly   135 AF----------VEWFAEEARRIYGEIVPSASPNREIIVMKQPIGVAALITPWNFPMAMITRKAG 189
            ||          :.::|....:|:|:.:| ...|.......:||||...|.|||||:.|:..|..
Zfish   129 AFFVDLDGSIKTLRYYAGWTDKIHGKTMP-VDENFVCFTKHEPIGVCGAIIPWNFPLLMLMWKIA 192

  Fly   190 AALAAGCTVVVKPSEDTPLTALAVAKLAVDAGIPKGVINVV----TTNKAAPIGDLFCKSPDVRG 250
            .|||.|.|||:||:|.||||||.||.|..:||.|.||:|||    .|..||..|.:     ::..
Zfish   193 PALACGNTVVLKPAEQTPLTALHVAALIKEAGFPPGVVNVVPGFGPTAGAAIAGHM-----NIDK 252

  Fly   251 ISFTGSTEVGKLLFRNSA-DGIKRICLELGGNAPFIVFDSADIEKAVDGAMASKFRNCGQTCVSA 314
            ::||||||||:|:...:| ..:||:.|||||..|.|||..:|::.||:......|.|.||.|.:|
Zfish   253 LAFTGSTEVGQLVKAAAASSNLKRVTLELGGKNPCIVFADSDLQLAVEETQKGAFFNQGQACTAA 317

  Fly   315 NRFFVQDSVYDKFVGQLKKRVEALKIGDGQGCDVQIGPLINEMQFNKVSGFVEDARSKKANIILG 379
            :|.:||:.||::||....:|.:.:.|||........||.|::.||.|:...|:..:.:.|.:..|
Zfish   318 SRVYVQEPVYEEFVRLSVERAKNIVIGDPMEPRTSHGPQIDQHQFEKILALVDSGKKEGAKLEFG 382

  Fly   380 GQPLPDKGSLFYAPTIVTDVPPSAQLYSEEVFGPVVSIIRFRDEEEAVKKANDTRRGLAGYFYSE 444
            |..:.|:| ||..|||.:||....::..||:||||..|::|..:::.:.:||.::.||....::.
Zfish   383 GCAVEDRG-LFIHPTIFSDVKDHMRIAKEEIFGPVQCIMKFECQQDVIDRANSSQFGLTAAVFTR 446

  Fly   445 NLQQVFRVAKRLEVGMVGVNEGIISAAEAPFGGVKESGVGREGSKHGIDDYVDIKYI 501
            ::|:...|:..||.|.|.||......|:.||||.|.||.|||..::.:.:|.::|.|
Zfish   447 DVQRAMSVSAALEAGTVWVNCYNALHAQTPFGGYKMSGNGRELGEYALAEYTEVKAI 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ssadh	NP_001014665.1	ALDH_F5_SSADH_GabD	49..503	CDD:143421	168/469 (36%)
aldh1a3	NP_001038210.1	ALDH_F1AB_F2_RALDH1	28..506	CDD:143459	174/493 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810